• The Hankook-Saengyark Bo
• /
• no.230
• /
• pp.2-2
• /
• 1998

'한약비닐팩 인체에 무해'(식약청, 인체에 해로운 항산화제 미검출) - 제천의 '약초향 거리'(작약 목단 꽃길 조성, 특산물 홍보효과) - 큰개암나무 북한풍토 맞게 개량 - '왕가시오갈피' 신종 최초발견, 신약자원 기대

• The Hankook-Saengyark Bo
• /
• no.249
• /
• pp.6-6
• /
• 2002

성남, 대규모 '자원식물원' - 인삼연, 홍삼 이용 신제품 개발 - 태국 과일, 약초 씨앗부분 항암성분 높아 - 한방화장품 브랜드 출시 산삼 추출물에 12종 한방성분 첨가

• Korean Journal of Medicinal Crop Science
• /
• v.8 no.2
• /
• pp.109-116
• /
• 2000

This study was carried out to screen herbs among herbal plants showing antimicrobial activity against some food spoilage and pathogenic microorganisms. One hundred fifteen kinds of herbal plants were extracted by 70% ethanol, and then they have been screened for antimicroorganisms. Six herbal plants such as Salviae radix, Dryopteris rhizoma, Terminaliae fructus, Araliae radix, Psoraleae fructus and Schisandrae fructus showed strong antimicrobial activities against Bacillus subtilis. Antimicrobial activities were showed in Anemarrhena radix and Dryopteris rhizoma on Candida albicans, and in Anemarrhenae radix, Dryopteris rhizoma and Polygalae radix on Schizosaccharomyces sp. It was revealed that eight herbal plants such as Dryopteris rhizoma, Salviae radix, Sappan ligunum, Sinomeniae radix, Schisandrae fructus, Rhui fructus, Sophorae radix and Inulae radix also showed antimicrobial activities on Streptococcus mutans. In addition, Anemarrhena radix, Curcuma tuber, Inulae radix, Polygonum radix, Sanguisorbae radix, Scutellariae radix and Terminaliae fructus and showed antimicrobial activities on Trichophyton mentagrophytes. Four kinds of herbal plants such as Dropteris rhizoma, Salviae radix, Terminaliae fructus and Scutellariae radix which showed broad antimicrobial spectrums were mixed by 1 : 1 ratio with the other herbal paints showing relatively strong microbial activities such as Terminaliae fructus, Sinomeniae radix and Scutellariae radix etc. The extracts of mixed herbal paints showed higher antimicrobial activities than those of single herbal plant.

• The Korea Journal of Herbology
• /
• v.30 no.2
• /
• pp.31-36
• /
• 2015

Objectives : In this study, we demonstrated the antioxidant activities and the inhibitory effect on oxidative DNA damage of ethyl acetate fractions extracted from Sophorae Flos and Sophorae fructus. Methods : Sophorae Flos and Sophorae fructus were extracted with methanol(MeOH) and divided to Petroleum ether, Ethyl acetate(EtOAC) and Water fraction. The antioxidant activities were conducted by the 1,1-diphenyl-2-picryl hydrazyl(DPPH) radical, 2, 2'-Azine-bis(3-ethylbenzothiazoline-6 sulfonic acid) diammonium salt(ABTS) radical scavenging assay, $Fe^{2+}$ chelating assay and Reducing power assay. The inhibitory effect of DNA damage were characterized on ${\varphi}$ X-174 RF I plasmid DNA cleavage assay. In addition, we analyzed the Total phenol contents and the Vitamin C contents of Sophorae Flos and Sophorae fructus. Results : The results of DPPH were 92.71% and 94.72%, ABTS were 87.16% and 62.44%, and $Fe^{2+}$ chelating were 95.81% and 85.11% at $200{\mu}g/m{\ell}$ of Sophorae Flos and Sophorae fructus respectively. The Sophorae Flos showed stronger effect than Sophorae fructus in Reducing Power assay. Total phenol content was 111.77 mg/g and 122.54 mg/g, and Vitamin C content was 2.59 mg/g and 3.03 mg/g. Also both Sophorae Flos and Sophorae fructus have inhibitory antioxidant effect on ${\varphi}$ X-174 RF I plasmid DNA cleavage assay. Conclusions : Over all, this study suggests that Sophorae Flos and Sophorae fructus can be used as not only effective antioxidant but also natural medicine.

• YAKHAK HOEJI
• /
• v.28 no.1
• /
• pp.35-48
• /
• 1984

우리나라 사람들에게는 유달리 높은 간염 발병률이 나타나고 있고 더우기 바이러스성 간염의 경우 풍토병 내지 전염병이라고 할 정도의 양상을 띠고 있다. 현재까지는 이러한 간질환에 적절한 치료약이 없는 점을 감안하여 저자들은 생약으로 부터 간질환에 유효한 성분을 분리하여 치료약으로 사용할 수 있도록 하기위하여 집중적인 연구를 지난 5년간 계속하여 왔다. 연구의 내용은 동서양의 고전및 연구보문을 조사하여 간보호 및 치료학으로 사용한 생약에 관한 문헌적 조사, 이들 생약중 채집 및 구입이 가능한 식물을 구하여 생약엑기스 제조, 이들 엑기스를 간염 동물 모델의 하나인 $CCl_{4}$로 유발시킨 간독성에 대한 보호작용의 검색, 보호작용을 나타내는 생약중에서 자원적 측면을 고려하여 국내에서 많이 생산되는 차전자(Plantago asiatica seeds)를 선택하였고, 차전자로 부터 간보호 작용을 나타내는 유효성분으로 iridoid 계열물질인 aucubin을 분리하였다. 그러나 aucubin이 차전자에 소량 밖에 없으므로 aucubin이 다량 함유된 식나무(Aucuba japonica)로 aucubin 추출자료생약을 바꾼후 aucubin의 간보호 작용을 간염 동물모델인, $CCl_{4}$ D-galactosamine 및 $\alpha$-amanitin등으로 유발시킨 간독성에 대한 보호작용을 보여 주었기 때문에, 이러한 간보호작용의 기전을 규명하는 연구를 진행하였고, 다음은 aucubin 자체의 급성 독성 및 기타 독성 유발여부를 밝히는 연구 등으로 요약 될 수 있다.

• The Hankook-Saengyark Bo
• /
• no.235
• /
• pp.2-2
• /
• 1999

인삼수요 큰폭 증가(수출실적 지난해보다 20$\%$ 증가전망) - 진안 홍삼 홍콩수출(전북인삼조합) - 원예$\cdot$특작 종합자금지원 확대(대상 '최소경영단위 이상 농가'로 완화) - 경기 민통선 지역 인삼 경작지 조성 - 녹용등급 상$\cdot$중$\cdot$하 표기 한약협, 복지부등에 건의

• Korean Journal of Pharmacognosy
• /
• v.8 no.2
• /
• pp.73-79
• /
• 1977

Plants in Haing-Dam Island, Chung-Cheong Nam-Do and their plants distibution are listed. They are 197 species, 137 genera, 58 families collected from July 1975 to June 1977.

• The Hankook-Saengyark Bo
• /
• no.255
• /
• pp.2-2
• /
• 2003

국산 당귀 수매키로(제50차 수급조절위 결정) - 인공 배양 삼 식품원료로 허용(인삼 재배농가에 영향 미칠듯) - 약용작물 소득화 추진(예천, 산초등 재배지 조성) - 속리산 '자생식물 유전자원실' 설립추진(오는 2004년까지 총 10억원 투입)

• Korean Journal of Pharmacognosy
• /
• v.7 no.4
• /
• pp.241-245
• /
• 1976

Spectrophotometric determination of aconitine at 231 $m{\mu}$ was carried out. By this means, content of poisonous alkaloids in several tubers of Aconitum spp. on Korean market and natural product of Korea were determined.

• Korean Journal of Plant Resources
• /
• v.36 no.1
• /
• pp.26-31
• /
• 2023

In this study, we investigated in vitro inhibitory activity of wild-simulated ginseng (WSG) against non-alcoholic fatty liver disease using HepG-2 cells. T0901317 treatment increased the lipid accumulation in HepG-2 cells, but WSG treatment inhibited T0901317-mediated lipid accumulation. In addition, WSG downregulated T0901317-mediated expression of SREBP-1c, ACC, FAS and SCD-1 protein. In addition, WSG increased the phosphorylation level of LKB1 and AMPK. Compound C treatment blocked WSG-mediated downregulation of SREBP-1c protein. In conclusion, WSG is considered to inhibit the accumulation of lipids and triglycerides in HepG-2 cells by inducing the activation of LKB1 and AMPK successively, thereby reducing the expression of FAS, ACC, and SCD-1 through suppression of SREBP-1c expression.