• 한국수자원학회논문집
• /
• 제51권5호
• /
• pp.461-470
• /
• 2018

지금까지 추진해 오던 제외지 중심의 하천복원에서 벗어나 최근에는 제내지까지 복원하고자 하는 노력이 시도되고 있다. 이의 일환으로 구하도의 복원이 추진되고 있으나 이로 인한 수리적 연결성 및 생태적 연결성 향상을 정량적으로 평가할 적합한 모형의 개발은 미진한 상태이다. 본 연구에서는 구하도 복원을 통한 생태적 연결성 회복을 평가할 수 있는 격자기반의 수리해석 모형을 개발하였다. 본 모형의 적용성을 검토하기 위하여 노탑리 일원의 청미천 하천복원 사업지를 대상으로 수리생태적 연결성을 평가하였다. 본 모형으로 수리 및 생태적 특성의 시 공간적 분포를 신속하고 간단하게 해석할 수 있었으며 향후 수리적 생태적 연결성을 평가하는 적절한 도구로 활용될 수 있을 것으로 판단된다.

• 대한예방한의학회지
• /
• 제17권3호
• /
• pp.19-30
• /
• 2013

This study was aimed to develop a new formula for herbal medicine-safety classification in terms of evidence-based medicine. Recently, human equivalent dose(HED)-based therapeutic index was developed for herbal medicine-safety classification by transforming $LD_{50}$ to HED. However, the use of the $ED_{50}$ and $LD_{50}$ to derive the therapeutic index may be misleading as to safety, depending on the slope of the dose-response curves for therapeutic and lethal effects. To overcome this deficiency, HED-based MOS(Margin of Safety)was developed and suggested in this study. The HED-based MOS developed by using $LD_1$, changing to ALD(approximate lethal dose), and $ED_{99}$. The HED-based MOS seems to be more useful and safer than HED-based therapeutic index since its values for several herbal medicines are basically two times less than the values from HED-based therapeutic index. Thus, HED-based MOS can be a good example of Evidence-based approach for herbal medicine-safety classification.

• 대한예방한의학회지
• /
• 제16권2호
• /
• pp.67-81
• /
• 2012

Objective : This study aimed to analyze the utilization of Korean Medicine clinics, and high-frequent diseases by sex, age, and region of outpatients and inpatients Methods : The data for this study were "Report on Usage Patterns of Korean Medicine Clinics" issued by the Ministry of Health and Welfare in 2008. Descriptive analysis and correspondence analysis were used to find the patterns of patient's utilization by sex, age and region Results : Diagnosis and examination methods mostly consisted of the pulse for diagnosis. Treatment methods consisted of acupuncture, medical herbs in package, and insurance extract powder. Fee for consultation was paid by Korean Medicine insurance. Usage increased when people's age was over 20 and climaxed among people who were in their 40s and 50s and decreased gradually afterwards. Also, there were differences between the sexes. There were differences in high-frequent diseases by regions, and in usage of Korean Medicine clinics according to sex and age. Conclusion : It was found that there were differences in usage and patterns of Korean Medicine Clinics according to sex, age, and region.

• 한국환경보건학회지
• /
• 제36권1호
• /
• pp.14-19
• /
• 2010

Based on a nationwide survey of the consumption of oriental medicine by the Korean population, we estimated the potential risk from the inadvertent ingestion of heavy metals such as Pb, Hg, As, and Cd as a result such consumption. Compared to the provisional daily intake limit, heavy metal intake through oriental medicine resulted in hazard quotients of less than one. The upper $90^{th}$ percentile exposure estimates for each metal also showed insignificant risk. In relation to inorganic forms that are known carcinogens the excess cancer risk was less than $1{\times}10^7$. Based on the results of this study exposure to Pb, Hg, As, or Cd through oriental medicine intake appeared to be negligible and would not cause a significant impact on health.

• 대한예방한의학회지
• /
• 제19권2호
• /
• pp.123-133
• /
• 2015

The new formular for herbal medicine-safety classification in terms of evidence-based medicine was developed and applied to evaluate various herbal medicines in the previous study. This study is aimed to evaluate the frequently-used herbal medicines inducing toxic metabolites or reactive intermediates(RI), such as Ligusticum wallichii Franch, Angelica sinensis, Glycyrrhizae Radix, Rehmanniae Radix, based on 6 safety grades calculated from human equivalent dose(HED)-based MOS(margin of safety). HED-based MOS can be explained as the ratio of theoretical ALD(approximate lethal dose) of human as $LD_1$(lethal dose of 1%)/ clinical maximum dose as $ED_{99}$(Effective dose of 99%). The herbal medicine showing the ratio less than 1 belongs to Class 1, but the herbal medicine showing the ratio more than 500 belongs to Class 6 with the lowest toxicity. As a result, they were evaluated as class 2 for Angelica sinensis and Glycyrrhizae Radix, class 3 for Ligusticum wallichii Franch and Rehmanniae Radix. These resultant grades for 4 herbal medicines were lower than the grade expected under consideration that these herbal medicines are used very frequently in oriental clinics. These low grades would be due to their ingredients which is biotransformed to toxic metabolites.

• 한국항공우주학회지
• /
• 제45권12호
• /
• pp.1059-1068
• /
• 2017

우주 탐사선은 다량의 액체 연료를 탑재하는데, 절반 이상을 넘는 경우가 많다. 이러한 경우, 액체 연료의 슬라슁 현상이 탐사선의 자세 안정성에 영향을 주기 때문에 탐사선 설계에 슬라슁 현상을 고려해야 한다. 본 논문에서는, 액체 연료의 슬라슁 현상과 이와 상호작용하는 탐사선의 동적 거동을 분석한 결과를 제시한다. 이를 위하여 탐사선의 기동이 액체 연료의 슬라슁 현상을 일으키는 모델과 슬라슁에 의한 반력 힘과 모멘트가 탐사선에게 전달되는 모델을 개발하였다. 모델리카 언어로 작성한 시뮬레이션 프로그램을 이용하여 탐사선의 거동을 분석하였다.

• 한국수자원학회논문집
• /
• 제33권1호
• /
• pp.39-50
• /
• 2000

일반적으로 동수역학 모형은 마찰인자(조도계수 또는 Chezy계수)와 와점성계수를 필요로 하고 수치계산에서 이들 계수의 갑은 통상 가정 또는 반복계산을 통하여 결정된다. 수치모형에서 와점성계수는 물리적인 확산뿐만 아니라 수치점성의 효과도 가지고 있어서 수치계산의 안정성에 영향을 미치므로 이들 계수의 일관된 결정방법이 필요하다. 수위 및 유량자료, 1차원 모형인 HEC-2와 NETWORK, 2차원 모형인 SMS를 이용하여 한강하류 구간에 대한 조도계수의 산정결과와 와점성 계수의 산정식이 제시되었으며 실측수위와 비교를 통해 검증되었다.

• 대한한의학회지
• /
• 제32권4호
• /
• pp.48-67
• /
• 2011

Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induced hepatotoxicity was reviewed on a basis of toxicological assessment. Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide. Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.

• 대한족부족관절학회지
• /
• 제17권1호
• /
• pp.64-67
• /
• 2013

Pigmented villonodular synovitis (PVNS) is a slowly, progressive, proliferative disorder of synovial tissue characterized by villous or nodular changes of synovial-lined joints, bursae, and tendon sheaths and most frequently affects the large joints, with the knee and hip. A few studies have been reported that occurred PVNS in small joint, but mainly in hands. It is a very rare condition that occurs in the small joints of the forefoot. We have experienced the case, which developed in small joint of the forefoot, and performed total synovectomy. After the operation, there was no recurrence. We report a case of PVNS in forefoot with a review of the literature.

• 한국측량학회:학술대회논문집
• /
• 한국측량학회 2010년 춘계학술발표회 논문집
• /
• pp.53-56
• /
• 2010

항공용 Multi-looking 카메라는 1대의 사진기 몸체에 5대의 카메라를 설치하여 동시에 1장의 연직사진과 4개의 경사사진을 획득하므로, 연직방향으로 촬영된 일반 항공사진에 비해 현장에 대한 다양한 정보를 제공한다. 그러나 3차원 공간정보 구축시 다각사진촬영시스템은 대형CCD를 사용하는것이 아니라 중형CCD를 사용하므로, 주요대상물의 전후좌우 영상을 취득하려면, 촬영시 중복도 설정을 고려하여야 하며, 특히 Sideward-looking 카메라의 경우 횡중복도 설정에 의해 특정대상물 촬영 여부를 확인할 수 있다. 이에 본 연구에서는 촬영시 횡중복도 변화에 의한 다각사진의 Sideward Footprint 및 촬영의 효율성에 대하여 분석하였다.