• Science of Emotion and Sensibility
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• v.24 no.1
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• pp.3-10
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• 2021

This study examined the effect of intentional thought avoidance(i.e., thought suppression and thought substitution) using "Think and No Think" task. Two syllable words were selected, and recall test was performed with a single subject group. recall accuracy of them was measured in two recall conditions(cue recall and target recall) and four training conditions(thought, thought suppression, thought substitution, and baseline). The results showed that recall accuracy in cue recall condition was better than in target recall condition, regardless of training conditions, and recall accuracy in thought condition was better than in other training conditions, regardless of recall conditions. Also there was significant interaction between recall and training conditions: For thought suppression. there was no difference between two recall conditions, whereas for thought substitution, recall accuracy in cue recall condition was better than in target condition. These findings indicate that thought avoidance strategies, including both thought suppression and thought substitution, are effective in avoiding the specific thought intentionally, and thought suppression and thought substitution could be applied by different mechanism.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.452-458
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• 2016

This is a descriptive study on visiting caregivers' perception of restraint use. Data were collected from 113 caregivers working at long-term facilities using a structured questionnaire from Feb to March 2016. The caregivers' perception of restraint use was the medium score. The items they considered the most important reasons for the restraints was "Protecting an older person from falling out of bed", which was primarily intended to prevent accidents of the elderly. The score of the knowledge of restraint use was 11.23 points out of 18 and those affected were more than 50 years of age. The attitude score to the use restraints was 9.19, and caregivers thought it should be possible to refrain from using restraints. Work experience of 3 years or less were higher. The perception of using restraints is affected by the knowledge and attitudes of restraint use. This is very important for the elderly in long-term care facilities and is related to health and human rights. Therefore, it is important to provide continuous education related to the use of restraints and regulations on their management.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.44-44
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• 1993

Rat 기관 평활근에서 GS 283은 Carbachol에 의한 수축을 용량 의존적으로 억제시켰으며 특히 $Ca^{2＋}$-free 용액에서 G5 283은 농도에 비례하여 $Ca^{2＋}$에 의한 수축을 억제 시켰으며, 전형적인 $Ca^{2＋}$ 길항제인 Verapamil도 유사한 효과를 나타내었으나 GS 283보다 강력하였다. GS 283은 칼슘 길항 효과 이외에도 약하지만 Antihistamine 및 Antimuscarine작용도 가지고 있는 것으로 나타났다. 한편 Rat 대동맥에서 GS 389는 Phenylephrine(PE)에 의한 수축을 용량 의존적으로 억제시켰으며 $Ca^{2＋}$-free 용액에서 PE에 의한 수축과 KCI에 의한 수축율 모두 억제시켰다. 이러한 결과는 GS283과 GS 389는 $Ca^{2＋}$에 길항적용이 있음을 암시하며 특히 수용체를 통한 $Ca^{2＋}$-channel과 세포막의 voltage를 통한 $Ca^{2＋}$-channel을 모두 억제함을 강력히 시사한다. 향후 in vivo model에 대한 이들 약물의 효과를 연구해 보아야 할 것으로 생각하며 이러한 효과가 직접 $Ca^{2＋}$-channel에 대한 작용인지 또는 GS화합물이 cyclic nucleotide를 증가시키는 효과가 있어서 이로 인한 2차적 작용인지를 더욱 밝혀야 할것으로 생각된다.

• The Korean Journal of Physiology
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• v.17 no.2
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• pp.143-159
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• 1983

Vanadate가 가토 신피질절편에서 PAH이동과 Na-K-ATPase활성에 미치는 효과를 관찰한 결과 다음과 같은 결론을 얻었다. 1) Vanadate는 Na-K-ATPase활성을 농도에 따라 억제하였으며 $7.94{\times}10^{-7}M$에서 이 효소의 활성이 50% 억제되었다. 2) Vanadate는 PAH의 능동적이동을 농도에 따라 억제하였으며 50%억제농도는 대략 $10^{-4}M$ 이었고, 수동적이동에는 영향을 미치지 못하였다. 조직내 Na과 K의 양도 vanadate가 PAH이동을 억제하는 농도 범위에서 같이 변화하였고 산소소모량은 $10^{-4}M$까지는 약간 감소하였으나 $10^{-3}M$에서는 오히려 증가하였다. 3) 30분간 preincubation한 후에도 15분까지의 PAH이동은 30분 이후에 비해 vanadate에 의해 적게 억제되었다. 4) $10^{-4}M$ vanadate와 $10^{-4}M$ ouabain은 가역적으로 PAH 이동을 억제하였으며 $10^{-3}M$ vanadate는 비가역적으로 억제하였고 장시간 세척후에도 거의 같은 정도의 억제양상을 나타내었다. 5) Vanadate에 의한 PAH이동의 억제정도는 incubation용액내 $Na^+$의 감소, $K^+$의 증가에 의하여 증가하였고 $Ca^{2+}$의 농도 변화에 의해서는 영향을 받지 않았다. 6) Vanadate가 존재치 않을 때 Tris완충용액 사용시는 pH 8.2까지 PAH축적정도가 증가하였고 phosphate완충용액 사용시는 pH 7.4에서 최대축적치를 보였다. pH가 증가함에 따라 억제정도는 증가하였으며 같은 pH에서도 완충용액의 종류에 따라 vanadate에 의한 억제정도가 달랐다. 7) Vanadate와 ouabain은 PAH이등과 Na-K-ATPase활성에 부가적 억제작용을 나타내었다. 이상의 결과로 vanadate는 가토신장의 세포내부에서 Na-K-ATPase를 가역적으로 억제함으로써 PAH의 이동을 억제하는 것으로 생각되며 PAH의 이동은 Na-K-ATPase활성과 기능적으로 밀접히 연결되어 있는 것으로 생각된다.

• 가정의 벗
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• v.37 no.5 s.429
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• pp.12-13
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• 2004

억제하면 억제할수록 불안해지는 생각을 더 많이 하게 된다는 강박증, 그 원인이 단순하지 않고 한가지 요인이 아닌 체질과 환경의 다양한 영향으로 생기게 되는 병이라 한다. 한의학을 통해 강박증의 원인과 치료에 대해서 알아보도록 하자.

• The Journal of the Korea Contents Association
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• v.17 no.1
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• pp.507-521
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• 2017

Purpose: The purpose of this study is to examine the relationship between attitude toward death among Korean hostess (room salon/bar) in Busan and their suicide-related factors. Methods: The questionnaires were administrated to 120 Korean hostess. The questionnaires consist of 7 major concepts: death as liberation, death as natural phenomenon, fear of death, avoidance of thought about death, fear for the impact of death on family, frequency of thought of death, their capacities to resist suicidal impulses. Results: Interestingly, satisfaction for hostess working in room salons with their monthly incomes was negatively correlated with frequency of thought of death and was positively related to their capacities to resist suicidal impulse. Moreover, in terms of the factors influencing 'their capacities to resist suicidal impulse', for hostess working in room salons, 'fear for the impact of death on family,' and 'satisfaction with their monthly income' were found to significantly influence 'their capacities to resist suicidal impulses'. However, for hostess working at bars, 'death as liberation' was found to be the only one factor showing significant effect on 'their capacities to resist suicidal impulses'. Conclusion: For hostess working in room salons, their perceived monetary reward seems to affect their attitudes toward death and suicide-related thoughts. Understanding a person's attitudes toward death can be another way to help people in a difficult situation to prevent them from carrying out the worst.

• 한국노년학
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• v.37 no.3
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• pp.601-616
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• 2017

Elderly suicide is a major public health issue in South Korea. The aim of this study was to systematically examine the current knowledge about suicidal ideation among Korean older adults with specific focus on risk and preventive factors. In order to achieve this aim, a meta-analysis was conducted using Korean academic peer-reviewed journals published since 2001. A total of 97 articles were selected that met the research criteria (e.g., original study findings and key words of suicidal ideation, suicidal thought, and suicide). Three domains were identified and used for further analysis: individual, family, and society. Results showed that among individual factors, depression and burden or stress increased the risk of suicidal ideation, while better mental health reduced the risk of suicidal ideation. Among family factors, living alone was a risk factor for suicidal ideation, while family cohesion was a preventive factor for suicidal ideation. Among social factors, elderly discrimination, social isolation, and negative relationships were significant risk factors, while social support, social environment, and social activities were significant preventive factors affecting suicidal ideation. The results suggest several practical implications for developing suicide prevention programs and counseling approaches to address suicidal ideation. For example, depression and stress can be reduced by MBSR (Mindfulness-Based Stress Reduction) program where meditation is used as a coping strategy. In addition, counseling programs specifically focused on improving family and social relations should be implemented. Government should continuously support for these programs to prevent suicide among older Koreans.

• Korean Journal of Food Science and Technology
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• v.20 no.3
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• pp.287-292
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• 1988

The inhibition mechanism of DNA damage by lipid peroxidation was studied through the reaction systems of plasmid pBR322 DNA, linoleic acid and the ethanol extracts obtained from ginger and garlic. The DNA damage was greatly inhibited by the addition of ginger and garlic extracts, and their scavenging effects of active oxygens were also great. It is considered that the inhibitory effects of these extracts on the DNA damage are mainly due to their scavenging effects of active oxygen radicals.

• Defense and Technology
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• no.7 s.173
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• pp.30-35
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• 1993

목표 주변의 부수피해를 줄이면서, 고도의 파괴력으로 적의 목표를 정확히 파괴할수 있는 신생기술무기는, 일반적으로 선제공격 억제효과의 측면에서 현재의 핵무기보다는 약하지만, 재래식 신생기술무기로도 적의 주요 목표에 대하여 전략적인 공격 성과를 달성할수 있으므로 전쟁 억제가 가능하게 될 것입니다 결국 신생기술무기의 출현은 세계적인 전면전의 가능성을 줄이게 될 것이며 핵전쟁으로의 확산을 방지하는데 커다란 영향을 주리라 생각됩니다

• The Journal of Korean Society for Radiation Therapy
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• v.14 no.1
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• pp.165-174
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• 2002

Vascular endothelial growth factor (VEGF) has been identified as a peptide growth factor specific for vascular endothelial cells. In this study, we examined the effect of VEGF on radiation induced apoptosis and receptor/second messenger signal transduction pathway for VEGF effect in human umbilical vein endothelial cells (HUVECs). VEGF was found to protect HUVECs against the lethal effects of ionizing radiation by inhibiting the apoptosis induced in these cells by radiation exposure. VEGF (1-30 ng/ml) dose dependently inhibited apoptosis by irradiation. Pre-treatment with Flt-1 and Flk-l/KDR receptor blocked the VEGF-in duced antiapoptotic effect. Phosphatidylinositol 3'-kinase (PI3-kinase) specific inhibitor, Wortman in and LY294002, blocked the VEGF-induced antiapoptotic effect. These data suggest that VEGF may play an important role in survival of HUVECs due to the prevention of apoptotic cell death caused by some stresses such as ionizing radiation.