• Proceeding of EDISON Challenge
• /
• 2017.03a
• /
• pp.708-711
• /
• 2017

전기적 신호의 이상으로 발생하는 심방 부정맥은 심방세동으로 발전하는 대표적 심장 질환이다. 이러한 원인에는 세포 내 이온 채널의 유전적 결함으로 인한 기전이 알려져 있다. 지속적인 연구로 밝혀진 대표적인 유전적 질환 중 하나로서 KCNH2 유전자 돌연변이가 있다. 본 연구에서는 KCNH2 유전자 돌연변이가 심방부정맥을 유발하는 연관성연구를 기반으로 심실에서의 심장 질환 발현 연관성을 확인하고 심실부정맥과 심실세동 가능성을 예측하였다. 이를 위해 Ten tusscher 세포 모델에 KCNH2 유전자의 N588K, L532P 변이를 적용하여 2차원과 3차원 시뮬레이션을 진행하였다. wild-type(WT)과 mutant-type(MT)의 전기전도 패턴을 비교했다. 그 결과 WT의 전도파형이 일찍 자가소멸(self-termination) 되는 것과 대조적으로 MT는 회귀성 파형이 유지되었다(WT : 3.6초간 유지, MT : 지속적). 따라서 본 연구를 통해 KCNH2 유전자 돌연변이가 심실 조직의 취약성 (Action Potential Duration 감소, WT : 270 ms, N588K : 130 ms, L532P : 100 ms)을 증가시켜 부정맥의 요인이 됨을 확인하였다.

• Proceedings of the Korean Institute of Surface Engineering Conference
• /
• 2007.11a
• /
• pp.166-168
• /
• 2007

스퍼터링법으로 제작된 FCCL은 PI필름(Poly-imide film)과 Cu layer사이에 Tie-coating layer로 Ni-Cr을 많이 사용한다. 하지만 완성된 FCCL에서 페터닝을 실시할 때 Cr성분이 소멸되지 않고 잔존하는 현상으로 누설전류가 발생 한다. 또한 Cr으로 인해 Eatching액의 오염으로 재사용의 어려움도 발생된다. 이러한 원인들은 제품의 특성들을 저하 시키므로 이를 개선할 필요가 있다. 따라서 본 연구에서는 기존의 Tie-coating layer를 대체할 물질로 Acrylic acid를 이용하여 FCCL을 제작하여 표면특성 평가를 위해 Contact angle측정과 부착력을 위한 Peel test측정과 조직분석 및 성분분석을 위해 SEM-EDS를 측정을 통하여 Polymerization을 이용한 Ti-coating layer 개발의 가능성을 확인하였다.

• Korean Journal of Ecology and Environment
• /
• v.45 no.3
• /
• pp.329-339
• /
• 2012

In the spring (March to June) in 2010, one diatom Skeletonema costatum occurred outbreaks in Lake Hwajinpo, one of the typical lagoons on the east coast of South Korea. We compared the characteristics of the phytoplankton community during the bloom and extinction period of S. costatum, and evaluated the water quality based on nutritional indices. Results indicate that 1) this bloom showed the highest cell density ($>10^5$ cells $mL^{-1}$) among outbreaks of S. costatum occurred Korea, 2) occurred in below or over $20^{\circ}C$ water temperature, and 3) was destroyed in the early summer with higher temperature than the bloom period. Water quality or trophic status of the lake was eutrophic to hypertrophic with high salinity, BOD, COD and phosphate, and low N/P ratios and transparency. Phytoplankton community in the spring bloom had a high dominance and low diversity, but rightly recovered to low dominance and high diversity in the summer season. Therefore, we temporarily conclude that the bloom of S. costatum in Hwajinpo was triggered by the extended spring drought and the reduced influx of river water, and appeal that the bloom can happen repeatedly every year.

• Korean Journal of Optics and Photonics
• /
• v.17 no.1
• /
• pp.89-93
• /
• 2006

We investigate a method to improve the extinction ratio of directional couplers by controlling the angle of approach to their input ports and controlling the error limit for improving the extinction ratio of the directional coupler. Although relatively large angle of approach to the input port usually causes an error in calculations made by mode propagation analysis(MPA), optimally designed angle of approach not only minimizes errors in MPA calculations but also can improve extinction ratio by precision control of coupling coefficients of optical modes. We show that abrupt changes in approaching angle, although not enough to cause modal leakage, give rise to field-profile overshooting, which degrades extinction ratio and other properties of the directional coupler. Using Beam Propagation Method (BPM) we calculate two types of input structures, linear and curved, for optimization of extinction ratio.

• Journal of the Korean association of regional geographers
• /
• v.12 no.6
• /
• pp.720-732
• /
• 2006

This study investigates the possibility in establishing the wine theme village in Youngwol area, and grape production and wine industry in world and Korea. Wine import market formed since 1988 in Korea. Because Korean wine production will be finished in 2011, Korean farmers need the strategy against foreign grape and wine importers. That is to establish the wine theme village, one of green tourism. Many pensions and raftsmen are concentrated along the Donggang river, where Geowoun-ri of Youngwol area is located. Possibility in establishing the wine theme village in Geowoun-ri is depend on the attractive program that people enjoy in Youngwol are. The programs have to consist in the regional image.

• Korean Journal of Cognitive Science
• /
• v.10 no.3
• /
• pp.29-37
• /
• 1999

Murakami and Cavanagh (1998a,b, 1999) reported a jitter aftereffect in a static random noise after a period of adaptation to a patch of dynamic random noise. To a account for this phenomenon. they proposed the retinal slip caused by a small eye movements in the unadapted area, which is usually compensated by the visual system to stabilize images but is unsuppressed due to the adaptation. We tested this hypothesis with new experimental method and stimuli that were supposed to nullify or reduce the effect. However. the aftereffect was still observed even under these stimuls conditions More importantly, the perceived aftereffect was rather different from Murakami and Cavanagh's. After adaptation to a counterphase flickering cosine grating, the adjacent unadapted region seems to move away from the observer during the test period instead of jittering in the frontoparallel plane. We proposed a possible explanation for this new phenomenon noting the severe contrast reduction of the adapted region during flickering period. The aftereffect might be due to the flicker-inducing contrast reduction during adaptation that produces different depth planes for the adapted and unadapted region and its restoration during the test period.

• Journal of Korea Game Society
• /
• v.19 no.3
• /
• pp.43-52
• /
• 2019

Advances in technology are enhancing the player's visual satisfaction in games. Reflexively, narrative satisfaction has not been highlighted. This led to a player's critical view of the absence of original games. Especially in gameplay, quests require repeat and similar content and imperative tasks. It is overlooked that a quest can cause players to produce various meanings and effects. The concept of editing ability to reorganize the designed rules of the player beyond the performance and behavioral rules is conceptualized, and the four types of players that operate the characteristics can see that the player can intensify game play and immerse himself in play saw.

• Journal of Korean Society of Archives and Records Management
• /
• v.12 no.3
• /
• pp.29-46
• /
• 2012

Electronic records are merely series of bits without understanding the formats of content files. There are numerous types of formats and also possibilities of extinction. For long term preservation, it is essential to understand and manage formats. In addition to managing format itself, accurate information on the format needs to be stored for electronic records. In this study, various types of electronic files, without checking with the naked eye, has developed a tool to extract the header information in the format of electronic files with the file extension validation tool to compare format and validate digital component.

• Journal of Plant Biology
• /
• v.35 no.4
• /
• pp.425-429
• /
• 1992

Cell elongation is known to be promoted by ethylene in petioles of Ranunculus sceleratus. Treatment of petiole segments with spermine resulted in an inhibition of cell elongation and of ethylene biosynthesis in the presence of applied auxin. Dose response curve for the spermine inhibition of auxin-induced ethylene production appeared similar to that of ACC-based ethylene production suggesting that the polyamine inhibits ethylene biosynthesis by blocking the conversion of ACC to etylene. Auxin-induced ethylene production was significantly promoted by treatment of the tissue with either DFMA or DFMO. specific inhibitors of polyamine biosynthesis. Increased level of ethylene production by DFMA was found to be completely abolished by application of exogenous spermine at a high concentration. These results indicate that endogenous spermine plays a regulatory role in the growth response of Ranunculus petioles to auxin and ethylene.hylene.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.19 no.2
• /
• pp.125-135
• /
• 2001

The research on Harmful Algal Blooms is generally in progress through field work, such as the naked eye and sampling. It was difficult to forecast exactly the course, from appearance of red tide to disappearance, with the established ways of investigation and analysis. Accordingly it is need to analyze environmental factors in time and space, the appearance of red tide and the path of its migration by more objective and scientific methods. In this study the remote sensing was used to diminish damage from the occurrence of red tide. Such as a temperature change of sea water and a change of tidal currents, the major cause for red tide. The probed data were utilized. The technique for forecast of red tide phenomenon on the south coast was researched by analyzing the cause of red tide, pollutant flowed from landand the possibility of application of the technique was showed.