• Clinical and Experimental Pediatrics
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• v.48 no.4
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• pp.395-400
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• 2005

Purpose :Rotavirus is one of the most important causes of nosocomial infections among children. The aim of this study is to determine the risk of nosocomial rotavirus infections and to evaluate the effectiveness of breast-feeding and probiotics in the prevention of nosocomial rotavirus infections. Methods : This study was carried out on admitted children without diarrhea between March 1, 2003 and February 29, 2004. Three hundred ninety patients aged 4 days to 13 years during this study were available. We examined the feces of all children for rotavirus by latex agglutination on admission, during hospital, and after discharge, to see whether they developed diarrhea or not. Results : Nosocomial rotavirus infections was significantly increased with children under 12 months of age(P=0.008). The monthly attack rate was great between December and March(P=0.046). Prolonged hospital stay was associated with an increased attack rate of nosocomial rotavirus infections (P=0.003). The risk of nosocomial rotavirus infections was not associated with the number of roommates and whether or not they were breast-fed or fed on probiotics. Conclusion : Nosocomial rotavirus infections are significantly more likely to occur in children under 12 months of age, admitted between December and March, and with prolonged hospital stays. Prompt identification and isolation of children with nosocomial rotavirus infections, even without diarrhea, may decrease rates of nosocomial rotavirus infections.

• Korean Journal of Clinical Pharmacy
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• v.10 no.3
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• pp.140-144
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• 2000

Reofecoxib는 용량 의존적으로 cyclo-oxygenase-2를 선택적으로 억제한다. 골관절염 환자를 대상으로 하여 이중맹검, 무작위, Western Ontario and McMasters Universi-ties Osteoarthritis Index를 이용하여 평가한 결과, rofecoxib 12.5, 25 mg는 신체적 기능을 크게 향상시키는 것으로 보여졌다. 또한 diclofenac (50 mg, 1일 3회), ibuprofen (800 mg, 1일 3회), nabumetone(1500 mg, 1일 1회)와 유사한 임상효과를 나타내었다. Rofecoxib는 원발성 월경곤란증과 수술 후 치통에 효과적으로 억제하였으며 naproxen sodium과 ibuprofen과 같은 진통 효과를 보였다. Rofecoxib는 안전성 면에서 우수하며 가장 흔한 부작용은 설사, 두통, 오심과 상기도 감염증이다. Rofecoxib 12.5, 25, 50 mg/day를 투여한 골관절염 환자에게서 위장관계 부작용(천공, 궤양, 출혈)은 ibuprofen, diclofenac, nabumetone을 투여한 환자보다 훨씬 낮은 발생빈도를 나타내었다.

• Journal of Yeungnam Medical Science
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• v.18 no.2
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• pp.297-301
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• 2001

The efficacy of injection sclerotherapy for treatment of acute esophageal variceal bleeding is well established. But several complications of endoscopic sclerotherapy have been reported. One of the complications is mesenteric venous thrombosis which develops when vasopressin is used for the sclerotherapy. We report a case of superior mesenteric venous thrombosis which developed after endoscopic sclerotherapy for control of esophageal variceal bleeding.

• Journal of the korean academy of Pediatric Dentistry
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• v.31 no.3
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• pp.400-405
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• 2004

Biliary atresia is defined as a complete obstruction of bile flow owing to destruction or absence of all or part of the extrahepatic bile ducts. This disease is occurring in approximately 1:10,000 live births and moderate predominance of female is noted. The etiology of biliary atresia remained unsolved. The signs and symptoms are hyperbilirubinemla, jaundice, clay-colored stools, steatorrhea, dark yellow urine and hepatomegaly. Currently biliary atresia is best managed by hepatic portoenterostomy with or without liver transplantation. Biliary atresia patients with these cases showed staining of the teeth. The stains ranged in color from yellowish-brown to deep green. Enamel hypoplasia was all erupted teeth present. Patients had poor oral hygiene and rampant caries.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.57-61
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• 2000

This study was designed to examine therapeutic effect of bee(Apis mellifera L.) venom in calves with bacterial diarrhea. Calves with bacterial diarrhea were administered with bee venom and therapeutic drug, respectively. In the bee venom-treated group, 69 calves were acupunctured once a day for 3 conseutive days. Two local acupoints of Jiao-chao(GV-1, at the indentation between the base of tail and the anus) and Bai-hui(GV -20, in the dorsal midline of the lumbo-sacral space) were stung by the bee. In the therapeutic drug-treated group, 55 claves were intramuscularly injected with a standard dosage of antibiotic (ciprofloxacin, 2.5 mg/kg of body weight) and antidiarrheal drug (berberine cholride, 10mg/head) once a day for 3 consecutive days. At post-treatment, 81.2% of the bee venom-treated calves and 76.4% of the therapeutic drugtreated calves were recovered from bacterial diarrhea. Bee acupuncture therapy showed in calves without side effects such as allergy hemorrhage, or infection. It might be concluded that apitherapy was affective in controlling of calves with bacterial diarrhea.

• Korean Journal of Veterinary Research
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• v.37 no.4
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• pp.809-816
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• 1997

In this presented study, we established a method for diagnosis of porcine epidemic diarrhea(PED) by in situ hybridization(ISH), which made distinct progress in diagnostic pathology. We also carried out the retrospective diagnosis through ISH to assume the exact time of the first outbreak and incidence of PED in Korea. The outbreak of PED in Korea reported in 1992. However, since the end of 1980's, some researches of pig-industry have already suspected the outbreak of PED, not transmissible gastroenteritis(TGE). In this experiment, we performed the ISH using 80 formalin-fixed and paraffin-embedded tissues of porcine intestine which were requests for pathological diagnosis from 63 farms whose primary sign was diarrhea from 1984 to 1991. We prepared biotinylated cDNA probe(492base pairs) for ISH by nick translation method and carried out the ISH, using $Microprobe^{TM}$ capillary action system(Fisher $Biotech^R$). We detected PED virus in intestinal mucosa of 2 cases in 1992, 1 case in 1988, and 1 case in 1987. As a result, we assume that the outbreak of PED in Korea have already started since 1987.

• Journal of Veterinary Clinics
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• v.23 no.4
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• pp.432-436
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• 2006

The therapeutic effects and immune responses with Oidenlandiae Herba administration(17.5%, 1g/30 kg, everyday, PO) were investigated in calves(1 to 3 months old) with diarrhea from 159 Korean native calves(76 heads from A farm and 83 heads from B farm) in Jeju. The causes of 47 calves with diarrhea were coronavirus(1 head) and rotavirus(1 head), coccidium(5 heads) and bacteria(40 herds). PCV values were significantly increased 2 weeks after administration of Oldenlandiae Herba in A form, compared by those of pre-treatment(p<0.05). However RBC, TP, WBC, fibrinogen levels were not significantly changed. The significant difference were not detected in changes of AST, BUN and creatinine. The CD14+ distribution rate were increased in 1 week after administration of Oldenlandiae Herba, compared by that of pre-treatment(p<0.05), however, certain tendencies of changes were not observed in distribution rates of CD4+ CD8+ and CD19+, respectively. The rate of death was 20.1%(36/179 calves) in 2004, however, it was decreased to 12.6%(20/159 calves) by Oldenlandiae Herba administration at 2 farms from Jeju in 2005. In conclusion, the administration of Oldenlandiae Herba was effective for treatment of calves with diarrhea.

• Korean Journal of Veterinary Research
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• v.60 no.3
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• pp.163-171
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• 2020

This study examined the prevalence of adherence factors, toxin genes, antimicrobial resistance phenotypes, and resistance genes in Escherichia coli (E. coli) isolated from piglets with diarrhea before and after the ban on antibiotic growth promoters (AGPs) in Korea from 2007 to 2018. In this period, pathogenic 474 E. coli isolates were obtained from diarrheic piglets. The virulence factors and antimicrobial resistance genes were assayed using a polymerase chain reaction, and the susceptibility to antibiotics was tested according to the Clinical and Laboratory Standards Institute guidelines. After the ban on AGPs, the frequency of F4 (12.5% to 32.7%) increased significantly, and LT (31.9% to 20.3%) and EAST-I (46.5% to 35.2%) decreased significantly. In addition, the resistance to streptomycin (45.8% to 67.9%), cephalothin (34.0% to 59.4%), and cefazlin (10.4% to 28.8%) increased significantly. Colistin resistance plasmid-mediated genes, mcr-1 and mcr-3, were detected after the ban on AGPs. The results of this study can provide useful data for analyzing the impact of the ban on AGPs on the virulence profiles and antimicrobial resistance of E. coli isolated from piglets with diarrhea in Korea.

• Korean Journal of Veterinary Research
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• v.31 no.3
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• pp.295-302
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• 1991

From 1988 to 1989, 8 strains of canine parvovirus-2(CPV-2) were isolated from the fecal specimens from the dogs that were clinically diagnosed as canine parvoviral enteritis in the veterinary hospitals located in the regions of Taejeon and Chungbuk province. The biological and physicochemical properties for the isolates were studied. Among 62 fecal samples collected from the dogs with enteric diseases, 24(38.7%) showed the haemagglutinating activity to porcine erythrocyte ranging from 16 to 16,384 of HA titers. In cytopathological studies with CRFK cells, intranuclear inclusion bodies were observed in all of eight specimens with the high HA titer over 1,000, of which three specimens showed cytoplasmic inclusions concurrently with the intranuclear inclusion bodies. It was found that the isolates revealed the highest haemagglutinating activity with porcine erythrocytes and the relatively lower haemagglutination titers with the erythrocytes from cat and rabbit. None of erythrocytes from the other animals reacted with the isolates. By the cross-haemagglutination inhibition test for the isolates with the reference viruses and sera, the isolates were evidently identified as the strains of CPV-2. In physicochemical property test, the isolates were stable in lipid solvent, pH and heat treatment at $56^{\circ}C$ for 30 min, and showed the virus particle size less than 25 nm, containing a DNA genome.

• Microbiology and Biotechnology Letters
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• v.13 no.3
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• pp.203-207
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• 1985

Bifidobacteria are normal inhabitants of the intestinal tract of humans. Using Bif. longum isolated from feces of Korean adult and Bifidus preparation, we observed the growth inhibitory actions of these organisms toward E. coli $A_2$ causing bacterial diarrhea. Bif. longum SKD-2001 SKD-2004 inhibited the growth of E. coli $A_2$ drastically. It is supposed that the mechanism of the growth inhibitory actions is due to acid conditions created by Bif. longum.