• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.71-78
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• 2022

Parkinson's disease (PD) is clinically characterized by a variety of motor and non-motor symptoms, including cognitive and neuropsychiatric symptoms. Integrating a large variety of symptoms into a small number of clinical subtypes could be valuable for appropriate and early therapeutic intervention. As a first step toward this aim, this study attempted to identify correlation patterns among motor, cognitive and neuropsychiatric symptoms in PD without dementia. One hundred four non-demented patients with PD underwent a comprehensive motor, neuropsychological, and neuropsychiatric assessments. Factor analysis was performed to identify correlation patterns among demographic, motor, cognitive and neuropsychiatric variables. The eight factors were extracted: 1 motor-related, 3 cognitive-related and 4 neuropsychiatric factors. We indentified that characteristics of correlation can have associated symptom pattern in the disease process of Parkinson's disease. The current results suggest that a broad range of motor and non-motor symptoms in PD may be reducible to a small number of clinical parameters, which may be useful for identifying clinical subtypes of PD for individual patients.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.11a
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• pp.665-667
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• 2012

안면신경마비(facial nerve paralysis)는 주로 편측성으로 발생하는 안면신경장애에 의한 안면표정근의 마비를 뜻한다. 이러한 안면신경마비는 중추성 안면신경마비와 말초성 안면신경마비 두 가지로 나뉜다. 안면신경마비의 증상으로는 이환측, 구각부의 처짐 및 침을 흘리는 등 입 주위의 증상이 있어 안면표정의 변화를 일으킨다.[1] 본 논문은 사진을 입력 받아 얼굴영역에서 입 특징점을 추출하여 입력 받은 데이터가 안면신경마비 환자인지 아닌지 판단하고자 한다.

• Journal of Dental Rehabilitation and Applied Science
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• v.27 no.3
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• pp.327-336
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• 2011

Reported causes of mandibular nerve injury in relation to neuropathic pain in dentistry include extraction, dental implant surgery, oral and maxillofacial surgery, periodontal treatment, and root-canal therapy. This study analyzed the characteristics of pharmacologic management of neuropathy after root-canal therapy. 32 patients who complain of abnormal sensation or pain after root-canal therapy and were referred to Department of Oral Medicine and the Temporomandibular Joint and Orofacial Pain Clinic at the Dental Hospital of Yonsei University, Seoul, Korea from 2004 to 2011 enrolled in this analysis and improvement of symptom was evaluated after pharmacologic management. Thirty-two patients who had hypoesthesia or dysesthesia at the initial visit were analyzed(9 men, 23 women; mean age: 44 years). The causes of neuropathy were local anesthesia(46.9%), chemical trauma from the sealant in root-canal(25%), endodontic surgery(15.6%), and unknown causes(12.5%). Medications such as steroids, anticonvulsants, antidepressants, and analgesics were took for improvement of symptoms and titrated for a variety of period from 1 week to 11 months. It was found that neuropathy of the inferior alveolar nerve and the lingual nerve was in 25 and 7 patients. The improvement of neurosensory disturbance and no improvement after pharmacotherapy was in 21(66%) and 11(34%) patients respectively. The hypoesthesia and dysesthesia was improved 67% and 65% respectively. These results suggest that symptomatic improvement by pharmacologic management can be possible in patients with neuropathy after root-canal therapy. But improvement of symptoms was influenced by the causes and degree of nerve injury, the periods of pharmacotherapy, and the choice of treatment methods. So, further investigation is needed by quantitative measurement of more variables in more individuals.

• The KIPS Transactions:PartB
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• v.9B no.4
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• pp.407-414
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• 2002

Being recently increased interests of our healthcare, a host of symptoms-diagnostic sites has been introduced on the World Wide Web. But conventional healthcare sites provide users with only a very restricted functions. In this paper, we propose the use of Artificial Neural Networks (ANNs) as a flexible symptoms-diagnostic tool that enables learning effects of ANNs (not expert's knowledge) to be incorporated into the diagnostic process. We develop a novel algorithm for predicting patient\`s disease that satisfy user (or expert)-specified symptoms on WWW. Our algorithm provides two important benefits : 1) enables users (patients) to be taken early diagnostic, and 2) enables experts to perform confidently diagnostic by referencing the predicted diseases-list with its respective possibility.

• Journal of Preventive Medicine and Public Health
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• v.26 no.2 s.42
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• pp.251-267
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• 1993

The relationship between lead related subject symptoms and lead exposure indices was studied in 435 male lead workers in thirteen lead using industries. 212 male office workers who were not exposed to lead occupationally were also studied as a control group. Fourteen lead related symptoms were selected. They were further subdivied into 4 sub-symptom groups such as 1) gastrointestinal, 2) neuromuscular and joint 3) constitutional, and 4) psychological symptoms. Symptom questionnaires were provided to the workers and filled up by themselves and reconfirmed by interviewer(doctor). The test used fer the evaluation of lead exposure were blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), hemoglobin(Hb), hematocrit (Hct), delta-aminolevulinic acid in urine(DALA). The results obtained were as follows; 1. The higher prevalence rate in the sub-group of neuromuscular and joint symptoms was observed in occupationally lead exposed subjects than non-exposed subjects. Among the sub-groups, the most frequent symptom was 'numbness of finger, hands or feet', and the prevalence of the symptom of 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia' were higher in order. 2. While the symptom which showed the biggest difference of prevalence rate among the 14 symptoms between exposed and non-exposed subjects was 'numbness of fingers, hands or feet', the symptom which showed the highest prevalence rate was 'feeling tired generally' in exposed and non-exposed subjects, but no statistical difference of symptom prevalence were observed. 3. In total study population, PbB and ZPP had dose-response relationship with 4 symtoms of neuromuscular and joint symptoms ('numbness of finger, hands or feet', 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia') and one symptom of gastrointestinal group('intermittent pains in lower abdomen'). 4. In lead exposed workers, only neuromuscular and joint symptoms group showed dose-response relationship with PbB and ZPP, 5. In lead exposed workers, the prevalance rate of overall symptoms of lead workers with age below 39 years was higher than that of lead workers with age above 40. While neuromuscular and joint symptoms group had a dose-response relationship with PbB in former group, it had a dose-response relationship with ZPP in latter group. 6. Age adjusted odds ratios of symptoms of non-exposed with exposed and odds ratios of low exposed with high exposed workers showed the dose-response relationship of lead exposure with neuromuscular and joint symptoms group('numbness of fingers, hands or feet', 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia') and gastrointestinal symptoms group('intermittent pains in lower abdoman').

• Journal of Chest Surgery
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• v.37 no.12
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• pp.1019-1021
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• 2004

Neurogenic tumors are common in posterior mediastinal tumors. In most cases, tumors were accidentally showed on simple chest X-ray. In some cases, they were presented by symptoms which were induced by nerve compression or airway compression. But as in our case, neurogenic tumor with spontaneous hemothorax is very rare. A 45-year-old man admitted to emergency room of other hospital because of acute right chest pain and dyspnea. A chest X-ray showed a right pleural effusion. Hemothorax was diagnosed after closed thoracostomy. Following chest CT showed posterior mediastinal mass. The patient was transferred to our hospital. T spine MRI showed dumbbell shaped mass. Diagostic impression was neurogenic tumor. The pathologic result was neurilemmoma after surgical resection.

• The Monthly Diabetes
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• s.137
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• pp.58-59
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• 2001

당뇨병 환자는 자율신경계 이상으로 위장병증이라는 소화기계통의 이상을 초래하는데 그 증상으로서 삼키기 곤란한 증상이나 소화불량, 오심, 구토, 변비, 설사 및 대변실금 등이 있다. 이러한 위장장애와 관련된 증상들은 단독으로 나타나기도 하고 여러 증상들이 반복적으로 나타나기도 한다. 원인은 당뇨병 자체의 고혈당에 의하거나 혹은 당뇨병의 만성합병증의 하나인 당뇨병성 신경병증 중에서 자율신경의 침범에 의한 장운동의 이상에 의해 초래되며 이러한 장운동의 이상은 식도, 위, 소장, 대장의 모든 위장관에서 발생된다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.06a
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• pp.283-288
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• 2007

본 논문에서는 전문적인 지식이 부족한 일반인들을 대상으로 자신의 건강 상태를 파악 할 수 있는 자가 진단 시스템을 제안한다. 제안한 시스템은 68가지 질병과 각 질병에 대한 대표 증상 데이터 베이스를 이용하여 사용자의 질병을 도출한다. 본 논문에서는 사용자가 자신의 대표증상을 입력하면 해당 증상과 관련 있는 질병만을 자율 학습 방법 신경망인 ART2 알고리즘을 적용하여 클러스터링하고 각 질병의 증상과 관련된 질의 결과를 입력 벡터로 적용하여 사용자의 건강 상태를 진단한다. 사용자의 건강 상태를 진단하는데 있어서 질병과 증상의 정확한 정보는 매우 중요하다. 따라서 데이터베이스를 이용하여 질병과 증상의 정보관리를 유용하게 할 수 있도록 하였다. 제안된 자가 진단시스템을 구현하여 간호학 전문의가 분석한 결과, 본 논문에서 제안한 시스템이 질병의 보조 진단 시스템의 도구로서의 가능성을 확인하였다.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.5 no.1
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• pp.41-45
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• 2012

Among the various reasons that can cause entrapment of suprascapular nerve, suprascapular cyst is not commonly found and more often, overlooked or misdiagnosed. Authors experienced one case of suprascapular cyst causing suprascapular nerve entrapment confirmed by ultrasonography and MRI. Symptom of the patient was confined to infrascapular nerve. Percutaneous aspiration of cyst was done under the guidance of ultrasonography through Neviaser portal on out-patient department. After 8 weeks of follow-up, no recurrent lesion was found and objective functional improvement was identified. When clinicians confront with the symptoms compatible with suprascapular nerve entrapment, every effort should be put on finding lesion under ultrasonography before attempting any further cost-ineffective or time-wasting evaluation. Symptoms caused by space-occupying cyst will be soothed by simple decompression. However, always be aware of concomitant lesions that might be the reason for the cystic lesion and in some cases, further evaluation is inevitable.

• Korean Journal of Psychosomatic Medicine
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• v.20 no.2
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• pp.98-104
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• 2012

Objectives : This study aimed to investigate the correlations between neurological and psychiatric symptoms at two weeks after stroke. Methods : For 412 stroke patients, stroke severity was evaluated by the National Institutes of Health Stroke Scale(NIHSS), disability by the Barthel Index(BI) and modified Rankin Scale(mRS), cognitive function by the Korean Mini-Mental State Examination(K-MMSE), and muscle power by grip strength. Psychiatric symptoms were assessed by Symptom check list-90-Revision(SCL-90-R), consisted of nine symptom domains : Somatization, Obsessive-compulsive, Interpersonal sensitivity, Depression, Anxiety, Hostility, Phobic anxiety, Paranoid ideation, Psychoticism, and Additional items. The correlations between the neurological and psychiatric symptoms were investigated at the time of admission and before discharge(i.e. before and after treatment). Results : At the time of admission, NIHSS score was associated with scores on Phobic anxiety and Additional items ; and scores on BI and mRS were associated with Depression, Phobic anxiety and Additional items. At the time of discharge, NIHSS score was associated with scores on Somatization, Depression, Phobic anxiety, and Additional items ; scores on BI and mRS were associated with scores on Depression, Phobic anxiety and Additional items ; MMSE score was associated with Obsessive-compulsive, Depression, Phobic anxiety, and Additional items ; and grip strength was associated with Somatization, Depression, Anxiety and Additional items. Conclusions : More severe neurological symptoms were associated with higher psychiatric morbidity particularly in depression, phobic anxiety, sleep and appetite disturbance at acute stage of stroke. More intensive psychiatric care and intervention are needed for the high risk group.