• Journal of Food Hygiene and Safety
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• v.13 no.4
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• pp.394-399
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• 1998

결명자의 주용성분인 노르-루브로푸사린의 함량이 높은 추출물을 얻기 위하여 결명자분말을 0~100%의 에탄올수용액으로 추출하여 고농도의 노르-루브로푸사린을 함유하는 결명자 추출물을 제조하였다. 결명자추출물과 주요 함유성분인 노르-루브로푸사린은 항산화활성과 프리라디칼소거 작용을 나타내었으며, H2O2 유도 세포독성에 대해서도 억제적으로 작용하여 cyto-protective effect를 나타내었다. 또한 DNA crosslinking agent 인 mitomycin C 유도 소핵생성에도 결명자 70% 에탄올추출물과 노르-루브로파사린이 매우 높은 억제활성을 나타내었다. 따라서 결명자 추출물과 노르-루브로푸사린은 산소라디칼들에 의한 산화적 손상 및 DNA 손상 등에 억제적으로 작용하는 기전을 활용하여 항산화성 스트레스를 통한 항노화 , 암예방제로서의 응용가능성이 높은 물질로 판단되었다.

• Korean Chemical Engineering Research
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• v.45 no.2
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• pp.172-177
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• 2007

The hydrolysis reaction of sarin(GB), one of the nerve agents was studied in aqueous sodium hydroxide(NaOH) solutions to find the experimental conditions which can convert GB into the less toxic compounds. 10 wt% of GB was added into the aqueous NaOH(2.05 eq) in a small-scale jacket-attached reactor connected to a circulator. The reaction rate constants were measured at three temperatures(50, 70 and $90^{\circ}C$) and the reaction times required to degrade the material to > 99% were calculated at different temperatures. In this study, 10 wt% of GB was degraded to 99.99% in 1.2hr at $90^{\circ}C$ by the aqueous NaOH solution. The major hydrolysate of GB was isopropyl methylphosphonate.

• Korean Journal of Veterinary Research
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• v.34 no.1
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• pp.141-146
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• 1994

돈육의 가열과 냉동저장시 잔류된 설폰아미드가 증가 또는 감소되는 정도를 조사하였다. 설파메라진, 설파메타진, 설파모노메톡신, 설파디메톡신, 설파퀴녹사린을 돈육에 100ng/g씩 주사하고 30분간 $60^{\circ}C$로 가열하였을 때 설파메타진은 40%증가하였으나, $60-120^{\circ}C$로 가열한 다른 설폰아미드는 12-22% 감소하였다. 4주간 $-20{^{\circ}C}$이하로 냉동하였을 때, 설파메라진과 설파퀴녹사린은 각각 12%, 19% 감소하였으나 다른 설폰아미드는 변화가 없었다. 설폰아미드의 검출한계는 고상분산을 이용한 정제시 2.6-27ng/g이있으며, 액상분배를 이용한 정제시 25-36ng/g이었다. 본 실험의 결과 돈육중의 설폰아미드는 가열과 냉동저장에 따라 안정성이 변화될 수 있으며, 잔류물 정제방법으로는 고상분산과 액상분배방법을 이용할 수 있을 것으로 생각된다.

• 한국상하수도협회지
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• s.15
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• pp.140-153
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• 2006

• Proceedings of the Optical Society of Korea Conference
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• 2006.07a
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• pp.201-202
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• 2006

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.1
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• pp.144-150
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• 2021

This study was designed to evaluate the prophylactic efficacy of a combinational patch system containing physostigmine and procyclidine against sarin and soman using guinea pig. The median lethal dose values of two nerve agents were calculated by a probit analysis of deaths occurring within 24 h. In this study, the values of median lethal dose of sarin and soman were determined to be 33.0 and 26.7 ㎍/kg in guinea-pigs, respectively. The guinea pigs treated with a prophylactic patch(4×5 ㎠) for 24 h were 100 % protected against a challenge of 1.5 LD50. The combinational KMARK-1(atropine and 2-PAM) and prophylactic patch were more effective than a single KMARK-1, a combination of pyridostigmine and KMARK-1 significantly. Epileptiform seizures in the guinea pigs treated with the combinational antidotes led to neuropathological changes, in comparison with intact feature of brain of the animal treated with the patch.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.15 no.1
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• pp.127-132
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• 2006

The present study deals with polishing machining of diamond for jewelry using developed automatic polishing machine that can cut diamond to have 58 facets in a brilliant cutting which has been hardly achieved by a conventional manually operating polishing machine. Upon the 3-dimensional Sarin M/C test and analysis on the machined diamond by the developed automatic polishing machine its proportion and finishing turned out to be better than the machined diamond by the conventional manually operating polishing machine.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.313-318
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• 2005

The present study deals design and manufacture of automatic polishing machine that can cut diamond to have 58 facets in a brilliant cutting which has been hardly achieved by a conventional manually operating polishing machine. Upon the 3-dimensional Sarin M/C test and analysis on the diamond processed by the automatic polishing machine developed in this study its proportion and finishing turned out to be better than the diamond processed by the conventional method, by being rated as 'very good'.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.05a
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• pp.474-475
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• 2018

전 세계적으로 9.11로 대표되는 자살테러, 비행기테러, 화학가스 테러 등에 의한 인명피해가 늘고 있다. 1986년 김포공항 폭발사고, 1995년 음진리교 지하철 사린가스 사건, 2001년 9.11 사건, 2003년 필리핀 공항 폭탄테러 사건 등의 큰 테러 외에도 작은 사건은 무수히 많다. 이러한 테러 사태를 미연에 방지하기 위한 지능형 영상 보안 감시 시스템이 사회적으로 연구되어왔고 도입되어 왔다. 기존의 지능형 영상 보안 시스템은 모션 디렉션 기반으로 금지구역의 침입자로 판단되는 사람을 찾는 기능 중심으로 발전해왔다. 또한 보안요원의 관찰 모니터를 통해 화면을 계속 주시하는 한계 시간의 존재와 모니터 증가에 따른 한계 시간은 더 급감하게 되는 것으로 판단되었다. 이에 본 연구를 통해 유기물 탐지의 자동화를 추구하고, 보안 요원의 감시 업무를 도와 국가 주요 시설물의 유기물 자동 탐지를 통해 테러로부터 안전하게 보호하고자 한다.

• Applied Chemistry for Engineering
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• v.26 no.1
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• pp.17-22
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• 2015

International interests in chemical warfare agents (CWAs) have been increased recently because of the use of sarin (GB) in Syrian civil war which caused around 1,300 casualties in 2013. After exposing to natural environments, CWAs undergo hydrolysis or photodegrade to non-toxic degradation byproducts. Generally, CWAs and their degradation byproducts are present at very low concentration (e.g. several ppb), thus pretreatment processes including separation, extraction and concentration are required prior to any analyses. Liquid-liquid extraction and solid-phase extraction (SPE) are common techniques to pretreat environmental samples. Recently, a novel pretreatment method, liquid phase miecoextraction (LPME), has been applied to CWAs analysis, which could reduce amounts of solvent used but promote analytical efficiencies. Fundamental backgrounds of LPME and its application to CWAs analysis were reviewed.