• Title/Summary/Keyword: 손상체적

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Feasibility and Efficacy of Adaptive Intensity Modulated Radiotherapy Planning according to Tumor Volume Change in Early Stage Non-small Cell Lung Cancer with Stereotactic Body Radiotherapy (폐암의 정위적체부방사선치료에서 육안적종양체적 변화에 따른 적응방사선치료의 효용성 및 가능성 연구)

  • Park, Jae Won;Kang, Min Kyu;Yea, Ji Woon
    • Progress in Medical Physics
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    • v.26 no.2
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    • pp.79-86
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    • 2015
  • The purpose of this study is to evaluate efficacy and feasibility of adaptive radiotherapy according to tumor volume change (TVC) in early stage non-small cell lung cancer (NSCLC) using stereotactic body radiotherapy (SBRT). Twenty-two lesions previously treated with SBRT were selected. SBRT was usually performed with a total dose of 48 Gy or 60 Gy in four fractions with an interval of three to four days between treatments. For evaluation of TVC, gross tumor volume (GTV) was contoured on each cone-beam computed tomography (CBCT) image used for image guidance. Intensity modulated radiotherapy (IMRT) planning was performed in the first CBCT (CBCT1) using a baseline plan. For ART planning (ART), re-optimization was performed at $2^{nd}$, $3^{rd}$, and $4^{th}$ CBCTs (CBCT2, CBCT3, and CBCT4) using the same angle and constraint used for the baseline plan. The ART plan was compared with the non-ART plan, which generated copying of the baseline plan to other CBCTs. Average GTV volume was 10.7 cc. Average TVC was -1.5%, 7.3%, and -25.1% in CBCT2, CBCT3, and CBCT4 and the TVC after CBCT3 was significant (p<0.05). However, the nine lesions were increased GTV in CBCT2. In the ART plan, $V_{20\;Gy}$, $D_{1500\;cc}$, and $D_{1000\;cc}$ of lung were significantly decreased (p<0.05), and $V_{30\;Gy}$ and $V_{32\;Gy}$ of the chest wall were also decreased (p<0.05). While D min of planning target volume (PTV) decreased by 8.3% in the non-ART plan of CBCT2 compared with the baseline plan in lesions with increased tumor size (p=0.021), PTV coverage was not compromised in the ART plan. Based on this result, use of the ART plan may improve target coverage and OAR saving. Thus ART using CBCT should be considered in early stage NSCLC with SBRT.

Dose Planning of Forward Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer using Compensating Filters (보상여과판을 이용한 비인강암의 전방위 강도변조 방사선치료계획)

  • Chu Sung Sil;Lee Sang-wook;Suh Chang Ok;Kim Gwi Eon
    • Radiation Oncology Journal
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    • v.19 no.1
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    • pp.53-65
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    • 2001
  • Purpose : To improve the local control of patients with nasopharyngeal cancer, we have implemented 3-D conformal radiotherapy and forward intensity modulated radiation therapy (IMRT) to used of compensating filters. Three dimension conformal radiotherapy with intensity modulation is a new modality for cancer treatments. We designed 3-D treatment planning with 3-D RTP (radiation treatment planning system) and evaluation dose distribution with tumor control probability (TCP) and normal tissue complication probability (NTCP). Material and Methods : We have developed a treatment plan consisting four intensity modulated photon fields that are delivered through the compensating tilters and block transmission for critical organs. We get a full size CT imaging including head and neck as 3 mm slices, and delineating PTV (planning target volume) and surrounding critical organs, and reconstructed 3D imaging on the computer windows. In the planning stage, the planner specifies the number of beams and their directions including non-coplanar, and the prescribed doses for the target volume and the permissible dose of normal organs and the overlap regions. We designed compensating filter according to tissue deficit and PTV volume shape also dose weighting for each field to obtain adequate dose distribution, and shielding blocks weighting for transmission. Therapeutic gains were evaluated by numerical equation of tumor control probability and normal tissue complication probability. The TCP and NTCP by DVH (dose volume histogram) were compared with the 3-D conformal radiotherapy and forward intensity modulated conformal radiotherapy by compensator and blocks weighting. Optimization for the weight distribution was peformed iteration with initial guess weight or the even weight distribution. The TCP and NTCP by DVH were compared with the 3-D conformal radiotherapy and intensitiy modulated conformal radiotherapy by compensator and blocks weighting. Results : Using a four field IMRT plan, we have customized dose distribution to conform and deliver sufficient dose to the PTV. In addition, in the overlap regions between the PTV and the normal organs (spinal cord, salivary grand, pituitary, optic nerves), the dose is kept within the tolerance of the respective organs. We evaluated to obtain sufficient TCP value and acceptable NTCP using compensating filters. Quality assurance checks show acceptable agreement between the planned and the implemented MLC(multi-leaf collimator). Conclusion : IMRT provides a powerful and efficient solution for complex planning problems where the surrounding normal tissues place severe constraints on the prescription dose. The intensity modulated fields can be efficaciously and accurately delivered using compensating filters.

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The Fiber Damage and Mechanical Properties of Short-fiber Reinforced Composite Depending on Nozzle Size Variations in Injection/Mold Sides (단섬유강화 복합재료에서 사출측/금형측 노즐 크기 변화에 따른 섬유손상 및 기계적 성질)

  • Lee, In-Seop;Lee, Dong-Ju
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.25 no.4
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    • pp.564-573
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    • 2001
  • The mechanical properties of short carbon/glass fiber reinforced polypropylene are experimentally measured as functions of fiber content and nozzle diameter. Also, these properties are compared with the survival rate of reinforced fibers and fiber volume fraction using image analysis after pyrolytic decomposition. The survival rate of fiber aspect ratio as well as fiber volume fraction is influenced by injection processing condition, the used materials and mold conditions such as diameter of nozzle, etc. In this study, the survival rate of fiber aspect ratio is investigated by nozzle size variations in injection/mold sides. It is found that the survival rate of glass fiber is higher that the survival rate of glass fiber is higher than that of carbon fiber. Both tensile modulus and strength of short-fiber reinforced polypropylene are improved s the fiber volume fraction and nozzle diameter are increased.

Development of Fire-Diagnosis Concrete using Composite Sensors (복합센서를 이용한 화재자현 콘크리트의 개발)

  • Choi, Young-Wha;Kim, Ie-Sung;Park, Kang-Geun
    • Journal of Korean Association for Spatial Structures
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    • v.10 no.4
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    • pp.85-92
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    • 2010
  • Use of concrete has undoubtedly become widespread in construction and civil engineering. Sensors are used to add functional characteristics to concrete. Self-diagnosis concrete is also being developed. The thermal protector used in the study is a sensor using the linear expansion and cubical expansion of metal. The LED(Light Emitting Diode) is a phototransistor type, and to secure high-sensitivity light, the prices of these sensors are low. Rising temperatures of concrete elements can be predicted from LED of the external virtual beam due to operation of thermal protector sensors of concrete beam caused by fire load on the concrete specimen. In this study, the development of fire-diagnosis concrete using composite sensors are the fundamental study for damage detection using simply measurements.

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Prevention of Insulation Damage Layer and Shell Corrosion in Thermal Storage Tanks for District Heating (지역난방용 축열조의 단열재 손상과 외각부식 개선방안)

  • Bang, Yong-Eoon;Yoo, Ho-seon
    • Plant Journal
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    • v.10 no.4
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    • pp.35-41
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    • 2014
  • The height and capacity of the thermal storage tank can be decided by the altitude and heat load of the heat supply area. Evaporation in heat pipe can be prevented by pressurizing it with the hydraulic head of the thermal storage tank. In addition, it absorbs the expanded volume from the temperature changes and supplies water to the pipelines in case of the shortage of water. One of the most important roles of the thermal storage tank is a stable heat supply facility. It can control the heat demand by accumulating the surplus heat and supplying in changing heat demand time. The purpose of this thesis is to be helpful for the operation and maintenance of the thermal storage tanks. The study has been carried out for 18 thermal storage tanks, which have been used polyurethane foam as insulation, among 27 tanks in district heating plants. The characteristics of the insulation materials, the reasons for the damages of the insulation and how impact the insulation damages to the corrosion of the thermal storage tank have been studied.

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Assessment of Pipe Wall Loss Using Guided Wave Testing (유도초음파기술을 이용한 배관 감육 평가)

  • Joo, Kyung-Mun;Jin, Seuk-Hong;Moon, Yong-Sig
    • Journal of the Korean Society for Nondestructive Testing
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    • v.30 no.4
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    • pp.295-301
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    • 2010
  • Flow accelerated corrosion(FAC) of carbon steel pipes in nuclear power plants has been known as one of the major degradation mechanisms. It could have bad influence on the plant reliability and safety. Also detection of FAC is a significant cost to the nuclear power plant because of the need to remove and replace insulation. Recently, the interest of the guided wave testing(GWT) has grown because it allows long range inspection without removing insulation of the pipe except at the probe position. If GWT can be applied to detection of FAC damages, it will can significantly reduce the cost for the inspection of the pipes. The objective of this study was to determine the capability of GWT to identify location of FAC damages. In this paper, three kinds of techniques were used to measure the amplitude ratio between the first and the second welds at the elbow area of mock-ups that contain real FAC damages. As a result, optimal inspection technique and minimum detectability to detect FAC damages drew a conclusion.

A Comparative Study of Radiation Therapy Planning between Volumetric-Modulated Arc Therapy and Three-Dimensional Conformal Radiotherapy in Nasopharyngeal Cancer (비인두암의 방사선치료 시 삼차원입체조형 치료기법과 용적세기조절회전치료기법의 비교연구)

  • Kim, Ji-Sung;Lee, Seok-Ho;Lee, Seung-Heon;Kim, Hye-Young;Choi, Jin-Ho;Lee, Kyu-Chan;Kim, Dong-Young
    • Korean Journal of Head & Neck Oncology
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    • v.26 no.2
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    • pp.171-177
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    • 2010
  • 연구목적 : 비인두암 환자들을 대상으로 방사선치료 시 삼차원입체조형치료기법과 용적세기조절회전치료기법을 비교하고 이하선을 포함한 정상조직 보호에 있어 그 차이점을 알아 보고자 본 연구를 시행하였다. 대상 및 방법 : 비인두암 환자 5명을 대상으로 치료계획용 CT(computed tomography)를 시행 후 삼차원입체조형방사선치료계획 과 용적세기조절회전치료계획을 시행하였다. 이를 바탕으로 얻은 선량분포, conformity index(CI) 그리고 선량체적 히스토그램을 통해 손상위험장기(organ at risk)와 계획용표적체적(planning target volume)을 비교 분석하였다. 결 과 : 분석결과 이하선에 조사되는 평균선량이 용적세기조절회전치료계획에서는 43.9%로 삼차원입체조형치료계획에서의 89.4% 보다 유의하게(p=0.043) 감소하였다. 계획용표적체적 conformity index의 경우 용적세기조절회전치료계획 (CI=1.06)에서 삼차원입체조형치료계획(CI=2.55) 보다 유의하게(p=0.043) 향상된 결과를 보였다. 결 론 : 비인두암 환자에서 용적세기조절회전 치료계획 시 삼차원입체조형치료계획 보다 유의하게 이하선에 평균선량이 줄었고 계획용 표적체적에 대한 conformity도 유의하게 향상되는 결과를 보였다. 본 연구가 적은 수의 환자를 대상으로 하였으나 용적세기조절회전치료기법을 시행 시 구강건조증의 발생을 줄일 수 있을 것으로 기대된다. 향후 더 많은 환자군을 대상으로 한 임상연구가 필요할 것으로 사료된다.

Evaluation of Thermal and Shrinkage Stresses in Hardening Concrete Considering Early-Age Creep Effect (초기재령 콘크리트의 크리프를 고려한 온도 및 수축응력 해석)

  • 차수원;오병환;이형준
    • Journal of the Korea Concrete Institute
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    • v.14 no.3
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    • pp.382-391
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    • 2002
  • This study is devoted to the problems of thermal and shrinkage stresses in order to avoid cracking at early ages. The early-age damage induced by volume change has great influence on the long-term structural performance of the concrete structures such as its durability and serviceability To solve this complex problem, the computer programs for analysis of thermal and shrinkage stresses were developed. In these procedures, numerous material models are needed and the realistic numerical models have been developed and validated by comparison with relevant experimental results in order to solve practical problems. A framework has been established for formulation of material models and analysis with 3-D finite element method. After the analysis of the temperature, moisture and degree of hydration field in hardening concrete structure, the stress development is determined by incremental structural formulation derived from the principle of virtual work. In this study, the stress development is related to thermal and shrinkage deformation, and resulting stress relaxation due to the effect of early-age creep. From the experimental and numerical results it is found that the early-age creep p)ays important role in evaluating the accurate stress state. The developed analysis program can be efficiently utilized as a useful tool to evaluate the thermal and shrinkage stresses and to find measures for avoiding detrimental cracking of concrete structures at early ages.

Damage Process Appraisal of Gears in Automobile Transmission (자동차 트랜스미션 기어의 손상과정 평가)

  • 배효준;조연상;이충엽;서영백;박흥식
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 1999.06a
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    • pp.272-278
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    • 1999
  • It is the effective method to diagnosis damage process of gear system such as automobile transmission to observe wear particle in gear oil. We tested with new transmission and took out gear oil according to drive distance. 4 shape parameters of wear particles in gear oil were calculated and wear volume were presumed with the image processing system. To be applied to damage diagnosis of gear system in transmission of automobile, we discuss number of wear particles, shape characteristics and total wear volume according to driving distance.

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The Detection of Main Spindle Bearing Defect for Machine Tool (공작기계 주축용 베어링 결함검출)

  • 오석영;정의식;임영호
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 1993.10a
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    • pp.351-356
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    • 1993
  • 최근의 프로세스 공업화에 있어서 생산Line의 장치나 기계류는 점차 대형화, 고속화,연속화,복잡화되고 있다. 또한, 기계가공공업,자동차공업,기계,전자부품의 가공조립등의 생산설비는 각설비가 고도로 자동화되고 있는 실정으로 공장 전체의 유기체적인 제어 및 감독을 필요로 하고 있다. 마찬가지로 기계부품제작산업도 CNC.FMS등으로 점차 조작화,자동화됨에 따라 공작기계 장치나 기계류등의 이상이나 고장으로 생산 및 품질에 미치는 영향도 종래와 비교할 수 없을 정도로 중요시 되고 있는 실정이다, 이와같이 설비의 안전성을 도모하고 고신뢰도를 부여하기위해서는 기계설비의 이상 및 고장진단이 필수적이며, 공장 자동화와 함께 공작기계자체의 고장 및 이상진단을 실시하고, 검출된 신호의 크기등으로 고장상태를 판정해야만 한다. 공작기계에서 동적인 회전시스템을 이루는 주축용베어링의 손상은 제작하고자 하는 제품의 정밀도 표면거칠기등의 저하 뿐만아니라 시스템 전체의 기능까지도 떨어뜨리는 요인이 될수 있으므로 베어링 상태를 진단하여 송상유무를 판단하는것은 필수적이라 생각된다.

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