• Journal of Nutrition and Health
• /
• v.49 no.1
• /
• pp.18-27
• /
• 2016

Purpose: Our previous study demonstrated the hypoglycemic effects of mulberry (Morus alba L.) leaf and the underlying mechanisms. Here we explored the potency of mulberry twigs (TW) and root barks (RB) in postprandial hypoglycemic effects in vitro and in vivo. Methods: The major components of TW and RB were determined by high performance liquid chromatography (HPLC). Alpha-glucosidase inhibition and glucose/fructose uptake inhibition in Caco-2 cells were determined for TW, RB, and their major components, followed by an oral sugar tolerance test (OSTT) in streptozotocin-induced diabetic rats. Male Wistar rats were fed a high-fat diet for 2 weeks and then a single dose of streptozotocin (35 mg/kg B.W) was administered by intraperitoneal injection. Rats with fasting blood glucose levels above 126 mg/dL were randomly divided into 5 groups (n = 8/group) for the following treatments by gavage for 4 weeks: vehicle (normal control and diabetic control), 200 mg/kg B.W of TW or RB or 100 mg/kg B.W of oxyresveratrol (OXY). Results: OXY and mulberroside A were identified as the major components of TW and OXY, mongolicin, and kuwanon H for RB. A significant inhibitory activity on ${\alpha}-glucosidase$ was found for TW, RB, and OXY (p = 0.0099). There was a dose-dependent inhibition of TW and RB on the intestinal sugar uptakes in Caco-2 cells, showing a greater impact on fructose compared to glucose. The OSTT showed that TW and RB significantly delayed time to maximal concentration (p = 0.0088) and decreased maximal concentration (p = 0.0043) compared to the control group. Conclusion: These results suggest that TW and RB may have a postprandial hypoglycemic effect, particularly in the case of high fructose or sucrose intake. OXY was suggested as a contributor to the hypoglycemic effect of TW and RB. Further studies are needed for the systemic effect of TW and RB in circulation.

• Korean Journal of Health Education and Promotion
• /
• v.13 no.1
• /
• pp.72-89
• /
• 1996

The oral health status and practices related to oral health among 44-54-year-, 55-64-year- and 65-year-old needy residents were assessed. The subjects were the residents at the Unbong Permanent Rental Apartment, Bansong-dong, Haeundae-gu. Pusan, Korea. An oral epidemiological survey was undertaken to determine the status of dental caries and periodontal health. Periodontal health were analyzed by the tool of CPITN (Community Periodontal Index of Treatment Needs). A questionnaire was used to interview for the practices of toothbrushing. The numbers of subjects were 192 for the interview on toothbrushing, 228 for the survey of dental status and 208 for the survey of periodontal status. The major results were as follows: 1. Toothbrushing frequencies per day were 1.9 among 44-54-year-, 1.7 among 55-64-year- and 1.7 among 65+-year-subjects. Percentages of after-meal-toothbrushings among total brushing frequencies per day were 73.7% among 44-54-year-, 70.6% among 55-64-year- and 76.5% among 65+-year-subjects. 2. DMFT indices were 15.5 among 44-54-year-, 16.4 among 55-64-year- and 26.6 among 65-year-subjects. Decayed teeth component of DMF teeth were 23.9% among 44-54-year-, 11.6% among 55-64-year- and 62.8% among 65+-year-subjects. Missed teeth component of DMF teeth were 55.59% among 44-54-year-, 62.8% among 55-64-year- and 77.4% among 65+-year-subjects. Filled teeth component of DMF teeth were 20.0% among 44-54-year-, 25.0% among 55-64-year- and 10.9% among 65+-year-subjects. 3. Sound permanent teeth were 16.4 among 44-54-year-, 15.6 among 55-64-year- and 5.4 among 65+-year-subjects. Present permanent teeth were 23.7 among 44-54-year-, 21.6 among 55-64-year- and 10.9 among 65-year-subjects. 4. Subjects who needed professional oral prophylaxis were 75.0% among 44-54-year-, 83.3% among 55-64-year-and 76.9% among 65-year-subjects. Subjects who needed complex periodontal treatments were 16.7% among 44-54-year-, 13.3% among 55-64-year- and 15.4% among 65+-year-subjects. 5. Sextants which needed professional oral prophylaxis were 59.3% among 44-54-year-, 71.5% among 55-64-year- and 71.5% among 65+-year-subjects. Sextants which needed complex periodontal treatments were 5.6% among 44-54-year-, 4.1% among 55-64-year- and 5.7% among 65+-year-subjects. 6. Systematic comprehensive oral health care services should be developed for old needy residents in urban area.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.36 no.8
• /
• pp.989-994
• /
• 2007

This study was designed to investigate whether Sasa borealis leaves extracts (SLE) may inhibit yeast ${\alpha}-glucosidase$ and ${\alpha}-amylase$ activities and postprandial hyperglycemia in STZ-induced diabetic mice. Freeze-dried SLE was extracted with 70% methanol and followed by a sequential fractionation with dicholoromethan, ethylacetate, butanol, and water. Both ethylacetate and butanol fractions showed high inhibitory activities against the ${\alpha}-glucosidase$ and ${\alpha}-amylase$ enzymes. The $IC_{50}$ of ethylacetate and butanol fractions against ${\alpha}-glucosidase$ were 0.54 and 0.63 mg/mL, respectively, indicating a greater inhibition effect than acarbose (0.68 mg/mL) (p<0.05). Likewise, the two fractions exhibited a smaller $IC_{50}$ against ${\alpha}-amylase$, compared with acarbose (p<0.05). However, the yield of ethylacetate fraction of SLE was relatively small. Postprandial blood glucose testing of normal mice and STZ-induced diabetic mice by starch soln. loading (2 g/kg B.W.) showed that postprandial blood glucose level at 30, 60, and 120 min were markedly decreased by single oral administration of SLE butanol fraction (200 mg/kg B.W.) in both normal (p<0.0l) and diabetic mice (p<0.0l). Furthermore, the incremental area under the curve (AUC) was significantly lowered via SLE administration (5,745 versus 12,435 $mg{\cdot}mim/dL$) in the diabetic mice (p<0.0l). The incremental AUC in normal mice corroborated the hypoglycemic effect of SLE (p<0.0l) found in the diabetic mice. These results suggest that SLE may delay carbohydrate digestion and thus glucose absorption. In addition, SLE may have the potential to prevent and treat diabetes via its ability on lowering postprandial hyperglycemia.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.51 no.spc1
• /
• pp.193-197
• /
• 2006

The optimum planting date, plant spacing, and harvest time for production of small-sized sweetpotato was evaluated in 2003 to 2004 at the Mokpo Experiment Station. Small-sized sweetpotato is important as snack food in Korea. Optimum planting date and plant spacing were with plastic mulch, and mid-April and $75{\times}15{\sim}20cm$ respectively, mid-June and $75{\times}15cm$ respectively without plastic mulch. Storage root yield decreased with early harvest, but the ratio of small-sized sweetpotato was higher in plots harvested after 100 days of planting (DAP) than that of 80 or 120 DAP. Considerable differences in storage root yield was noted with planting dates and plant spacings, but the use of plastic mulch resulted to smaller yield variations in plots, harvested in mid-April. Planting in mid-April and harvesting after 100 DAP increased income by about $32{\sim}61%$ compared with plantings mid-May.

• Childhood Kidney Diseases
• /
• v.6 no.1
• /
• pp.123-130
• /
• 2002

Posttransplant lymphoproliferative disease (PTLD) represents a diverse lymphoproliferative disorder ranging front nonspecific reactive hyperplasia to malignant immunoblastic sarcoma developed in a setting of immunosuppression following organ or cellular transplantation. It is often associated with Epstein-Barr virus (EBV) infection and high dose immunosuppression. PTLD after renal transplantation was reported at first in adult in Korea in 1997. In children there have been several cases of PTLD after liver transplantation but PTLD after renal transplantation has not been reported. This is a case report of PTLD developed 4 months after renal transplantation in a 9-year-old boy. The major clinical manifestations were fever, multiple lymph nodes enlargement and blood-tinged stool. EBV was detected by in-situ hybridization in the enlarged cervical lymph node and the colonic tissue. Histological examination revealed B-cell lineage. Use of ganciclovir and reduction of the immunosuppression level resulted in complete remission of PTLD. This is the first pediatric case report of PTLD following renal transplantation in Korea. (J Korean Soc Pediatr Nephrol 2002 ; 6 : 123-30)

• Journal of Chest Surgery
• /
• v.29 no.7
• /
• pp.713-722
• /
• 1996

Poor long term patient survival (60% at 2 years) in lung allograft recipients are mainly due to rejection and complications associated with the use of nonspecific immunosuppressants. Better means to achieve waft acceptance is desperately needed. 1 have investigated whether mixed allogeneic chimerism in the form of bone marrow stem cell engraftment would induce donor-specific tolerance for lung allografts. Fisher (F344) and Wistar Forth (WF)rats were lethally irradiated (1100c0y) and reconstituted with a mixture of T-cell depleted syngeneic and allogeneic bone marrow (F344+WFIWF, ACI +F344- F344). After Mixed chimerism was documented by peripheral blood Ipnphocyte typing at 28 days, orthotopic left single lung transplantation was performed, using donor-s ecific or third party allografts. No immunosuppressants were administered. Graft rejection was monitored by chest rentgenography, and con- firmed by histology Mixed chimeric rats accepted lung allografts permanently, and it was not strain specific effect. Tolerance was all or none phenomenon which had nothing to do with the percentage of chimerlsm. Mixed chimeras rejected third party allografts in less than 10 days, a time course similar to that of unmanipulated controls. No acute or chronic rejection was observed in donor specific grafts more than 150 days posttransplant. These data suggest that mixed chimerism in the form of bone marrow stem cell engraftment results in stable, systemic donor-specific transplantation tolerance for lung allografts.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.8
• /
• pp.348-358
• /
• 2020

The purpose of this study was to examine the effects of auricular acupressure in patients with type 2 diabetes mellitus. Data collection was conducted from March 16 to May 11, 2018. A total of 44 participants with type 2 diabetes were recruited from welfare facilities. Participants in the experimental group (n=22) and placebo control group (n=22) received auricular acupressure on diabetes-related points (shenmen, pancreas, appetite control point, thirst point, and master endocrine point) and diabetes-unrelated points. The intervention was implemented on 5 consecutive days per week for a total of 6 weeks. To examine the effects of treatment, postprandial glucose, glycated hemoglobin, and blood lipid levels were evaluated. Postprandial glucose levels in the experimental group exhibited significant reduction over time compared to those in the placebo control group (p=.030). Glycated hemoglobin levels in the experimental group decreased significantly (t=-2.44, p=.024). However, there were no significant differences in blood lipid levels between the two groups. This study demonstrates that auricular acupressure on diabetes-related points for 6 weeks was highly effective in decreasing blood glucose levels in patients with type 2 diabetes.

• Proceedings of the KAIS Fall Conference
• /
• 2011.05b
• /
• pp.806-809
• /
• 2011

본 연구는 구강보건행태 방법을 이해하고 다양한 연령층과 직업, 잇솔질 횟수와 잇솔질 시기를 분석하여 개개인의 구강건강을 증진시키기 위한 연구자료 및 구강보건 인식 증진 프로그램 개발에 기초자료를 제공하고자 2007년 10월 22일에서 23일까지 대전광역시에 거주하는 만 19세 이상 남녀를 대상으로 무작위 표본추출로 선정된 응답자를 대상으로 구조화된 설문지를 활용하여 분석하였다. 3회 이상 잇솔 사용을 분석한 결과 성별인 경우 여자가, 연령은 20대, 교육 수준 별로 대학교 재학 이상, 직업은 화이트칼라(전문직), 가계 수입별로는 500만원이상, 체질당지수는 저체중, 흡연 여부에서는 비흡연이, 최근 2년간 건강검진 경험의 경우 경험이 있는 사람이, 주관적 건강상태의 경우 좋을수록 통계적으로 유의한 차이를 보였다. 식사 직후 잇솔 사용에 대하여 분석한 결과 교육수준에서 학력이 높을수록, 전문직일수록, 평균 월 수입이 많을수록, 흡연 유무에서는 비흡연, 최근 2년간 건강검진 경험의 경우 경험이 있는 사람이, 관적 건강상태의 경우 좋을수록 통계적으로 유의한 차이를 보였다. 3회 이상 잇솔 사용을 종속변수로 로지스틱회귀분석을 실시한 결과 남성에 비해 여성이, 학력은 중졸이하에 비해 고졸이, 직업은 학생에 비해 가정주부가, 주관적 건강상태는 좋을수록 잇솔 사용 횟수가 식후 3회일 경향을 보였다. 식사 직후 잇솔 사용을 종속변수로 로지스틱회귀분석을 실시한 결과 학력은 중졸이하에 비해 고졸, 대졸이, 직업은 학생에 비해 자영업과 가정주부가, 흡연자에 비해 비흡연자가, 건강검진 경험자, 주관적 건강상태는 좋을수록 잇솔 사용 횟수가 식후 잇솔질의 경향을 보였다. 이상과 같은 결과를 볼 때 높은 교육수준이나, 건강에 대한 자기 신념이 높은 사람들은 구강 관리도 소홀하지 않다는 것을 보여주고 있다. 또한 그렇지 못한 그룹은 지속적인 교육 및 관리를 하여 구강관리의 중요성을 일깨워줘야 됨은 물론이며, 구강관리 뿐만 아니라 전체적인 건강관리에 대한 교육 프로그램을 개발 연구되어야 할 것이다.

• KIISE Transactions on Computing Practices
• /
• v.23 no.6
• /
• pp.371-378
• /
• 2017

In modern society, awareness of diabetes is growing with an increase in the elderly population and an increase in the incidence of diabetes. In particular, diabetic patients can suddenly develop hypoglycemic shock; therefore, it is important to measure blood glucose periodically. However, self-monitoring blood glucose meters are difficult to carry and it is difficult to manage the value. To solve these problems, the blood glucose measurement system has been developed as a sensor attached to the body or as one of the functions of smart devices, but it has not been commercialized. In this paper, we propose a smart band with a blood glucose measurement function. If a user enters a schedule to measure blood glucose level, such as before/after meals, in the app, he/she can receive a measurement alarm from the band. The user can measure the blood glucose level at any time using the band, and the measured value is transmitted and managed by the app including behavior history such as before/after meals and the time. This will help the user to manage, diagnose and prevent health problems. The system has been tested using two medical device-certified products, and each blood glucose measurement value has been confirmed to be more accurate.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.13 no.2
• /
• pp.129-136
• /
• 1991

The fibrin sealant was first designed as an alternative to surgical suture for the purpose of surface-to-surface union especially in parenchymal organs like the liver, spleen and kidney. The clinical application of currently used fibrin sealant was first introduced in 1972. The fibrin sealant consists of principal two components; lyophilized human fibrinogen and bovine thrombin. The fibrinogen component also contains coagulation factor XIII. A solution of aprotinin, an inhibitor of fibrinolysis is used to dissolve the fibrinogen and to provide the first component, and a solution of calcium chloride is also used to provide the second component. From July to December in 1990, during 6 months, we used fibrin sealant in the 28 patients of 33 various cases, in the following ways; supportive application of fibrin sealant after free autogenouse nerve graft for the repair of inferior alveolar nerve, facial nerve or accessory nerve, treament of hemangioma or lymphangioma to thrombosize and lead to the tumor shrinking, skin grafting to stimulate the adhesion and tissue repair, bone grafting in the patients of cleft alveolus, mandibular reconstruction or orthognathic surgery to facilitate the knitting of bone chips, tissue adhesion after tumor resection, radical neck dissection or flap reconstructions, and supportive adhesion of external auditory cannal after TMJ surgery via postauricular approach. No adverse effects were observed, none of the patients developed hepatitis or other blood transmitted disease, and the wound healing were acceptable.