• Journal of Nutrition and Health
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• 제33권5호
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• pp.491-496
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• 2000

Food intake is regulated by both central and peripheral mechanisms. In the central nervous, the hypothalamus acts for autonomic and endocrine homeostasis. The paraventricular nucleus(PVN) of hypothalamus is an imprtant site of interaction in central feeding pathways. Neuroepetide Y(NPY)is one of the most powerful neurochemical stimulants of food intake known. Also brain nitric oxide(NO), known as neurotransmitter, is involved in the mechanisms that regulate food intake. In this experiment, 24h fasting mice and anorexia mutant mice have been to examine the expression of NPY, which is the major neuropeptide increasing food intake. Double staining with NPY and nicotinamide-adenine-dinucleotide-phosphate diaphorase(NADPH-d), followed by immunohistochemical method and image analysis, have been used to observe coexisting neurons and the level of expression of each neurons. The results were as follows. 1) NPY-immunoreactivitys reduced immune response of the hypothalamus, particularly paraventricular nucleus(PVN), in anorexia mutant mice. Decreased level of NPY is assumed to be a major pathological factor in anorexia mutant mice. On the other hand, PVN in hypothalamus of fasting mice showed increased immunoreactivity which is in agreement of other researchers. 2) NPY and NADPH-d double staining revealed coexisting neurons in the cerebral cortex. Fasting mice had a tendency to have increased level of coexisting neurons compared to the control group. Compared to the control group, fasting mice express is not increase level of NPY-immunoreactivity, while anorexia mutant mice tended to have a decreased level.

• 대한한방내과학회지
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• 제42권5호
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• pp.793-799
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• 2021

Objectives: This study examined the effects of Gamisachil-tang on an anorexic patient with depression. Methods: A patient suffering from anorexia and depression was treated with Korean herbal medicine (Gamisachil-tang) for 14 days. To evaluate the therapeutic effect, we measured the daily food intake of the patient and used the Visual Analogue Scale (VAS) for anorexia. Results: Following treatment, both the patient's daily food intake of the patient and VAS score for anorexia had improved. Conclusion: These results suggest that Gamisachil-tang has a beneficial effect on both anorexia and depression.

• 대한한방내과학회지
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• 제43권2호
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• pp.219-228
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• 2022

Objective: The aim of this study is to describe the effects of traditional Korean medicine on a patient with dysphagia and anorexia following an acute lumbar compression fracture. Methods: The patient was treated with acupuncture and herbal medicine (Bojungikgi-tang and Insamyangyoung-tang), and the effects of the treatment were evaluated by monitoring oral feeding and using the Modified Barium Swallow (MBS) test. Results: After treatment, the amount of oral feeding more than doubled and the MBS was also improved. Conclusion: The results suggest that traditional Korean medicine may be effective for treating dysphagia and anorexia after an acute lumbar compression fracture.

• 대한상한금궤의학회지
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• 제13권1호
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• pp.145-153
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• 2021

Objective : This study aimed to report the improvement of a patient with anorexia by treatment with Jinmu-tang (Hyunmu-tang) based on the disease pattern identification diagnostic system (DPIDS) of the Shanghanlun provisions. Methods : We evaluated the progress of symptoms, patient compliance, and presence of side effects after the patient was administered Jinmu-tang. The clinical response was estimated according to the number of meals a day, the size of meals, the number of complaints of abdominal pain in a week, and a Likert scale. Results : According to the DPIDS, the patient was diagnosed according to provision 316 with soyinbing. After administration of Jinmu-tang for 45 days, the number of meals a day and the size of meals increased, the number of complaints of abdominal pain in a week decreased, and the Likert scale score decreased from 3 to 0. Conclusions : This case report suggests that the word "腹痛" (abdominal pain) in the 316th Shanghanlun provision indicates anxiety about abdominal pain, which affected anorexia in this case.

• 사상체질의학회지
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• 제35권1호
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• pp.46-55
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• 2023

Objectives The purpose of this case study was to report a case of anorexia and fatigue after getting vaccinated COVID-19 treated based on Sasang Constitutional Medicine. Methods The patient was hospitalized for 4 days and treated with herbal medicine and moxibustion. The patient was asked to score for daily energy level out of 100 on his own and we used Karnofsky Performance Score(Karnofsky PS) on daily health status to evaluate the clinical effects. We also checked daily amount of meal and evaluated original symptoms such as insomnia, gastric discomfort, bowel movement and dysuria in four stages. Results At initial, the patient could only eat one spoon of a meal and was unable to carry on herself without any assistance, so she used a wheelchair on the day of admission. When discharged, the patient can eat half of a meal at each mealtime and perform normal activities by herself. Discussion This case demonstrates that Sasang constitutional approach to anorexia and fatigue caused by COVID-19 vaccination can be an useful treatment.

• 한국임상수의학회지
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• 제26권4호
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• pp.336-339
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• 2009

5킬로그램의 4년령의 중성화된 수컷 시츄견이 식욕부진과 만성 기침을 주증상으로 내원하였다. 이 환견은 병력청취, 신체검사, 임상병리검사, 방사선 진단, 심초음파 검사 및 기관지경 검사를 근거로 기관기관지 이물로 진단되었다. 그 이물은 밥알 부스러기들로 확인되었고 기관지경을 이용한 세기관지 세척 후 진공 흡인을 통해 제거되었다. 진공 흡인으로 채취된 세척 이물의 세균 및 곰팡이 배양과 폐 기생충에 대한 검사는 음성을 보였다. 환견은 진단 후 7일 동안 테오필린, 프레드니솔론, 독시사이클린, 엔로플록사신, 아세틸시스테인, 실리마린, 수크랄페이트를 처방 받았다. 이물제거와 약물치료 후 식욕의 증진과 기침 증상은 완전히 없어졌다. 이 증례 보고는 기관지경 기술을 통해 호흡기의 이물의 진단평가와 제거가 가능함을 보여준다.

• 대한한방소아과학회지
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• 제26권1호
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• pp.60-69
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• 2012

Background Children's Eating Behaviour Questionnaire (CEBQ) is a parents-targeted questionnaire to measure eating behavior of children, developed in United Kingdom and verified validity and reliability in several countries. Validity of Korean version of CEBQ (K-CEBQ) was verified in 2009. Objectives The study was conducted to assess the appetite improvement after herbal treatment in children who have anorexia. Methods The parents of the 26 children(anorexia 11, non-anorexia 15; $79.54{\pm}38.17$ months) who visited one university hospital was surveyed using K-CEBQ from April 2010 to April 2011. It was re-surveyed at intervals of 3 months. Differences between the anorexia group and the non-anorexia group were analyzed by Mann-Whitney U test, and comparisons of pre-treatment and post-treatment in anorexia group and non-anorexia group were verified by Wilcoxon signed-rank test. Results Depends on the presence of anorexia in child, Slowness in eating/Satiety responsiveness (SE/SR), Enjoyment of food (EF), Emotional undereating (EUE) and total scores were significantly different ($p$<0.05). Also, there were significant difference in SE/SR and total scores before and after the herbal treatment in anorexia group (p<0.05), and all scores tended to increase a few. However there were no significant difference before and after the herbal treatment in non-anorexia group, and the scores except for Desire to drink (DD) and Emotional overeating (EOE) were decreased. Conclusions Herbal treatment in children who have anorexia has improved their appetite in terms of eating sensitivity.

• 한국임상수의학회지
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• 제23권4권
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• pp.458-460
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• 2006

체중 3.8 kg의 2년령 암컷인 잡종견이 10일전부터의 구토 및 식욕저하를 주증상으로 내원하였다. 이 개는 2개월 전에 자동차 사고에 의한 골반골절로 진단되었으나, 골절은 정복되지 아니 하였다. 2개월 후에 간헐성의 구토 및 식욕부진으로 고통을 받았다 Barium조영 방사선 검사에서, 장폐색으로 진단되었다. 외과수술을 통하여 골절 부위에서 장의 교액 및 유착에 의한 폐색이 확인되었다. 수술후 18개월이 경과된 시점에서 확인한 결과, 전신적인 신체상태가 양호하였다.

• Journal of Hospice and Palliative Care
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• 제8권2호
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• pp.183-189
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• 2005

목적: 의학의 발달에도 불구하고 암 환자의 발생과 더불어 사망률은 점점 더 증가하고 있는 실정이다. 그러므로 암의 완치도 중요하지만 환자의 남은 삶에 대한 가치와 의미는 더욱더 중요하게 대두되고 있다. 이에 저자 등은 본 연구를 통해 말기 암 환자들이 수행능력에 따라 삶의 짚 신체적, 정신적 증상에 어떤 차이가 있는지를 보고자 하였다. 방법: 2003년 9월 1일부터 2005년 8월 31일까지 관동의대 명지병원 가정의학과에 내원한 암 환자를 대상으로 수행능력 상태, 인구통계학적 자료, 혈액검사, 삶의 질을 평가하였다. 수행능력을 두 군으로 나누어 혈액검사, 삶의 질에 차이가 있는지를 ANOVA를 통해서 분석하였다. P값이 0.05이하일 때 의미 있는 것으로 하였다. 결과: 대상이 된 환자는 총 104명이고, 수행능력 상태가 $0{\sim}1$인 경우 71명(남자 23명, 여자 48명), $2{\sim}4$인 경우 33명(남자 8명, 여자 25명)이었다. 혈액 검사를 보면 수행능력 상태가 $2{\sim}3$기일수록 림프구, 헤모글로빈, 단백질, 알부민, 나트륨 수치가 의미 있게 낮았다. 삶의 질을 평가 해 보면 수행능력 상태가 $2{\sim}4$일수록 전반적인 건강 상태(P=0.02)가 나빴다. 또한 수행능력 상태가 $2{\sim}4$일수록 기능적인 측면에서는 신체적 점수(P=0.05)와 역할 점수(P=0.01)가 나빴고, 증상적인 측면에서는 식욕부진(P=0.01)이 의미 있게 차이가 났다. 결론: 수행능력이 떨어지면 혈액검사 상 일부 영양과 관련된 수치가 떨어지고, 전반적인 건강상태가 나빠진다. 그러나 증상에서는 식욕부진을 제외한 나머지 것에는 차이가 없게 나왔다. 결론적으로 수행능력이 떨어진 환자에서 식욕을 증진시키는 것이 가장 중요하다고 생각한다.

• 생물정신의학
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• 제20권3호
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• pp.74-79
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• 2013

Objectives This paper aims to understand the emotional-biological pathogenesis of eating disorders, and translate the understanding into new brain directed treatments. Methods The first part of the review sets the eating behavior into the context of what is now understood about the central control of appetite and molecular biology. The second part of the review sees how emotion relates to the brain circuit involving eating disorders. Results In general, patients with anorexia nervosa restricting type were less sensitive to reward, whereas patients with bulimia nervosa and anorexia nervosa binge purging type were more sensitive to it. The emotional life of people with eating disorders centers on food, weight, and shape. The abnormalities in social and emotional functioning both precede and persist outside of eating disorders. Conclusions Research into understanding the biological framework of the brain in eating disorders suggests that abnormalities may exist in emotional and information processing. This aspect can be translated into novel brain-directed treatments, particularly in anorexia nervosa.