• Journal of Powder Materials
• /
• v.9 no.3
• /
• pp.141-147
• /
• 2002

21세기를 선도할 기술로 전 세계적으로 각광을 받고 연구가 활발히 진행되고 있는 분야는 나노기술(W), 생명공학기술(BT), 정보통신기술(IT)이라고 할수 있다. 우리나라에서도 최근 이에 대한 연구 및 교육 지원 프로그램을 세워 법정부적으로 지원을 하고 있다. 특히 나노기술은 다른 분야와의 기술융합이 가장 활발하게 진행되고 있다. 이러한 분야들은 우리나라와 같이 부존자원이 매우 적은 나라로써는 세계열강과 경쟁하기 위한 새로운 돌파구로 활용될 수 있을 것으로 판단된다. 본 고에서는 신기술 분야 중에서 나노기술과 생명공학기술의 접목분야로써 자성 나노입자의 생의학적 응용(biomedical applications)에 대하여 알아보고자 한다.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.32 no.5
• /
• pp.585-596
• /
• 2012

PVDF(poly vinylidene fluoride) and P(VDF-TrFE)(poly vinylidene fluoride-tetrafluoroethylene) are the typical piezoelectric polymers with unique properties. Even they are inferior to conventional piezoelectric ceramics PZT in electromechanical conversion efficiency and interior loss, though they are superior in receiving sensitivity and frequency bandwidth. Their acoustic impedances are relatively close to water or biological tissue and it is easier to make thin film than other piezoelectric materials. Futhermore, the film is so flexible that it is easy to attach on a complex surface. Those properties are suitable for the ultrasound transducers which are useful for medical and biological application, so that various types of polymer transducers have been developed. In this paper, several important considerations for design and fabrication of piezoelectric polymer transducers were described and their effect on the transducer performance were demonstrated through the KLM model analysis. Then, it was briefly reviewed about the structures of the polymer transducers developed for obtaining images as well as the characteristics of the images in several important medical and biological application fields.

• Journal of Industrial Technology
• /
• v.36
• /
• pp.77-81
• /
• 2016

Superparamagnetic $Fe_3O_4$ nanoparticles with particle size from 10 to 20 nm were synthesized by coprecipitation method. Subsequently, the $Fe_3O_4$ nanoparticles were used to fabricate $Fe_3O_4/SiO_2$ core-shell nanoparticles by sol-gel method. The $Fe_3O_4/SiO_2$ nanoparticles synthesized by sol-gel method exhibit the high uniformities of particle size and shape. We also investigated the heating characteristics of $Fe_3O_4$ and $Fe_3O_4/SiO_2$ nanoparticles for biomedical applications. The $Fe_3O_4$ nanoparticles show the faster temperature increase and the higher specific loss power(SLP) value than the $Fe_3O_4/SiO_2$ nanoparticles.

• Applied Chemistry for Engineering
• /
• v.34 no.1
• /
• pp.1-8
• /
• 2023

Polyethylenimine (PEI) is a cationic polymer that can bind to negatively charged biomaterials such as nucleic acids through strong electrostatic interactions. Based on these properties, PEI has been used as an efficient drug delivery system for a long time. However, the strong cationic nature of PEI has the problem of causing cytotoxicity by non-specific interaction with anionic biological materials in the cells. In order to overcome these problems, many researchers have developed various types of biocompatible PEI-based materials. In this review, we would like to introduce the recent developments of functional PEI and their applications in biomedical research.

• Broadcasting and Media Magazine
• /
• v.18 no.3
• /
• pp.95-108
• /
• 2013

디지털 홀로그래픽 현미경이나 정량적 위상 현미경(quantitative phase microscopy)과 같은 기존의 간섭현미경은 3차원 이미징 기술로 분류되는데, 이는 획득한 이미지의 복소장(complex field)을 계산을 통해 다른 깊이로 전파시킬 수 있기 때문이다. 그러나 엄밀한 의미에서는 하나의 복소장 이미지는 단지 2차원 맵이기 때문에 근본적으로는 샘플의 2차원 정보만을 가지고, 물체의 3차원 구조의 일부분을 측정하는 것에 지나지 않는다. 본 논문에서는 1969년에 Wolf가 제안한[1,2] 홀로그래픽 회절 토모그래피(Optical Diffraction Tomography: ODT)를 실험적으로 구현한 3차원 위상 현미경(Tomographic Phase Microscopy: TPM)을 소개하고자 한다. TPM은 샘플을 다양한 각도로 조명하여 서로 다른 입사각에 대해 복소장 이미지를 얻고, ODT를 통해서 샘플의 3차원 구조를 복원해내는 기술이다. 보다 구체적으로는 다양하고 독립적인 2차원 이미지들을 샘플의 3차원 푸리에 공간에 맵핑함으로써 샘플 단면의 흡수율과 굴절률을 복원할 수 있다. 굴절률은 분자 농도와 비례하기 때문에, 살아있는 세포에 대한 굴절률의 3차원 맵을 얻을 수 있으면 세포 내부의 분자 구성을 연구할 수 있고, 이를 통해 다양한 생의학적 응용을 연구할 수 있다.

• Polymer(Korea)
• /
• v.29 no.5
• /
• pp.518-521
• /
• 2005

Biodegradable polymers and hydrogels have been increasingly applied in a variety of biomedical applications including current drug delivery system and tissue engineering field. ${\alpha},\;{\beta}-Poly$(N-2-hydroxyethyl-DL-aspart-amide), PHEA. is one of poly(amino acids) with hydroxyethyl pendants, which is hewn to be biodegradable and potentially biocompatible. So that, the utilization and various chemical modifications of PHEA have been attempted for useful biomedical applications. In this wort chemical gels based on PHEA were prepared by crosslinking with diisocyanate compound in DMF in the presence of catalyst. Here, the PHEA was prepared from polysuccinimde, the thermal polycondensation product of aspartic acid, via ring-opening reaction with ethanolamine. The preparation of gels and their swelling behavior, depending on the different medium and pH, were investigated. Also the morphology by SEM and simple hydrolytic degradation were observed.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2016.02a
• /
• pp.193.1-193.1
• /
• 2016

본 연구에서 개발된 새로운 유형의 마이크로파 대기압 플라즈마 공진기는 전송선로 이론을 기반으로 하여 임피던스 값을 $50{\varphi}$으로 설계함으로써 장비 자체에 구조적인 매칭이 이루어지도록 구성하였다. 안정적인 마이크로파 대기압 플라즈마 발생을 위해 컴퓨터 시뮬레이션(HFSS, High Frequency Structural Simulator)을 이용하여 공진기의 반사계수, 공명주파수, 급전점 그리고 전기장을 계산하였다. 전송선로의 이론에서 구한 급전점과 실제 제작한 마이크로파 대기압 플라즈마 공진기의 급전점 값이 큰 차이가 없음을 확인하였다. 이를 바탕으로 제작한 공진기는 급전점 5.6 mm에서 공명주파수는 0.89 GHz, 반사계수는 -37.5 dB임을 측정하였고 신호가 입사되는 정도는 90 % 이상인 것을 확인하였다. 공진기에서 발생된 플라즈마는 6 W의 정도의 저 전력으로 발생되었으며 기체유량과 인가전력에 따른 플라즈마의 기체온도를 측정하고 광 방출 특성을 고찰하였다. 실제 제작한 마이크로파 대기압 플라즈마 발생장치는 생의학적 응용을 포함한 여러 넓은 분야에서 활용될 전망이다.

• Proceedings of the KOSOMBE Conference
• /
• v.1993 no.05
• /
• pp.7-14
• /
• 1993

Nowadays, microspheres are expected to be applied to biomedical areas and many studies are being performed. For biomedical applications, many kinds of microspheres were synthesized by emulsion polymerization, emulsifier-free emu]sion polymerization, and emulsifier-free emulsion polymerization with ionic surface-active comonomers. Further synthesis techniques about microencapsulation and magnetic microspheres are introduced. Among the practical applications of microspheres, some interesting subjects are introduced. These include solid-phase immunoassays, labeling and identification of lymphocyte populations, extracorporeal and hemoperfusion systems, drug delivery systems, and immunomagnetic cell separation. In addition, basic theories, problems and research trends are also introduced.

• Journal of Industrial Technology
• /
• v.42 no.1
• /
• pp.29-36
• /
• 2022

The CRISPR system has revolutionized gene editing field. Cas9-mediated gene editing such as Indel induction or HDR enable targeted gene disruption or precise correction of mutation. Moreover, CRISPR-based new editing tools have been developed such as base editors. In this review, we focus on gene editing in human pluripotent stem cells, which is principal technique for gene correction therapy and disease modeling. Pluripotent stem cell-specific drug YM155 enabled selection of target gene-edited pluripotent stem cells. Also, we discussed base editing for treatment of congenital retina disease. Adenine base editor delivery as RNP form provide an approach for genetic disease treatment with safe and precise in vivo gene correction.

• Journal of the Korean Applied Science and Technology
• /
• v.39 no.6
• /
• pp.769-782
• /
• 2022

The purpose is van Manen's interpretation of verbal violence experienced by nursing students during their growing up period in order to use it as basic data to improve the verbal communication essential for solving nursing problems and performing tasks with guardians and peers. For this, 10 students enrolled in the nursing department of A University in Gyeonggi-do were selected and data were collected through in-depth interviews. Data analysis conducted an existential inquiry process to focus on the essence of experience. Five thematic statements in this study were as follows: 'Beginning with a trivial conversation', 'Getting confused mind', 'Being an opportunity to reflect on myself', 'Changing the frame of my thought' and 'Making a mature me'. As a result, it confirmed the necessity of strengthening language usage and personal competency that respect the other party. Therefore, it is suggested that follow-up studies on empathy or self-positive effects are needed for effective communication techniques.