• 건강소식
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• v.31 no.12 s.349
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• pp.6-13
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• 2007

남성과 여성의 생식 기관은 태어날 때부터 모양이나 기능이 뚜렷하게 구별되고, 성장하여 사춘기에 이르면 생식기관이 성숙하며 생식 세포가 남성은 정자를, 여성은 난자를 만들어 자손을 남길 수 있게 한다. 이는 신의 선물로서 생식기관의 건강정보와 이해를 통해 더 건강하고 아름다운 남성과 여성으로서 역할을 할 수 있어야 할 것이다. 이번 호에서는 여성전문클리닉 미체원의 고영익 대표 원장과 고려대학교 안암병원 비뇨기과 김제종 교수의 도움말로 인체의 신비 생식기관에 대해서 알아본다.

• The Journal of the Korea Contents Association
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• v.17 no.12
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• pp.202-214
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• 2017

This study figured out the influence of parenting attitudes and parenting efficacy on parents educational needs. Accordingly, it is for the purpose of being tried to establish a basic data for educational programs and intervention strategy to promote parenting attitudes and parenting efficacy for marriage immigration women. This is a study on descriptive correlation among 130 marriage immigration women with adolescent children. As the results of this study, parenting attitudes and parenting efficacy showed to be affected on the parents educational needs and had positive correlation(r=.248, p<.01). Receptive parenting attitudes and autonomous ones in the parenting attitudes had also positive correlation(r=.192, p<.05). It showed that the higher the excessive expectant parenting attitudes are, the higher the educational needs of social instruction are, and the higher the receptive parenting attitudes are, the higher the educational needs to understand growth development are. Also it showed that the lower the parenting efficacy is, the higher the social instruction and the educational need on growth for parents themselves are. The parents educational needs were high in the educational needs on learning, career instruction and education of effective communication. Based on the results above, this study hoped to develop structured education program develop for marriage immigration women and have more education opportunities for enhancing receptive parenting attitudes, autonomous ones and parenting efficacy.

• Journal of the korean academy of Pediatric Dentistry
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• v.37 no.1
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• pp.57-64
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• 2010

The purpose of this investigation was to study the relationship between vertical facial pattern and dental maturation in children in pubertal and pre-pubertal periods. The material consisted of lateral head films and panoramic radiographs of 1306 patients. The subjects were selected according to Ricketts's VERT index and other including criteria. These subjects were divided by VERT index to brachyfacial group and dolichofacial group. In each selected subject, dental age was determined according to Demirjian's dental maturity score. All subjects were distributed according to age, vertical facial type and sex, mean and standard deviation of chronological age, dental age and age difference were determined in each group. And the data were analysed to find the difference of tooth maturation by facial pattern. Findings of this study include: 1. In all groups, dental age was determined higher than chronological age in statistically significant level. 2. Compared by vertical facial pattern, in pubertal age groups, it seems that subjects with brachyfacial type presented the tendency to have an advanced dental maturation, only in female group. 3. Compared by pubertal period, brachyfacial groups presented more advanced dental maturation in pubertal groups than pre-pubertal groups.

• Clinical and Experimental Pediatrics
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• v.48 no.12
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• pp.1317-1323
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• 2005

Purpose : This study was performed to evaluate the recent frequency of karyotypes in different sex chromosome abnormalities and to evaluate the age and clinical manifestations at diagnosis. Methods : Peripheral blood leukocytes were obtained from subjects who were clinically suspected to have sex chromosome abnormalities and referred to the cytogenetic laboratory in the Department of Pediatrics, Kyungpook National University Hospital from February 1981 to August 2001. Results : The relative frequencies of different sex chromosome abnormalities were Klinefelter(52 percent), Turner(42 percent), XXX syndrome(3 percent) and mixed gonadal dysgenesis(3 percent). The populations of different karyotypes in Klinefelter syndrome were 47,XXY(97 percent) and 46,XY/47,XYY(3 percent). The populations of different karyotypes in Turner syndrome were 45,X(67 percent,), mosaicism(23 percent), and structural aberrations(10 percent). The populations of different karyotypes in XXX syndrome were 47,XXX(67 percent,) and 46,XX/47,XXX(33 percent). All mixed gonadal dysgenesis were 45,X/46,XY. Eighty one percent of sex chromosome abnormalities was diagnosed after puberty. Patients diagnosed with Klinefelter and Turner syndrome in infancy showed nearly normal phenotypes or had minor congenital malformations. Conclusion : Early diagnoses of sex chromosome abnormalities is required to prevent associated morbidities and to maximize growth and development. We have to pay careful attention in diagnoses of Turner syndrome because of the high proportion of mosaicism and structural aberrations.

• The korean journal of orthodontics
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• v.30 no.4 s.81
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• pp.399-411
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• 2000

This study was designed to evaluate the correlations between the morphology and growth of cranial base and the position of nasomaxillary complex and mandible in complete unilateral cleft lip and palate patients. Craniofacial skeletal morphology Pattern was analyzed on the lateral cephalometric radiographs of the 100 subjects of complete unilateral cleft lip and palate group and the 100 normal grower group and each group was divided three sub-groups by age-range like spheno-ethmoidal synchodrosis growing group, spheno-occipital synchondrosis growing group and finished synchondrosis growth group. These data were statistically analyzed to examine significant difference between both groups and between each sub-groups. The results of this study were as follows: 1. In complete unilateral cleft group, the length, thickness of clivus, and the rate of increase in length of clivus showed smaller amount by adolescence. The anterior length of cranial base and the rotation pattern of clivus with age showed no significant difference between two group. 2. In complete unilateral cleft group, nasomaxillary complex were located more posteriorly. This difference between two groups is larger by adolescent group than adult. Vertical position showed no significant difference between two groups. There was significant correlation between the cranial base of cleft group and the horizontal measurements(p<0.01). PtmS showed no significant increment in cleft group. This showed the deficiency of growth in posterior part of maxilla. 3. In mandible, there was no significant difference between normal group and complete unilateral cleft group but articular angle showed significantly smaller in cleft group than in normal one. And the measurements of nasomaxillary complex position, cranial base and the position of mandible had significant correlation(p<0.01).

• The korean journal of orthodontics
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• v.25 no.5 s.52
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• pp.557-566
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• 1995

Postpubertal craniofacial growth changes were assessed from serial lateral cephalograms taken at which subjects were 16 and 18 years of age. The sample consisted of 19 male and 14 female subjects with no previous orthodontic treatment who had normal occlusion. The craniofacial growth changes of these samples during this study period might be summarized as follows 1. Significant increase in mean maxillary and mandibular length, cranial base length, posterior md anterior facial height were observed at the age period studied in male(P<0.05), however, in female significant increase was observed only mandibular length(Ar-Gn, Ar-Go) and anterior and posterior facial height(P<0.05). 2. Total growth increment of all measumenats were below 1mm in female, but in male, total mandibular(Ar-Gn) growth increment was 2.0mm and those of mandibular tody length, ram length, posterior facial height, and anteior facial height were 1 to 1.54mm and the others were below 1mm 3. A closing, forward rotation of the mandible occured with a significant decrease in mandibular plane angle of $0.61^{\circ}$ in male(P<0.01). 4. Summarized the findings, even though statistically significant growth changes in some dimensions of female were observed, the amount of growth change were very small, however, in male the growth changes of some dimensions associated with mandible were significant and considerable amount.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.1
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• pp.63-70
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• 2001

Purpose: The aim of this study is to evaluate the effective role of living-related liver transplantation (LRLT) on posttransplant linear growth in children. Methods: Thirty six children were enrolled who received LRLT at Asan Medical Center from December, 1994 to February, 1999 and showed more than one-year postoperative survival. Mean height standard deviation score (zH) was analyzed according to medical records including heights during pretransplant and posttransplant follow-up periods. Results: zH of total children showed significant linear growth after LRLT from -1.58 to 0.33 at 24 posttransplant month (p<0.05). zH in children under 6 years of age, to exclude the effect of adolescent linear growth spurt, showed increment in height (p<0.05). Linear growth of children with liver cirrhosis improved and that with fulminant hepatitis was matained same. While stunted children (mean zH=-2.30) achieved good catch-up growth after transplantation, children with normal growth remained same. Children with significant hepatic dysfunction after LRLT such as chronic rejection or posttransplant lymphoproliferative disorder showed retarded posttrasplant linear growth. There was no statistical difference according to the type of immunosuppressants. Conclusion: LRLT resulted in adequate or catch-up linear growth in children with acute, chronic and metabolic liver disease. Successful LRLT suggested to be a promising option not only in long term survival but also in normal linear growth.

• Development and Reproduction
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• v.11 no.3
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• pp.245-251
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• 2007

Vinclozolin(VCZ), a systemic dicarboximide fungicide, has been used in the control of diseases caused by microorganism of some species in fruits, vegatables and ornamental plants. Although VCZ itself is a very weak antagonist for androgen receptor binding, both melabolites M1 and M2 are effective antagonists. The present study was undertaken to examine whether prepubertal exposure to VCZ affects on the onset of puberty and the associated reproductive parameters such as hormone receptor expressions in female rats. VCZ(10 mg/kg/day) was administered daily from postnatal day 21(PND 21) through the day when the first vaginal opening(V.O.) was observed. Gross anatomy and weight of reproductive tissues were compared to test the VCZ's effects on the cell proliferation. Furthermore, histological studies were performed to assess the structural alterations in the tissues. To determine the transcriptional changes in progesterone receptor(PR), total RNAs were extracted and applied to the semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). As a result, delayed V.O. was shown in the VCZ group(PND $34.00{\pm}1.22$) compared to the control group(PND $38.20{\pm}1.92$; p<0.01). VCZ treatment significantly decreased the wet weight of ovaries and uteri compared to the control group(p<0.01). Graafian follicles and corpora lutea were observed only in the ovaries from the control animals, while numerous primary, secondary follicles and small atretic follicles were observed in the ovaries from VCZ group. Similarly, hypotrophy of luminal and glandular uterine epithelium was found in the VCZ group. In the semi-quantitative RT-PCR studies, the transcriptional activity of PR in ovary(p<0.01) from VCZ group were significantly lower than those from the control group while in uterus were similar compared with the control group. The present studies demonstrated that the acute exposure to VCZ during the critical period of prepubertal stage could inactivate the reproductive system resulting delayed puberty in female rats.

• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.111-118
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• 2009

Puopose : Exposure to dietary phytoestrogens such as genistein during early childhood is a growing public health concern. We examined the effect of early exposure to genistein on sexual maturation in immature rats. Methods : Weaning (3wk-old) Sprague-Dawley female rats were assigned to three groups (n=6 for each): fed by high dose of genistein (100 mg/kg/d), low dose of genistein (10 mg/kg/d) and control group. First vaginal opening (VO) day was observed. Structural alterations in the ovary and uterus were assessed by histologically. Expression of genes of $ER{\alpha}$, $ER{\beta}$, and progesterone receptor (PR) in the ovary and uterus were investigated by RT-PCR. Results : High genistein group had earlier VO than control and low genistein group. Graafian follicles and corpora lutea were observed from the ovary of genistein-treated groups, while primary, secondary follicles and small atretic follicles were observed in the control group. Hypertrophy of luminal and glandular uterine epithelia were found in the genistein-treated groups while poor development of gland and fewer myometrial cell layers were evident in control group. In ovary, the transcriptional activities of $ER{\alpha}$ and $ER{\beta}$ were higher in high genistein group than in controls. In uterus, the transcriptional activities of $ER{\alpha}$, $ER{\beta}$ and PR were higher in low genistein group than in controls. Conclusion : Acute exposure to genistein during the prepubertal period could activate the reproductive endocrine system resulting in the early onset of puberty in female rats. Further clinical investigation on the effect of genistein on the sexual maturation in children is warranted.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.1
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• pp.47-57
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• 2001

Heights of children ranged from 91.10 to 144.70 and the mean height rate after the administration of Boyangsungjangtang was significantly greater than that, 0.036, of prepuberty children who are in 50 percentile(One sampled T test, p<0.001). A highly significant difference was observed among three groups, divided according to the duration of taking Boyangsungjangtang(ANOVA, p=0.015). Further analysis(Tukey's Multiple Range test) indicated that the mean height rate of the group taking Boyangsungjangtang for under 3 months was significantly higher than that of both group for 3 to 6 months and group for over 6 months. The mean height rate of the latter two groups were not significantly different.