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http://dx.doi.org/10.5392/JKCA.2010.10.7.297

Radiation Damage Mechanism of the Small Intestine's Absorptive Epithelium and Radioprotection Effect after Propolis Abdominal Cavity Injection  

Ji, Tae-Jeong (가야대학교 방사선학과)
Lee, Sang-Hun (가야대학교 방사선학과, 한국물리학회)
Publication Information
The Journal of the Korea Contents Association / v.10, no.7, 2010 , pp. 297-304 More about this Journal
Abstract
As Small Intestine Absorptive Epithelium Cells are surrounded by mucus polysaccharide and lymphocytes and mitochondria, they are sensitive to radiation energy. Damaged cells lead to a deficiency of nutrients and the imbalance of electrolyte metabolism, which in turn can becomes a major cause of an intestine tract death. This research observed ultra structures after injecting propolis into the abdominal cavity in order to reveal the radiation damage mechanism and radioprotection effect of intestine absorptive epithelium cells. The result of this research's observation found that stenosis occurred in the small intestine in some tissues 20 days after 5Gy irradiation, their surface turned black, and their elasticity dropped. Through observation with an optical microscope, it was found that the size of the goblet cells decreased, while the paneth granulate cells atrophied and were vacuolated. Observation with an transmission electron microscope(TEM) revealed that while microvill and lysosome were normally observed in jejunum tissues, mitochondria membrane was damaged and uneven surfaces were formed on lymphocytes. The membrane of absorptive epithelium cells hypertrophied in tissues of the ileum, and vacuole was observed. However, the observation after injecting propolis into the abdominal cavity found that mitochondria damage dropped dramatically, and radioprotection effects were to some extent confirmed, considering that glycocalyx of villi was clear, and M cells could be observed.
Keywords
Small Intestine Tissue; Mitochondria; TEM; Propolis; Radioprotection;
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