• Proceedings of the KAIS Fall Conference
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• 2010.05b
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• pp.890-893
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• 2010

알코올 섭취 후 발생하는 해부생리학적 변화가 눈의 일시적인 근시화에 미치는 영향을 알아보고자 하였다. 평균 24.5${\pm}$1.5세의 남자 8명(16 안)을 대상으로 0.42 g/kg의 알코올을 30분 간에 걸쳐 섭취토록 한 다음, 알코올 섭취 1시간, 4시간, 24시간 후의 교정굴절력, 각막곡률반경과 두께, 동공직경, 안압, 그리고 안구축의 길이변화를 측정하여 알코올 섭취 전과 비교하였다. 알코올 섭취 1시간 후에 알코올 섭취 전과 비교하여 호흡 중 알코올 농도가 가장 높았고(p<0.001), 교정굴절력의 구면 (-)굴절력 증가(p<0.05), 동공 크기의 감소(p<0.05), 안압의 하강(p<0.001), 그리고 안구축의 길이 증가가 나타났다. 알코올 섭취 4시간 후에도 모든 측정값들이 섭취 1시간 후와 동일한 경향이었다. 그러나 알코올 섭취 24시간 후에는 알코올 섭취 전과 비교하여 의의있는 변화를 보이지 않았다. 알코올 섭취로 인한 일시적인 근시화는 안압하강과 안구축의 길이변화와 관련성이 있을 것으로 판단된다.

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2004.10a
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• pp.402-406
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• 2004

신선야채를 섭취한 후 타액에 분비되는 아질산 함량 변화를 관찰하여 채소와 육제품 소비에 대한 안전성을 평가하는 자료로 제시하고자 하였다. 건강한 20-40대 성인 남녀를 대조군, 야채 제한섭취군, 자유섭취군 등의 3 군으로 나누어 하루동안 실험식이를 섭취하도록 한 후 타액의 아질산 농도를 측정하였다. 하루 동안 김치와 야채, 염지육제품 등 질산과 아질산 함유 식품을 섭취하지 않은 대조군의 경우 식전 타액의 아질산 농도는 1.93 ppm으로 매우 낮았으며, 식후 1 시간과 3 시간에도 각각 2.79 및 2.54 ppm으로 큰 변화가 없었다. 대조구와 같이 하루 동안 김치와 야채를 비롯한 질산과 아질산 함유 식품 섭취를 제한한 야채 제한섭취군도 식전 타액의 아질산 농도는 3.24 ppm으로 비교적 낮은 값을 보였으나 점심으로 야채 쌈밥을 섭취한 후 1 시간과 3 시간에는 28.3과 33.05 ppm으로 매우 높았다. 타액 채취 전 하루 동안 일상적인 식사를 자유롭게 섭취한 자유섭취군의 경우는 식전 타액 아질산 함량이 7.91 ppm으로 비교적 높은 값을 보였으며, 야채 쌈밥 식사 후 1 시간과 3 시간 후에는 21.51과 28.37 ppm으로 증가하였다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.8
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• pp.1042-1049
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• 2009

It has been reported that trans fat (tFA) may have adverse or beneficial effect depending upon the position and number of double bonds. The presence of tFA in human tissues and fluids is related to dietary intake, intestinal absorption, metabolism and storage, exchanges among compartments. This study investigated the effect of breads containing tFA, soybean or rice on postprandial plasma fatty acid and lipid composition. 33 healthy volunteers were divided into 3 groups and fed soybean bread, rice bread or wheat bread groups containing equivalent amounts of tFA (elaidic acid rich, 3.75 g/day), respectively. Postprandial lipid profiles at 0, 1, 2, 3 and 4 hours after a respective meal were studied. Plasma fatty acid was extracted by the method of Folch and methyl ester of fatty and prepared by acid transmethylation and analyzed by Gas Chromatography. Peaks were identified using pure reference compounds and quantified. Postprandial data indicated that consumption of soybean and rice breads with 3.75 g tFA retarded the appearance of C18:1 and C18:2 tFA in plasma lipid compared to that of wheat bread. Futhermore, soybean and rice bread groups showed lower plasma saturated fatty acid levels than wheat bread group. Postprandial TG level was significantly lowered in soybean bread group compared to that of rice and wheat bread groups. These results imply that soybean bread with high dietary fiber content and biologically active substances may inhibit or delay lipid absorption.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.2
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• pp.195-199
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• 2010

Purpose: This study was to investigate the relevance between refractive and anatomical changes temporarily on the eyes after alcohol ingestion. Methods: Eight subjects (16 eyes) which were $24.5{\pm}1.5$ aged males drunk the alcohol of 0.42 g per kg of body weight within 30 minutes. Refractive errors, the radius of corneal curvature, corneal thickness, pupillary size, intraocular pressure, and the length of the ocular axis at 1 h, 4 h, and 24 h after alcohol ingestion were compared with them of non-alcoholic state. Results: At 1 h after alcohol ingestion, breath alcohol concentration was the highest (p<0.001), more negative spherical power was needed (p<0.05) for correction, pupillary diameter was decreased (p<0.05), intraocular pressure was decreased (p<0.001), and the length of the ocular axis was increased compared with each one of non-alcoholic state. At 4 h after alcohol ingestion, all anatomical changes were the same tendency as at 1 h after alcohol ingestion. But at 24 h after alcohol ingestion, both refractive changes and anatomical changes were not significant compared with them of non-alcoholic state. Conclusions: Temporary changes of refractive error after alcohol ingestion may be related with decrease of intraocular pressure and increase of the length of ocular axis.

• Bulletin of Food Technology
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• v.14 no.4
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• pp.3-12
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• 2001

이소플라본은 대두와 대두가공제품에 들어있으며 화학적으로 두가지 형태 즉 아글리콘(aglycone)과 배당체(glucoside)로 존재한다. 본 논문은 사람에게 대두의 이소플라본이 흡수되는데 아글리콘과 배당체가 차이가 있는지를 연구하였다. 이소플라본을 저농도(0.11mmol)로 1회 투여했을 때 아글리콘형은 섭취 2시간 후에 혈장의 이소플라본 농도가 최고치에 도달하였으며 배당체형은 섭취 4시간 후에 최고치에 도달하였다: 이때 피험자는 4명의 남성(41세)과 4명의 여성(45세) 이었다. 또한 8명의 피험자〔남성 4명(40세), 여성 4명(47세)〕를 대상으로 고농도(1.7mmol) 이소플라본을 1회 섭취시킨 후 혈장의 이소플라본 농도 변화를 비교하였으며, 아글리콘 섭취 후 혈장 이소플라본의 최고 농도는 배당체로 섭취한 경우보다 5배가 높았다. 저농도와 고농도의 두 실험에서 모두, 제니스테인과 다이드제인의 섭취수준은 유사함에도 불구하고 혈장의 제니스테인의 농도가 다이드제인보다 유의적으로 높았다. 또한 8명의 남성(45세)을 대상으로 4주간의 장기간 이소플라본(0.30mmol/ 일)을 섭취시킨 후 혈장의 이소플라본 농도를 측정하였다. 2주와 4주째에 혈장내 농도는 배당체형보다 아글리콘 섭취 후에 100% 이상 높은 것으로 나타났다. 이소플라본 아글리콘은 배당체보다 사람에게 더 빠르고 더 많은 량이 흡수되었다. 이소플라본 아글리콘이 풍부한 제품은 이소플라본 배당체가 풍부한 제품보다 관상 심장질환 등 만성질환 예방에 더 효과적일 수 있을 것이다.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.1
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• pp.133-138
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• 2009

Purpose: This study was designed to investigate the changes of vision and ocular functions induced by increase of blood alcohol level. Methods: Blood alcohol level, vision, refractive errors, near point convergence, heterophoria, and relative convergence were measured at 1 h, 4 h, and 24 h after acute alcohol ingestion of 0.7 g per kg body weight. Results: At 1 h after alcohol ingestion, myopization and ocular functions which measured near point convergence, positive and negative convergences, and degree of heterophoria remarkedly worked a changes accompanied with the maximum value of blood alcohol level. But at 24 h after that, all of ocular functions were recovered to degree of 90~99% compared with non-alcoholic normal conditions. Conclusions: As the increase of blood alcohol level is able to induce the significant changes of visual acuity and ocular functions, opticians have to understand thoroughly the patient's conditions by alcohol ingestion before refractive test and ocular examinations.

• Journal of Radiation Protection and Research
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• v.34 no.4
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• pp.184-189
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• 2009

In pressurized heavy water reactors, workers who enter radiation controlled areas must submit their urine samples to health physicists after radiation work; these samples are then used to monitor internal radiation exposure from tritium intake. This procedure assumes that the samples submitted represent tritium concentration inside the body at equilibrium. According to both technical reports from the International Commission on Radiological Protection and experimental results from Canadian nuclear utilities, tritium inside the body generally reaches equilibrium concentration after approximately 2-3 hours of intake. In practice, urine samples can be submitted either before the 2 hours mark or after several hours of radiation work because of the numerous tasks that workers must perform and their frequent entries during nuclear power plant maintenance. In this paper, tritium concentration in workers' urine samples was measured as a function of time submitted after radiation work. Based on the measurement results, changes in the tritium concentration inside the body and its effect on internal dose assessment were then analyzed. As a result, it was found that tritium concentration reaches equilibrium concentration before the 2 hours mark for most workers' urine samples.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.4
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• pp.621-626
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• 2003

The aim of this study was to evaluate the effects of 40% sucrose replacement with oligosaccharides (fructo- orisomalto-) in sponge cakes. The 18 female college students were divided into two groups; fructooligosaccharide sponge cake group (FOS) and isomaltooligosaccharide sponge cake group (IMOS). In each group, the subjects received 50 g/d of sponge cake which contained about 8 g oligosaccharides for 2 weeks. The results were as follows: (1) Frequency of stool evacuation tended to increase after 1 week and significantly increased after 2 weeks in both groups. (2) Shape and color of stool did not change in FOS group but the IMOS group showed significant improvement. (3) The stool amounts per defecation were not significantly different in both groups. (4) The time of defecation decreased 50% after 1 week in FOS group and tended to decrease gradually in IMOS group. (5) Consistency of stool was significantly decreased after 1 week in both groups and continuously decreased until 2 weeks. (6) Effort for evacuation and comfort feeling after evacuation were significantly improved only in IMOS group after 2 weeks. (7) Gastrointestinal complaints concerning diarrhea, abdominal pains, nausea, flatulence, loss of appetite and weight and bloating were apparent. The symptoms such as abdominal pains, flatulence, and bloating in FOS group lasted for 2 weeks. However, the complaints appeared only during two or three days in IMOS group. In conclusion, our results suggest that isomaltooligosaccharide was more effective than fructooligosaccharide for preventing constipation because isomaltooligosaccharide worked safely in gastrointestinal lumen.

• Journal of the Korean Society of Food Science and Nutrition
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• v.21 no.6
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• pp.627-632
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• 1992

The effect of dietary pectin in the upper gastrointestinal transit rate was studied. Rats fed fiber-free diet or 10% pectin diet were offered 51-$CrCl_3,$ a transit marker. The movement of 51-Cr dose through the gastrointestinal tract was measured at intervals from 20 minutes to 6 hours after dosing. pectin significantly increased gastric emptying rate upto 3 hours after dosing. Pectin also increased small intestinal transit rate from 3 hours to 4 hours after dosing. The results suggest that delayed gastric emptying is not likely the important aspect of the mechanism by which pectin could flatten the post-prandial response of serum glucose and insulin.

• Proceedings of the Korea Contents Association Conference
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• 2012.05a
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• pp.407-408
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• 2012

요약은 이 연구는 다양한 식이 섭취와 일회 지구성 운동으로 야기되는 근육(백색 비복근) 내 AMP-activated protein kinase(AMPK), Extracellular signal-regulated kinase(ERK 1/2)와 p38 mitogen-activated protein kinase(MAPK)의 신호전달체계를 구명해 보고자 실시되었다. 실험에 사용된 쥐(Sprague-Dawley)는 총 160마리로 크게 일반 탄수화물 식이(CHO; 40마리), 포화지방 식이(SAFA; 40마리), 단일불포화 식이(MUFA; 40마리)와 다불포화 식이(PUFA; 40마리)로 나누어 연구를 진행하였다. 운동 프로그램은 일회 지구성 운동으로 30분 운동 후 5분 휴식의 사이클을 지속적으로 6번 반복하여 총 3시간의 지구성 수영 운동을 실시하였고, 분석을 위한 조직 샘플링은 운동 전, 운동 후 0시간, 1시간, 4시간, 24시간에 걸쳐서 이루어졌다. 연구의 결과는 서로 다른 식이 섭취와 운동에 따른 AMPK의 신호전달 단백질의 발현은 유의한 치이가 나타나지 않았다. 그러나 서로 다른 식이를 섭취한 쥐의 근육에서 ERK 1/2(p<.01)와 p38 MAPK(p<.001)의 신호전달 단백질의 발현은 유의한 차이를 보였다(p<.05). 흥미로운 결과는 운동에 대한 유의한 차이는 AMPK, ERK1/2와 p38 MAPK 모두 유의한 차이를 보이지 않았다는 것이다. 결론적으로 일회 지구성 운동보다 서로 다른 식이의 섭취가 근육 내(백색 비복근)의 대사적 변화를 일으키는데 주도적인 영향을 미칠 수 있음을 시사할 수 있다.