• Journal of agriculture & life science
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• v.45 no.6
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• pp.21-32
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• 2011

This research is intended to study literatures relating to western rocking chairs style in early 20th century in order to provide basic data of designs for rockers of today in Korea and investigate characteristics of rocking chair from academic, formative and pragmatic perspectives. During the first half of 20th century, western rocking chairs (1925~1945) embodied actively the simple functionalism concept that furniture design must follow functionality considerations. Therefore, bare wood rocking chairs were without any surface decoration and tubular steel frame rocking chairs often included black leather upholstery in a bold attempt to express exposed structure. And the fact that tubular steel produced such lightweight furniture was crucial importance. Many Modernist designer created curvaceous lines of new pattern changes in their furniture. The structure of Modern rocking chair became all-important, for stylistic as well as functional reasons. Designers equated exposed structure of tubular steel and wooden frame with integrity and rationality and create an equalitarian style of design. Especially, designers in the early 20th century did use various brilliantly colored upholstery and wooden frame with simple forms of modern characteristics.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.279-282
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• 2008

단백질의 구조는 그 기능과 밀접히 연관되어 있기 때문에 구조에 조금이라도 변화가 생기면 바로 생체기능에 이상이 생긴다. 그래서 단백질 구조연구는 필수적이고 구조의 유사성 검색을 이용하여 단백질 기능을 예측한다. 그러나 전체적인 구조가 유사한 단백질이라도 기능에 중요한 특정구조가 다르게 되면 다른 기능을 수행 할 수 있고 구조가 다른 단백질이라도 핵심 영역의 구조가 유사하다면 유사한 기능을 수행할 수 있다. 이는 단백질의 기능이 특정 하위구조의 잘 보존된 활성 사이트에 따라 결정되기 때문이다. 이 논문은 단백질의 3차원 공간정보를 matrix로 표현 할 수 있는 가장 작은 평면도형인 삼각형을 이용하여 단백질 표면에 대한 상세한 형태비교를 제공한다. 단백질 표면에서 활성 사이트 아미노산 잔기의 side chain은 일반적으로 바깥을 향하여 표면의 형태를 결정짓기 때문에 단백질 표면을 비교하기 위해 side chain 정보가 필수적이다. 우리는 아미노산 잔기의 Cα원자에 side chain을 포함하여 Cα삼각형과 side chain 삼각형 2개를 하나의 특정하위구조 set으로 정의하고 이 하위구조로 distance matrix를 구축한다. 만들어진 distance matrix에 RMSD를 이용하여 활성 사이트의 표면을 비교한다. 제시한 기법은 단백질의 전체적인 서열과 구조 정보를 이용하지 않고, 활성 사이트의 특정하위 영역만을 고려함으로써 더욱 효과적이고 빠른 시간 내에 상세한 비교를 수행할 수 있다.

• Biomedical Science Letters
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• v.5 no.1
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• pp.27-40
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• 1999

This study was focused on the evaluation of MarB alongside with MarA for its regulatory effects upon the efflux function of AcrAB pump, which were induced or not, perhaps as a target. Transductions of marR and/or acrAB mutation which were derived from Mar and/or AcrAB mutants of wild type E. coli K-12, respectively, into the multicopy plasmid in wild type E. coli backgrounds or into the chromosome of isogenic parents were done. Minimal inhibitory concentration (MIC) of transduced mutants was compared with their original mutants. This study reports the indirect evidences that suggests a model in which MarB along with MarA have a putative negative regulatory effect upon the efflux function of AcrAB/TolC pump while MarA alone have a positive regulatory effect to the expression of acrRAB operon at transcription level. The target of MarB with MarA for its putative negative regulator might be the AcrAB efflux pump. Another efflux system (s) might be negatively regulated by MarB with MarA, and be involved in the efflux of antibiotics which were otherwise extruded preferentially by AcrAB efflux pump.

• The Journal of the Korean life insurance medical association
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• v.22
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• pp.121-137
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• 2003

현행 생명보험업계는 중복가입계약에 대한 정보교환제도를 시행함으로써 잠재적 위험에 대한 위험평가를 하고는 있으나 실제 언더라이팅 과정에서는 효율적인 활용을 못하고 있다. 따라서 언더라이팅 실무 입장에서 현행 정보교환제도의 문제점을 파악하고 각 보험회사가 취할 수 있는 효율적인 대응방안을 제시할 필요성이 대두되고 있다. 현행 정보교환제도의 문제점을 크게 몇가지로 나눌 수 있다. - 교환기준에 미달하는 다수의 계약건을 가입한 경우 위험평가 불가 - 위험평가상 고지의무에 충실한 계약자의 상대적 불리 - 정해진 기준과 다른 임의적 기준적용 등 선별적 자료교환으로 위험선택에서 배제된 잠재적 위험들의 계속적인 계약 및 지급 등 역선택 방조기능 - 실시간 반영된 정보부재 및 교환된 자료만으로 one-stop 위험평가를 할 수 없는 어려움 내재 - 정보교환에 대한 전체적 참여노력 부족 및 자기정보에 대한 방어와 자체 활용 이런 문제점들을 인식하고 이에 대한 효율적 대응방안을 제시해 본다. - 언더라이팅 측면에서 판매채널 다변화, 업무겸업화 둥 대외 환경변화에 따른 위험분석 및 평가, 위험분산을 위한 multi-player로서의 언더라이터 양성 필요 - 지급, 조사건의 분석 및 통계화 등 feed back 기능 강화통한 언더라이팅 활용 - 방문진단 통한 적부기능 활용 또는 모집자 사정평점제 등 언더라이팅 과정에서 활용할 수 있는 위험평가 자료축적 - 영업환경적 측면에서 고보장 상품의 경쟁적인 개발제한 - 정보교환제도 측면에서 정보교환 기준 변경 및 교환내용 추가 및 공동의 계약인수 guideline 필요 - 진단거절체, 표준미달체, 사절체 등 새로운 정보교환의 추진 필요 - 종합적인 피보험자의 정보를 획득할 수 있는 피보험자 종합정보의 데이터 구축 및 활용 효율적인 위험관리 외에도 각 보험회사별로 역선택 위험에 대한 심각성을 인식하고 업계간 정보교환에 적극적인 참여와 노력이 필요하며 잠재적 위험평가를 하는데 있어 계약자에게는 객관적 근거없이 불편을 갖지 않도록 언더라이팅 서비스하는 것 또한 중요하다. 지속적인 피보험자의 위험통계축적으로 잠재위험에 대한 보다 객관화된 위험평가를 할 수 있는 언더라이팅 기법을 체득함으로써 언더라이팅 경쟁력을 갖을 수 있다.

• Journal of Science Education
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• v.41 no.3
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• pp.318-333
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• 2017

In this study, we analyzed activities in life science chapters of middle school 'science' textbooks for the 2009 revised Korea national curriculum and examined the difference between the analysis based on scientific practices and the analysis based on inquiry skills. As a results, there was a lot of inquiry skills in the order of 'reasoning', 'observing', 'classification' in the all of grade. In scientific practices, 'data analysis and interpretation' and 'constructing explanations and devising problem solving' were biased. This shows that life science inquiry activities in middle school 'science' textbooks are lacking in diversity in scientific practice elements as well as inquiry skills, and that the goals of the activities are limited. In addition, through the interrelationships between scientific inquiry skills and scientific practice elements, we examined contents relevance in the transition from inquiry function center to scientific practice, and compared with the results of inquiry activities in textbook, The results of this study were matched monotonously due to the tendency to basic inquiry-data interpretation / basic inquiry-explanation. This comes from results of the lack of diversity in activities presented in middle school 'science' textbooks. In this study, it is suggested that efforts should be made to include diverse scientific practice elements in the process of realizing 2015 revised Korea national curriculum from the simple and diversity-less inquiry activity through analyzing the textbooks of the 2009 revised Korea national curriculum.

• Journal of Life Science
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• v.33 no.10
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• pp.842-850
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• 2023

Pyrrolnitrin, pyrrolomycin, and pyoluteorin are functional halogenated phenylpyrrole derivatives (HPDs) derived from microorganisms with diverse antimicrobial activities. Pyrrolnitrin is a secondary metabolite produced from L-tryptophan through four-step reactions in Pseudomonas fluorescens, Burkholderia cepacia, Serratia plymuthica, etc. It is currently used for the treatment of superficial dermatophytic fungal infections, has high antagonistic activities against soil-borne and foliar fungal infections, and has many industrial applications. Since pyrrolnitrin is easily decomposed by light, it is difficult to widely use it outdoors. As an alternative, fludioxonil, a synthetically produced non-systemic surface fungicide that is structurally similar and has excellent light stability, has been commercialized for seed and foliar treatment of plants. However, due to its high toxicity to aquatic organisms and adverse effects in human cell lines, many countries have established maximum residue levels and strictly control its levels. Pyrrolomycin and pyoluteorin, which have antibiotic/antibiofilm activity against Gram-positive bacteria and high anti-oomycete activity against the plant pathogen Pythium ultimum, respectively, were isolated and identified from microorganisms. This review summarizes the biosynthesis and production of natural pyrrolnitrin derived from bacteria and the characteristics of synthetic fludioxonil and other natural phenylpyrrole derivatives among the HPDs. We expect that a plethora of highly effective, novel HPDs that are safe for humans and environments will be developed through the generation of an HPD library by microbial biosynthesis and chemical synthesis.

• Journal of Life Science
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• v.12 no.5
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• pp.622-631
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• 2002

The purpose of this study is to analyze the effects of aerobic exercise on immune function, physical fitness and fat mass in middle-aged women. Twenty subjects were divided into two groups : experimental group(N:10) and control group(N:10). Experimental subjects were under the exercise conditions to perform the aerobic exercise using the movement of dance-sports with intensity of 60~80% HRmax for 60 min/day, 3 times/week during 12 weeks. After the aerobic exercise, the numbers of neutrophil, Iymphocyte, eosinophil, basophil, 73, 74 and B4 were significantly different. Crip-strength and sit-up ability significantly improved and all so weight and fat mass decreased on experimental group. Therefore, the aerobic exercise using the movement of dance-sports applying to middle-aged women would contribute them healthy life and prevention of chronic disease.

• Journal of the Korea Society of Computer and Information
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• v.16 no.12
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• pp.113-120
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• 2011

Information system gradually increases the complexity and scale of the project, while if the project fails to occur. To analyze the causes of failure of the project a lack of understanding of your project, unclear requirements and requirements change, etc. of the software development life cycle from requirements analysis phase is to find the source of most. In this paper, a software development project needs analysis derived from the traceability between features and functionality, and development needs throughout the life cycle requirements during the ongoing change management tool was designed to allow. And among those related to the project through consultation with a sufficient consensus to build a common understanding of effective communication will discuss the features required to support.

• Journal of Information Management
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• v.40 no.1
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• pp.157-181
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• 2009

As the information technology is evolved and the human genome project is finalized over the world, the Bioinformatics - the integration of abundant Biological science and information technology - has shown up and is continuously being advanced. Together with the evolution of Bioinformatics, the websites dealing with Bioinformation have been set up to provide relevant information to the Bioscientists. Among the numerous global websites, the preferred websites by the majority of domestic Bioscientists are BRIC (Biological Research Information Center) of POSTECH(Pohang University of Science and Technology) in Korea, CCBB(Center for Computational Biology and Bioinformatics) of KISTI(Korea Institute of Science and Technology Information), KOBIC(Korean Bioinformation Center) of KRIBB(Korea Research Institute of Bioscience and Biotechnology), NCBI(National Center for Biotechnology Information) in USA, EBI(European Bioinformatics Institute) in Europe and DDBJ(DNA Data Bank of Japan) in Japan. In this paper, the comparative analysis was executed by investigating contents status and functions of the above-mentioned 6 websites. In addition, questionnaire survey of Bioscience Researchers' utilization status and their needs to those 6 websites was conducted.

• Proceedings of the Korea Information Processing Society Conference
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• 2006.11a
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• pp.673-676
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• 2006

생명현상을 이해하기 위해서는 단백질의 기능 규명이 이루어져야한다. 단백질 기능 규명을 위한 서열분석 방법은 서열 상동성이 현저히 낮은 경우 단백질 기능 예측이 불가능하고, 과거의 전체적인 단백질 구조 분석을 통한 기능 예측의 문제점이 보고되고 있다. 이 논문에서는 기능상 중요한 의미를 가지고 있는 단백질의 특정하위구조의 기하학적 특징을 추출하여 이 특징과 잔기의 위치와의 관계를 규명하였다. 또한 NaiveBayes, SVM, C4.5의 분류알고리즘을 이용하여 각 알고리즘별 분류성능을 평가하였다. 기능상 중요한 의미를 가지고 있는 특정하위구조를 비교함으로써 모르는 단백질의 기능을 예측할 수 있다.