• Korean Journal of Psychosomatic Medicine
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• v.8 no.1
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• pp.122-140
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• 2000

Somatization disorder is a chronic condition characterized by multiple somatic complaints that are not due to any apparent organic illness. Somatization disorder is related historically to hysteria and hysteria has been defined by the existence of somatic complaints for which no organic reason can be found. Therefore most theories of somatization have focused on the psychodynamic and sociological perspectives. However, the concept that the somatic presentation of emotional distress or psychiatric illness might have a neurobiological basis has also aroused considerable interest. Relative to this perspective, the case of Anna O. which has been considered the prototype of hysteria, was reformulated from a neuropsychological perspective. Several neurophysiological and neuropsychological studies, studies concerning hemispheric differences in symptom presentation of the patients with hysteria have been shown the evidences for the biological basis of somatization. Moreover, recent neuroimaging studies in somatization disorder also show that brain dysfunction in somatization. The author reviewed several candidate theories which could help to explain the process of somatization in the perspective of biological basis and proposed the new neuropsychological model of somatization. The author also examined the possible application of this model to the treatment of somatization disorder and discussed it's limitation and the future directions in this field.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2001.09a
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• pp.36-36
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• 2001

원충성 질병인 Neospora caninum은 소와 개를 비롯한 여러 동물에서 유ㆍ사산 및 신경증상을 유발하는 질병으로 전 세계적으로 그 피해가 증가하고 있으며, 최근국내에서도 젖소농가를 중심으로 발생보고가 있으나, 한우에 대해서는 거의 역학적조사가 되어있지 않은 바, 본 연구에서는 도축되는 한우, 유ㆍ사산 및 기형송아지를 중심으로 간접형광 항체검사법(IFAT)을 이용한 혈청학적 조사 및 면역조직화학적 방법에 의한 Neospora caninum의 동정을 실시하였다. (중략)

• The Korean Journal of Zoology
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• v.30 no.1
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• pp.29-43
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• 1987

Incilaria fruhstorferi daiseninana의 뇌는 쌍을 이루고 있는 뇌(cerebral), 측(pleural), 노(parietal), 족(pedal)신경절과 단일 복부(abdominal)신경절로 구성되어 있으며, 이들은 융합된 신경고리를 이루고 있었다. 복부신경절로부터 나오는 내장신경은 생식, 장, 심장, 신장신경등으로 분지되어 이들 각 기관에 신경을 공급하고 있었다. 다음 3가지 방법, 즉, 내장신경을 Ni$^2$+로 역방향으로 충진하여 세포체를 염색하는 방법, 형광화합물 Lucifer yellow를 세포내로 주입하는 방법, 세포내활동전위와 내장신경의 세포외 활동전위를 동시에 측정하는 방법으로 적어도 12가지의 동정된 뉴우런이 내장신경과 관련되고 있음을 알았다. 알아낸 각 세포의 전기생리학적인 특성을 검지하고, 이것과 각 세포의 돌기 분지상태와의 관련 및 일부 세포간의 상호관계를 검사하였다. 이들중 8가지 세포가 내장신경에 축색돌기를 내보내는 효과신경세포라는 증거를 얻었다.

• Proceedings of the KSLP Conference
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• 2003.11a
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• pp.174-175
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• 2003

후두기능의 전기생리학적 특징에 대한 관심은 1940년대부터 시작되어 1950년대와 1960년대에는 유럽 및 일본에서 Faborg-Anderson, Hirano 등이 후두근전도의 임상적 적용에 대해서 보고한바 있으며, 1970년대부터는 미국에서도 Bleir, Miller등이 후두근전도의 임상적 역할에 대해 보고하고 있다 이와 같이 후두근전도가 임상에 도입된 지 오래되었고 신경후두학 분야에서 후두근육의 전기생리상태를 알 수 있는 아주 중요한 진단도구이나 아직까지 후두근전도는 양적인 평가가 가능한 표준화된 검사는 아니고 내시경이나 방사선학적 검사처럼 경험이 있는 의사에 의해 판독되어지는 검사로 음성장애가 있는 모든 환자에서 집단검진(screening test)으로 이용될 수 있는 검사도구는 아니다. 후두근전도가 임상에서 유용하게 이용되고 있는 질환은 성대운동 장애와 연축성 음성장애이다. 최근 성대운동 장애에 대한 다양한 수술방법이 개발되면서 수술 방법 및 시기 결정, 예후측정에 후두근전도의 이용이 필수적이 되었으며 또한 연축성 음성장애 환자에서 어떤 후두 근육에 botulinum toxin을 주사할 지를 결정하는 데 이용하고 있다. 이번 강의에서는 위 두 가지 질환을 중심으로 후두근전도의 임상적 유용성을 살펴보기로 하겠다.

• Korean Journal of Psychosomatic Medicine
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• v.5 no.1
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• pp.89-96
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• 1997

This study was designed to determine whether cognitive impairment was evident in patients with SLE. Also, it aimed to examine the association of cognitive impairment with other clinical variables. The subjects consisted of 20 patients with mildly active SLE and 20 healthy controls. Methods : A total of 20 SLE patients and 20 normal controls completed a computerized neuropsychological test battery using Vienna Test System. These included Cognitrone test, Continuous attention test, Corsi block tapping test, Standard progressive matrices. Also, neuro-behavioral cognitive status examination was done. The symptom severity of depression was measured with Beck Depression Inventory, Hamilton Depression Rating Scale, and current medications were documented. Disease activity was rated using the SLE diasease activity index (SLEDAI). Results : SLE patients had poorer performance than normal controls on the tests of Cognitrone, attention, nonverbal IQ and memory, independent of age, education, disease activity, steroid use and depression status. Conclusion : Cognitive dysfunction was not uncommon in ambulatory SLE patients as measured by standardized neuropsychological tests. It seemed to occur independently of various clinical variables. These findings would suggest that cognitive dysfunction in SLE may be explained by reflecting subclinical central nervous system(CNS) involvement, rather than coexisting psychological distress due to chronic illness or side effect of medication.

• Proceedings of the KSLP Conference
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• 1994.06b
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• pp.85-85
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• 1994

본 연구에서는 환자의 쓰기 과제에 있어서 득점에 영향을 주는 요인이 연령차인지 학력 차인지를 검토하였다. 연구대상은 40세 이상의 정상자 162명이며 남성 82명, 여성 80명으로서 다음의 3가지 조건을 갖춘 자로 하였다. 1) 정신·신경학적인 기왕력이 없을 것, 2. 오른손잡이이며, 3. 교육수준은 최저 국민학교 졸업이상인 것 등이다. 검사 항목은 1) 한자 문자의 재현, 2) 한자 단어의 스스로 쓰기, 3) 한자 단어의 받아쓰기 등이며, 검사득점 분석결과 한자의 쓰기 능력 득점에 영향을 주는 것은 학력 차보다는 오히려 연령차이에 의한 영향이 주 요인인 것이 명백하게 되었다. (중략)

• Proceedings of the KSLP Conference
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• 1996.11a
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• pp.88-88
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• 1996

본 연구목적은 한국어판 실어증감별진단검사를 이용하여 2회 이상 경과를 검토할 수 있었던 Broca실어의 3증례에 있어서의 개선경과를 초회평가시의 실어증 중등도가 거의 같은 일본의 장기 관찰예와 비교하여 장애 pattern의 검출 및 개선경과의 추적에 있어서의 한국판 실어증 감별진단검사의 유효성을 검토하였다. 그 결과, 신경학적으로 안정되어있는 실어증환자의 경우 중증도별로 보면, 언어과정 전반의 득점 profile은 유사성이 높았으며, 치료경과에 양국어의 일반성과 특수성이라고 하는 면에서는 금후 한층 더 상세한 토의가 요구되었다.

• Clinical and Experimental Pediatrics
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• v.48 no.10
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• pp.1132-1138
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• 2005

Purpose : The mucopolysaccharidoses (MPSs) are a heterogeneous group of lysosomal storage disorders. They are caused by a deficiency of the enzymes involved in the degradation of glycosaminoglycans. Early recognition is important because recombinant enzyme replacement therapy is now available for MPS. We studied the clinical characteristics of 80 MPS children with the object of determining the epidemiological, clinical and radiological features in Korean MPS children. Methods : Diagnosis of MPS was confirmed by skin fibroblast enzyme analysis in 80 patients between February 1995 and December 2004. Charts were retrospectively reviewed for clinical and radiological findings, as well as for intelligence and speech evaluations. Results : Hunter syndrome (MPS type II) was the most prevalent type, appearing in 51/80 cases (64 %), followed by Sanfilippo syndrome (MPS III-18%), Hurler syndrome (MPS I-15%), and Morquio syndrome (MPS IV-4%). The average age at diagnosis was 5.5 years (range 1 to 20), and the male-to-female ratio was 4.7 : 1. Typical radiographic changes were observed in 45/54 cases (83%). Mitral regurgitation was the most common cardiac defect. Moderate to profound mental retardation and hearing loss were present in 14/35 cases (56%) and 33/38 cases (82%), respectively. Four MPS II patients had bone marrow transplantation, with mixed outcomes. Five MPS I patients are currently on enzyme replacement therapy. Conclusion : Our study showed a high proportion of MPS II cases (64%), which may represent population variability. By studying the clinical features of these patients, we hope to alert pediatricians of the warning signs of MPS.

• Journal of Korean Orthopaedic Sports Medicine
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• v.11 no.2
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• pp.92-95
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• 2012

Iliacus muscle tears are a rare injury seen after the high-energy trauma or as a result of low-energy injuries in patients with a bleeding diathesis as coagulopathy, receiving anticoagulation therapy and hemophiliac. Femoral nerve palsy due to compression from a hematoma by iliacus muscle rupture are rarely reported. Routine evaluation includes MRI to confirm and define the pathologic abnormality supplemented by EMG and nerve conduction studies to evaluate patterns and extent of femoral nerve injury. Hematologic evaluation for bleeding diathesis may preceded, if suspicion of coagulopathy is present. We report the case of a healthy 32-year-old male with iliacus rupture and concomitant femoral nerve palsy sustained by kicking motion during soccer game. After 6 months of observation with non-operative treatment regimen, satisfactory results were obtained, so we report it with a review of the literatures.

• Childhood Kidney Diseases
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• v.1 no.2
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• pp.155-160
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• 1997

Purpose : Tethered cord syndrome is characterized by progressive motor and sensory disturbances in lower extremities, foot deformities caused by a pathologic fixation of spinal cord resulting in excessive stretching of the spinal cord. It is also frequently associated with urological symptoms include urinary frequency, incontinence, enuresis, urgency and recurrent urinary tract infection. Because there is few report in the literature about urological manifestations of theterd cord syndrome, we conducted a retrospective study on the patients diagnosed as tethered cord syndrome to delineate the characteristics of urologic manifestations in tethered cord syndrome and to establish the policy to evaluate patients who is suspected of tethered cord syndrome. Method : A retrospective study was conducted by reviewing the medical records of nine patients who was diagnosed as tethered cord syndrome from November 1991 to July 1996 in Yeungnam University Hospital. Result : 1) The age distribution of nine patients was as follows; 5 patients were under 2 years, 1 case from 2 to 6 years and 3 cases from 6 to 10 years. 2) Of 9 patients 6 had voiding frequency, urinary incontinence, enuresis, urgency and loss of micturation sense. Radiologic urodynamic studies revealed neurogenic bladder in 5 patients, hydronephrosis and hydroureter in 3, vesicoureteral reflux in 3. 3) Of 6 patients with urological abnormal manifestations 4 underwent spinal cord surgery (detethering). In spite of surgical intervention, the urological manifestations improved in only one patient. Conclusion : Urological abnormalities were common in tethered cord syndrome. Abnormal laboratory findings including urodynamic study were found even before the onset of urological symptoms. We have to concern tethered cord syndrome as one of common causes of voiding frequency and enuresis and to evaluate urological abnormalities as thetered cord syndrome is diagnosed.