• Proceedings of the Korean Information Science Society Conference
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• 2004.04a
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• pp.667-669
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• 2004

본 논문에서는 경제성, 효율성, 확장성 및 개발의 편의성을 고려한 환자 모니터링 모바일 시스템의 개발 사례를 보고한다. 특히 생명징후(Vital Sign) 중에서도 체온(Body Temperature)을 모니터링 하는 모바일 시스템 MBTMS 개발을 다루었다. MBTMS(Mobile Body Temperature Monitoring System)는 다음과 같이 세 부분으로 구성된다: (1) 환자의 체온들 수집하기 위한 센서, (2) 센서를 통해 체온을 측정하는 모듈, (3) 모듈에서 전달받은 자료를 처리 분석, 저장하는 PC(Personal Computer) Application으로 구성된다. 이러한 MBTMS는 입원환자 및 노약자를 위한 경제적인 PMS(Patient Monitoring System) 개발 및 e-Health 연구의 한 부분으로 활용될 수 있을 것이다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.9 no.2
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• pp.169-175
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• 2006

Purpose: Esophagogastroduodenoscopy (EGD) is a very useful procedure in diagnosing gastrointestinal diseases. However, there can be some difficulty in performing this procedure in children due to the associated discomfort. Recently, sedative agents such as midazolam have been introduced to alleviate this problem quite successfully. In our study, we attempted to confirm the safety and efficacy of midazolam use by monitoring the vital signs of children undergoing endoscopy. Methods: We analyzed data on 244 children who received EGD in the department of pediatrics at Severance Hospital, Yonsei University between August 2003 and July 2005. We evaluated $O_2$ saturation, heart rate and change of mental status before and during the procedure and analyzed the results using the SPSS 12.0 package (Chi-square test, cross table method, etc.). Results: There was no significant difference in vital signs measured before and during EGD between midazolam treated and non treated children. There was no significant relationship between the amount of midazolam given and $O_2$ saturation or a change of mental status. Regarding the $O_2$ saturation, it was decreased during EGD in both groups with p<0.01 though no difference was noted between the groups; the $O_2$ level was maintained above 95% in all patients. The heart rate was also increased during EGD in both groups with a p<0.01; however, no significant difference was noted between the groups. Conclusion: We confirmed the safety of low dose midazolam by evaluating the vital signs of children during endoscopies. However, the doses used were not sufficient for sedation or to obtain an amnestic effect.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.24-24
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• 2022

제주는 면적에 비해 생물종다양성이 높은 지역으로 평가된다. 한반도 자생 관속식물은 4,500여종으로 이 중 50%에 달하는 2,200종이 제주에 분포하고 있으며 최근 30년간 80여종의 미기록 식물이 출현하였다. 이러한 특성은 선태식물과 산림버섯 분야에서도 유사하게 나타나는 것으로 지리적 위치, 기후적 조건, 한라산으로 인한 수직 식생 분포, 특이산림생태계로 인한 입지 환경의 다양성과 관련이 있다. 동시에 제주는 희귀 및 유용 산림생명자원의 보고이다. 제주에서 수집하여 종의 실체를 확인한 2,167종을 대상으로 희귀성과 유용성을 평가한 결과 제주고사리삼, 구상나무, 갯취 등의 희귀·특산 식물이 400종, 흑오미자, 제주백서향, 황칠나무 등의 유용식물이 781종에 달하였다. 또한 제주는 우리나라에서 기후변화에 가장 민감한 지역으로 동북아시아 기후변화의 요충지로 전망되고 있다. 한라산의 구상나무가 쇠퇴하는 등 이상 징후가 지속적으로 증가하고 있으며 동북아시아 아열대 최북한계지로서 한반도 생물지리의 징검다리 역할을 하기 때문이다. 따라서 나고야의정서 발효와 기후위기로 산림생명자원의 보존과 활용의 중요성이 더욱 강조되고 있는 현재의 시점에서 제주는 우선 연구 대상지라 해도 과언이 아니다. 이에 국립산림과학원 난대·아열대산림연구소는 절멸 위기에 처한 종의 보존과 유용 산림생명자원의 활용 기반 마련을 위해 수집 및 탐색-빅데이터 기반 구축-증식기술 개발-현지내·외보존원 조성 및 관리 기술 개발 등의 일련의 연구를 20년 이상 수행해 왔다. 여기에서는 제주지역 산림생명자원의 가치와 함께 보존과 활용 연구 성과를 소개하고 향후 연구 방향을 제안함으로써 산림 바이오 소재 산업화와 관련된 학계와 임업인 및 기업에 도움이 되고자 한다.

• Journal of the Health Care and Life Science
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• v.11 no.1
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• pp.87-96
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• 2023

This descriptive research study aims to identify the importance and satisfaction of new advanced safety education and marine telemedicine service, and to identify the priority of educational needs for trainees who have received advanced safety reeducation. Data from 190 trainees who conducted advanced safety retraining at the MarineCom were used for the study. As a result of the study, the vital sign measurement method was selected as the top priority for the new advanced safety education, and the nervous system, circulatory system, and surgical system were selected as the top priority for the educational need by type of marine telemedicine guidance. These results suggest that there was a high demand for education on vital sign measurement methods in order to determine the appropriate first aid by grasping the overall condition of the patient in the event of an emergency. Working and monotonous daily life acted as a cause of mental and physical stress, so the incidence of patients in the nervous system, circulatory system, and surgical system was high, and compared to other systems, it was judged that the demand for education was high because the patient was related to life.

• Publications of The Korean Astronomical Society
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• v.38 no.2
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• pp.37-57
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• 2023

"Are we alone in the universe?" is the fundamental question of mankind. To search for the life signatures in the universe, there have been a lot of researches and space explorations, especially in our solar system. In this review paper, we introduce the definition and characteristics of the "biosignature". The current situations and future plans for searching for biosignatures in our solar system are reviewed, especially at Venus, Mars, and Ocean Worlds such as Europa and Enceladus where life signatures are more likely to exist than in other places in the solar system. Finally, we discuss the opportunities and strategies for the Korean scientific society to participate in searching for biosignatures in the solar system.

• Journal of the Korean Society of Radiology
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• v.82 no.4
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• pp.791-807
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• 2021

Vasculitis is a systemic disease, characterized by inflammation of the vascular wall. Although rare, it is sometimes life-threatening due to diffuse pulmonary hemorrhage or acute glomerulonephritis. Besides primary vasculitis, whose cause is unknown, numerous conditions such as autoimmune diseases, drugs, infections, and tumors can cause secondary vasculitis. Vasculitis displays various non-specific symptoms, signs, and laboratory findings; hence, diagnosis of the disease requires integration of various results including clinical features, imaging findings, autoantibody tests, and pathological findings. In this review, we have discussed the clinical, radiologic, and pathological features of vasculitis. Further, we elaborated the imaging findings and differential diagnosis of typical vasculitis that frequently involves the lung and introduced a new international classification of vasculitis, the Diagnostic and Classification Criteria in Vasculitis.

• 발명특허
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• v.31 no.9 s.363
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• pp.36-39
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• 2006

1% 가량 인간의 뇌세포를 보유한 쥐가 탄생했다는 기사가 있을 만큼 생명공학이 발달하고 있고, 의학이 발달함에 따라 난치병들도 그 치료방법을 찾아가고 있다는 반가운 소식이 종종 들린다. 그러나 그만큼 듣도 보도 못한 새로운 희귀병들이 속출하고 있고, 오랜 시간 인류에게 무서운 난치병, 암은 속시원한 치료법을 아직도 찾지 못한 채 여전히 그 위용을 떨치고 있다. 일상생활을 하며 너무나도 건강하게 살다가 그 징후가 느껴져 병원을 찾으면 이미 치료시기가 지나버리기도 하고, 정기검진을 받는 사람에게도 잦은 병으로 자리잡게 되었다. 또한 최근에는 어린 아이들에게도 소아암이라는 이름 아래 예외없이 발병률를 보이고 있다. 먹을거리의 오염과 바쁜 일상 속에서 그 누구에게나 찾아올 수 있는, 영원한 난치병 암백신의 개발은 현대인들에겐 영원히 풀어야 할 숙제인 것이다.

• Journal of Life Science
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• v.19 no.7
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• pp.892-898
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• 2009

MIF is a progesterone analogue and is known as a potent progesterone antagonist. Although MIF has been known to inhibit prostate cancer cell growth, its molecular mechanisms are not yet clear. In the present study, when the cells were treated for 2-4 days with 5-40 $\mu$M of MIF, the growth and viability of LNCaP cells were significantly decreased in a dose- and time-dependent manner. When the cells, cultivated in a normal 2 mM calcium concentration medium, were treated with 15 $\mu$M MIF for 1 day, the intracellular calcium level increased by 26% compared to the control. Similar results were also found in cells located in the calcium-free reaction buffer, indicating that MIF induced the increase of intracellular Ca$^{2+}$ levels, regardless of the presence of calcium in the surrounding medium. In the cells treated with various concentrations of MIF, the intracellular calcium levels increased in a dose dependent manner. Cells treated with MIF revealed typical early apoptotic signs, i.e., chromosome condensation and nuclei fragmentation. In cells treated with 40 11M MIF, Bcl-2 decreased to 19% of the control. The expression of Bax increased to almost 2 fold of the control. These results demonstrated very clearly that MIF treatment blocks the expression of Bcl-2 but stimulates the expression of Bax. According to the results of the present investigation, the apoptotic mechanism of MIF is triggered by intracellular modulation.

• Journal of Chest Surgery
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• v.37 no.12
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• pp.999-1002
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• 2004

Thirteen year old boy who had been stabbed in his left chest by the knife was transferred to our department from a general hospital, because of the massive bleeding from the intercostal tube drainage. Chest X-ray showed homogeneous density in the left lung field. He was confused and his vital signs were unstable. He was moved into a operating room as soon as possible. After resuscitation, his lacerated left ventricle wound was sutured through median sternotomy. The interventricular shunt was detected with intraoperative transesophageal echocardiography. The traumatic ventricular septal defect was closed via left ventricle using Dacron patch. His postoperative course was uneventful, and he was discharged with small residual shunt.

• Journal of the Korean Society of Radiology
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• v.83 no.5
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• pp.1128-1133
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• 2022

Common carotid artery (CCA) rupture during parathyroid cancer surgery is extremely rare and is generally life-threatening. We present a case of successful management of a ruptured CCA following the emergency placement of stent-graft in a 59-year-old male diagnosed with recurrent parathyroid cancer. During recurrent parathyroid cancer surgery, his right CCA ruptured unexpectedly, and his vital signs deteriorated rapidly despite surgical management. After stent replacement, his unstable vital signs improved and, thereafter, he was discharged without any complications.