• 한국항행학회논문지
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• 제20권6호
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• pp.568-573
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• 2016

현재 아날로그 방식의 마을방송 시스템은 기술 적용의 문제 및 시설 노후화로 인한 성능 저하 등의 문제로 인하여 디지털 시스템으로의 전환과 이에 따른 시스템 표준이 요구되고 있다. 효율적인 디지털 무선 마을 방송 시스템의 구축을 위해서 파라미터를 토대로 전파환경 특성에 기반을 두어 전파의 실측값과 예측 값의 비교분석이 필요하다. 본 논문은 지역 환경을 고려하여 도시지역, 산간지역, 평야지역으로 경로를 설정하여 전파 측정을 하였으며, 측정을 통한 실측값과 예측 값을 SMIS (spectrum management intelligence system) 및 Matlab을 이용하여 전계강도 및 오차를 비교분석하였다. 본 논문의 결과는 전파수신 전력 및 지형별 환경 등의 전파 특징을 예측하고 마을 방송 표준의 확립과 시범 사업화를 위한 자료로 활용될 것이다.

• 폴리머
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• 제37권3호
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• pp.294-301
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• 2013

Polymersomes made of biodegradable triblock copolymers based on poly(fumaric acid-co-sebacoyl chloride)/PEG (PEG-co-P(FA/SC)-co-PEG) were prepared and studied in aqueous solutions. TEM confirmed the formation of vesicles in aqueous media. Aggregation behavior of the copolymers was studied by fluorescence spectroscopy of 8-anilino-1-naphthalenesulfonic acid, and the critical aggregation concentration (c.a.c.) of the copolymer was found to be ${\sim}26.2{\mu}M$ indicating desirable stability of the vesicles. Dynamic light scattering revealed that the size of the vesicles was distributed within the range of 170-270 nm. Turbidity measurements confirmed the relative short-term stability of the polymersomes. Carboxyfluorescein, a hydrophilic compound, was simply encapsulated in the vesicles during polymersome preparation. The release of encapsulant from the polymersomes at 25 and $37^{\circ}C$ lasted about 3 weeks, and the rate of release followed a first-order kinetics. The release is speculated to be primarily carried out through diffusion. These results confirm that these polymersomes are promising as controlled-release carriers of various drugs.

• 대한수의학회지
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• 제43권4호
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• pp.579-585
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• 2003

The studies were carried out on the correlation between microsomal lipid peroxidation level and drug metabolizing enzyme activities in rat liver microsomal suspensions on various ages (2-week-old, 2, 4, 8, and 12-month-old). The lipid peroxidation levels of liver homogenates tended to be elevated in a 4-month-old rat livers, but it was a little decreased in 8 and 12-month-old rat livers. The lipid peroxidation levels of microsomal suspension was not shown any significant differences by ages. Lipid peroxidation levels and microsomal cytochrome P450 and NADPH-cytochrome c reductase activity showed a direct correlation (r=0.72 and r=0.64), respectively. The activities of cytochrome P450-dependent aminopyrine-N-demethylase and benzpyrene hydroxylase in rat liver microsomes were increased by ages up to 8-month-old rats and maintained in 12-month-old rats. The correlation between lipid peroxidation levels and these cytochrome-dependent enzyme activities showed a high direct correlation (r=0.97 and r=0.81), respectively.

• 약학회지
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• 제38권6호
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• pp.637-645
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• 1994

The effect of various drugs on the stability of the liposomal membrane of phosphatidylcholine and cholesterol was studied, employing the fluorescence self-quenching method. Calcein was entrapped into the phospholipid small unilamellar vesicles and the leakage of the fluorescence probe was monitored on adding the drug to the system. The results of the experiments showed that phenothiazine derivatives, some potent local anesthetics and surface active agents were very effective in inducing the leakage of calcein from the liposome. The leakage-inducing activity of these drug substances has been ascribed to their surface activity and the perturbation of the liposomal membrane by these substances. On the other hand drug substance with low surface activity or without amphiphilic moieties did not show any effect or only small effect on the leakage of calcein from the liposomes. The effect of lipid concentration on the stability of the liposomes was also investigated to show that the higher concentrations of lipid more drug was required to induce the leakage. The effect of surface charges of vesicles was also studied, and the results showed that the charge on the liposomes enhanced the stability of the liposomes against the leakage-inducing activity of these drug substances.

• 약학회지
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• 제38권2호
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• pp.131-139
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• 1994

Calcein-encapsulated small unilamellar vesicles of various lipid composition were prepared using the sonication technique, and their stabilities at $20^{\circ}C$ were examined by measuring calcein leakage from the liposomes. The fluidity of these liposomal bilayers was also investigated by measuring the fluorescence polarization of DPH labelled into the liposomes. The results showed that liposomes made of PC mixtures with different acyl chain length were very stable, which may be due to the formation of interdigitated bilayer structure. The addition of cholesterol further stabilized these PC liposomes. However, addition of cholesterol reduced the encapsulation efficiences of liposomes. The fluidity of the liposomes was significantly decreased by cholesterol in the liquid crystalline state, but not changed in the gel state. These results suggest that the enhanced stability of PC mixture liposomes may be ascribed to the formation of stable interdigitated bilayer structure. In membrane-mimetic and drug-delivery studies, vesicles made of mixtures of various phospholipids are recommended instead of addition of cholesterol to the phospholipid.

• 식품기술
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• 제12권2호
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• pp.26-38
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• 1999

조리가공 중 생성되는 주요 발암성 이환방향족아민(heterocyclic aromatic amine)인 Trp-P-1 및 Trp-P-2가 human 및 rat keratinocytes에 대해 나타내는 세포 독성을 colony expansion법의 의해 조사, 비교하였다. 특히 Trp-P-2는 human keratinocytes에 대해서는 독성을 나타내지 않은데 반해 rat keratinocytes(계대수 2-5)에 대해서는 독성을 나타내는 선택성을 나타내었다. 이러한 Trp-P-2의 종(species)간 독성감수성 차이가 대사 효소계 활성이나 mutagenic activation상의 차이에 기인되는지를 살펴본 결과, CYP4501As 및 독성감수성 차이가 크게 나타났던 human 및 rat keratinocytes의 microsome에서 거의 같았다. 이와 같은 결과는 CYP4501A1 및 CYP1B1의 mRNA의 발현정도를 northernblot에 의해 살펴보았던 결과에서도 일치하였다. 반면 Trp-P-2의 대사활성화 및 해독화에 관여하는 효소인 N.O-acetyltransferase(NAT)활성은 rat keratinocytes보다 human keratinocytes에서 높았다. 일반적으로 독성물질의 해독화에 관여하는 glutathione S-transferase(GST) 또한 rat keratinocytes보다 human keratinocytes에서 높게 나타났다. Trp-P-2가 mutagenic metabolite로 활성화되는 정도를 salmonella microsome microsuspension assay로 살펴본 결과, 독성 감수성 차이가 크게 나타났던 human 및 rat keratinocytes간의 활성은 비슷한 것으로 나타났다. DNA 및 단백질 adduct형성능의 경우, human 및 rat keratinocytes간 DNA adduct형성능에는 차이가 없었고, 단백질 adduct형성능의 경우만 Trp-P-2에 대한 독성감수성 정도가 컸던 rat keratinocytes가 다른 세포들에 비해 크게 나타났다. 이상의 결과를 종합해 볼 때, CYP1A- 또는 CYP1B1-관련 마이크로솜 효소활성이나 mutagenic activation은 human 및 rat keratinocytes간에 나타났던 독성 감수성의 차이를 설명할 수 없으며, 해독화에 관여하는 효소활성이 종간 관찰되었던 독성 감수성의 차이에 더 중요한 역할을 하는 것으로 보인다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 학술대회
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• pp.308-315
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• 2008

극저온 유체를 운반하는 선박의 화물창은 보통 1차 방벽과 2차 방벽으로 구성되어 있다. 1차 방벽에 소량의 극저온 유체의 누출이 생기더라도, 액밀이 되는 2차 방벽에서 추가적인 극저온 유체의 누출을 방지할 수 있기 때문이다. 그러나 2차 방벽에 추가적인 손상이 생길 경우 유리솜으로 만들어진 Flat Joint를 거쳐 선체내벽까지 극저온 유체에 노출될 가능성이 있게 된다. 본 연구의 관심사는 2차 방벽의 손상 정도에 따라, 그리고 누출되는 극저온 유체의 양에 따라, 내측선체에 얼마나 영향이 미치는가를 알아보는 것이다. 이를 위해 본 연구에서는 극저온 유체를 운반하는 선박의 화물창을 구성하는 2차 방벽에 구멍을 뚫어 Flat Joint 사이로 극저온 유체가 흘러 들어가도록 격자를 생성한 후, CFD 소프트웨어를 이용하여 극저온 유체의 누출에 대한 계산을 수행 하였으며 이를 실험 결과와 비교 분석 하였다. 실험과 계산 결과를 살펴보면, 극저온 유체량에 따라 내측 선체에의 피해를 최소화 할 수 있음을 확인하였다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년 추계학술대회논문집
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• pp.308-315
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• 2008

극저온 유체를 운반하는 선박의 화물창은 보통 1차 방벽과 2차 방벽으로 구성되어 있다. 1차 방벽에 소량의 극저온 유체의 누출이 생기더라도, 액밀이 되는 2차 방벽에서 추가적인 극저온 유체의 누출을 방지할 수 있기 때문이다. 그러나 2차 방벽에 추가적인 손상이 생길 경우 유리솜으로 만들어진 Flat Joint를 거쳐 선체내벽까지 극저온 유체에 노출될 가능성이 있게 된다. 본 연구의 관심사는 2차 방벽의 손상 정도에 따라, 그리고 누출되는 극저온 유체의 양에 따라, 내측선체에 얼마나 영향이 미치는가를 알아보는 것이다. 이를 위해 본 연구에서는 극저온 유체를 운반하는 선박의 화물창을 구성하는 2차 방벽에 구멍을 뚫어 Flat Joint 사이로 극저온 유체가 흘러 들어가도록 격자를 생성한 후, CFD 소프트웨어를 이용하여 극저온 유체의 누출에 대한 계산을 수행 하였으며 이를 실험 결과와 비교 분석 하였다. 실험과 계산 결과를 살펴보면, 극저온 유체량에 따라 내측 선체에의 피해를 최소화 할 수 있음을 확인하였다.

• 한국의류산업학회지
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• 제9권4호
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• pp.445-449
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• 2007

The results of warmth retaining, heat transfer and compressive elastic recovery of the five kinds of bedspread fabrics, which were produced from packing weft of 2700 denier and 3600 denier batt yarn treated with raw material of Polyester $150^D$/48 DTY, are as follows: 1) 3600 denier packing weft showed lover count in compressive elastic recovery than 2700d packing weft, so it took longer time to recover. 2) When packing weft of the same count is used, a sample of packing weft with higher density showed lower recovery. 3) It took 2700d packing weft 30min to get approximately 98% recovery in temperature $30^{\circ}C$. But, 3600d packing weft stayed under 98% recovery in the same temperature. Considering only the result of compressive elastic recovery, we should use 2700d packing weft. 4) The higher the density of packing weft is, the higher warmth retaining becomes. Although sharp increase appeared until 5min, equilibrium was kept without any increase after that time. 5) When 2700d packing weft was used, the maximum warmth retaining was approximately 60% and 64% in the conditions of density 12(thread/in) and 22(thread/in) respectively.

• 대한간호학회지
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• 제46권2호
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• pp.271-282
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• 2016

Purpose: This study was done to explore adaptation experience of living kidney donors after donation. Specific aims were to identify challenges donors face in the process of adaptation following surgery and how they interact with recipients and other people. Methods: Grounded theory methodology was utilized. Participants were 13 living kidney donors at six months or more after donation. Data were collected by in-depth interviews with individual participants. Data were analyzed using constants comparative method with theoretical saturation. Results: A core category emerged as 'keeping the fences of my family in spite of vulnerability'. The adaptation process after donation was manifested in four phases: exploration, balance, maintenance, and acclimatization. Phenomenon was perception of vulnerability. Strategies to manage the vulnerability were assessing changes of body awareness, tailoring regimen to one's own body condition, coping with health problems, keeping restoration of health, and ruminating on the meaning of one's kidney donation. Consequences were reestablishing family well-being, realizing the values of one's kidney donation, and living with uncertainty. Conclusion: Findings of the study indicate that there is a need for health professionals to understand the vulnerability of living kidney donors and help their family system maintain a healthy and productive life. The results of this study can be used to develop phase-specific, patient-centered, and tailored interventions for living kidney donors.