• Food Industry And Nutrition
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• v.9 no.3
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• pp.34-39
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• 2004

콩의 배당체 isoflavone류를 생리 활성형 aglycone으로 전환율을 증진시켜 콩 발효식품의 기능성을 증진시키고자, 식용버섯 균사체와 청국장 발효균 B. megateriw SMY-212를 이용하여 단독과 2단계 배양한 발효대두의 메탄올 추출물에 대한 항산화능과 인체 전립선암과 자궁암 세포주의 성장억제 효과를 조사하였다. 2단 발효대두 추출물의 수소공여능 효과는 1,000 $\mu$g/mL 농도에서 17.8∼26.9%로서 단독 발효대두보다 30∼40% 높았으며, 그 중에 동충하초와 SMY-212를 배양한 것이 가장 높았다. Linoleic acid에 대한 항산화 효과는 단독 발효대두는 동충하초가 가장 높았으며, 2단계 배양한 발효대두는 팽이균사체와 SMY-212가 오히려 높게 나타났다. 인체 전립선암 세포주(DU145)와 자궁암 세포주(Hela)에 대한 성장억제 효과는 단독배양에 서 모두 팽이버섯 균사체를 이용한 발효대두가 가장 높았으며, 2단계 배양에서 DU145에서는 팽이버섯과 아가리쿠스 균사체 배양물에 SMY-212를 이용한 발효대두가 높았고, HeLa에서는 팽이버섯, 동충하초, 새 송이버섯 균사체의 추출물 순으로 높았다. 결론적으로 삶은 콩에 버섯 균사체의 단독배양보다는 버섯균사체와 SMY-212를 2단 배양한 발효대두 추출물이 암세포주 성장억제 효과가 높게 나타났다.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.9 no.3
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• pp.273-279
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• 1999

The home-made hot wall epitaxy (HWE) system was utilized for GaN epitaxial layer growth on the Si(001) substrate. It was appeared that GaN epilayer grow with mixed phase of Zinc blende and Wurtzite structure from photoluminescence (PL) and x-ray diffraction (XRD) analysis at the room temperature. We found that intial growth layer has Wurtzite structure from photoluminescence (PL) and x-ray diffractio (XRD) analyses at the room temperature. Wefound that initial growth layer has Wurtzite structure when initial deposition time, the temperature of substrate and source are 4 min, $720^{\circ}C$ and $860^{\circ}C$ respectively, and at the epi growth process GaN, epilayer was grown with relatively stable Wurtzite structure when the temperature of substrate and source are $1020^{\circ}C$ and $910^{\circ}C$ respectively.

• Journal of Life Science
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• v.22 no.4
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• pp.492-498
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• 2012

To investigate whether phytochemicals affect cancer cell viability, human colorectal HCT116 cells were treated with four different phytochemicals. Among these phytochemicals, curcumin is the strongest inhibitor of cell proliferation. In addition, it decreased cell viability in a dose-dependent manner. To unveil the molecular mechanisms involved in the inhibition of cell proliferation by curcumin, we carried out oligo DNA microarray analysis. We found that 137 genes were up-regulated more than 2-fold, and 141 genes were down-regulated more than 2-fold by 25 ${\mu}M$ curcumin treatment. Among the up-regulated genes, we selected 3 genes (ATF-3, GADD45A, and NR4A1) to confirm microarray data. The results of RT-PCR strongly agreed with those of the microarray data. Among the phytochemicals used in this study, curcumin is the strongest inducer of ATF3 expression, and increased ATF3 expression in a dose-dependent manner. Interestingly, FACS analysis showed that the inhibition of cell growth by curcumin was recovered by ATF3-siRNA transfection. Finally, we detected the changes of gene expression by ectopic expression of ATF3. The results indicated that many up-regulated genes were related to apoptosis. Overall, these results suggest that ATF3 may play an important role in the anti-proliferative activity of curcumin in human colorectal cancer cells.

• Journal of Korea Technology Innovation Society
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• v.18 no.3
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• pp.516-538
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• 2015

This study applies policy network theory to examine the main policy actors and their relations in the green growth policy making process. Also the development of and changes in South Korean government's green growth strategy are analyzed. The results demonstrate that the president and the presidential council were the key players to introduce and to push green growth policy in a short time. Policy influence and key roles were concentrated on them. The development of green growth policy were initiated from the president's change in perceived problems and preferences. He set green growth policy on the government's top priority. These changes lead to another changes in strategies, rules, norms and resources within the network. As a result, the president-led green growth policy established new laws, environmental regulations and governmental structures to facilitate the policy implementation. Green growth policy, however, was almost stopped after new presidential election in 2013. Because new government has a different national agenda, the previous governmental agenda lost its status as national priority. In addition, this study shows that government-led green growth in Korea has policy consistency problem after administration was changed by presidential election. Former president-led green growth policy making under the situation of the lack of policy participation from the private sector led to discontinuities in policy after a presidential term was over.

• Korean Journal of Ichthyology
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• v.13 no.1
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• pp.6-18
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• 2001

Larvae of the gunnel Pholis fangi were collected in coastal waters off Daecheon with a bag net from March to June, 1988, and with a ring larva net in February 1989. Maturity and spawning period were analyzed by examination of the gonads of adult fish collected with a bag net from May 1998 through November 1999. In February, the larvae were widely distributed in the outer and inner Cheonsu Bay. From March to April the larvae were present mainly the inner bay; they were absent there in May and found mainly in the outer bay. After June, few gunnel larvae were collected in the study area. This suggests a seaward movement of gunnel from the nursery grounds of the bay to offshore feeding grounds. The otolith of larvae smaller than 10 mm in total length did not show a distinct growth stop. The growth stop is believed to be formed in the early larval stage when the total length is about 10 mm. This period coincides with the time of shoreward migration, suggesting a metabolic change during this period. At a total length of 30 to 40 mm, the shape of the otolith changes from spherical to elongate. Daily growth rate in length was estimated by the Gompertz equation, which is represented as follows: TL = 6.702exp{2.925"1-exp (-0.008 t)"} ($r^2=0.94$, N = 92) Assuming daily deposition of growth increments in the otolith, the time of first growth increment formation was shown to be from December to January. Gonad observations show that Pholis fangi spawns from November to December. So, the hatching time is thought to be about one month.

• Information Systems Review
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• v.23 no.3
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• pp.1-23
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• 2021

The national economic policy paradigm is constantly changing according to the global business environment. Among them, fostering SMEs is a core policy of many developed countries. The growth of SMEs contributes to the creation of jobs and the development of local communities in the era of employment-free growth. In particular, the growth of SMEs is the foundation for growth into mid-sized and large enterprises. Therefore, the growth of SMEs plays an important role in the national economy. Information and communication technology (ICT) became important much more with the emergence of the 4th industrial revolution. Among them, the growth of ICT SMEs is the nation's future asset. Therefore, this study examines and verifies the main factors affecting the performance of ICT SMEs from the view of their R&D resources. On the basis of 1,999 SMEs dataset, empirical analysis was performed to investigate the influence of R&D resources on their corporate performance. Its results are as follows. First, based on theresource-based theory, ICT SMEs' R&D investment, R&D manpower, and government support policies were found to have a positive effect on securing a company's competitive advantage. Second, it was found that the level of product has a positive effect on the company's performance. Finally, it was found that M&A and technology acquisition method strategies differ according to the growth stage of the company. Therefore, in order to achieve technological innovation and corporate performance of ICT SMEs, the government support policy and investment into internal R&D personnel play as main factors. In addition, it was found that technology acquisition strategies differ depending on the growth stage of the company.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.05a
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• pp.241-264
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• 2017

본 연구는 일과 삶의 균형(WLB : Work-Life Balance)이 대인 조화와 창의적 노력 및 조직 내 혁신 행동을 향상시키는지 여부, 그리고 대인 조화와 창의적 노력이 일과 삶의 균형(WLB)과 혁신 행동 간 관계에 간접 효과가 있는지 여부를 알아보기 위해 수행되었다. 본 연구의 가설 검증을 위해서는 Hayes(2013)의 PROCESS Macro를 활용하였다. 분석 결과 혁신 행동에 영향을 주는 것은 일과 성장의 균형(WLB_G)과 대인 조화 그리고 창의적 노력으로 나타났고 대인 조화에 영향을 주는 변수는 일과 가정의 균형(WLB_F)과 일과 성장의 균형(WLB_G)으로 나타났다. 또한 창의적 노력에 영향을 미치는 변수는 일과 성장의 균형(WLB_G)과 대인 조화였다. WLB의 세 개 하위 변수와 혁신 행동 사이의 관계에서 대인 조화와 창의적 노력의 간접 효과 역시 일부 확인 되었다. 더불어 PROCESS Macro 분석을 통하여 매개변수 간의 효과의 크기를 알아보았다. 이를 통해 일과 가정의 균형(WLB_F)이나 일과 성장의 균형(WLB_G)과 대인조화, 창의적 행동 및 혁신행동 간에는 시너지 관계가 존재하고, 일과 여가의 균형(WLB_L)과 대인조화, 창의적 노력 및 혁신행동 간에는 배타적 관계가 존재함을 알 수 있었다. 향후 다양한 다른 산업 간의 일과 삶의 균형(WLB)에 대한 연구와 일과 삶의 균형(WLB)과 혁신행동에 이르는 다양한 매개변수에 대한 연구가 기대된다.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.429-429
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• 2012

본 연구에서는 분자선 박막 성장법(MBE)으로 성장된 GaAs single junction solar cell의 광학적 특성 변화를 photoreflectance (PR)을 이용하여 연구하였다. 본 연구에 사용된 태양전지 구조는 n+-GaAs (100)기판 위에 n+-GaAs buffer를 200 nm 성장 후 그 위에 i-GaAs 250 nm와 p+-GaAs 200 nm 성장 하였다. 상온에서 PR 측정 결과, 변조빔 세기가 증가할수록 Franz-Keldysh oscillation (FKO)의 주파수가 증가하는 현상이 관측되었다. 이는 변조빔의 세기가 강해질수록 광케리어수의 증가로 인한 스크리닝 효과에 기인한 것으로 사료된다. 아울러 Fast Fourier transform (FFT) 결과, 변조빔의 세기가 약할 때는 세 개의 주된 피크가 나타났으며, 이러한 현상은 GaAs에서 가전자대의 heavy hole (HH)과 light hole (LH)의 전이로 인해 나타나는 FKO 신호가 중첩되어 HH과 LH 피크가 HH과 HH-,LH과 LH-로 나뉘어진 것으로 사료된다. 여기광의 세기가 $1.40mW/cm^2$ 이상일 때는 주된 세 개 피크 이외에 부가적인 피크가 상대적으로 고 주파수 영역에서 관측되었다. 이러한 고주파수 영역에서의 나타나는 FKO 주파수는 시료의 내부전기장이 여기광의 세기가 증가할수록 감소하는 결과로 사료된다.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.1
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• pp.155-165
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• 2006

이 연구는 MCF-7 인간 유방암 세포주에 대한 귀출파징탕(歸朮破癥湯) 추출물의 증식억제효과 세포독성효과 세포사 유발효과를 확인하기 위하여 이루어졌다. MCF-7 인간 유방암 세포주는 Dulbecco's modified Eagle's medium/F12 (DMEM/F12)에 10% fetal bovine serum(FBS;Gibco) 와 항생제를 가하여 만든 배지를 이용하여 배양하였고, MCPF-7 세포를 96- well plate에 접종한 후 다양한 농도(0~2000g/ml)의 귀출파징탕(歸朮破癥湯)이 든 배지로 처리하고 다양한 시간(48, 96, 192)동안 배양하여 현미경으로 관찰하고 각각 MTS assay kit를 이용하여 세포생존율을 측정하였다. 세포독성은 Sulforhodamine B assay 방법을 이용해 측정하였고 세포사 과정에서 MCF-7세포에서의 caspase 활성화를 측정하기 위해 Western blotting을 수행하여 poly ADP ribose polymerase(PARP)의 절단을 확인하였다. 실험결과 귀출파징탕(歸朮破癥湯) 추출물에 의한 세포성장 및 독성효과는 시간 및 농도에 비례하는 것으로 나타났고 세포고사과정에서 작용하는 caspase의 전 기질인 PARP 절단량이 귀출파징탕(歸朮破癥湯) 처리 농도와 시간에 비례하여 증가하였다. 이것은 caspase-3가 MCF-7 세포의 성장을 억제하는데 중요한 역할을 수행함을 의미한다. 따라서 귀출파징탕(歸朮破癥湯)은 다양한 기전에 의해서 유방암 세포에 대한 억제효과를 가진다는 것을 인식할 수 있다.

• Korean Chemical Engineering Research
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• v.44 no.6
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• pp.563-571
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• 2006

Vapor grown carbon fiber (VGCF) nano-materials such as carbon nanotubes and carbon nanofibers were directly grown on the surface of the stainless steel mesh pre-treated by reduction. The reduction of the stainless steel mesh by hydrogen formed small catalytic particles and large particles with bi-modal distribution on the metal surface. When the VGCFs were synthesized on the reduced mesh, carbon nanotubes (CNTs) were dominantly grown from the small catalytic particles without supplying hydrogen gas. However, carbon nanofibers (CNFs) were dominantly grown from the large catalytic particles with hydrogen.