• The Journal of Korean Society for Radiation Therapy
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• v.16 no.1
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• pp.57-65
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• 2004

Introduction : The phantom that includes high density materials such as steel was custom-made to fix lung and bone in order to evaluation inhomogeneity correction at the time of conducting radiation therapy to treat lung cancer. Using this, values resulting from the inhomogeneous correction algorithm are compared on the 2 and 3 dimensional radiation therapy planning systems. Moreover, change in dose calculation was evaluated according to inhomogeneous by comparing with the actual measurement. Materials and Methods : As for the image acquisition, inhomogeneous correction phantom(Pig's vertebra, steel(8.21g/cm3), cork(0.23 g/cm3)) that was custom-made and the CT(Volume zoom, Siemens, Germany) were used. As for the radiation therapy planning system, Marks Plan(2D) and XiO(CMS, USA, 3D) were used. To compare with the measurement value, linear accelerator(CL/1800, Varian, USA) and ion chamber were used. Image, obtained from the CT was used to obtain point dose and dose distribution from the region of interest (ROI) while on the radiation therapy planning device. After measurement was conducted under the same conditions, value on the treatment planning device and measured value were subjected to comparison and analysis. And difference between the resulting for the evaluation on the use (or non-use) of inhomogeneity correction algorithm, and diverse inhomogeneity correction algorithm that is included in the radiation therapy planning device was compared as well. Results : As result of comparing the results of measurement value on the region of interest within the inhomogeneity correction phantom and the value that resulted from the homogeneous and inhomogeneous correction, gained from the therapy planning device, margin of error of the measurement value and inhomogeneous correction value at the location 1 of the lung showed $0.8\%$ on 2D and $0.5\%$ on 3D. Margin of error of the measurement value and inhomogeneous correction value at the location 1 of the steel showed $12\%$ on 2D and $5\%$ on 3D, however, it is possible to see that the value that is not correction and the margin of error of the measurement value stand at $16\%$ and $14\%$, respectively. Moreover, values of the 3D showed lower margin of error compared to 2D. Conclusion : Revision according to the density of tissue must be executed during radiation therapy planning. To ensure a more accurate planning, use of 3D planning system is recommended more so than the 2D Planning system to ensure a more accurate revision on the therapy plan. Moreover, 3D Planning system needs to select and use the most accurate and appropriate inhomogeneous correction algorithm through actual measurement. In addition, comparison and analysis through TLD or film dosimetry are needed.

• The Journal of Korean Society for Radiation Therapy
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• v.18 no.2
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• pp.75-80
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• 2006

Purpose: In radiation therapy, precise calculation of dose toward malignant tumors or normal tissue would be a critical factor in determining whether the treatment would be successful. The Radiation Treatment Planning (RTP) system is one of most effective methods to make it effective to the correction of dose due to CT number through converting linear attenuation coefficient to density of the inhomogeneous tissue by means of CT based reconstruction. Materials and Methods: In this study, we carried out the measurement of CT number and calculation of mass density by using RTP system and the homemade inhomogeneous tissue Phantom and the values were obtained with reference to water. Moreover, we intended to investigate the effectiveness and accuracy for the correction of inhomogeneous tissue by the CT number through comparing the measured dose (nC) and calculated dose (Percentage Depth Dose, PDD) used CT image during radiation exposure with RTP. Results: The difference in mass density between the calculated tissue equivalent material and the true value was ranged from $0.005g/cm^3\;to\;0.069g/cm^3$. A relative error between PDD of RTP and calculated dose obtained by radiation therapy of machine ranged from -2.8 to +1.06%(effective range within 3%). Conclusion: In conclusion, we confirmed the effectiveness of correction for the inhomogeneous tissues through CT images. These results would be one of good information on the basic outline of Quality Assurance (QA) in RTP system.

• The Journal of Korean Society for Radiation Therapy
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• v.18 no.2
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• pp.89-96
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• 2006

Purpose: To study effectiveness of heterogeneity correction of internal-body inhomogeneities and patient positioning immobilizers in dose calculation, using images obtained from CT-Simulator. Materials and Methods: A water phantom($250{\times}250{\times}250mm^3$) was fabricated and, to simulate various inhomogeneity, 1) bone 2) metal 3) contrast media 4) immobilization devices(Head holder/pillow/Vac-lok) were inserted in it. And then, CT scans were peformed. The CT-images were input to Radiation Treatment Planning System(RTPS) and the MUs, to give 100 cGy at 10 cm depth with isocentric standard setup(Field Size=$10{\times}10cm^2$, SAD=100 cm), were calculated for various energies(4, 6, 10 MV X-ray). The calculated MUs based on various CT-images of inhomogeneities were compared and analyzed. Results: Heterogeneity correction factors were compared for different materials. The correction factors were $2.7{\sim}5.3%$ for bone, $2.7{\sim}3.8%$ for metal materials, $0.9{\sim}2.3%$ for contrast media, $0.9{\sim}2.3%$ for Head-holder, $3.5{\sim}6.9%$ for Head holder+pillow, and $0.9{\sim}1.5%$ for Vac-lok. Conclusion: It is revealed that the heterogeneity correction factor calculated from internal-body inhomogeneities have various values and have no consistency. and with increasing number of beam ports, the differences can be reduced to under 1%, so, it can be disregarded. On the other hand, heterogeneity correction from immobilizers must be regarded enough to minimize inaccuracy of dose calculation.

• Journal of Radiation Protection and Research
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• v.23 no.3
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• pp.139-147
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• 1998

Purpose: Tissue inhomogeneity such as lung affects tumor dose as well as transmission dose in new concept of on-line dosimetry which estimates tumor dose from transmission dose using the new algorithm. This study was carried out to confirm accuracy of correction by tissue density in tumor dose estimation utilizing transmission dose. Methods: Cork phantom (CP, density $0.202\;gm/cm^3$) having similar density with lung parenchyme and polystyrene phantom (PP, density $1.040\;gm/cm^3$) having similar density with soft tissue were used. Dose measurement was carried out under condition simulating human chest. On simulating AP-PA irradiation, PPs with 3 cm thickness were placed above and below CP, which had thickness of 5, 10, and 20 cm. On simulating lateral irradiation, 6 cm thickness of PP was placed between two 10 cm thickness CPs additional 3 cm thick PP was placed to both lateral sides. 4, 6, and 10 MV x-ray were used. Field size was in the range of $3{\times}3$ cm through $20{\times}20$ cm, and phantom-chamber distance (PCD) was 10 to 50 cm. Above result was compared with another sets of data with equivalent thickness of PP which was corrected by density. Result: When transmission dose of PP was compared with equivalent thickness of CP which was corrected with density, the average error was 0.18 (${\pm}0.27$) % for 4 MV, 0.10 (${\pm}0.43$) % for 6 MV, and 0.33 (${\pm}0.30$) % for 10 MV with CP having thickness of 5 cm. When CP was 10 cm thick, the error was 0.23 (${\pm}0.73$) %, 0.05 (${\pm}0.57$) %, and 0.04 (${\pm}0.40$) %, while for 20 cm, error was 0.55 (${\pm}0.36$) %, 0.34 (${\pm}0.27$) %, and 0.34 (${\pm}0.18$) % for corresponding energy. With lateral irradiation model, difference was 1.15 (${\pm}1.86$) %, 0.90 (${\pm}1.43$) %, and 0.86 (${\pm}1.01$) % for corresponding energy. Relatively large difference was found in case of PCD having value of 10 cm. Omitting PCD with 10 cm, the difference was reduced to 0.47 (${\pm}$1.17) %, 0.42 (${\pm}$0.96) %, and 0.55 (${\pm}$0.77) % for corresponding energy. Conclusion When tissue inhomogeneity such as lung is in tract of x-ray beam, tumor dose could be calculated from transmission dose after correction utilizing tissue density.

• The Journal of the Petrological Society of Korea
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• v.9 no.3
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• pp.142-168
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• 2000

The granites distributed in the Kyongsang basin contain the rocks which are different from the host rocks, and they are known as magic microgranular enclaves. The genesis of the magic micro-granular enclaves can be divided into four types: (1) rock fragments from country rocks; (2) cumulation of the early crystals in host magma or disruption of early chilled borders; (3) magma mingling; and (4) restite. These enclaves can be easily found in the granites around Mt. Wonhyo, Yangsan city. They are ellipsoidal in shape, and have phenocrysts might be originated from the host rocks and sharp contacts with the granites. Under the microscope, textures such as oscillation zoning, horn-blende-mantled quartz, rapakivi texture, and acicular apatite are observed, and these indicate that the enclaves were originated from magma and then produced by chilling. The evidences showing that the enclaves were formed by magma mingling are: (1) petrographical characteristics; (2) similarity of the compositions between the rim of plagioclase in the enclave and plagioclase in the granite; (3) linear trends of the major elements; (4) total REE content of the enclaves; and (5) Textural and compositional variations from rim to core in zoned enclaves. The magic end member of the enclave is regarded as the aphyric basaltic andesite in Mt. Sinbul-Youngchui area. The granites around Mt. Wonhyo experienced the magma mingling process which was produced by the injection of mafic magma at about 70 Ma, during the crystal differentiation, and then continued the crystallization. The equigranular granites and the micrographic granites in the study area are considered as the results after the magma mingling process.

• Journal of Radiation Protection and Research
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• v.27 no.1
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• pp.37-49
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• 2002

The accuracy of radiation dose delivery to target volume is one of the most important factors for good local control and less treatment complication. In vivo dosimetry is an essential QA procedure to confirm the radiation dose delivered to the patients. Transmission dose measurement is a useful method of in vivo dosimetry and it's advantages are non-invasiveness, simplicity and no additional efforts needed for dosimetry. In our department, in vivo dosimetry system using measurement of transmission dose was manufactured and algorithms for estimation of transmission dose were developed and tested with phantom in various conditions successfully. This system was applied in clinic to test stability, reproducibility and applicability to daily treatment and the accuracy of the algorithm. Transmission dose measurement was performed over three weeks. To test the reproducibility of this system, X-tay output was measured before daily treatment and then every hour during treatment time in reference condition(field size; $10 cm{\times} 10 cm$, 100 MU). Data of 11 patients whose pelvis were treated more than three times were analyzed. The reproducibility of the dosimetry system was acceptable with variations of measurement during each day and over 3 week period within ${\pm}2.0%$. On anterior- posterior and posterior fields, mean errors were between -5.20% and +2.20% without bone correction and between -0.62% and +3.32% with bone correction. On right and left lateral fields, mean errors were between -10.80% and +3.46% without bone correction and between -0.55% and +3.50% with bone correction. As the results, we could confirm the reproducibility and stability of our dosimetry system and its applicability in daily radiation treatment. We could also find that inhomogeneity correction for bone is essential and the estimated transmission doses are relatively accurate.

• Radiation Oncology Journal
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• v.22 no.2
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• pp.155-163
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• 2004

Purpose : To confirm the reproducibility of in vivo transmission dosimetry system and the accuracy of the a1gorithms for the estimation of transmission dose in head and neck radiation therapy patients. Materials and Methods : From September 5 to 18, 2001, transmission dose measurements were peformed when radiotherapy was given to brain or head and neck cancer patients. The data of 35 patients who were treated more than three times and whose central axis of the beam was not blocked were analyzed in this study. To confirm the reproducibility of this system, transmission dose was measured before dally treatment and then repetitively every hour during the treatment time, with a field size of 10$\times$10 cm$^{2}$ and a delivery of 100 MU. The accuracy of the transmission dose calculation algorithms was confirmed by comparing estimated dose with measured dose. To accurately estimate transmission dose, tissue inhomogeneity correction was done. Results : The measurement variations during a day were within $\pm$0.5$\%$ and the dally variations in the checked period were within $\pm$ 1.0$\%$, which were acceptable for system reproducibility. The mean errors between estimated and measured doses were within $\pm$5.0$\%$ in Patients treated to the brain, $\pm$2.5$\%$ in head, and $\pm$ 5.0%$\%$in neck. Conclusion : The results of this study confirmed the reproducibility of our system and its usefulness and accuracy for dally treatment. We also found that tissue inhomogeneity correction was necessary for the accurate estimation of transmission dose in patients treated to the head and neck.

• Journal of the Korean Ceramic Society
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• v.25 no.3
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• pp.225-230
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• 1988

The strength and thermal shock resistance of $Al_2O_3-ZrO_2$ composites have been studied. The tetragonal $ZrO_2$ powder containing 1 mol.% $Y_2O_3$ and monoclinic $ZrO_2$ powder were prepared by coprecipitation method and subsequently mixed with $Al_2O_3$ powder and granulated by sieving. Duplex composites were prepared by dry mixing matrix agglomerate with 15 to 30 vol.% of dispersion agglomerate, followed by pressing and sintering at 1$600^{\circ}C$ for1 hr. These $Al_2O_3-ZrO_2$ 2 composites having heterogeneous structure showed improved thermal shock behaviors because of the microcracking and pores in dispersed granules, and compressive stresses around dispersed granules resulting from $ZrO_2$ transformation.

• Progress in Medical Physics
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• v.9 no.4
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• pp.247-257
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• 1998

For effective radiotherapy, it should always be considered that calculation of different dose distribution in heterogenous tissue is important particularly on lung which has low density and large volume. To take precise dose distribution of 6MV X-ray in the thoracic cage, the authors had made a tissue equivalent phantom for thorax, measured dose distribution by thermoluminescent dosimeter and mm dosimeter, and derived methmetical equation coincided with provided theoretical formula. In comparision with isodose curve on case of homogeneous soft tissue, dose of heterogeneous lung tissue had been shown increase about 4% per cm depth on one and multiportal field, less than 15% difference on rotation field for esophagus, and around 20% difference on rotation field for lung according to the degree of rotation angle that must be corrected by dose compensation.

• 한국지형공간정보학회:학술대회논문집
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• 2002.03a
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• pp.106-112
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• 2002

최근 급속한 도시의 팽창 및 신도시 건설과 산업의 발전으로 가스시설은 꾸준히 확대되고 있는 실정이다. 그리고 94년 아현동 도시가스사고와 95년 대구 도시가스사고 이후로 도시 가스 시설물의 대한 안전 대책 및 시설물 관리에 대한 국민들의 관심이 증대되었다. 이러한 흐름에 따라 가스회사들은 GIS 기술을 도입하여 기존에 수작업으로 관리되고 있는 가스시설 정보체계를 전산화하여 항상 최신의 현황을 유지하고, 사고 발생시 신속한 대처 방안 및 피해예측을 위한 시스템을 개발하기 위하여 많은 연구를 진행하고 있는 실정이다. 본 연구의 목적은 안전이 중요시되는 가스시설물에 대하여 가스사고 발생시 신속한 대처 및 처리방안을 제시할 수 있는 GIS 기반의 가스사고 관리시스템을 개발하는데 있다. GIS의 가스사고 관리시스템에서는 사고 발생시에 시설물 관리자가 사고 지점을 선택하여 우선적으로 공급을 중단해야 할 관로를 제시하고 사고지점을 검색하여 차단해야 할 밸브에 대한 정보를 신속히 제공하여 대응 방안을 제시 할 수 있도록 하였다. 아울러 가스공급이 중단되는 지역에 대한 정보를 추출하여 피해범위를 산정하여 효율적인 사고 관리를 지원하도록 구성되었으며, 이와 함께 잔존가스량을 구하여 사고후의 대처방안을 마련할 수 있는 기능을 제공하도록 하였다. 향후 연구과제로는 원격으로 가스 시설물을 감시하고 제어할 수 있는 원격감시/제어시스템(SCADA System)과 연계를 통하여 가스사고 후에 신속한 피해예측 및 피해를 최소화 할 수 있는 방안제시 및 GPS를 활용하여 신속한 사고처리를 할 수 있는 활용 방안을 연구하여 체계적이고 종합적인 가스사고의 관리가 필요하다고 사료된다. 또한, 사고 후의 긴급 대처방안 뿐만 아니라 잔존가스량을 이용하여 수용가에 가스의 신속한 재공급을 위한 정보의 제공까지 한 단계 발전된 시스템의 개발이 추진되어야 한다.남산지역에 대해 정사영상과 10m간격의 DEM을 제작하였으며 1:1000 수치지도를 통해 제작된 DEM과 비교한 결과 총 43990개 격자점의 표고 차이는 평균 5.98m였다.여재 높이 100 cm에서 원수를 하향류 및 상향류로 주입하면서 하향류 20, 40, 80, 100 cm, 상향류 20, 40, 60, 80, 100 cm에서 시료를 채취하여 분석한 결과 모두 원수가 주입되는 부근 여재 높이 20 cm에서 가장 많이 제거되었다. 상향류 보다 하향류로 원수를 주입했을 때 제거효율이 높았다. $Fe^{+++}$을 $Fe^{++}$로 환원하는 $O^{-}_{2}{\cdot}$의 작용을 대신할 수 있음을 증명하며 이와같은 ascorbate 의존적인 $OH{\cdot}$ 의 생성은 ascorbate가 조직손상에 관여할 가능성을 시사하였다.었다. 정확한 예측치를 얻기 위하여 불균질 조직이 조사야에 포함되는 경우 보정이 요구되며, 골반의 경우 골 조직의 보정이 중요한 요인임을 알 수 있었다. 이를 위하여 불균질 조직에 대한 정확한 정보가 요구되며, 이는 CT 영상을 이용하는 것이 크게 도움이 되리라 생각된다.전시 슬러지층과 상등액의 온도차를 측정하여 대사열량의 발생량을 측정하고 슬러지의 활성을 측정할 수 있는 방법을 개발하였다.enin과 Rhaponticin의 작용(作用)에 의(依)한 것이며, 이는 한의학(韓醫學) 방제(方劑) 원리(原理)인 군신좌사(君臣佐使) 이론(理論)에서 군약(君藥)이 주증(主症)에 주(主)로 작용(作用)하는 약물(藥物)이라는 것을 밝혀주는 것이라고 사료(思料)된다.일전 $13.447\;{\mu}g/hr/g$, 섭취 7일중 $8.123\;{\mu}g/hr/g$, 절식 14일후 $10.612