• Title/Summary/Keyword: 사립체

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Lack of Association of the Mitochondrial DNA 5178 A/C Polymorphism with Hypertension in a Korean Population (한국인 집단에서 사립체 DNA에 존재하는 5178 A/C 다형성과 고혈압과의 관련성에 관한 연구)

  • Kang, Byung-Yong;Kim, Seon-Jeong;Jang, Dai-Ho;Kim, Hyun-Hee;Lee, Kang-Oh
    • Environmental Analysis Health and Toxicology
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    • v.18 no.1
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    • pp.27-32
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    • 2003
  • 고혈압은 다양한 유전적 요인과 환경적 요인이 상호작용하는 다인자성 질환으로 알려져 있으며, 최근의 연구에 의하면 사립체 DNA에 존재하는 유전적 다형성이 고혈압과 유의한 관련성을 나타낸다는 보고가 있다. 이에 본 연구에서는 한국인 집단을 대상으로 하여 사립체 DNA의 5178번째 위치의 염기서열에 존재하는 A/C 다형성이 고혈압과 관련성을 나타내는 지를 분석하였다. 환자-대조군 연구를 수행한 결과, 사립체 DNA의 5178번째 위치에 존재하는 다형성의 대립 유전자 빈도는 한국인에서 고혈압군과 정상 혈압군 사이에 유의한 차이를 나타내지 않았다. 따라서, 이 다형성은 적어도 한국인에 대해서는 고혈압에 유의하게 영향을 미치는 유전적 소인은 아닌 것으로 사료된다.

A Patient with Mitochondrial Myopathy who Experienced Diabetic Ketoacidosis with Auto-antibody (사립체 근병증 환자에서 발생한 자가항체 양성의 당뇨병성 케톤산증 1례)

  • Nam, Soon Young;Huh, Rimm;Kwun, Younghee;Lee, Jieun;Cho, Sung Yoon;Jin, Dong-Kyu
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.14 no.2
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    • pp.191-194
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    • 2014
  • Mitochondrial myopathy results from a primary dysfunction of the respiratory chain and is frequently accompanied with endocrine manifestations. Among the endocrine manifestations of mitochondrial disease, diabetes mellitus is relatively common. Diabetes mellitus in the mitochondrial myopathy is usually insulin dependent due to the defect in insulin secretion resulted from mitochondrial dysfunction. But it is seldom manifested as diabetes ketoacidosis and doesn't usually have an auto-antibody. We report a patient with mitochondrial myopathy who was diagnosed as having diabetes mellitus by presenting as diabetes ketoacidosis and had both of the auto-glutamic acid decarboxylase (GAD) antibody and anti-insulin auto-antibody.

Histological Study on the Effects of the Green-Tea in Rat Liver Toxicated by Lead (녹차가 납 중독된 흰쥐의 간장에 미치는 형태학적 연구)

  • Chung, Kyoung-A;Roh, Young-Bok
    • Applied Microscopy
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    • v.30 no.2
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    • pp.165-172
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    • 2000
  • To investigate the defensive effect of green tea against the lead toxicity, Sprague-Dewley rats (150 gm) were divided into 5 groups; the control group, the group treated with lead for 4 weeks (Group A-1), the group treated with lead and green tea for 4 weeks (Group A-2), the group treated with lead for 8 weeks (Group B-1), and the group treated with lead and green tea for 8 weeks (Group B-2). The lead acetate (500 ppm) was injected two times for one week into the abdomen and green tea solution (3 g/100 ml distilled water) offered freely. In the liver cell, The cristae of mitochondria were enlarged, the rough endoplasmic reticulum (rER) extended and many lysosome observed on the Group A- 1. The cristae of mitochondria were enlarged and many lysosome observed, but nucleus was normal on the Croup A-2. All of observed parts on the Group B-1 deeply wounded by lead than the group A-1. In the Group B-2, the mitochondria and rER were increased in number than the Group B-1 and the nucleus was observed normally.

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A Case of Leber's Hereditary Optic Neuropathy Showing 11778 Point Mutation of Mitochondrial DNA (사렵체 DNA의 11778 점돌연변이가 확인된 Leber씨 유전성 시신경병증 1례)

  • Jung, Yun-Seok;Park, Seung-Kwon;Lee, Seung-Yeop;Hah, Jung-Sang;Park, Mee-Yeoung;Lee, Se-Jin;Lee, Jun
    • Journal of Yeungnam Medical Science
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    • v.16 no.1
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    • pp.114-118
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    • 1999
  • Leber's hereditary optic neuropathy(LHON) is an optic nerve disease that causes blindness and is associated with maternally inherited mitochondrial DNA(mt DNA) mutations. The most common mitochondrial DNA mutation among LHON patients is a point mutation at the nucleotide 11778 in the subunit 4 of complex I. In one 45-year old male LHON patient with bilateral optic neuropathy. we investigated the presence of a point mutation of mitochondrial DNA and identified a single guanine to adenine transition mutation in the mitochondrial DNA at nucleotide point 11778.

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Visually evoked potential in children with mitochondrial respiratory chain defects (소아 사립체 질환에서 시각 유발전위검사의 유용성)

  • Song, Ji Eun;Kim, He Min;Lee, Sang-Chul;Park, Yoon-Gghil;Byeon, Suk-Ho;Lee, Young-Mock;Lee, Joon-Soo;Kim, Heung-Dong
    • Clinical and Experimental Pediatrics
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    • v.52 no.4
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    • pp.471-475
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    • 2009
  • Purpose : Mitochondrial disorders are a clinical entity characterized by diverse symptoms and signs of involvement of various systems. Furthermore, the disorders are known to show ophthalmologic manifestations as well as neurological findings. Visually evoked potential is a sensitive measure to check the integrity of the visual pathway. In this study, we have investigated the value of visually evoked potential in mitochondrial disorders with respiratory chain defects. Methods : Nineteen patients diagnosed with mitochondrial respiratory chain complex I defect as confirmed by spectrophotometric enzyme assay in muscle samples were enrolled for this study. The patients underwent a visually evoked potential study. We classified the results into four groups and compared these with clinical ophthalmologic findings. Results : Among the 19 patients, 14 showed abnormal visually evoked potential findings. Seven patients showed abnormal clinical ophthalmologic findings. All patients with abnormal ophthalmologic findings showed abnormal visually evoked potential findings. Among the 12 patients with normal ophthalmologic findings, seven showed abnormal results in visually evoked potential. Conclusion : Visually evoked potential study could be used as an effective screening tool for mitochondrial disorders to detect ophthalmologic and neurological abnormalities.

Metabolic Abnormalities in Patients with Mitochondrial Myopathy Evaluated by In Vivo $^{31}$P Magnetic Resonance Spectroscopy (인($^{31}$P) 자기공명분광법을 사용하여 사립체 근질병환자와 정상인과의 대사물질 비교조사)

  • Bo-Young Choe
    • Investigative Magnetic Resonance Imaging
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    • v.2 no.1
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    • pp.89-95
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    • 1998
  • Purpose : To investigate the phosphorus metabolic abnormalities in skeletal muscle of patients with mitochondrial myopathy using in vivo $^{31}P$ magnetic resonance spectroscopy(MRS). Materials and Methods : Patients with mitochondrial myopathy(N=10) and normal control subjects (N=10) participated. All in vivo $^{31}P$ MRS examinations were performed on 1.5T whole-body MRI/MRS system by using an image selected in vivo spectroscopy (ISIS) pulse sequence that provided a $4{\times}4{\times}4{\;}cm^{3}$ volume of interest (VOI) in the right thigh muscle tissue. Peak areas for each phophorus methabolite were measured using a Marquart algorithm. Results : The specific features in patients with mitochondrial myopathy were a significant increase of Pi/PCr ratio (p=0.003) and a significant decrease of ATP/PCr ratio (p=0.004) as compared with normal controls. In particular, the ${\beta}-ATP/PCr$ ratio between controls and patients with mitochondrial myopathy was predominantly altered. Conclusions : In vivo $^{31}P$ MRS may be a useful modality in the clinical evaluation of patients with mitochondrial myopathy based on ATP/PCr and Pi/PCr ratios in skeletal muscle tissue and provides a valuable information in further understanding disorders of muscle metabolism.

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Morphometrical Analysis of Developing Renal Tubular and Glomerular Cells in Rabbit (토끼의 발생기 뇨세관과 사구체 세포들의 형태계측학적인 분석)

  • 정호중;양영철;배기원
    • Journal of Life Science
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    • v.8 no.4
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    • pp.449-456
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    • 1998
  • Using morphometric technique, the present study was made of the kidney of rabbit embryo in the 13 days of the gestation. Their section areas of the renal tubules and the glomerular cells were compared with the those of adult rabbit, 1. In the developing renal tubule, the tubular section areas were larger than that of the adult, but the nuclear section areas of tubular calls were smaller than the adult. The microvilli of their cell surface were poorly developed, and their cytoplasm contained well developed mitochondria with euchromatic nucleus. 2. In the developing glomeruli. the nuclear section area of the cells of the parietal layer, the podocytes, and the endothelial cells were similar size, but their nuclei were larger than those of the adult. The cytopalsm of the podocytes contained well-developed rough endoplasmic reticulum, Golgi apparatus, and round mitochondria.

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사립체 질환

  • Lee, Yeong-Mok
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.11 no.1
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    • pp.99-102
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    • 2011
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Radiation Damage Mechanism of the Small Intestine's Absorptive Epithelium and Radioprotection Effect after Propolis Abdominal Cavity Injection (프로폴리스 복강 주사 후 소장 흡수상피조직의 방사선 손상 기전과 방어효과)

  • Ji, Tae-Jeong;Lee, Sang-Hun
    • The Journal of the Korea Contents Association
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    • v.10 no.7
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    • pp.297-304
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    • 2010
  • As Small Intestine Absorptive Epithelium Cells are surrounded by mucus polysaccharide and lymphocytes and mitochondria, they are sensitive to radiation energy. Damaged cells lead to a deficiency of nutrients and the imbalance of electrolyte metabolism, which in turn can becomes a major cause of an intestine tract death. This research observed ultra structures after injecting propolis into the abdominal cavity in order to reveal the radiation damage mechanism and radioprotection effect of intestine absorptive epithelium cells. The result of this research's observation found that stenosis occurred in the small intestine in some tissues 20 days after 5Gy irradiation, their surface turned black, and their elasticity dropped. Through observation with an optical microscope, it was found that the size of the goblet cells decreased, while the paneth granulate cells atrophied and were vacuolated. Observation with an transmission electron microscope(TEM) revealed that while microvill and lysosome were normally observed in jejunum tissues, mitochondria membrane was damaged and uneven surfaces were formed on lymphocytes. The membrane of absorptive epithelium cells hypertrophied in tissues of the ileum, and vacuole was observed. However, the observation after injecting propolis into the abdominal cavity found that mitochondria damage dropped dramatically, and radioprotection effects were to some extent confirmed, considering that glycocalyx of villi was clear, and M cells could be observed.