• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.57-57
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• 1993

단백질 분해효소는 염증주변에 축적된 파괴조직이나 변성단백질등을 분해하여 염증, 특히 만성염증의 순환을 정상화함으로써 소염제로서 사용되어 왔으며 현재, Chymotrypsin, Trypsin, Promelain, Papain, Serrathiopeptidase, Pronase 등이 소염효소제로써 사용되고 있다. 이들은 주로 미생물 배양액에서 통상적인 방법으로 정제하여 사용하며, 유전자 재조합기술을 사용하여 재조합 균주에서 생산할 경우 그 생산성을 증대시킬수 있을 것이라 기대된다.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2009.11a
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• pp.130-133
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• 2009

The sequence of the propellant supply is very important for the reliable and safe operation of a LRE combustion test. So combustion performance tests were performed to find an optimum test sequence by changing supply time of propellants and purge gas in the moment of ignition and extinction. The liquid rocket engine consisted of a catalytic ignitor and six swirl-coaxial injectors which used hydrogen peroxide and kerosene. Conclusively, an optimum sequence was found for stable combustion in the moment of ignition and extinction.

• Journal of Acupuncture Research
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• v.24 no.2
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• pp.73-81
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• 2007

목적 : 본 연구는 화피의 연골 보호 및 소염 진통 작용을 알아보고, 화피를 이용한 관절염치료 약침액 개발의 기초자료를 얻기 위해 고안되었다. 방법 : In vitro에서는 토끼 무릎관절에서 배양된 연골조직에 5ng/ml IL-1${\alpha}$ 처리 후， 화피의 연골보호 효과, 연골세포에 대한 독성을 조사하였다. In vivo에서는 토끼 무릎관절내 collagenase를 주입, CIA 유발 후, 28일간 매일 토끼의 구강으로 화피, 증류수, CEX를 투여하였으며, 연골보호, 소염, 진통에 대한 측정을 하였다. 결과 : 화피는 proteoglican 및 collagen분해 억제, MMPs 활성 억제로 연골 보호 효과가 있었으며, 연골 세포에 대한 독성이 없었다. 소염작용은 PGE2 생산 억제 및 COX-2발현 억제, carrageenan 유발 쥐 모델에서의 부종 억제로 확인되었다. 진통작용은 tail flick test에서의 latency time 증가, formalin test에서의 염증성 통증억제로 나타났다. 결론 : 화피가 퇴행성관절염에 대한 연골 보호 효과 및 소염 진통 작용이 있으므로, 이를 근거로 약침액을 개발 응용하면 퇴행성관절염 치료에 활용될 수 있다고 사료된다.

• Journal of the Korean Chemical Society
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• v.47 no.3
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• pp.237-240
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• 2003

A synthetic method for the title compounds (2a-o) was carried out. The title compounds (2a-o)were prepared by the condensation of various thioureas and maleic anhydride. Anti-inflammatory activities in vivo were evaluated and compared with standard drug diclofenac sodium. Some compounds showed moderate activity. The structures of all the new compounds were established on the basis of $^1H$ NMR and IR spectral data.

• Proceedings of the Korean Nuclear Society Conference
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• 2001.05a
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• pp.227.1-227
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• 2001

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.5 s.248
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• pp.405-412
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• 2006

In order to realize a stably propagating flame in a narrow channel, flame instabilities resulting from flame-wall interaction should be avoided. In particular flame quenching is a significant issue in micro combustion devices; quenching is caused either by excessive heat loss or by active radical adsorptions at the wall. In this paper, the relative significance of thermal and chemical effects on flame quenching is examined by means of quenching distance measurement. Emphasis is placed on the effects of surface defect density on flame quenching. To investigate chemical quenching phenomenon, thermally grown silicon oxide plates with well-defined defect distribution were prepared. ion implantation technique was used to control defect density, i.e. the number of oxygen vacancies. It has been found that when the surface temperature is under $300^{\circ}C$, the quenching distance is decreased on account of reduced heat loss; as the surface temperature is increased over $300^{\circ}C$, however, quenching distance is increased despite reduced heat loss effect. Such abberant behavior is caused by heterogeneous surface reactions between active radicals and surface defects. The higher defect density, the larger quenching distance. This result means that chemical quenching is governed by radical adsorption that can be parameterized by oxygen vacancy density on the surface.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.5 s.248
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• pp.397-404
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• 2006

Effects of surface defect distribution on flame instability during flame-surface interaction are experimentally investigated. To examine chemical quenching phenomenon which is caused by radical adsorption and recombination processes on the surface, thermally grown silicon oxide plates with well-defined defect density were prepared. ion implantation technique was used to control the number of defects, i.e. oxygen vacancies. In an attempt to preferentially remove oxygen atoms from silicon dioxide surface, argon ions with low energy level from 3keV to 5keV were irradiated at the incident angle of $60^{\circ}$. Compositional and structural modification of $SiO_2$ induced by low-energy $Ar^+$ ion irradiation has been characterized by Atomic Force Microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS). It has been found that as the ion energy is increased, the number of structural defect is also increased and non-stoichiometric condition of $SiO_x({\le}2)$ is enhanced.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.8
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• pp.857-864
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• 2012

A linear stability analysis of a diffusion flame with radiation heat loss is performed to identify linearly unstable conditions for the Damk$\ddot{o}$hler number and radiation intensity. We adopt a counterflow diffusion flame with unity Lewis number as a model. Near the kinetic limit extinction regime, the growth rates of disturbances always have real eigenvalues, and a neutral stability condition perfectly falls into the quasi-steady extinction. However, near the radiative limit extinction regime, the eigenvalues are complex, which implies pulsating instability. A stable limit cycle occurs when the temperatures of the pulsating flame exceed the maximum temperature of the steady-state flame with real positive eigenvalues. If the instantaneous temperature of the pulsating flame is below the maximum temperature, the flame cannot recover and goes to extinction. The neutral stability curve of the radiation-induced instability is plotted over a broad range of radiation intensities.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2000.11a
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• pp.22-22
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• 2000

고체 추진제에서 연소실 압력이 급격히 변하는 비정상 상태에서의 연소 특성은 정상 상태와 다른 경향을 보인다. 고체 추진 시스템에서 안정적이고 필요한 성능을 얻기 위해서는 이러한 비정상 상태에서 일어나는 현상에 대한 예측이 필요하다. 고체 추진제에서 비정상 연소는 크게 두 가지 경우에 나타나게 된다. 그 중 하나는 소염을 위하여 연소실내 압력강하가 일어나는 경우이며, 다른 하나는 점화 후 압력이 상승하는 경우이다. 급격한 압력 강하로 인한 고체 추진제의 소염에 대하여 그 동안 많은 연구들이 진행되었다.(중략)

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.6
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• pp.493-500
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• 2014

Nonlinear characteristics of cellular counterflow diffusion flame near the radiative extinction limit at large Damk$\ddot{o}$hler number are numerically investigated. Lewis number is assumed to be 0.5 and flame evolution is calculated by imposing an infinitesimal disturbance to a one-dimensional(1-D) steady state flame. The early stage of nonlinear development is very similar to that predicted in a linear stability analysis. The disturbance with the wavenumber of the fastest growing mode emerges and grows gradually. Eventual, an alternating pattern of reacting and quenching stripes is developed. The cellular flame temperature is higher than that of 1-D flame because of the gain of the total enthalpy. As the Damk$\ddot{o}$hler number is further increased, the shape of the cell becomes circular to increase the surface area per unit reacting volume. The cellular flames do not extinguish but survive even above the 1-D steady state extinction condition.