• Title/Summary/Keyword: 생체지표

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Fetal Bio Index Difference Analysis by Country and Quadratic Regression Model Design for The Gestational Age Prediction (태아 생체지표 국가별 차이분석 및 임신주수 예측의 2차 회귀모형 설계)

  • Kim, Changsoo;Yang, Sung-Hee
    • The Journal of the Korea Contents Association
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    • v.20 no.8
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    • pp.685-691
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    • 2020
  • Standard values for fetal bio index measurements should be applied differently depending on the past present and general characteristics of the target population. Therefore, we tried to predict the number of gestational week(GA) and analyze the differences by country based on the measurements of Korean fetal bio index. 480 fetal bio index measurements between 15~38 weeks of pregnancy using ultrasound were compared retrospectively with USA ad Japanese data. One Way ANOVA was used for the analysis of differences by country, and quadratic regression model was designed to predict the GA of fetal bio index in order to predict the standard pregnancy number of Korean fetuses(p<0.005). Mean difference in the 95% confidence interval is BPD was Korea and USA 0.17, Korea and Japan 0.11, AC was Korea and USA -0.35, Korea and Japan 0.42, FL was Korea and USA -0.18, Korea and Japan 0.14. Therefore, fetal bio index for GA predict is considered to be the standard of the fetal growth assessment by applying the country specific standard in consideration of differences between races.

Comparison of Hsp90 and CYP1A Expression Patterns by Water Temperature Stress in Atlantic Salmon (Salmo salar) (대서양 연어(Salmo salar)의 수온 스트레스에 의한 Hsp90 및 CYP1A 발현 양상 비교)

  • Kang, Han Seung;Song, Jae-Hee;Kang, Hee Woong
    • Journal of Marine Life Science
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    • v.3 no.2
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    • pp.51-58
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    • 2018
  • Variations in water temperature are known to affect almost every part of fish physiology. The rise in water temperature due to climate change can physically damage fish. This study was conducted to evaluate the health status of the Atlantic salmon (Salmo salar) at high water temperature (20℃) than the optimum water temperature (15℃). Liver tissue exerts important metabolic functions in thermal adaptation. Therefore, liver tissue was used in this study. The evaluation method is to develop the biomarker gene using NGS RNAseq analysis and to examine the expression pattern using RT-qPCR analysis. The NGS RNAseq analysis revealed 1,366 differentially expressed genes, among which 880 genes were increase expressed and 486 genes were decrease expressed. The biomarker genes are such as heat shock protein 90 alpha (Hsp90α), heat shock protein 90 beta (Hsp90β) and cytochrome P450 1A (CYP1A). The selected genes are sensitive to changes in water temperature through NGS RNAseq analysis. Expression patterns of these genes through RT-qPCR were similar to those of NGS RNAseq analysis. The results of this study can be applied to other fish species and it is considered to be useful industrially.

Evaluation of Biomass and Nitrogen Status in Paddy Rice Using Ground-Based Remote Sensors (지상원격측정 센서를 이용한 벼의 생체량 및 질소 영양 평가)

  • Kang, Seong-Soo;Gong, Hyo-Young;Jung, Hyun-Cheol;Kim, Yi-Hyun;Hong, Suk-Young;Hong, Soon-Dal
    • Korean Journal of Soil Science and Fertilizer
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    • v.43 no.6
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    • pp.954-961
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    • 2010
  • Ground-based remote sensing can be used as one of the non-destructive, fast, and real-time diagnostic tools for quantifying yield, biomass, and nitrogen (N) stress during growing season. This study was conducted to assess biomass and nitrogen (N) status of paddy rice (Oryza sativa L.) plants under N stress using passive and active ground-based remote sensors. Nitrogen application rates were 0, 70, 100, and 130 kg N $ha^{-1}$. At each growth stage, reflectance indices measured with active sensor showed higher correlation with DW, N uptake and N concentration than those with the passive sensor. NIR/Red and NIR/Amber indices measured with Crop Circle active sensors generally had a better correlation with dry weight (DW), N uptake and N content than vegetation indices from Crop Circle passive sensor and NDVIs from active sensors. Especially NIR/Red and NIR/amber ratios at the panicle initiation stage were most closely correlated with DW, N content, and N uptake. Rice grain yield, DW, N content and N uptake at harvest were highly positively correlated with canopy reflectance indices measured with active sensors at all sampling dates. N application rate explains about 91~92% of the variability in the SI calculated from NIR/Red or NIR/Amber indices measured with Crop Circle active sensors on 12 July. Therefore, the in-season sufficiency index (SI) by NIR/Red or NIR/Amber index from Crop Circle active sensors can be used for determination of N application rate.

Biomarkers for Combat-Related Stress and Fatigue-Mitigating Drugs Discovery (전투 스트레스 및 피로 완화 약물 탐색을 위한 생체지표)

  • Koo, Hyojin;Kim, Chang Yul;Kim, Yeonkyung;Sin, So Jung;Cheon, Kicheol;Kim, Dongsoo
    • Journal of the Korea Institute of Military Science and Technology
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    • v.21 no.2
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    • pp.246-254
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    • 2018
  • Psychological stress and physical fatigue, such as anxiety, fear, sleep disturbance, etc., caused by exposure to the war, can lead to post-traumatic stress syndrome(PTSD) or war syndrome. The military has also prepared for drug use to minimize war syndrome and preserve combat strength. However, efforts to prevent war syndrome are still lacking. This study was conducted to identify biomarkers that can track psychophysiological changes. Psychophysiological changes associated with PTSD can be divided into four main categories. The four categories are behavioral changes, changes in brain cognition, neuroimmunological changes, and changes in innate immunity. This study suggest that biomarker profile can be made by the distance moved and the anxiety-like behavior in the open field for behavior category, brain BDNF levels in the brain cognition category, serum corticosterone in the neuroimmunology category, and inflammatory cytokine levels in the innate immunity category.

Biophoton Emission as a Biomarker of Mouse Fatty Liver induced by Carbon Tetrachloride (사염화탄소를 이용한 마우스 지방간에서의 새로운 생체발광 측정법)

  • 김정대;임재관;최준호;이병천;유혜란;박대훈;천병수;소광섭
    • KSBB Journal
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    • v.19 no.1
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    • pp.12-16
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    • 2004
  • Recently the measurement of biophoton emission has attracted increasing attention in the study on physiological state of biological systems. We report the measurements of biophoton emission from the mouse fatty liver induced by carbon tetrachloride, CCl$_4$. The hepatotoxin, CCl$_4$ in olive oil, was injected intraperitoneally into two groups of ICR mice which were made of 6 mice in each group. The control groups corresponding to the treated groups were prepared with the injections of olive oil only. After the injections, livers of two groups were extracted and measured biophoton emission in 24 hours and 72 hours later, respectively. We also extracted the plasma in the blood and measured the transaminase activity. Results show that biophoton emission from the livers in 24-hour treated group is 69.3${\pm}$21.2 counts/min/$\textrm{cm}^2$, which is two times more larger than that in 24-hour control group, 29.5${\pm}$5.9 counts/min/$\textrm{cm}^2$ Biophoton emission from the livers in 72-hour treated group is 37.0${\pm}$14.8 counts/min/$\textrm{cm}^2$. These biophoton results correlate with those of the biochemical assays. We conclude that biophoton emission can be used as a biomarker of mouse fatty liver induced by CCl$_4$.

Evaluation of Biomass and Nitrogen Nutrition of Tobacco under Sand Culture by Reflectance Indices of Ground-based Remote Sensors (지상원격측정 센서의 반사율 지표를 활용한 사경재배 연초의 생체량 및 질소영양 평가)

  • Kang, Seong-Soo;Jeong, Hyun-Cheol;Jeon, Sang-Ho;Hong, Soon-Dal
    • Korean Journal of Soil Science and Fertilizer
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    • v.42 no.2
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    • pp.70-78
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    • 2009
  • Remote sensing technique in agriculture can be used to identify chlorophyll content, biomass, and yield caused from N stress level. This study was conducted to evaluate biomass, N stress levels, and yield of tobacco (Nicotiana tabacum L.) under sand culture in a plastic film house using ground-based remote sensors. Nitrogen rates applied were 40, 60, 80, 100, 120, and 140 percent of N concentration in the Hoagland's nutrient solution. Sensor readings for reflectance indices were taken at 30, 35, 40, 45, 50 and 60 days after transplanting(DAT). Reflectance indices measured at 40th DAT were highly correlated with dry weight(DW) of tobacco leaves and N uptake by leaves. Especially, green normalized difference vegetation index(gNDVI) from spectroradiometer and aNDVI from Crop Circle passive sensor were able to explain 85% and 84% of DW variability and 85% and 92% of N uptake variability, respectively. All the reflectance indices measured at each sampling date during the growing season were significantly correlated with tobacco yield. Especially the gNDVI derived from spectroradiometer readings at the 40th DAT explained 72% of yield variability. N rates of tobacco were distinguished by sufficiency index calculated using the ratio of reflectance indices of stress to optimum plot of N treatment. Consequently results indicate that the reflectance indices by ground-based remote sensor can be used to predict tobacco yield and recommend the optimum application rate of N fertilizer for top dressing of tobacco.

Design and Implementation of Real-Time ECG Monitoring System Using Cortex-M3 Microprocessor (Cortex-M3 Microprocessor를 이용한 실시간 ECG Monitoring System 설계 및 구현)

  • Kim, Tae Wan;Kwon, Chun Ki;Lee, On Seok
    • Proceedings of the Korea Information Processing Society Conference
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    • 2016.04a
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    • pp.893-895
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    • 2016
  • 세계적으로 헬스케어 산업의 발전 가능성은 눈에 띄게 증가하고 있다. 그 중에서도 환자 혹은 각종 디바이스 사용자의 생체신호를 다루는 기술은 다양한 중요정보를 얻을 수 있다. 본 논문에서는 심전도의 미세한 생체 전위를 측정하기 위해 각종 필터와 증폭기를 이용하여 회로를 설계하고 이를 Cortex-M3 Microprocessor와 MATLAB 프로그램을 이용하여 필터링과 데이터통신을 통해 최종적으로 실시간으로 모니터링 하였다. 일반적으로 임상이나 진단에 이용되는 ECG 신호는 각종 심장질환의 지표로 사용되지만 전문적인 지식을 갖추지 않은 일반 사용자가 사용하기에는 어려운 점이 없지 않아 있다. 따라서 이 연구는 아날로그 신호를 디지털 신호로 변환하여 생체신호를 다루는 다양한 분야에서 용이할 수 있다.

A Model of Vital Signs Analysis based on Big Data using OCL (OCL을 이용한 빅데이터 기반의 생체신호 분석 모델)

  • Kim, Tae-Woong
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.12
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    • pp.1485-1491
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    • 2019
  • As the type and size of vital signs become extensive at the moment lately, a research is actively progressing to define vital signs as big data and analyze it. We generally use a similar method of processing big data on social network as a way to treat vital signs as big data. Vital Sign Big Data should be extracted as feature data, stored separately, and analyzed with various analytical instruments. In other words, it should ensure interoperability and compatability of data, and the index expression in analytical tools should be concise. For this end, I defined the vital sign as the standard meta-model base of HL7 in this dissertation, and I propose a model for analyzing vital signs using OCL, the OMG's standard mathematical specification language. In addition, the proposed model can be confirmed the applicability by figuring out the consumption of calories using ECG data.

Indicatrors of Carbon Storage and Uptake by Tree Growth in Natural Ecosystem (자연생태계 수목의 생장에 따른 탄소저장 및 흡수량 지표)

  • 조현길;안태원
    • Korean Journal of Environment and Ecology
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    • v.14 no.3
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    • pp.175-182
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    • 2000
  • 본 연구는 자연생태계 소목의 생장에 따른 탄소저장 및 흡수량 지표를 도출하고 용인시를 대상으로 임상유형의 영급별 탄소저장 및 흡수를 계량하였다. 침엽수 1주당 탄소저장 및 흡수량은 중부와 남부의 생장지역간 유의한 차이가 없었으나(p>0.05). 활엽수의경우는 남부지역에서 중부지역보다 더욱 많았다. 수목 1주당 탄소저장 및 흡수량은 활엽수가 동일 직경의 침엽수보다 더욱 많았으며, 그 차이는 직경생장과 더불어 증가하는 경향을 보였다. 용인시 자연생태계의 단위면적당 평균 탄소저장 및 흡수량은 역시 영급이 높을수록 많았으며, II 영급을 제외한 동일 영급내에서는 침엽수림보다는 혼효림이, 혼효림보다는 활엽수림이 더욱 많았다. 중부지역에서 생장하는 흉고직경 20cm 의 활엽수 1주는 약 175리터의 휘발유 소비로 인하여 배출되는 탄소량을 저장하고, 1ha의 IV 영급 활엽수림은 시민 57명이 화석연료 소비로 연간 배출하는 탄소량을 저장하였다. 본 연구의 탄소저장 및 흡수 지표는 직경 생장에 따른 삼림수목의 대기탄소농도 저감 가치를 용이하게 추정하는데 활용될 수 있다.

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Effects of Heavy Metals on Amphibian Embryos, Tadpoles, and Adults (중금속이 양서류 배아, 유생 및 성체에 미치는 영향에 관한 소고)

  • Park, Chan Jin;Ahn, Hyo Min;Gye, Myung Chan
    • Korean Journal of Environmental Biology
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    • v.30 no.4
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    • pp.287-306
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    • 2012
  • Amphibian population declines globally. Environmental contamination by heavy metals has been suspected to the one of the reason for distinction of amphibian which has obligate aquatic life style during larval period. Amphibians have been widely accepted as animal model for the study of endocrine disruption in aquatic ecosystem at molecular as well as individual levels. There are increasing need for toxicological data in amphibians at multiple endpoints for management of contamination and development of safety guidelines. Here, we reviewed toxicological information about toxicity of heavy metals (arsenic, cadmium, chromium, copper, lead, mercury, nickel, zinc) on various end-point of amphibian.