• Korean Journal of Soil Science and Fertilizer
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• v.23 no.1
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• pp.49-52
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• 1990

This study was carried out to find out favourable soil conditions to give good quality of Bupleuri Radix for Korean medicine. The major ingredients were saikosaponin a and c, which were determined by HPLC. The contents of saikosaponin a and c in the root were determined to be 0.141-0.479% and 0.042-0.094%, respectively. The content of saikosaponin a was negatively correlated with the total nitrogen contents in surface soils, but that of saikosaponin c was independent of physico-chemical properties of the soil. The contents of saikosaponin a and c were decreased in the root with high Ca and Fe.

• Korean Journal of Medicinal Crop Science
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• v.4 no.3
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• pp.199-204
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• 1996

We investigated the structures of floral organs and the developmental process of each floral organs in Bupleurum falcatum. The overall size of a floral was about 2mm. The lengths of ray, pedicel, pistil and stamen were 22.5mm, 3.6mm, 1.0mm and 1.3mm respectively. The ovary surface was 0.9mm in length and 1.4mm in width. And the developmental periods of each floral organs were as follows; 1 through 6 days in stamen emergence, 6 through 9 days in petal detachment and pistil emergence, 9 through 16 days in pistil ma­turation, and above 16 days in pistil degeneration after onset of flowering. This plant was admitted to be a allogamous plant, especially with the protandry form of dichogamy.

• Korean Journal of Medicinal Crop Science
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• v.2 no.2
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• pp.140-145
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• 1994

B. falcatum plants were classified into six groups from group I to grop VI by the complete linkage cluster method depending on 8 charactenstics such as plant height. number of nodes, number of branches, position of the first branching node root diameter, root length, number of lateral root, dry weight of root. These groups are divided into two plants types, such as multi-branching and non multi-branching type by the number of branches, group II and group VI were the multi-branching types and the other groups were nonmulti-branching ones, Dry weight of root had highly positive correlation with the number of branches and negative correlation with the position of first branching nodes.

• Korean Journal of Medicinal Crop Science
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• v.5 no.1
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• pp.7-13
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• 1997

Calli induced from the leaf segment of Bupleurum falcatum were cultured on Mu-rashige and Skoog's(MS) medium supplemented with 2, 4-D, IBA, IAA and NAA of 0.1 mg/l , The induction of adventitious roots from callus was the best in MS medium supplemented with 0.1 mg/l 2, 4-D and the lateral root was the same. The pretreatment of 0.1 mg/l 2, 4-D for 120 hours was most effective for the formation and grwoth of adventitious roots. The number of adventitious roots per micro callus pre-treated with 0.1 mg/l 2, 4- D was 5. 3 which was the highest level. The callus subcultured for 4 weeks were best for the adventitious root formation. The callus subcultured for more than 4 weeks decreased the adventitious root formation and turned to brown in color.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.1
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• pp.10-16
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• 2017

Objectives : Atopic Dermatitis is a recurrent, chronic, allergic eczema with severe itching sensation. This study designed to research Sihocheonggan-tang & Sihocheonggan-san to find out treatability for atopic dermatitis. Methods : We got 14 search results with searching word '시호청간탕', '시호청간산' in 'OASIS', 'NDSL', 'RISS'. We classified these studies according to the type of study, diseases, treatment methods and treatment outcomes. Results : In the analysis of the diseases, Sihocheonggan-tang & Sihocheonggan-san was given for Eczema nummulare, Ermatitis seborrheica, Erythema multiforme, Eczema and Atopic dermatitis. In the analysis of the treatment methodes, the dosage form of Sihocheonggan-tang & Sihocheonggan-san was herbal medication, pill, granules and herbal medication & pill. In the analysis of the treatment outcomes, the symptoms of all patients were improved. In the experimental researches, it was proved that Sihocheonggan-tang & Sihocheonggan-san has effects that affect anti-inflammatory, skin protection and recovery of keratinocyte. Conclusions : For this study, we can consider Sihocheonggan-tang & Sihocheonggan-san is effective for atopic deramatitis. So, it is necessary to carry out clinical trial for Sihocheonggan-tang & Sihocheonggan-san in atopic dermatitis to evaluate safety and efficacy.

• Journal of Korean Medical classics
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• v.19 no.1 s.32
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• pp.194-201
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• 2006

일반래설(一般來說), 상한소양병포괄소시호탕증(傷寒小陽病包括小柴胡湯證), 시호계지탕증(柴胡桂枝湯證), 대시호탕증(大柴胡湯證), 황금탕증(黃芩湯證), 시호계지건강탕증(柴胡桂枝乾薑湯證), 시호가용골모려탕증(柴胡加龍骨牡蠣湯證). 가시한국대표성적임상의서(可是韓國代表性的臨床醫書)${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$, 주요재잡병편중(主要在雜病篇中)${\ulcorner}$한(寒)${\lrcorner}$문적소양형증용약리참천술료소양병(門的少陽形證用藥裏參闡術了少陽病) 종차가이간출(從此可以看出)${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$대소양병적인식정도여(對少陽病的認識程度與一般的傷寒體系具有明顯的區別). 필자통과분석(筆者通過分析)${\ulcorner}$동의보감(東醫寶鑑) 잡병편(雜病篇) 한(寒)${\lrcorner}$당중적유관소양형증용약적조문(當中的有關少陽形證用藥的條文), 득출여하결론(得出如下結論): ${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$당중(當中), 소양병시이구고(少陽病是以口苦), 인건(咽乾), 목현(目眩), 협만(脇滿), 건구(乾區), 왕래한열등증상위주(往來寒熱等症狀爲主), 발병부위시소양병호발부위태양양명지간화흉협(發病部位是少陽病好發部位太陽陽明之間和胸脇); 기재적주요치방시소시호탕(記載的主要治方是小柴胡湯), 황금탕(黃芩湯), 십조탕등삼개처방(十棗湯等三個處方). 종저일점가이간출(從這一點可以看出)${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$불구니어(不拘泥於)${\ulcorner}$상한론(傷寒論)${\lrcorner}$적체계(的體系), 갱가중시실용성(更加重視實用性), 즉이증상위중심료해병정(卽以症狀爲中心了解病情), 심조갱가적합적치법여치방(尋更加適合的治法與治方). 기대금후능유인연구유관십조탕시부가이열입소양병치방화(期待今後能有人硏究有關十棗湯是否可以列入少陽病治方和)${\ulcorner}$동의보감(東醫寶鑑)${\lrcorner}$육경형증용약당중적표본개념(六經形證用藥當中的標本槪念).

• Korean Journal of Plant Tissue Culture
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• v.26 no.3
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• pp.171-175
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• 1999

We examined the effects of various basal media and exogenous auxins on the growth and saikosaponin production in hairy root cultures of Bupleurum falcatum. Of the various media tested, 2RCM medium was superior for growth and saikosaponin content, in which saikosaponin a, c, and d was produced, however MS medium was resulted in extremely low level in saikosaponin production. By the treatment of 0.5 mg/L IBA the growth rate was increased by about 60% in 2RCM medium, whereas both IAA and IBA showed a potent inhibition effect in saikosaponin biosynthesis by the treatment of 0.01 mg/L~5mg/L.

• Journal of muscle and joint health
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• v.31 no.1
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• pp.31-41
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• 2024

Purpose: This study aimed to measure the relationship between the recognition of well-dying, health-related quality of life (HRQoL), and repulsion-related nursing homes and community-dwelling older adults. Method: A descriptive survey was conducted among 505 community-dwelling older adults aged over 65 years. Data were collected from October 25 to November 30, 2023, and analyzed using a t-test, one-way ANOVA, and Pearson's correlation coefficients with SPSS/WIN 26.0. Results: The results reveal that the subjects' recognition of well-dying was 2.30, HRQoL was 0.84, and repulsion-related nursing home was 3.31 points. Recognition of well-dying was significantly correlated with HRQoL (r=.10, p=.024). Conclusion: The results indicate that consumer-centered, well-dying education programs for community-dwelling older adults should be developed and applied continuously through effectiveness verification.

• Journal of Food Hygiene and Safety
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• v.13 no.4
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• pp.355-359
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• 1998

Platelet activation is originated by the intracellular or/and extracellular $Ca^{2+}$. Agonist-induced $Ca^{2+}$ entry through a plasma-membrane pathway has been reported repeatedly, but the mechanisms has proven harder to elucidate. Recently, a number of natural products have been isolated from medicinal plants and marine organisms and have proved to be useful chemical tools for resolving the mechanism of cellular functions. In an attempt to understand the mechanism of platelet activation in Bupleuri Radix, we have studied some aspects of the isolation of active components and their dependence of external $Ca^{2+}$> on platelet activation. Acetone extract of Bupleuri Radix has the most activity on platelet activation and it's active components were identified as saikosaponin a and d. Their optimal concentration was respectively $20\;\mu\textrm{g}/ml$ and $5\;\mu\textrm{g}/ml$ and their platelet activation was not dependent on external $Ca^{2+}$>, whereas optimal concentration of each agonist was arachidonic acid ($10\;\mu\textrm{M}$), collagen ($10\;\mu\textrm{M}/ml$), thrombin (0.1 unit/mi), PAF (5 nM), PMA ($5\;\mu\textrm{M}$), ionophore A23187 ($2\;\mu\textrm{g}$) and their dependence of external $Ca^{2+}$> on platelet activation appeared to thrombin > collagen $\geq$ PAF > PMA > arachdonic acid> ionophore A23187. These results suggest that saikosaponin is different from each agonists in the dependence of external $Ca^{2+}$ on platelet activation.

• Korean Journal of Food Science and Technology
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• v.40 no.2
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• pp.135-140
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• 2008

In this study, the macromineral content ratios of four herbal medicine samples(Saposhnikoviae Radix, Bupleuri Radix, Cnidii Rhizoma, and Astragali Radix) were analyzed to discriminate their geographical origins using an energydispersive x-ray fluorescence (EDXRF) technique. EDXRF is a rapid, non-destructive, and multi-elemental analysis technique. Initially, samples of both domestic and imported herbal medicines were pulverized, and then their macromineral contents, including P, S, K, and Ca, were analyzed using EDXRF. For the discrimination of their geographical origins, canonical discriminant analysis was carried out based on the estimated macromineral relative content ratios of the samples. According to the results, the discrimination accuracies were as follows: 93.3% for Saposhnikoviae Radix, 95.7% for Bupleuri Radix, 98.8% for Cnidii Rhizoma, and 87.5% for Astragali Radix. Overall, the results imply that this technique could be used as a standard method, to discriminate their geographical origins between domestic and imported herbal medicines.