• Journal of the Korean Society of Propulsion Engineers
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• v.4 no.4
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• pp.78-86
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• 2000

The objective of this research is to understand the characteristics of a nonpremixed, turbulent, hydrogen jet flame which is stabilized in Mach 1.8 coflowing air flows. In order to investigate the flame structure, flame lengths and fuel trajectories were measured by using direct photography, acetone PLIF, Mie scattering techniques, and numerical simulation. Effect of increasing air velocity was investigated when fuel velocity is fixed. The subsonic flame length was decreased drastically, however the supersonic flame length was increased slowly Then the change of flame blow out characteristics was observed as varying fuel nozzle lip thickness. The flame stability can be increased when fuel nozzle lip thickness was increased, which indicates that the minimum fuel lip thickness ratio is required for the stable supersonic flames. Also, it is found that fuel jet is blocked by high pressure zone and low scattering zone is made. Then the fuel that was moving along the recirculation zone had longer residence time within the supersonic flames, which made partially premixed zone.

• The Journal of Korean Obstetrics and Gynecology
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• v.32 no.3
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• pp.128-141
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• 2019

Objectives: This study was performed to investigate the pain relief effect of lower abdomen warmer on primary dysmenorrhea patients taking nonsteroidal anti-inflammatory drugs and whether the using of warmer can supplement or replace the drugs. Methods: 30 women with primary dysmenorrhea were assigned to treatment group (n=15) and control group (n=15). At 1st visit, the treatment group was provided with a wirless multiuse warmer and trained to use at least three times per menstrual cycle. The control group was not provided with the warmer, and both groups were provided with a menstrual diary and instructed to record their pain intensity and dose of analgesic every menstrual period. Visual Analogue Scale (VAS) were used to assess the intensity of overall pain and the most severe pain during the menstrual period. And the total number of analgesic taken during menstruation and the average number of analgesic taken during a single dose were measured. Results: There was significant pain relief in the treatment group compared to before baseline, and there was a significant difference from the control group. In addition, there was no significant difference in the frequency of taking analgesic during the menstrual period between the treatment group and the control group, but the dose of analgesic was significantly lower in the treatment group than in the control group. Conclusions: This clinical trial showed that lower abdomen warmer would helpful in relieving primary dysmenorrhea and could help reduce the use of nonsteroidal anti-inflammatory drugs.

• Journal of the Korea Convergence Society
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• v.12 no.8
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• pp.309-315
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• 2021

Pycnogenol extracted from pine bark is a component with great antibacterial activity and antioxidant effect. It is applied as a natural anti-inflammatory agent with various medical effects including anti-inflammatory effects, regulation of blood pressure, regulation of the immune system, and inhibition of cancer cell growth. However, research related to cosmetics is limited. Therefore, in this study, the effect of Pycnogenol on the skin was studied through a clinical approach. Changes in skin condition were observed after using cosmetics with Pycnogenol and without Pycnogenol for 6 weeks for 10 clinicians in each group. We observed the effect of pore reduction, wrinkle reduction around eyes, a decrease of the number and angle of loose pores, and reduction of pigmentation. Therefore, cosmetics containing Pycnogenol have the effect of improving skin problems of aging skin.

• KIPS Transactions on Software and Data Engineering
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• v.10 no.11
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• pp.465-472
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• 2021

In this paper, we present an approach for detection of adverse drug reactions from drug reviews to compensate limitations of the spontaneous adverse drug reactions reporting system. Considering negative reviews usually contain adverse drug reactions, sentiment analysis on drug reviews was performed and extracted negative reviews. After then, MedDRA dictionary and named entity recognition were applied to the negative reviews to detect adverse drug reactions. For the experiment, drug reviews of Celecoxib, Naproxen, and Ibuprofen from 5 drug review sites, and analyzed. Our results showed that detection of adverse drug reactions is able to compensate to limitation of under-reporting in the spontaneous adverse drugs reactions reporting system.

• Journal of Korean Medicine Rehabilitation
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• v.32 no.3
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• pp.109-117
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• 2022

Objectives To compare the therapeutic effect of ultrasound guided soyeom pharmacopuncture therapy and unguided soyeom pharmacopuncture therapy on cervical facet joint of patient who have cervical pain caused by traffic accidents. Methods The study was planned as a retrospective study that analyzes the patient's medical records. We analyzed medical records of 20 patients with acute cervical pain caused by traffic accidents from April 1, 2022 to May 31, 2022. 10 patients (Group A) were treated ultrasound guided soyeom pharmacopuncture therapy on cervical facet joint, 10 patients (Group B) were treated unguided soyeom pharmacopuncture therapy on cervical facet joint. We used visual analogue scale (VAS) and neck disability index (NDI) to evaluate improvements in cervical functions and pain, five point Likert scale to estimate patient's satisfaction. We used the IBM SPSS Statistics version 25 program (IBM Co., Armonk, NY, USA) for statistical analysis. Results Group A showed a significant decrease in the VAS on the 5^th day of the soyeom pharmacopuncture therapy (p=0.001). However, there was no statistically significant difference of VAS between two groups (p=0.142). Group A showed significant decrease in the NDI on the 5^th day of the therapy (p=0.002). Also, there was statistically significant difference on NDI between two groups (p=0.018). Difference of five point Likert scale between two groups was not statistically significant (p=0.407). Conclusions In patients of acute cervical pain caused by traffic accidents, ultrasound guided soyeom pharmacopuncture therapy on cervical facet joint showed significant efficacy on reduction of neck disability compared with unguided therapy.

• Journal of Korean Medicine Rehabilitation
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• v.31 no.3
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• pp.85-93
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• 2021

Objectives This study aims to compare the effect of an ultrasound on a guided group and an unguided group on Soyeom pharmacopuncture therapy on the facet joint in patients with acute low back pain caused by traffic accidents. Methods 21 patients with acute low back pain caused by traffic accidents from March 1, 2021 to May 31, 2021 were included in this study. The study was conducted as a retrospective study which analyzes the patient's medical records. 11 patients (Group A) received ultrasound guided Soyeom pharmacopuncture therapy and 10 patients (Group B) received unguided Soyeom pharmacopuncture therapy on the facet joint. Visual analogue scale (VAS) and Oswestry disability index (ODI) was used to evaluate improvements in functions and pain, and five point Likert scale to evaluate patient's satisfaction. Results Both groups showed a statistically significant decrease in the VAS and ODI on the 5th day of hospitalization. However, there was no statistically significant difference between the groups. Difference in the Likert scale between the groups was not statistically significant either. Conclusions We found that ultrasound guided Soyeom pharmacopuncture therapy on the facet joint showed similar efficacy compared with unguided Soyeom pharmacopuncture therapy at facet joint on acute low back pain patients caused by traffic accidents.

• The Korea Journal of Herbology
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• v.29 no.5
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• pp.45-53
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• 2014

Objectives : The purpose of the study is to test the antibacterial, anti-inflammatory and antioxidant effects of BPH, which is composed of Pini Densiflorae Nodi Lignum and Querci Acutissimae Fructus, Angelicae Gigantis Radix, Cnidii Rhizoma, Angelicae Dahuricae Radix, Angelicae Tenuissimae Radix. Method : Antibacterial and anti-inflammatory effects of BPH on Propionibacterium acnes, one of anaerobic bacteria species were evaluated by measuring the levels of 2,2-diphenyl-1-picrylhydrazyl (DPPH) elimination and lipid peroxidation. Result : When BPH was applied to CCD-986sk (Human normal fibroblast) to confirm the level of cytokine(tumor necrosis factor-alpha, interleukin-8), its level increased in proportion to that of BPH's concentration, which indicated dose-dependent relationship. Using the Disk diffusion to measure the bacterial growth inhibition zone varying BPH concentration, it was found that the antibacterial effect of BPH was less than that of erythromycin, the control group, but was higher than that of saline, and it increased with higher concentrations. In a liquid culture medium containing BPH, the growth rate of Propionibacterium acnes was decreased by more than 10% at 25% BPH. After adding P. acnes to THP-1 monocyte, and treated it with BPH, and measuring the concentration of TNF-a and IL-8, it was observed that the amount of TNF-alpha and IL-8 significantly decreased depending on the level of BPH concentration. The ability to eliminate DPPH increased with higher BPH concentration. The inhibition of lipid peroxidation was increased by BHT treatment in a dose-dependent manner. Conclusion : Using Propionibacterium acnes, an anaerobic bacteria, we confirmed that BPH has antibacterial, anti-inflammatory and antioxidant effects.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.4
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• pp.161-173
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• 2022

Objectives: This study was conducted to evaluate the effectiveness of acupuncture in patients with primary menstrual difficulties taking NSAIDs. Methods: 30 women with primary menstrual difficulties with NSAIDs were assigned to treatment groups (n=15) and control groups (n=15). On their first visit, both groups were provided with a menstrual diary and were required to record the intensity of pain and the dosage of painkillers during each menstrual cycle. The treatment group received two acupuncture treatments per cycle during two cycles, and the control group did not receive acupuncture. Pain strength during menstruation was evaluated using Visual Analogue Scale (VAS), and the total number of painkillers taken during menstruation and the average number of painkillers taken during a single dose was measured. Results: The treatment group had significant pain relief compared to the pre-test group and significant differences from the control group. In addition, there was a significant difference between the treatment group and the control group in the frequency of taking painkillers during the menstrual period and the dose in the test group was significantly lower than before treatment. Conclusions: This clinical trial showed that this acupuncture can help alleviate primary menstruation and reduce the use of nonsteroidal anti-inflammatory drugs.

• Journal of Hydrogen and New Energy
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• v.33 no.6
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• pp.776-785
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• 2022

Hydrogen combustion in modern gas-turbine engine is the cutting edge technology as carbon-free energy conversion system. Flashback of hydrogen flame, however, is inevitable and critical specially for premixed hydrogen combustion. Therefore, this experimental investigation is conducted to understand flashback phenomenon in premixed hydrogen combustion. In order to investigate flashback characteristics in premixed hydrogen (H₂)/air flame, we focus on pressure conditions and nozzle shapes. In general, quenching distance reduces as pressure of combustion chamber increases, causing flashback from boundary layer near wall. The flashback regime for reference and modified candidate configurations can broadly appear with increasing combustion chamber pressure. The later one can improve flashback-resist by compensating flow velocity at wall. Also, improved wall flow velocity profile of suggested contraction nozzle prevents entire flashback but causes local flashback at nozzle exit.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.102-102
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• 2020

가시오가피(Acanthopanax senticosus)는 오갈피나무과(두릅나무과, Araliaceae)에 속한 낙엽관목인 가시오갈피나무 Acanthopanax senticosus Seem. 또는 기타 동속 식물의 뿌리 및 줄기 껍질이다. Acanthopanax 속 식물의 잎에 대한 약리 연구로는 위장보호작용, 항산화작용, 소염진통작용, 항암작용, 항균작용, 심근경색 개선 작용, 혈당강하작용 등에 대한 탁월한 효과가 알려져 있다. 그 중 가시오가피는 모든 오갈피 나무를 통틀어 약효가 가장 높고 보약의 역할을 한다. 인삼의 가공 과정을 적용하여 가시오가피를 증숙하면 수배에서 수십배까지 생이용성과 생리활성이 증진되나, 이렇게 제조하기 위해서는 증숙 및 냉각하는 공정을 반복적으로 가하고 효소 처리하는 증 가공 공정으로 의해 가격이 증가하게 된다. 콩단백은 콩기름이나 두부를 제조하고 남은 부산물로 영양학적으로 쇠고기 단백질과 비견할 만큼 우수한 영양학적 가치를 가지지만, 이용되는 양은 현저히 적어 이에 따른 활용도가 요구되고 있다. 압착대두 단백은 압착방식으로 기름을 짜고 남은 부산물을 파우더 형태로 가공하여 6% 가량의 지방질과 Glutamic acid, Arginine, Aspartic acid, Alanine 등 여러 가지 필수 아미노산을 제공한다. 이에, 본 연구에서는 압착대두단백과 두부건조분말을 가시오가피 소재의 기능증진 소재로 활용하고자 한다. 건조 가시오가피와 콩단백 분말의 비율을 1:0, 1:1, 1:10, 10:1로 하여, 고온고압 혼합 가공한 효과를 측정하였다. 가시오가피 단독 가공한 것에 비하여, 가시오가피-콩단백 가공물에서 가시오가피 단독 열가공에 비해, 가시오가피의 항산화도가 약 2-4배 증가하였고, 가시오가피 사포닌의 생이용성이 현격하게 증가함을 확인하였다. 본 연구는 콩가공 부산물의 고부가가치 산업화에 기여할 뿐만 아니라, 가시오가피 산업 활성에도 기여할 수 있을 것으로 기대된다.