• The monthly packaging world
• /
• s.356
• /
• pp.94-101
• /
• 2022

식품의약품안전처는 지난 10월 14일 「기구 및 용기·포장의 기준 및 규격」을 일부 개정했다. 개정이유로는 기구 및 용기·포장의 원재료로 사용할 재생원료의 인정 절차 등이 마련될 예정임에 따라 인정을 신청하는 경우 제출하여야 하는 자료를 구체적으로 정하고, 환경부에서 「식품용기 사용 재생원료 기준」을 고시함에 따라 이에 맞추어 재생원료 기준을 개선하는 한편, 지속가능한 사회실현을위한 산업현장의 요구를 반영하여 폴리부틸렌아디페이트테레프탈레이트(PBAT) 수지를 등재하고, 시험법에 대한 신뢰도 제고 등을 위하여 시험용액 등의 조제방법 및 분석기기의 측정조건을 개선하는 등 현행 기준 및 규격의 일부 미비점을 개선하기 위함이다.

• Korean Journal of Environmental Agriculture
• /
• v.40 no.2
• /
• pp.108-117
• /
• 2021

BACKGROUND: Dichlobentiazox is a newly registered pesticide in Korea as a triazole fungicide and requires establishment of an official analysis method for the safety management. Therefore, the aim of this study was to determine the residual analysis method of dichlobentiazox for the five representative agricultural products. METHODS AND RESULTS: Three QuEChERS methods were applied to establish the extraction method, and the EN method was finally selected through the recovery test. In addition, various adsorbent agents were applied to establish the clean-up method. As a result, it was found that the recovery of the tested pesticide was reduced when using the d-SPE method with PSA and GCB, but C₁₈ showed an excellent recovery. Therefore this method was established as the final analysis method. For the analysis, LC-MS/MS was used with consideration of the selectivity and sensitivity of the target pesticide and was operated in MRM mode. The results of the recovery test using the established analysis method and inter laboratory validation showed a valid range of 70-120%, with standard deviation and coefficient of variation of less than 3.0% and 11.6%, respectively. CONCLUSION: Dichlobentiazox could be analyzed with a modified QuEChERS method, and the method determined would be widely available to ensure the safety of residual pesticides in Korea.

• The monthly packaging world
• /
• s.247
• /
• pp.44-52
• /
• 2013

식품의약품안전처는 "약사법", "의약품 등의 안전에 관한 규칙", "의약외품 표시에 관한 규정"(식약처 고시 제2013-32호)에 혼재되어 있는 의약외품에 관한 표시 기재를 종합하고 그 내용을 알기 쉽게 설명하고자 본 해설서를 배포했다. 본 고에서는 의약품 표시 기재 관련 일반 사항과 함께 용기 등의 기재사항, 기재상의 주의 사항 등에 대해 살펴보도록 한다. 단, 본 해설서는 현재의 법령 및 규정에 대한 일반적인 해석을 기술하고 있는 것으로서 법적 효력이 있는 사항이 아니며, 개별 사항에 따라 다르게 해석할 수 있음을 알린다.

• The monthly packaging world
• /
• s.273
• /
• pp.130-131
• /
• 2016

식품의약품안전처는 "의약품 바코드 또는 전자태그(RFID tag) 표시 대상 등에 관한 기준"(식품의약품안전처 고시 제2013-5호, 2013. 4. 5.)을 일부 개정함에 있어 국민에게 미리 알려 의견을 수렴하고자 그 취지, 개정 이유 및 주요내용을 "행정절차법" 제46조에 따라 다음과 같이 공고했다. 개정 이유와 함께 주요 내용을 살펴 본다.

• Journal of Radiation Industry
• /
• v.7 no.1
• /
• pp.15-21
• /
• 2013

The detection characteristics of irradiated spices were investigated depending on radiation sources and doses by photostimulated luminescence (PSL) and Thermoluminescence (TL). 6 kinds of spices (turmeric, onion powder, red pepper, basil, parsley, black pepper) were irradiated at 0 to 10 kGy under ambient conditions by both a $^{60}Co$ gamma irradiator and an electron beam (EB) accelerator, respectively. The PSL analysis showed negative results for non-irradiated spices, while irradiated spices gave intermediate and positive value, which presented the limited potential of PSL technique. In TL measurement, TL glow curves on non-irradiated samples appeared at about $300^{\circ}C$ with low intensity. All irradiated samples were easily distinguishable through radiation-specific strong TL glow curves with maximum peak in range of $150{\sim}200^{\circ}C$. TL ratio ($TL_1/TL_2$) obtained by a re-irradiation step could verify the detection result of $TL_1$ glow curves, showing ratios lower than 0.1 in the non-irradiated sample and higher than 0.1 in irradiated ones. Therefore, in PSL measurement, the identification of irradiated spices showed more clear results in electron beam irradiated samples. TL analysis showed obvious difference between non-irradiated and irradiated samples in gamma ray and electron beam irradiated samples.

• The monthly packaging world
• /
• s.253
• /
• pp.102-103
• /
• 2014

식품의약품안전처는 4월 16일 "화장품 가격표시제실시요령"(식품의약품안전처고시 제2013-8호, 2013. 4. 5.)을 일부 개정함에 있어 국민에게 미리 알려 의견을 수렴하고자 그 취지, 개정 이유 및 주요 내용을 "행정절차법" 제46조에 따라 공고했다. 본 고에서는 자세한 내용과 함께 신구조문을 비교해 살펴보도록 한다

• Journal of Food Hygiene and Safety
• /
• v.39 no.2
• /
• pp.61-71
• /
• 2024

In this study, we analyzed chlorogenic acid indicator components in preparation for the additional listing of green coffee bean extract in the Health Functional Food Code and optimized caffeine for simultaneous analysis. We extracted chlorogenic acid and caffeine using 30% methanol, phosphoric acid solution, and acetonitrile-containing phosphoric acid and analyzed them at 330 and 280 nm, respectively, using liquid chromatography. Our analysis validation results yielded a correlation coefficient (R²) revealing a significance level of at least 0.999 within the linear quantitative range. The chlorogenic acid and caffeine detection and quantification limits were 0.5 and 0.2 ㎍/mL and 1.4, and 0.4 ㎍/mL, respectively. We confirmed that the precision and accuracy results were suitable using the AOAC validation guidelines. Finally, we developed a simultaneous chlorogenic acid and caffeine analysis approach. In addition, we confirmed that our analysis approach could simultaneously quantify chlorogenic acid and caffeine by examining the applicability of each formulation through prototypes and distribution products. In conclusion, the results of this study demonstrated that the standardized analysis would expectably increase chlorogenic acidcontaining health functional food quality control reliability.

• Journal of Food Hygiene and Safety
• /
• v.34 no.1
• /
• pp.13-21
• /
• 2019

A method was developed for the simultaneous detection of an antibiotic fungicide, streptomycin, and its metabolite (dihydrostreptomycin) in agricultural products using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The samples were extracted using methanol adjusted to pH 3 using formic acid, and purified with a HLB (Hydrophilic lipophilic balance) cartridge. The matrix-matched calibration curves were constructed using seven concentration levels, from 0.001 to 0.1 mg/kg, and linearity of five agricultural products (hulled rice, potato, soybean, mandarin, green pepper), with coefficients of determination $(R^2){\geq}0.9906$, for streptomycin and dihydrostreptomycin. The mean recoveries at three fortification levels (LOQ, $LOQ{\times}10$, $LOQ{\times}50$, n = 5) were from 72.0~116.5% and from 72.1~116.0%, and relative standard deviations were less than 12.3% and 12.5%, respectively. The limits of quantification (LOQ) were 0.01 mg/kg, which are satisfactory for quantification levels corresponding with the Positive List System. All optimized results satisfied the criteria ranges requested in the Codex guidelines and the Food Safety Evaluation Department guidelines. The present study could serve as a reference for the establishment of maximum residue limits and be used as basic data for detection of streptomycin and dihydrostreptomycin in food.

• Journal of Food Hygiene and Safety
• /
• v.34 no.1
• /
• pp.30-39
• /
• 2019

An analytical method was developed for the determination of sedaxane in agricultural products using liquid chromatograph-tandem mass spectrometry (LC-MS/MS). The samples were extracted with acetonitrile and partitioned with dichloromethane to remove the interference, and then purified by using silica SPE cartridges to clean up. The analytes were quantified and confirmed by using LC-MS/MS in positive ion mode using multiple reaction monitoring (MRM). The matrix-matched calibration curves were linear over the calibration ranges ($0.001-0.25{\mu}g/mL$) into a blank extract with $r^2$>0.99. For validation, recovery tests were carried out at three different concentration levels (LOQ, 10LOQ, and 50LOQ, n=5) with five replicates performed at each level. The recoveries were ranged between 74.5 to 100.8% with relative standard deviations (RSDs) of less than 12.1% for all analytes. All values were consistent with the criteria ranges requested in the Codex guidelines (CAC/GL 40, 2003) and Food Safety Evaluation Department guidelines (2016). The proposed analytical method was accurate, effective and sensitive for sedaxane determination in agricultural commodities.

• Journal of Food Hygiene and Safety
• /
• v.38 no.3
• /
• pp.79-88
• /
• 2023

Trifludimoxazin is a triazinone herbicide that inhibits the synthesis of protoporphyrinogen oxidase (PPO). The lack of PPO damages the cell membranes, leading to plant cell death. An official analytical method for the safety management of trifludimoxazin is necessary because it is a newly registered herbicide in Korea. Therefore, this study aimed to develop a residual analysis method to detect trifludimoxazin in five representative agricultural products. The EN method was established as the final extraction method by comparing the recovery test and matrix effect with those of the QuEChERS method. Various sorbent agents were used to establish the clean-up method, and no differences were observed among them. MgSO₄ and PSA were selected as the final clean-up conditions. We used LC-MS/MS considering the selectivity and sensitivity of the target pesticide and analyzed the samples in the MRM mode. The recovery test results using the established analysis method and inter-laboratory validation showed a valid range of 73.5-100.7%, with a relative standard deviation and coefficient of variation less than 12.6% and 14.5%, respectively. Therefore, the presence of trifludimoxazin can be analyzed using a modified QuEChERS method, which is widely available in Korea to ensure the safety of residual insecticides.