• Clinical and Experimental Pediatrics
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• v.52 no.3
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• pp.356-363
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• 2009

Purpose : A polymorphism in the IGF-I gene promoter region is known to be associated with serum IGF-I levels, birth weight, and body length, suggesting that IGF-I gene polymorphism might influence postnatal growth. The present study aimed to investigate the role of this polymorphic cytosine-adenine (CA) repeat of the IGF-I gene in children with idiopathic short stature. Methods : The study involved 131 children (72 boys and 59 girls) diagnosed with idiopathic short stature, aged 715 years. Genomic DNA was extracted from anticoagulated peripheral whole blood. The primers were designed to cover the promoter region containing the polymorphic CA repeat. Data were analyzed using GeneMapper software. The correlations between age and serum IGF-I levels were analyzed using Spearmans correlation coefficient. Results : The CA repeat sequences ranged from 15 to 22, with 19 CA repeats the most common with an allele frequency of 40.6%. Homozygous for 19 CA repeat was 13.0%, heterozygous for 19 CA repeat was 56.5%, and 19 CA non-carrier was 30.5%. The three different genotype groups showed no significant differences in height, body weight and body mass index, and serum IGF-I levels. The serum IGF-I level and age according to the IGF-I genotypes were significantly correlated in the entire group, 19 CA repeat carrier group, and the non-carrier group. The three groups also showed no significant differences in the first year responsiveness to GH treatment. Conclusion : There were no significant different correlations between 19 CA repeat polymorphism and serum IGF-I levels according to genotype. Our results suggest that the IGF-I 19 CA repeat gene polymorphism is not functional in children with idiopathic short stature.

• The korean journal of orthodontics
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• v.28 no.1 s.66
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• pp.17-27
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• 1998

Study on growth change of dental arch is considered to both an important data in orthodontic diagonsis and treatment planning as well as analysis of treatment results , also, arch form is important in anthropology and dentistry, even more so in prosthodontics and orthodontics. In the field of orthodontics, studies on the functional aspect of upper and lower teeth and maintenance of stability of dentition and occlusion were carried out from the early days. Some of the early studies include explanation of growth change in dental arch from measuring directly fom human stroll, and afterwards, cephalometrics x-rays were introduced; accordingly, studies using cephalometric measurement and linear measurements of study models were often performed. By this method, arch width, arch depth and perimeters were measured, and growth change or dental arch was studied. The subject ror this study were sn children(boys and girls or ages from 3 yens to 12 years from Kang-won district and Seoul, who has no history of orthodontic treatment and who show healthy status and normal growth and development. Cephalometric x-ray, panoramic x-ray, and study model were taken for each subject consecutively for 2 years, and the subjects are still followed up. 400 pairs of study models from the past two years were used in this study; mesio-distal diameater of each tooth, intercanine width, intermolar width, canine depth, molar depth and arch perimeters were measured. Afterwards, mean value and each standard deviation of each age group and each gender were obtained, and representation graph were drawn. The following conclusion were obtained. 1. Intercanine width showed gradual increase until the age of 10-years and after that, showed no increase. 2. Intermolar width in upper arch showed gradual increase : intermolar width in lower arch showed no significant chang, and after the age of 9-years, showed increase. 3. Cainine arch depth showed relatively rapid increase after the age of 6-years, and this pattern was more obvious in lower arch. 4. Molar arch depth increased gradually in both archs and it decrease after the age of 10-years : this phenomenon was more prominent in the lower arch. 5. Arch perimeter showed gradual inerease and convert to plateau at the age of 10-years, after that, it decreased. this pattern was more prominent in lower arch.

• Journal of Animal Science and Technology
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• v.48 no.2
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• pp.151-160
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• 2006

This study was conducted to investigate the genetic characteristics of growth stages in Hanwoo, to provide useful information in farm management decisions. Data were taken from the nucleus herds of three farms, Namwon, Daegwalyong and Seosan, comprising 27,647 cows, 14,744 bulls, and 1,290 steers in between 1980 and 2004. According to the growth curve by year, the residuals for cows and bulls were 68.49 and 54.29, respectively, under the Gompertz model. The values were lower than in other years. Parameters, A, b and k were estimated as 423.6±5.8, 2.387±0.064 and 0.0908±0.0033 in cows and 823.3±15.3, 3.584±0.070, 0.1139±0.0032 in bulls, respectively. The fitness was higher under the Gompertz model than under the logistic model: monthly and daily estimation for cows were 379.3±7.509, 2.499±0.057, 0.114±0.0045 and 367.1±1.9003, 2.3983±0.012, 0.004±0.00003, respectively. Estimated residual mean squares were 31.85 and 998.4 in their respective models. Monthly and daily estimation of bulls were 834.6±22.00, 3.319±0.062, 0.104±0.0037 and 796.0±6.128, 3.184±0.014, 0.003±0.00003, respectively. Estimated residual mean square were 66.18 and 2106.5. Monthly and daily estimation of steers were 1049.1±144.2, 3.024±0.008, 0.067±0.0096 and 1505.1±176.6, 2.997±0.067, 0.001±0.0001, relatively. Squares, 186.0 and 1119.1. In terms of growth characteristic estimated by Gompertz model, body weight for cows and bulls were 139.53kg and 307.03kg, and the daily gains were 0.52kg and 1.04kg, respectively. Body weight for steers was 385.94kg at the inflection point. Body weight gain was 0.84kg in both models. Our results showed that cows had lower mature weight and daily weight gain, and reached the inflection point earlier than bulls or steers.

• The korean journal of orthodontics
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• v.32 no.4 s.93
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• pp.265-274
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• 2002

Among many maturation indicators of growing patients, menarche and skeletal maturity are useful to assess growth and development, and the changes of the first and third finger are relatively important in hand-wrist X-rays. The objective of this study was to evaluate the relationship between menarche and the changes of the phalanx of the first and third finger and compare skeletal maturation among different malocclusion types. The sample used in this study was 29 Class 1,27 Class II and 27 Class III females whose hand-wrist X-rays had been taken with 6 month interval before the appearance of ulnar sesamoid ossification till the phalanges of the fingers were almost fused. The results were as follows. 1. There was no skeletal maturity difference among malocclusion types. 2. There was no difference in the mean chronologic age of menarche among different malocclusion types and that was $12.30\pm0.98$ years. 3. The ulnar sesamoid was observed at $10.35\pm1.01$ years, and on distal phalanx of the first finger, epiphyseal capping appeared at $11.26\pm1.04$ years and fusion at $13.12\pm1.06$ years. The epiphyseal capping on middle phalanx of the third finger was observed at $11.57\pm1.02$ years and fusion at $13.72\pm1.04$ years. 4. The timing of menarche occurred around the same time as the fusion process of distal phalanx of the first finger(p<0.001, r=0.82) and the initiation of fusion of middle phalanx of the third finger(p<0.001, r=0.78). Therefore, we can give the aid when we evaluate the growth and development of growing females seeing the changes at phalanx of the first and third finger.

• Journal of Food Hygiene and Safety
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• v.26 no.1
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• pp.49-56
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• 2011

To investigate the toxicological effects of ${\beta}$-glucan, we performed basic studying on ${\beta}$-glucan in Sprague-Dawley (SD) rats. Standard endpoints in this study included mortality, clinical observations, changes of body weights, analysis on food consumption, ophthalmoscopic examination, hematologic examination, serum biochemistry, analysis of organ weights, gross anatomic pathology and histopathology. No clinical signs and mortality were observed in animals treated with beta-glucan throughout the experimental period. The average body weight of each treatment groups showed similar levels at end of experiment. There were no treatment-related changes in mortality, body weights changes, food consumption, ophthalmoscopic examination. Although there were statistically significant differences between the control and treated groups in some relative and absolute organ weights, and hematological and biochemical analysis, the data were in biologically normal ranges and did not show a dose-dependent manner. In the morphological change, hepatic tissue were not showed ballooning degeneration and irregular arrangement of hepatic cell in ${\beta}$-glucan treatment groups with control group. Also, organs weights (liver, heart, kidney and stomach) and hematological indices (WBC, RBC, Hb, Hct and Platelet) did not show statistically significant differences among the experimental groups. In summary of these results, there were no changes in mortality, mean body weight, clinical signs, food consumption. There were no changes in ophthalmological examination, hematology, blood chemistry, necropsy and histopathology. In conclusion, although further investigation of glucan should be performed in the functions registered in many ancient literatures, ${\beta}$-glucan is physiologically safe and may have potential as candidate food for human health.

• Reproductive and Developmental Biology
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• v.39 no.3
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• pp.89-95
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• 2015

The addition of growth factors and cytokines to in vitro culture (IVC) media could affect embryo development and the quality of the resulting blastocysts. The present study was performed to investigate the effect of porcine induced pluripotent stem cell (piPSC)-culture conditioned medium (CM) on the in vitro maturation (IVM) and development of parthenogentic embryos (parthenotes) in pigs. Cumulus-oocyte complexes (COCs) or activated oocytes were cultured in IVM or IVC medium supplemented with 0 (control), 25, or 50% of stem cell medium (SM) or CM, respectively. The maturation rate of CM-25% group was significantly improved when compared with control group (p<0.05), but that was not different among SM or CM groups. Blastocyst formation rate was significantly higher in CM-25% group (29.2%) than that of control (20.7%), SM-50% (19.6%) and CM-50% (23.66%, p<0.05). Cell number and the apoptotic cell index in blastocysts was significantly lower in SM-25% than in CM-25% group (p<0.05). The embryo quality related genes, OCT4, KLF4, TERT and ZFP42, were significantly increased in CM-25% group compared with control (p<0.05). In conclusion, the addition of 25% of CM to IVM and IVC medium positively influences not only the developmental potential also quality of parthenotes in pig.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.8
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• pp.1164-1168
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• 2005

Korean traditional deer decoction (Nogjungtang), composed of oriental herbs and almost deer parts, has been used as an important resource for human health. For basic studying on Nogjungtang, this experiment was conducted to evaluate nutritional effects of Nogjungtang, and estimate its effect on growth, food efficiency, organ development and hematological indices in growing and adult Sprague-Dawley rats. The rats were divided into three groups as follows; control: non-supplementation, Notiungtang I: recommended dose, and Nogjungtang II: thrice recommended dose. Nogjungtang was composed of various general nutrients with up 93$\%$ moisture.Crude protein is the highest value as 22.78$ \%$, Mg is a major mineral as 0.48$\%$ compared to other minerals, and methionine and proline are higher by 1.31 and 1.67$\%$ than other amino acids based on dry matter, re-spectively. In both growing and adult rats, there were no significant difference in body weight gain and feed intake between the control and Nogjungtang groups. Also, organs weights (liver, heart, kidney and stomach) and hematological indices (WBC, RBC, Hb, Hct and Platelet) did not show statistically significant differences among the experimental groups. However, all of experimental rats were normal growth without hypertrophy or negative development of organs by Nogjungtang. Hematological indices maintained in normal value by thrice recommended dose of Nogjungtang. The average body weight of each treatment groups showed similar levels at end of experiment. In case of the feed efficiency ratio (feed intake/body gain), the growing rats showed 6.00, 5.81 and 5.99 and adult rats showed 9.03, 8.98 and 9.10 in control, Nogjungtang I and Nogjungtang II, respectively. In conclusion, although further investigation of Nogjungtang should be performed in the functions registered in many ancient literatures, Nogjungtang is physiologically safe and may have potential as candidate food for human health.

• Journal of Korean Academy of Nursing
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• v.1 no.1
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• pp.77-84
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• 1970

A survey was conducted on 2,321 Chung Rhang Middle School boys to check out their physical growth, development and the number of parasite carriers during the period from June 16. to June 23. 1970 As the results of this study, the following conclusions were revealed. A) Physical Growth and Development State. 1. Direct curve in physical growth and development was observed during the period from 13 to 16 years of age. 2. The age and quantity of maximum growth and development. Height; 13~14 years of age 6.1cm Body weight; 14~15 years of age 5.1kg Chest circumference; 13~14 years of age 9.9cm Sitting height; 14~15 years of age 3.4cm 3. Comparison with Japanese students Most Korean students are shorter than Japanese students, though the standard of height became higher than before. The standard of body weight is visibly lower than Japanese students. The standard of chest circumference of the students of age 14 is higher than counter part of Japanese students and the all boys are lower than Japanese students except at the age of 14. The standard of the sitting heights of the Korean students are growing steadily, but every students are shorter than Japanese students. 4. The greatest differences in physical growth and development were shown in 13~14 years of age. 5. The students of 13~15 years of age developed their bodies most highly according to index of Rohrer. 6. Body weight and chest circumference have not grown enough compared with height. The development of sitting height was made highly and the development is steadily growing as they grow old. B. The Number of Parasite Carriers The number of parasite carriers was shown 79.4 per cent among all the student checked out. The number of trichuris was shown 79.7 per cent. The number of parasite carriers was shown higher per cent as the grow old.

• Journal of Food Hygiene and Safety
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• v.5 no.4
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• pp.171-178
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• 1990

Potential teratogenicity of Azinphos-methyl and Carbaryl was investigated in developing chick embryos. $100\;\mu\textrm{l}$ of Azinphos-methyl and Carbaryl was injected into air sac on day 4 of incubation. Body weight changes and morphological changes were examined. The results obtained were summarized as follows; 1. Body length, limb lengths and claw length of groups treated with high dose of Azinphosmethyl and Carbaryl were significantly shortened compared to untreated of vehicle control and body weights of them were significantly lower than those of control groups. 2. Treatment of Azinphos-methyl and Carbaryl increased incidence ratios of dead embryo by dosage (Azinphos-methyl: 18%, 21%, 41%, Carbaryl: 26%, 50%). 3. One case of beak malformation occurred in Carbaryl treatment group.

• Korean Journal of Community Nutrition
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• v.4 no.2
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• pp.123-131
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• 1999

The nutritional status of 125 preschool children(Female : 56, Male : 69) residing in low income area of Seoul was surveyed. The mean family size was 4.3 and the mean monthly income was 921,000 won which was below the poverty level. Average heights of boys aged 3, 4, 5 and 6 were 98.6cm, 106.1cm, 111.9cm and 116.0cm and those for girls were 99.4cm, 106.4cm, 110.9cm, and 116.0cm, respectively. There was no significant difference between the height of boys and girls. The proportion of children showing stunted growth(<90% of Korean standard of height) was 3.2%. The mean weight of boys for each age group(3, 4, 5, 6) were not significantly differient from that of girls. The proportion of children assessed as moderately underweight (<80-90% of Korean Standard of weight) was 10.4% and 3.2% of children was underweight(<80% of weight standard). The group of children aged 3 were taking adequate energy, whereas the mean energy intake of children aged 4.5 and 6 were within 77.3-78.6% of RDA. The proportion of energy derived from carbohydrate, fat and protein was 60.1%, 24.6% and 15.3%. The high proportion of energy derived from fat seems partly due to high energy intake from fat in the snack. The nutrients which did not meet 75% of the RDA were vitamin A and calcium for children aged 5, and iron for children aged 3 to 5. Carbohydrate intake was positively correlated with the height, weight and girth of chest(P<0.05-P<0.001). There was positive correlation between protein intake and weight, girth of chest and BMI, respectively(P<0.05). Iron intake showed positive relationship with height, weight and BMI(P<0.05).