• 대한한방부인과학회지
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• 제22권1호
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• pp.31-40
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• 2009

Purpose: This study was carried out to investigate the anti-tumor metastasis effect and activation of innate immunity by extracts of Mori radicis cortex. Methods: Anti-tumor metastatic experiment was conducted in vitro and in vivo by using colon 26-M3.1 carcinoma cell, L5178Y-R lymphoma cell and HeLa cell. To observe the activation of innate immunity by extracts of Mori radicis cortex, we estimated IL-6, IL-10, IL-12, TNF-${\alpha}$ from peritoneal macrophages. And we evaluated the activation of NK cell by using anti-asialo-GM1 serum. Results: We found that the administration of Mori radicis cortex extracts significantly inhibited tumor metastasis. In an in vitro cytotoxicity analysis, Mori radicis cortex affected tumor cell growth above specific concentration. Mori radicis cortex also stimulated peritoneal macrophage, which was followed by the production of various cytokines such as IL-6, IL-10, IL-12, TNF-${\alpha}$. The depletion of NK cells by anti-asialo GM1 serum partly abolished the inhibitory effect of Mori radicis cortex on tumor metastasis. Conclusion: Mori radicis cortex appears to have considerable activity on the anti-metastasis by activation of innate immunity.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제61권12호
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• pp.644-649
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• 2018

Background and Objectives The objective of this study was to examine the effect of early cochlear implantation (CI) performed in infants less than 12 months of age. Subjects and Method Twenty-five children who received their first CI before 12 months of age were included in this study (infant group). The speech perception and language outcomes of these children were compared with those of 14 children who received their first CI between 13 and 24 months of age (older group). All children received sequential bilateral CI with the inter-stage interval of less than 2 years. Speech perception was measured using Categories of Auditory Performance, monosyllabic word test and sentence test, and language ability was measured using Sequenced Language Scale for Infants, Preschool Receptive-Expressive Language Scale, or Receptive & Expressive Vocavulary Test, depending on the age at the time of testing. Results There were no significant differences in speech perception abilities between the infant group and the older group. The mean expressive language score of infant group was higher than that of the older group, but the difference was not statistically significant. However, the receptive language score of infant group was significantly higher than that of the older group. Conclusion Children who received CI before 12 months of age achieved better receptive language ability than those who received it after 12 months of age. Thus CI should be performed as early as before 12 months of age to achieve better language ability.

• 대한한방부인과학회지
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• 제34권3호
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• pp.15-28
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• 2021

Objectives: This study was designed to examine the anti-cancer activity by innate immunomodulating and anti-inflammatory effects of liriopis tuber water extract (LPE). Methods: Cell cytotoxicity was tested with 4T1 mouse mammary carcinoma cells, spleen cells, macrophage, and RAW264.7 cells. To investigate innate immunomodulating effects of LPE on macrophage, we measured tumor necrosis factor-alpha (TNF-α), interleukin-12 (IL-12), and interleukin-10 (IL-10). To investigate innate immunomodulating effects of LPE on RAW264.7 cell, we measured TNF-α, interleukin-6 (IL-6). In addition, TNF-α and nitric oxide (NO) induced by lipopolysaccharide (LPS) were measured after treating with LPE to observe innate immunomodulating effect of LPE on RAW264.7 cell. Also, mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) were examined by western blot analysis. Results: In an in vitro cytotoxicity analysis, LPE affected tumor cell growth above specific concentration. As compared with the control group, the production of TNF-α, IL-12, and IL-10 were increased in macrophage. As compared with the control group, the production of TNF-α and IL-6 were increased in RAW 264.7 cell. The expression of TNF-α and NO induced by LPS after treating LPE was decreased. In addition, treatment of RAW 264.7 cell with LPE increased the phosphorylation levels of p-extracellular signal-regulated kinase (p-ERK), p-Jun N-terminal kinase (p-JNK), and p-p38. Conclusions: LPE might have impact on the anti-cancer effect by activation of innate immune system and inflammation control.

• 대한치과보철학회지
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• 제51권4호
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• pp.339-346
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• 2013

외상이나 선천적 결손에 의한 영구치아의 결손은 치료 방법과 적용 시기의 결정이 치료의 예후에 중요한 영향을 미친다. 본 증례는 성장기 환자로서 치아와 두개안면골 상태에 대한 정확한 진단 및 적절한 치료방법을 선택하고 성장 양식을 고려해서 일정기간 임시수복물과 임시 가철성 보철물을 사용하였으며, 성장 완료 후 임플란트 등을 이용한 고정성 보철수복 치료를 시행한 경우로써 교정과와 보철과의 협진 진료, 붕괴된 교합고경의 재확립 과정, 임플란트 보철치료 시 고려해야할 사항들에 대해 발표하고자 한다.

• 대한두경부종양학회지
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• 제36권2호
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• pp.33-36
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• 2020

Cutaneous horn is the clinical entity, which is circumscribed, conical, markedly hyperkeratotic lesion in which the height of the keratotic mass amounts to at least half of its largest diameter. It may be associated with many different pathological lesions. It is a relatively rare and a kind of epidermal tumor that generally appears as a conical projection. Here, we report rare case of congenital cutaneous horn. A 39-month-old female Korean patient presented at our clinic with a mass at the tip of her nose present since birth. Under general anesthesia, cutaneous horn of nasal tip was completely excised without any complications. The operation site was small enough to perform a primary closure, without any nasal deformity. Histopathologically, it was reported as a fibroepithelial polyps. After operation, there is no evidence of recurrence at 16 months of follow-up.

• 대한치과교정학회지
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• 제37권4호
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• pp.305-314
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• 2007

상악 우측 견치의 선천 결손과 전치부 반대교합을 보이는 III급 부정교합 환자의 문제중심의 치료계획 수립과 치료과정, 치료결과를 보이고자 한다. 상악 우측 견치와 상악 측절치 보철 공간을 위해 상악 우측 구치부 원심 이동을, 전치부 반대교합 해소를 위해 mini-implant를 적용하여 하악 전 치열의 원심 이동을 빠르고 쉽게 이루었다. 치료기간은 17개월이 소요되었으며, 치료 1년 후에도 교합은 안정적으로 유지되었다.

• 대한두경부종양학회지
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• 제33권2호
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• pp.49-53
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• 2017

Foregut cystic developmental malformations are rare developmental anomalies. It is important to diagnose the diseases and manage them properly because these cysts may generate feeding or respiratory difficulties depending on the size and location of the lesions. A newborn was referred for a congenital cervical swelling to our clinic on the second day of his life. Neck SONO and MRI showed an about 6cm sized cystic mass at left submandibular area. Aspirations and sclerotherapies were done repeatedly due to recurred cystic mass. Under the suspicious of cystic hygroma, the mass and submandibular gland were excised. Histologically, it was a benign cyst including gastrointestinal and bronchogenic mucosa and pancreatic tissue. Foregut cyst was suggested for the final diagnosis and the patient was discharged at 9 days after the operation without a complication. He has visited our out-patient department. Although several image studies have been introduced to find out foregut cyst, it is difficult to go through differential diagnosis because of similarity of other benign tumor. Further studies for early diagnosis of cervical foregut cyst are needed for preventing possible related problems.

• 대한한의학회지
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• 제20권2호
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• pp.177-186
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• 1999

Okbyungpoongsan(OBPS) has long been known to have anti-allergic effect. In order to evaluate the influence on innate and specific immune response, the effects of OBPS on vascular permeability. hypersensitivities and phagocytic functions were measured. As the results, OBPS increased phagocytic activity of peritoneal macrophages in vitro and in vivo. But OBPS depressed formation of reactive oxygen intermediates(ROI) in vitro and in vivo, while the drug enhanced generation macrophages. Foot pad swelling in the mouse and contact hypersensitivity against dinitroflouorobenzene were decreased. OBPS had no effect on NK cells. But OBPS decreased vascular permeability induced by histamine without statistical significance. These results demonstrate that OBPS suppresses hypersensitivity reactions without affecting phagocytic functions and formation of ROI from macrophages. It also means that OBPS acts as a effective inducer to synthesis of nitric oxide which is effective for the infectious disease while it does damage to tissue less as it suppresses ROI, So we can conclude that OBPS could be used for the treatment of the disease related with immune function.

• 대한소아치과학회지
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• 제7권1호
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• pp.85-93
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• 1980

This study was undertaken in order to observe the prevalence of congenital dental anomalies especially that of oligodontia and supernumerary teeth in 1024 children at age from 4 to 14 years, through history taking, oral examinations, roentgenographic observations of subjects, and statistic analysis was made. The following results were obtained: 1. The prevalence of oligodontia in 1024 children was $6.45{\pm}.8$ percent with a total of 122 teeth absent in sixty-six subjects, excluding 3rd molars, and most of children (86.4%) who have congenitally missing teeth showed abscence of one or two teeth individually. 2. The teeth most frequently absent were the mandibular second premolar, maxillary second premolar, maxillary lateral incisor, mandibular central incisor, and mandibular lateral incisor in order. 3. There was no statistically significant difference found in tooth abscence in the following comparisons; .Male vs Female .Bilateral vs Unilateral .Maxilla vs Mandible .Right vs Left 4. The prevalence of supernumerary teeth in 1024 children was $4.79{\pm}.67$ percent with a total of 59 supernumerary teeth in forty-nine subjects, all of children who have supernumerary teeth showed one or two supernumerary teeth individually. 5. Statistically significant difference was found in supernumerary teeth in the comparison of male vs female, and they were more frequent in male.

• 대한소아치과학회지
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• 제7권1호
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• pp.41-45
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• 1980

The term "Oligodontia" or "Hypodontia" have been used to describe variable degrees of reduction in number of teeth. Oligodontia may occur alone or as a result of some syndrome. Although the teeth are derived in part from ectoderm, the current opinion of reason of oligodontia should be reserved for those disorders in which there is abnormal development of one or more ectodermal tissues. 7 year 5 months old female was refered to the department of pedodontics, college of dentistry Yonsei university for evaluation and replacement of absent teeth. She had no special inf.ectious disease in her childhood, and her parents were healthy. She had no special syndrome of ectodermal disorders except the saddle nose, yellow and fine hair, and notched upper anterior central incisor. Panex radiogram was showing 6 anterior primary teeth, 2 permanent first molars and 2 unerupted first bicuspid in mandible. Another permanent teeth were absent. and normal number of primary and permanent teeth in maxilla. Lateral cephalogram showed no special abnormality in growth pattern. We had evaluated lower anterior decayed teeth with jacket resin and chrome steel crown and removable partial denture at missing area. We had got good results for rehabilitation of function and aesthetic.