• Journal of the Korean Data and Information Science Society
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• v.27 no.5
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• pp.1253-1262
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• 2016

When there exists a change-point in hazard function, it should be estimated for exact parameter or hazard estimation. In this research, we compare the hazard change-point estimators. Matthews and Farewell (1982) parametric change-point estimator is based on the likelihood and Zhang et al. (2014) nonparametric estimator is based on the Nelson-Aalen cumulative hazard estimator. Simulation study is done for the data from exponential distribution with one hazard change-point. The simulated data generated without censoring and the data with right censoring are considered. As real data applications, the change-point estimates are computed for leukemia data and primary biliary cirrhosis data.

• Korean Journal of Environment and Ecology
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• v.10 no.2
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• pp.171-183
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• 1997

Diversity, abundance, species distributions and distributions of two strategists (specialist and geceralist) of butterflies were investigated monthly from June 1996 to Oct. 1996 by line transect method in the Chunbul-dong valley from park gate to Yangpok Sanjang. The butterfly faunas of the eight regions in Kwangwon province, Gyunggi proavince and Pusan were also studied by the same method to assess diversity and abundance of butterfly community in the study region. The 18 butterfly species in 7 families were found in this study and the 48 butterfly species in 7 families were distributed in the study area from thes study and the other researches. The 30 butterfly species reported in the other studies were not found in this study and Kaniska canace L. of them would be to decrease in density. In the study area, the common species were Artogeia melete M., Neptis sappho P. and Libythea celtis F.. The representative Korean common butterflies such as Artogeia rapae L., Colias erate E. and Papillio xuthus L. were rare. The PCA(Principal Component Analysis) ordinations indicate that habitat disturbance by human would be major factor for butterfly community and species distribution. Difference was not found in diversity according to habitat disturbance. Abundance, however, was higher in the disturbed region than the undisturbed region. Compared with the other regions, abundance was greatly lower and diversity was slightly lower than that of the other regions. Two strategists exhibited different distribution patterns. Generalists were found more commonly in the disturbed region and widely distributed in both of the disturbed region and the undisturbed region than specialists.

• Korean journal of applied entomology
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• v.47 no.1
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• pp.9-15
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• 2008

This study was conducted to investigate the seasonal occurrence of chestnut weevil, Curculio sikkimensis. The chestnuts infected by the weevils were collected from Gongju, Buyeo, and Cheongyang in Chungnam Province, Republic of Korea. Investigation was focus on the escape period of chestnut weevil larvae from the fruits, invading time and vertical distribution in soil, survival rates of larvae during overwintering, emergence period, emergence rate, and sex ratio and longevity of adults. For precocious species, larvae escaped the chestnut from the mid-September to the early-October, middle species and slow species, were escaped from the late-September to the mid-October and from the early-October to the mid-November. After escaping from the chestnut fruits all of the larvae burrowed into the soil within 35 minutes. Overwintering larvae inhabited in the range of $0{\sim}48cm$ from the soil surface and highly distributed in the range of $18{\sim}36cm$. The 74.1 % of wintering chamber were distributed within $18{\sim}36cm$ from the surface. Survival rates observed were 38.0% in 1st year, 16.0% in 2nd years, and 2% in 3rd years, respectively. Seasonal occurrence period of C. sikkimensis was from the early-Aug. to early-Oct. and the optimal occurrence period was the early and mid-Sept. Emergence rate decreased to 8.4% in 1st year, 3.6% in 2nd years, and 0.8% in 3rd years, respectively. Sex ratio was showed in the range of 0.51-0.55. It is female biased ratio. Longevity of adults was 9.9 days for female and 8.9 days for male.

• Journal of Chest Surgery
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• v.29 no.11
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• pp.1241-1247
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• 1996

From January 1989 to March 1996, we have operated on 102 cases of non-small cell lung cancer at the department of Thoracic and Cardiovascular Surgery, Yonsei University Wonju College of Medicine. They were clinically evaluated. The results are as follows; 1. The peak incidence of age of primary lung cancer was 5th decade(34.3%) and 6th decade(38.2%). Male to female ratio was 2.5:1. 2. Most of symptoms were respiratory, which were cough(61.8%), sputum(43.l%), chest discomfort and pain(30.4%), dyspnea(27.5%), and hemoptysis(9.8%). Asymptomatic cases were 1.9% of study group. 3. Methods of diagnostic confirmation were bronchoscopic biopsy(59.8%), sputum cytology(17.6%), percutaneous needle aspiration(11.8%) and open biopsy(10.8%). 4. Histopathologic classifications were squamous cell carcinoma(55.9%), adenocarcinoma(30.5%), adenosquamous cell carcinoma(6.9%), large cell carcinoma(4.9%), bronchioalveolar cell carcinoma(0.9%), and mixed cell carcinoma(0.9%). 5. Methods of operation were pneumonectony(47.1%), lobectomy(38.2%), bilobectomy(5.9%), wedge resection(1.9%), exploration(6.9%), and overall resectability was 93.1%. 6. Postoperative staging classifications were Stage I (13.7%), Stage II(31.4%), Stage IIIa(38.3%), Stage IIIb(14.7%), and Stage IV(1.9%). 7. The postoperative complications developed in 9.8%, and operative mortality was 1.9 %. 8. One year survival rate was 81.7%, 3 year 49.7% and 5 year 21.8%. According to stage, 5 year survival rate was 39% in stage I, 24.3% in stage II, 23.9% in stage IIIa.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.121-126
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• 2022

This study analyzed the survival rate of commercial districts before and after the outbreak of COVID-19 by analyzing Gangnam-gu, Seoul and Suseong-gu, Daegu as independent regions, although the background and distribution of commercial districts are similar. In the basic analysis, the size of the commercial districts was much larger in Gangnam-gu, Seoul, but it was confirmed that the distribution by industry was similar. In both regions, there were more openings than closings before the outbreak of COVID-19 in common, but as the COVID-19 outbreak occurred, the closure ratio of businesses centered on face-to-face services increased significantly. As a result of the survival analysis, it was analyzed that most industries were indifferent to the risk of closure of private institutes before Corona 19, but after the outbreak of Corona 19, it was confirmed that the risk of closure of private institutes increased, especially in Daegu, which was the initial spread of Corona 19. As a result of comparing the survival rate between regions, it was analyzed that the risk of business closure in Gangnam-gu increased relatively after the outbreak of Corona 19, confirming that the contraction in the commercial area of Seoul with a large floating population was greater.

• Radiation Oncology Journal
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• v.15 no.2
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• pp.105-111
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• 1997

group($22\%\;vs.\;38\%$, p=0.24). The 5YSRs of 21 patients of primary tumor extension to adjacent sites and the other 13 patients of tonsillar proper site were $28\%\;and\;38\%$, respectively but the difference was not significant statistically(p=0.52) There was a statistically significant difference in 5YSRs between the groups of the Patients who received radiotherapy in less than 61days vs more than 60days($60\%\;vs.\;18\%$, p=0.027). All living Patients without any tumor progression(n=11) had suffered from serious late sequelae such as xerostomia, edentia, dental caries and one patient had the osteoradionecrosis of mandible. On univariate analysis. the duration of radiotherapy and T-stage were the significant prognostic factors affecting 5YSR. On multivariate analysis, also the duration of radiotherapy was the only significant Prognostic factor(p=0.01). Conclusion : There was no survival difference between the radiotherapy alone and with neoadiuvant chemothe groups. Although it was a retrospective study, the role of conventional radiotherapy alone could be effective as the local treatment modality only for the early stage of tonsillar carcinomas. But for the purpose of more improved survivals and better quality of lives of living patients, other altered fractionation such as hyperfractionated radiotherapy with shorter treatment time and smaller fraction size rather than conventional radiotherapy might be beneficial and these prospective studies are needed.

• The Korean Journal of Applied Statistics
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• v.11 no.1
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• pp.163-175
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• 1998

The change of hazard rates at some unknown time point has been the interest of many statisticians. But it was restricted to the constant hazard rates which correspond to the exponential distribution. In this paper we generalize the change-point model in which any specific functional forms of hazard rates are net assumed. The assumed model includes various types of changes before and after the unknown time point. The Nelson estimator of cumulative hazard function is introduced. We estimate the change-point maximizing slope changes of Nelson estimator. Consistency and asymptotic distribution of bootstrap estimator are obtained using the martingale theory. Through a Monte Carlo study we check the performance of the proposed method. We also explain the proposed method using the Stanford Heart Transplant Data set.

• Radiation Oncology Journal
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• v.17 no.2
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• pp.91-99
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• 1999

Propose : This study was performed to find out the prognostic factors affecting local control, survival and disease free survival rate in nasopharyngeal carcinomas treated with chemotherapy and radiation therapy. Materials and Methods : We analysed 47 patients of nasopharyngeal carcinomas, histologically confirmed and treated at Chonnam University Hospital between July 1986 and June 1996, retrospectively. Range of patients' age were from 16 to 80 years (median; 52 years). Thirty three (70$\%$) patients was male. Histological types were composed of 3 (6$\%$) keratinizing, 30 (64$\%$) nonkeratinizing squamous cell carcinoma and 13 (28$\%$) undifferentiated carcinoma. Histoiogicai type was not known in 1 patient (2$\%$). We restaged according to the staging system of 1997 American Joint Committee on Cancer Forty seven patients were recorded as follows: 71: 11 (23$\%$), T2a; 6 (13$\%$), T2b; 9 (19$\%$), 73; 7 (15$\%$), 74: 14 (30$\%$), and NO; 7 (15$\%$), Nl: 14 (30$\%$), N2; 21 (45%), N3: 5 (10%). Clinical staging was grouped as follows: Stage 1; 2 (4$\%$), IIA: 2 (4$\%$), IIB; 10 (21$\%$), III; 14 (30$\%$), IVA; 14 (30$\%$) and IVB; 5 (11$\%$). Radiation therapy was done using 6 MV and 10 MV X- ray of linear accelerator. Electron beam was used for the Iymph nodes of posterior neck after 4500 cGy. The range of total radiation dose delivered to the primary tumor was from 6120 to 7920 cGy (median; 7020 cGy). Neoadjuvant chemotherapy was performed with cisplatin +5-fluorouracil (25 patients) or cisplatin+pepleomycin (17 patients) with one to three cycles. Five patients did not received chemotherapy. Local control rate, survival and disease free suwival rate were calculated by Kaplan-Meier method. Generalized Wilcoxon test was used to evaluate the difference of survival rates between groups. multivariate analysis using Cox proportional hazard model was done for finding prognostic factors. Results: Local control rate was 81$\%$ in 5 year. Five year survival rate was 60$\%$ (median survival; 100 months). We included age, sex, cranial nerve deflicit, histologic type, stage group, chemotherapy, elapsed days between chemotherapy and radiotherapy, total radiation dose, period of radiotherapy as potential prognostic factors in multivariate analysis. As a result, cranial none deficit (P=0.004) had statistical significance in local control rate. Stage group and total radiation dose were significant prognostic factors in survival (P=0.000, P=0.012), and in disease free survival rates (P=0.003, P=0.008), respectively. Common complications were xerostomia, tooth and ear problems. Hypothyroidism was developed in 2 patients. Conclusion : In our study, cranial none deficit was a significant prognostic factor in local control rate, and stage group and total radiation dose were significant factors in both survival and disease free survival of nasopharyngeal carcinoma. We have concluded that chemotherapy and radiotherapy used in our patients were effective without any serious complication.

• Radiation Oncology Journal
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• v.15 no.2
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• pp.97-104
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• 1997

of $PLC-\gamma$ 1 activity. Results : In the immunohistochemistry, the expression of $PLC-\beta$ was negative for all grnups. The expression of $PLC-\gamma$ 1 was highest in the group III followed by group II in the proliferative zone of mucosa. The expression of PKC-01 was strong1y positive in group I followed by group II in the damaged surface epithelium. The above findings were also confirmed in the immunoblotting study. In the irnrnunoblotting study, the expressions of $PLC-\beta,\;PLC-\gamma\;1,\;and\;PLC-\delta$ were the same as the results of immunohistochemistry The expression of ras oncoprotein was weakly Positive in groups II, III and IV. The of EGFR was the highest in the group II, III, followed by group W and the expression of PKC was weakly positive in the group II and III. Conclusion : $PLC-\gamma$ 1 mediated signal transduction including ras oncoprotein, EGFR, and PKC play a significant role irL mucosal regeneration after irradiation. $PLC-\delta$ 1 mediated signal transduction might have an important role in mucosal damage after irradiation. Further studies will be necessary to confirm the signal transduction mediating the $PLC-\delta$ 1.

• KOREAN POULTRY JOURNAL
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• v.33 no.6 s.380
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• pp.93-97
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• 2001

우리나라에는 19세기부터 21세기형의 육계농장이 다양하게 분포되어 있다. 육계농장의 계사시설도 중요하지만 그것을 어떻게 관리하느냐구 보다 더 중요할 것이다. 기본 중의 기본을 다시 강조하는 것은 지키지 않고 있기 때문이다. 항상 닭(병아리)의 입장에서 관리가 이뤄져야 하므로 미국의 자료를 인용하여 새삼 강조하고자 간략히 요약하였다. 현대 육계사육에 필요한 3가지 조건이 있다면 아래와 같을 것이다. (1)급이와 급수 (2)환경 관리 (3)질병 방어 이 세 가지 요소를 모두 우선하여 충족시켜 주기란 쉽지만은 않을 것이다. 왜냐하면 육계의 생존이나 사육성적에 아주 커다란 영향을 주기 때문이다. 이중 환경관리야말로 가장 큰 변수에 해당하는데 농장 관리자 입장에서는 육성율과 사육성적을 개선할 수 있는 좋은 기회이기도 하다.