• Title/Summary/Keyword: 생명주

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Study on the Properties of Lagerstroemia indica Extract as an Anti-acne Cosmetic Material (배롱나무 꽃 추출물의 항여드름 화장품 소재로서의 특성 연구)

  • Jiyoung You;Se-young Oh;Yeji Im;Suwon Jeon;Kyung-Baeg Roh;Song-ah Choi;Eunae Cho;Deokhoon Park;Eunsun Jung
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.50 no.1
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    • pp.19-27
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    • 2024

  • This study is to propose Lagerstroemia indica flower as an anti-acne cosmetic material, and confirmed the sebum control, anti-inflammatory, and antioxidant effects using Lagerstroemia indica flower extract (LIFE) . As a result of evaluating the sebum control effectiveness, it was confirmed that LIFE inhibited the production of sebum excessively induced with palmitic acid up to 65%. Subsequently, it was confirmed that LIFE has an antibacterial effect and the ability to inhibit lipase activity against Cutibacterium acnes (C. acnes), which mainly appears in acne lesions, and can also reduce the inflammatory response caused by virulence factors secreted by C. acnes. It was also confirmed that LIFE inhibited the secretion of nitrogen monoxide (NO) and prostaglandin E2 (PGE2), which are inflammatory mediators induced by LPS in macrophages, by 75% and 54%, respectively, and that it also had a high DPPH radical scavenging ability similar to that of ascorbic acid. These results suggest that LIFE, a natural extract, can be used as an anti-acne material to relieve and treat acne, a complex disease, by controlling sebum production and having antibacterial and lipase activity inhibiting against C. acnes, and anti-inflammatory, antioxidant properties.

  • https://doi.org/10.15230/SCSK.2024.50.1.19 인용 PDF

벤처기업을 찾아서 - (주)네오딘, 질병의 진단 킷트 생산ㆍ판매

  • Korean Federation of Science and Technology Societies
    • The Science & Technology
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    • v.35 no.3 s.394
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    • pp.24-25
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    • 2002

  • (주)네오딘은 1997년 에스렘이라는 진단 킷트를 수입.판매하는 회사로 출범하여 2000년 상호를 바꾼 바이오벤처기업이다. 현재 네오딘에는 15명의 연구진을 갖춘 생명공학연구소 내에 인체의 질병 진단 킷트를 생산하는 생명과학 사업부와 애완동물 등의 질병을 진단하는 수의생명과학사업부를 두고 있다.

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Andrographolide Promotes the Stemness of Epidermal Cells through the Extracellular Signal-regulated Kinase (ERK) Pathway (Andrographolide의 Extracellular Signal-regulated Kinase Pathway (ERK)를 통한 상피 세포 줄기세포능 향상)

  • You, Jiyoung;Roh, Kyung-Baeg;Shin, Seoungwoo;Park, Deokhoon;Jung, Eunsun
    • Korean Journal of Pharmacognosy
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    • v.50 no.1
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    • pp.18-24
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    • 2019

  • Andrographolide, the main compound of Andrographis paniculata (A. paniculata), shows various biological properties including anti-viral, anti-inflammatory, anti-diabetic, and hepatoprotective effects. Our previous study has shown that A. paniculata extract exerts antiaging effects by activation of stemness in epidermal stem cells (EpSCs). In this study, we investigated the effect of andrographolide as a main compound of A. paniculata on EpSCs and its mechnism of action using several in vitro assays. Andrographolide increased the proliferation of EpSCs and induced cell cycle progression. Additionally, andrographolide increased VEGF production and the expression of stem cell markers integrin ${\beta}1$ and p63. Furthermore, phosphorylation levels of extracellular signal-regulated kinase 1/2 (ERK1/2), S6 ribosomal protein (S6RP) and Akt were increased by andrographolide. Taken together, these results indicate that andrographolide-induced proliferation of EpSCs is mediated by the ERK1/2, Akt-dependent pathway with increased production of VEGF and upregulated stemness through integrin ${\beta}1$ and p63.

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The effects of Stigma Removal and Auxin Treatment on Fruit Shape and Quality in Strawberry (딸기의 주두 제거와 옥신 처리가 딸기의 과형 및 품질에 미치는 영향)

  • Lee, Jung-Eun;Lee, Gyu-Bin;Je, Byoung-Il;Lee, Yong-Jae;Park, Young-Hoon;Choi, Young-Whan;Son, Beung-Gu;Kang, Nam-Jun;Kang, Jum-Soon
    • Journal of Bio-Environment Control
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    • v.28 no.1
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    • pp.55-65
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    • 2019

  • The effects of stigma removal from floral organ and treatment of auxin on those regions were evaluated on the fruit growth and quality in strawberry (Fragaria ananassa Duch.). The removal of stigma reduced the fruit weight, fruit length, and fruit width, while fruit growth declined as the number of removed stigma increased. The removal of stigma also resulted in reduced fruit firmness, sugar content, and total anthocyanin content, and decreased value of Hunter a for red color and increased value of Hunter b for yellow. The number of seeds deceased as the regions of removed stigma increased. The treatment of auxin on the region of removed stigma improved fruit size, while it reduced fruit firmness, sugar content, and anthocyanin content. The delay in fruit ripening was observed from both stigma removal and auxin treatment. The incidence of malformed fruits increased as the regions with removed stigma increased. The treatment of auxin also promoted fruit malformation.

  • https://doi.org/10.12791/KSBEC.2019.28.1.55 인용 PDF KSCI