• Clinical and Experimental Pediatrics
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• v.46 no.4
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• pp.363-369
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• 2003

Purpose : Pharmacologic provocation test of growth hormone(GH) is a non-physiologic method and has several limitations for diagnosing growth hormone(GH) deficiency. Spontaneous GH release studies could be important in understanding the pathophysiology of children with poor growth but normal responses to GH provocation tests. Also, the relationship between nocturnal GH secretions and sleep patterns in short stature children is poorly understood. The aim of this study is to determine whether there are differences in sleep patterns and nocturnal GH secretory profiles between idiopathic short stature children and a normal stature group. Methods : Spontaneous nocturnal GH secretions and sleep patterns were evaluated in 12 prepubertal idiopathic short stature children with normal responses to provocation tests and 9 normal stature controls. Blood samples were taken every 30 minutes from 22:00-06:30 and sleep patterns were analyzed by polysomnography. Results : The mean GH level during sleep was significantly lower in short stature children than in controls. The peak GH level after sleep, coincident with the first slow wave sleep, was lower in the short stature group. The slow wave sleep times of short stature children were decreased compared with those of normal subjects. Conclusion : These results suggest that overnight serial GH sampling is helpful to identify short stature children with subnormal GH secretions, and sleep structure differences may be associated with decreased overnight GH secretions in short stature children.

• Journal of Korean Public Health Nursing
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• v.19 no.2
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• pp.305-315
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• 2005

Purpose: The purpose of this study was to investigate the relationships among depression, sleep patterns and health promoting behavior in female college students. Methods: The subjects of this study consisted of 350 college students. The data was collected through self-administered questionnaires from November to December of 2004. The data was analyzed via the SPSS computer program by using descriptive statistics, t-tests, ANOVA and Pearson's correlation coefficients. Results: There are significant differences and impacts on depression according to the amount of coffee consumed, the time spent on computer and the amount of smoke inhaled. Sleep patterns differ depending on one's college major, the time spent on computer, and the amount of smoke inhaled. Health promotion behavior was shown to be significantly different according to the living style, college major and how much TV was watched The mean scores for depression, sleep patterns, health promoting behavior were 1.45 (on a 3 points scale), 2.71 (on a 4 points scale), and 3.03 (on a 5 point scale), respectively. There was a significant positive correlation between sleep patterns and health promoting behavior, and there was negative correlation between depression and health promoting behavior, and between depression and sleep patterns in college students. Conclusion: The findings of this study give useful information to create further studies on intervention programs related to health promoting behavior for college female students.

• The Journal of the Convergence on Culture Technology
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• v.5 no.2
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• pp.287-297
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• 2019

The purpose of this study was to investigate the factors influencing suicidal ideation among the elderly over 60 years old living in the community centered on sleep and depression. A total of 210 elderly people living in a metropolitan city were surveyed about suicidal ideation, sleep pattern (sleep time, quality of sleep) and depression. Data analysis showed that 14.3% of the subjects were seniors with a high suicidal ideation, 23.3% were sleeping less than 5 hours, 17.6% were poor sleep quality, and 33.3% were depressed. According to multiple logistic regression analysis, the factors influencing suicidal ideation were identified as depression (OR=6.889, 95% CI=2.679-17.712), sleep quality (OR=3.770, 95% CI=1.469-9.679), and gender (OR=3.080, 95% CI=1.266-7.491). These three factors accounted for 31.6% of suicidal ideation variables. Based on the results of this study, it is suggested that reducing the depression and improving the quality of sleep in consideration of gender should be an essential strategy for the elderly in the community to reduce the suicidal ideation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.652-662
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• 2019

This study demonstrates the association between total sleep duration of adolescents, and its effects on their physical and mental health. Chi-square test and the multiple logistic regression model were applied to analyze the data collected in 2018 by the Korean Youth Health Behavior Survey (n = 52,928), conducted by the Korea Centers for Disease Control & Prevention. Our analysis indicates increased suicidal ideation with insufficient total sleep duration as per the recommended amount and grade (OR: 1.17, 95% CI: 1.06-1.29, p-value: 0.00]. Especially, insufficient sleep among adolescent girls significantly increases the risk of suicidal thoughts (OR: 1.22, 95% CI: 1.06-1.41, p-value: 0.01). Sufficient sleep showed reduced risk of suicidal ideation among boys (OR: 0.83, 95% CI: 0.71-0.96, p-value: 0.02). We propose that to reduce the risk of suicide among teenagers, policy considerations are required to ensure sufficient sleep.

• Sleep Medicine and Psychophysiology
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• v.25 no.2
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• pp.82-91
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• 2018

Objectives: Synchronous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has been used to explore sleep stage dependent functional brain networks. Despite a growing number of sleep studies using EEG-fMRI, few studies have conducted network analysis on whole night sleep due to difficulty in data acquisition, artifacts, and sleep management within the MRI scanner. Methods: In order to perform network analysis for whole night sleep, we proposed experimental procedures and data processing techniques for EEG-fMRI. We acquired 6-7 hours of EEG-fMRI data per participant and conducted signal processing to reduce artifacts in both EEG and fMRI. We then generated a functional brain atlas with 68 brain regions using independent component analysis of sleep fMRI data. Using this functional atlas, we constructed sleep level dependent functional brain networks. Results: When we evaluated functional connectivity distribution, sleep showed significantly reduced functional connectivity for the whole brain compared to that during wakefulness. REM sleep showed statistically different connectivity patterns compared to non-REM sleep in sleep-related subcortical brain circuits. Conclusion: This study suggests the feasibility of exploring functional brain networks using sleep EEG-fMRI for whole night sleep via appropriate experimental procedures and signal processing techniques for fMRI and EEG.

• Journal of Convergence for Information Technology
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• v.10 no.11
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• pp.148-155
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• 2020

The purpose of the study was to test the reliability and validity of the Korean version of Pittsburgh Sleep Quality Index (PSQI-K) and to examine the cutoff point of the PSQI-K for screening insomnia among young adults. The subjective quality and patterns of sleep in 64 participants were measured using PSQI-K and Fitbit Charge 3^TM. The properties of the instrument were analyzed using Cronbach's alpha coefficient for the internal consistency reliability, factor analysis for the construct validity, and Spearman's rho correlation coefficient for the correlation between the PSQI-K total scores and Fitbit tracker scores. The Cronbach's alpha coefficient of the PSQI-K was 0.69. The Spearman's rho correlation coefficient between the PSQI-K and Fitbit tracker was higher than 0.67. A cutoff point of ≥6.0 had a sensitivity of 0.93 and a specificity of 0.84. In conclusion, the PSQI-K is a reliable and valid instrument to evaluate sleep disturbance in Korean young adults.

• Korean Journal of Biological Psychiatry
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• v.29 no.1
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• pp.32-32
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• 2022

• Sleep Medicine and Psychophysiology
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• v.4 no.1
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• pp.57-65
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• 1997

As jet lag of modern travel continues to spread, there has been an exponential growth in popular explanations of jet lag and recommendations for curing it. Some of this attention are misdirected, and many of those suggested solutions are misinformed. The author reviewed the basic science of jet lag and its practical outcome. The jet lag symptoms stemed from several factors, including high-altitude flying, lag effect, and sleep loss before departure and on the aircraft, especially during night flight. Jet lag has three major components; including external de synchronization, internal desynchronization, and sleep loss. Although external de synchronization is the major culprit, it is not at all uncommon for travelers to experience difficulty falling asleep or remaining asleep because of gastrointestinal distress, uncooperative bladders, or nagging headaches. Such unwanted intrusions most likely to reflect the general influence of internal desynchronization. From the free-running subjects, the data has revealed that sleep tendency, sleepiness, the spontaneous duration of sleep, and REM sleep propensity, each varied markedly with the endogenous circadian phase of the temperature cycle, despite the facts that the average period of the sleep-wake cycle is different from that of the temperature cycle under these conditions. However, whereas the first ocurrence of slow wave sleep is usually associated with a fall in temperature, the amount of SWS is determined primarily by the length of prior wakefulness and not by circadian phase. Another factor to be considered for flight in either direction is the amount of prior sleep loss or time awake. An increase in sleep loss or time awake would be expected to reduce initial sleep latency and enhance the amount of SWS. By combining what we now know about the circadian characteristics of sleep and homeostatic process, many of the diverse findings about sleep after transmeridian flight can be explained. The severity of jet lag is directly related to two major variables that determine the reaction of the circadian system to any transmeridian flight, eg., the direction of flight, and the number of time zones crossed. Remaining factor is individual differences in resynchmization. After a long flight, the circadian timing system and homeostatic process can combine with each other to produce a considerable reduction in well-being. The author suggested that by being exposed to local zeit-gebers and by being awake sufficient to get sleep until the night, sleep improves rapidly with resynchronization following time zone change.

• Sleep Medicine and Psychophysiology
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• v.25 no.2
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• pp.51-57
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• 2018

Objectives: Previous studies have shown that periodic limb movements in sleep (PLMS) could be one of risk factors for cardiovascular morbidity. The purpose of this study was to investigate the association between PLMS and blood pressure changes during sleep. Methods: We analyzed data from 358 adults (176 men and 182 women) aged 18 years and older who were free from sleep apnea syndrome (Respiratory Disturbance Index < 5) and sleep disorders such as REM sleep behavior disorder or narcolepsy. Demographic characteristics, polysomnography records, and clinical variable data including blood pressure, body mass index, alcohol, smoking, and current medications were collected. In addition, self-report questionnaires including the Beck Depression Index, Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index were completed. Blood pressure change from bedtime to awakening was compared between the two periodic limb movement index (PLMI) groups [low PLMI ($PLMI{\leq}15$) and high PLMI (PLMI > 15)]. Blood pressure change patterns were compared using repeated measures analysis of variance. Results: Systolic blood pressure in the high PLMI group was lower than that in the low PLMI group (p = 0.036). These results were also significant when adjusted for gender and age, but were not statistically significant when adjusted for BMI, alcohol, smoking, anti-hypertension medication use and sleep efficiency (p = 0.098). Systolic blood pressure dropped by 9.7 mm Hg in the low PLMI group, and systolic blood pressure in the high PLMI group dropped by 2.9 mm Hg. There was a significant difference in delta systolic blood pressure after sleep between the two groups in women when adjusted for age, BMI, alcohol, smoking, antihypertensive medication use and sleep efficiency (p = 0.023). Conclusion: PLMS was significantly associated with a decreasing pattern in nocturnal BP during sleep, and this association remained significant in women when adjusted for age, BMI, alcohol, smoking, antihypertension medication use and sleep efficiency related to blood pressure. We suggest that PLMS may be associated with cardiovascular morbidity.

• Tuberculosis and Respiratory Diseases
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• v.66 no.2
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• pp.83-92
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• 2009