Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

A Comparative Study of Radiation Therapy Planning between Volumetric-Modulated Arc Therapy and Three-Dimensional Conformal Radiotherapy in Nasopharyngeal Cancer

비인두암의 방사선치료 시 삼차원입체조형 치료기법과 용적세기조절회전치료기법의 비교연구

  • Kim, Ji-Sung (Department of Radiation Oncology, Gachon University of Medical and Science) ;
  • Lee, Seok-Ho (Department of Radiation Oncology, Gachon University of Medical and Science) ;
  • Lee, Seung-Heon (Department of Radiation Oncology, Gachon University of Medical and Science) ;
  • Kim, Hye-Young (Department of Radiation Oncology, Gachon University of Medical and Science) ;
  • Choi, Jin-Ho (Department of Radiation Oncology, Gachon University of Medical and Science) ;
  • Lee, Kyu-Chan (Department of Radiation Oncology, Gachon University of Medical and Science) ;
  • Kim, Dong-Young (Department of Otolaryngology, Gachon University of Medical and Science)
  • 김지성 (가천의과학대학교 의학전문대학원 방사선종양학교실) ;
  • 이석호 (가천의과학대학교 의학전문대학원 방사선종양학교실) ;
  • 이승헌 (가천의과학대학교 의학전문대학원 방사선종양학교실) ;
  • 김혜영 (가천의과학대학교 의학전문대학원 방사선종양학교실) ;
  • 최진호 (가천의과학대학교 의학전문대학원 방사선종양학교실) ;
  • 이규찬 (가천의과학대학교 의학전문대학원 방사선종양학교실) ;
  • 김동영 (가천의과학대학교 의학전문대학원 이비인후과학교실)
  • Published : 2010.11.26
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Abstract

연구목적 : 비인두암 환자들을 대상으로 방사선치료 시 삼차원입체조형치료기법과 용적세기조절회전치료기법을 비교하고 이하선을 포함한 정상조직 보호에 있어 그 차이점을 알아 보고자 본 연구를 시행하였다. 대상 및 방법 : 비인두암 환자 5명을 대상으로 치료계획용 CT(computed tomography)를 시행 후 삼차원입체조형방사선치료계획 과 용적세기조절회전치료계획을 시행하였다. 이를 바탕으로 얻은 선량분포, conformity index(CI) 그리고 선량체적 히스토그램을 통해 손상위험장기(organ at risk)와 계획용표적체적(planning target volume)을 비교 분석하였다. 결 과 : 분석결과 이하선에 조사되는 평균선량이 용적세기조절회전치료계획에서는 43.9%로 삼차원입체조형치료계획에서의 89.4% 보다 유의하게(p=0.043) 감소하였다. 계획용표적체적 conformity index의 경우 용적세기조절회전치료계획 (CI=1.06)에서 삼차원입체조형치료계획(CI=2.55) 보다 유의하게(p=0.043) 향상된 결과를 보였다. 결 론 : 비인두암 환자에서 용적세기조절회전 치료계획 시 삼차원입체조형치료계획 보다 유의하게 이하선에 평균선량이 줄었고 계획용 표적체적에 대한 conformity도 유의하게 향상되는 결과를 보였다. 본 연구가 적은 수의 환자를 대상으로 하였으나 용적세기조절회전치료기법을 시행 시 구강건조증의 발생을 줄일 수 있을 것으로 기대된다. 향후 더 많은 환자군을 대상으로 한 임상연구가 필요할 것으로 사료된다.

Keywords

References

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