• Journal of the Korean Society of Radiology
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• v.85 no.3
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• pp.631-636
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• 2024

Pleural metastasis is the most common cause of malignant diseases involving the pleura, and characterized by pleural effusion, nodules, and thickening. Pleuroparenchymal fibroelastosis (PPFE) is a disease characterized by apical pleural thickening and subjacent parenchymal fibrosis. We report a case of a 60-year-old male with lung cancer in the left lower lobe and underlying PPFE combined with left apical pleural metastasis. Initially, asymmetric left apical pleural thickening due to pleural metastasis was mistaken for PPFE. Additionally, we describe the imaging and histopathological findings of PPFE, including MRI findings.

• Investigative Magnetic Resonance Imaging
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• v.13 no.2
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• pp.199-202
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• 2009

Desmoplastic fibroma of bone is an extremely rare tumor that was first described by Jaffe in 1958. It histologically resembles the desmoid tumor of soft tissue. It is known as locally aggressive tumor but we experienced definitely benign and resembling simple bone cyst radiographically. We report a case of desmoplastic fibroma of bone and it should be included in the differential diagnosis list of any lytic bone lesion. The radiograph, MR imaging features, radiological and pathological differential diagnosis of the case are described, and literatures are reviewed.

• Journal of the Korean Society of Radiology
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• v.83 no.5
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• pp.1175-1181
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• 2022

Progressive massive fibrosis (PMF) with atypical findings is often misdiagnosed as lung cancer. Atypical features of PMF have been described in some reports; however, these reports only introduced their cases with a short literature review. We report two cases of solitary PMFs with no underlying simple pneumoconiosis or rapid growth at atypical location that were mistaken for lung cancer. We also suggest the useful CT findings to aid in the differential diagnosis.

• Journal of Life Science
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• v.23 no.5
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• pp.710-720
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• 2013

Radiotherapy is commonly used in treating many kinds of cancers which cannot be cured by other therapeutic strategies. However, radiotherapy also induces the damages on the normal tissues. Radiation-induced fibrosis is frequently observed in the patients undergoing radiotherapy, and becomes a major obstacle in the treatment of intrahepatic cancer. Hedgehog (Hh) that is an essential in the liver formation during embryogenesis is not detected in the healthy liver, but activated and modulates the repair process in damaged livers in adult. The expression of Hh increases with the degree of liver damage, regulating the proliferation of hepatic progenitors and hepatic stellate cells (HSC). In addition, Hh induces epithelial-to-mesencymal transition (EMT) and activation of myofibroblasts. In the irradiated livers, up-regulated expression of Hh signaling was associated with proliferation of progenitors, EMT induction, and increased fibrosis. Female-specific expression of Hh leaded to the expansion of progenitors and the accumulation of collagen in the irradiated livers of female mice, indicating that gender disparity in Hh expression may be related with radiation-susceptibility in female. Hence, Hh signaling becomes a novel object of studies for fibrogenesis induced by radiation. However, the absence of the established experimental animal models showing the similar physiopathology with human liver diseases and fibrosis-favorable microenvironment hamper the studies for the radiation-induced fibrosis, providing a few descriptive results. Therefore, further research on the association of Hh with radiation-induced fibrosis can identify the cell and tissue-specific effects of Hh and provides the basic knowledge for underlying mechanisms, contributing to developing therapies for preventing the radiation-induced fibrosis.

• Clinical and Experimental Pediatrics
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• v.50 no.3
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• pp.306-310
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• 2007

Restrictive dermopathy is a rare autosomal recessive disorder in which rigidity or tautness of the skin from the second trimester causes a fetal akinesia deformation sequence (FADS) and early death. Characteristic features include taut skin with prominent subcutaneous vessels, widely open fontanelles and cranial sutures, distinctive facies, flexion contractures, pulmonary hypoplasia, sparse eyelashes and and eyebrows, thin dysplastic clavicles. The histologic abnormalities of the skin are located in a thin dermis, consisting of compactly arranged collagen fibers, scanty elastic fiber. The dermoepidermal junction is flat, and epidermal appendages are absent, miniaturized or immature. The presence of adipose tissue may be increased. We report on the first Korean case of restrictive dermopathy with typical clinical features and histological findings.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.3
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• pp.338-345
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• 1991

Velopharyngeal incompetence (VPI) is a condition of inadequate functional valving between the oral and nasal cavities that results in hypernasal speech and nasal air escape. VPI is caused by the following factors ; cleft palate, soft palate defect, pharyngomegaly, velopharyngeal sphincter muscle anomaly and maxillary advancement surgery, etc. Velopharyngeal function is assessed by a variety of measures that include speech evaluation, cephalogram, airflow study, videofluoroscopy and nasoendoscopy. The management of VPI is classified into four main groups ; prosthesis, insertion of implant, palatoplasty and pharyngoplasty. Pharyngeal flap is the most common surgical procedure for correcting VPI since Schoenborn's report in 1875. We report seven cases of VPI which were treated by modified modified superiorly based pharyngeal flap with good results.

• Bulletin of Food Technology
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• v.10 no.1
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• pp.121-132
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• 1997

코레스테롤은 대표적 sterol로서 세포막, oganella막 등의 구성 성분인 동시에 담즙 및 각종 hormon, vitamin D의 전구체가 되는 등 생체기능유지에 있어 매우 중요한 물질이다. 이와같은 콜레스테롤은 체내에서 항상성을 유지하도록 조절되고 있으나 지속적인 동물성위주의 식생활로 인하여 체내 콜레스테롤 농도의 평형이 깨어지기 시작했고 콜레스테롤의 과잉축적은 동맥경화증, 심근경색, 허혈성 뇌질환 등과 순환기계질병을 유발하는 원인이 되는 것으로 알려지고 있다. MRFIT(Mutiple Risk Factor Intervention Tria)에서는 콜레스테롤의 함량이 높을수록 심근경색증으로 인한 사망율이 증가하고, 혈장콜레스테롤이 300mg/dl 이면 200mg/dl인 사람보다 위험도가 4배가 높다고 보고하고 이다. 따라서 콜레스테롤의 조절은 건강과 직결되어 있다고 해도 과언이 아니다. 본고에서는 콜레스테롤의 주요기능을 살펴보고 혈중 콜레스테롤의 저하에 도움이 되는 소재 및 최근 주목받고 있는 동물성 식이섬유인 chitosan의 콜레스테롤의 저하기능을 중심으로 살펴보고자 한다.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1991.06a
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• pp.17-17
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• 1991

산업의 발전과 함께 최근 카드뮴 중독이 사회적 문제가 되고 있다. 카드뮴 중독은 특히 건전지 제조공장, 카드뮴 광산 등에서 잘 발생하며 카드뮴 분진의 흡입, 음식물내 카드뮴 복합물의 섭취 등에 의해 유발된다. 중독증상으로는 폐부종 및 섬유화, 신부전증, 폐부전증, 고혈압, 생식선 위축, 골연화증, 무취증, itai-itati 질환등을 일으키는 것으로 알려져 있으나 무취증에 대한 정확한 발생기전은 밝혀져 있지 않다. 이에 저자들은 카드뮴 중독을 유발시키기 위하여 흰쥐에 $CaCl_2$ 11.2 mg/kg을 3주일간 매일 피하주사한 후 3주 후에 두개골을 제거하고 후구를 절취한 후 투과전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. 사구체 주위 부위에 있는 사구체 주위 세포의 세포돌기와 신경축삭에 퇴행성 변화가 발생하였다. 2. 외상망 부위와 승모세포, 과랍세포 등에서는 뚜렷한 변화를 발견할 수 없었다.

• The Korean Journal of Zoology
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• v.34 no.3
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• pp.382-388
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• 1991

쥐의 교핵내에서 대뇌피질(또는 소뇌핵) 면면시 소뇌교핵계(또는 대뇌교핵계)의 연접구조의 변화에 대한 전자현미경적 관찰결과, 대뇌교핵계의 수입로 차단의 경우 소뇌교핵계의 신경섬유는 교핵세포의 원위 가지돌기쪽으로 발아하며, 소뇌핵 병변시 서뇌교핵계의 신경섬유는 근위가지돌기와 연접을 형성하거나 또는 여러개의 가지돌기 부속물들과 사구체형 연접복합체를 형성함이 밝혀졌다. 이상의 연구는 광학현미경적 관찰에서 언급된 대뇌피질(또는 소뇌핵) 병변에 따른 교핵내 신경종말의 밀도증가에 대한 보고를 뒷받침해주며, 소뇌핵 병변시 운동결핍증의 시간경과에 따른 회복에 대한 신경해부학적 근거를 제시한다.

• Journal of Veterinary Clinics
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• v.24 no.2
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• pp.292-294
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• 2007

Endometrial biopsy in the horse is an important technique for maintaining breeding soundness by detecting changes related with reduced fertility and monitoring response to specific uterine therapy. A 13-year-old thoroughbred mare had been in trouble with repeated breeding for getting pregnant before the sample of endometrial biopsy was offered to investigate the possibility of pregnancy in the future. Based on the tissue sections examined, the prognosis for this mare to conceive and successfully carry a foal to term was estimated to be 10 to 50%.