• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.155-163
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• 2007

Purpose: Dysmenorrhea is a women's common disease. The aim of this study is to investigate the relation between body composition and VAS, VRS, MVRS of dysmenorrhea. Methods: The subject were 17 women who took body composition(body mass index, percent body fat, waist-hip ratio) analysis(Inbody 720) and answered the questionnaire have been calculated VAS, VRS and MVRS in Kangnam Korean Hospital, Kyunghee Univ. from Apr. 6, 2007 to Mar. 25, 2007. Results: There was statistically significant correlation between BMI and dysmenorrhea VRS, MVRS. There was statistically significant correlation between BMI and dysmenorrhea VRS, MVRS. There was statistically significant correlation between percent body fat and dysmenorrhea VRS, MVRS. There was statistically significant difference of dysmenorrhea VRS, MVRS between BMI underweight group and BMI normal or overweight group. There was statistically significant difference of dysmenorrhea VAS between waist-hip ratio normal group and waist-hip ratio abnormal group. Conclusion: Body composition analysis(body mass index, percent body fat, waist-hip ratio) is useful to predict pain grade of dysmenorrhea.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.164-177
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• 2007

Purpose: The purpose of this study is to analysis on the Heart Rate Variability(HRV) of some dysmenorrhoea patients. Methods : We studied 30 patients visiting Kyung Hee University East-West Neo Medical Center from 7th Febrary 2007 to 22th Febrary 2007. Women with organic disease were excluded from this study. The severity of dysmenorrhoea were measured by Multidimensional Verbal Rating scale(MVRS), Verbal Rating scale (VRS) and Visual Analog Scale(VAS). And HRV was recorded. Results : According to comparison of Means of HRV values among the groups of None, Mild and Moderate, the points of almost all values were kept by order of Moderate group-Mild group-None group. Among these, the statistically significant things are PR, SDNN, Ln (TP), Ln (VLF), Ln (LF). According to correlation analysis between dysmenorrhoea and HRV, specially, there were many correlations in VRS2. Among these, the statistically significant things are LF norm, HF norm, LF/HF ratio(p<0.05L). Conclusion : The results suggest that HRV is related to dysmenorrhoea. We may analyze that dysmenorrhoea is related to, specially, increased activities of sympathetic nerve. We need more study for settling this.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.81-90
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• 2007

Purpose: This study was conducted to investigate the muscle anti-fatigue effects of Allii tuberosi semen after long term administration. Materials and Methods: 4-6 weeks old ICR mice were used in this study and we administered the water soluble extracts of Allii tuberosi semen in the concentration of 1, 10 and 100mg/0.3ml to each 5 mice (ATS group) and same volume of normal saline was administered to 5 mice (control group) once a day for 90 or 120 days. After the administration we performed the swimming exercise test and the grip strength test. And we measured the concentration of glucose and the activity of lactate dehydrogenase in plasma regarded as biochemical indicator related with the muscular fatigue. Results: In swimming exercise test, all ATS groups showed increased time compared with relative control group after 90 days administration. But after 120 days adminstration 10 and 100mg/0.3ml ATS groups showed increased results. In grip strength test, all ATS group increased grip strength after 90 days administration and 10mg/0.3ml ATS group showed increased result after 120 days administration. All the results of plasma glucose didn't showed statistically significant difference after 90 and 120 days administration. In the plasma concentration of activity level of lactate dehydrogenase, 1mg/0.3ml and 10mg/0.3ml ATS groups showed decreased concentration compared with relative control group after 90 days administration. But after 120 days adminstration 1mg/0.3ml ATS groups showed decreased results. Conclusion: From this study we could find the anti-fatigue effect of Allii tuberosi semen in the muscle strength related test.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.185-199
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• 2007

Purpose: This study was designed to establish safety and efficacy of using herbal medicine during pregnancy. Methods : We searched through 23 sources, which had been previously published frome 1988 to 2007, concerned patients that used herbal medicine during pregnancy. We searched diseases for that used herbal medicine, kinds of herbal medicine taken, the period of herbal medicine taken, the duration of herbal medicine taken and results of herbal medicine taken. Results: 1. Whaltae(habitual abortion) was the most of diseases that used herbal medicine during pregnancy. Second disease was hyperemesis gravidum. Third disease was Taegibulan (fetal restlessness). 2. The most of Herb medicines of used for Whaltae was Kyoesamultang and Anjeonecheontang. The most of Herb medicines of used for hyperemesis gravidum was Bosaengtang. The most of Herb medicines of used for Taegibulan was Kyoesamultang. 3. The time of herbal medicine taken mostly was the first period of pregnancy. The rate was 78%. 4. The duration of herbal medicine taken mostly was $18.58{\pm}14.24day$ at mean. 5. The rate of normal delivery was 85% and herbal medication during pregnancy does not cause any deformity to the newborn and of patients used herbal medicine. 6. The patients of taken herbal medicines were recovered from their symptoms and prevented miscarriage. The rate of recovery was 87%. Conclusion: The results of this study show that herbal medication during pregnancy is effective to cure disease and maintain the pregnancy. It is thought that have to actively try to treat diseases and symptoms on pregnancy by using herbal medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.91-110
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• 2007

Purpose : These experiments were undertaken to evaluate the effect of administration of Palmultang on ovarian functions and differential gene expressions related cell viabilities caspase-3, MAPK and MPG in female mice. Materials and Methods : We administered the Palmultang to 6-week-old female ICR mice for 4, 8, or 12 days. The female mice were injected PMSG and hCG for ovarian hyperstimulation. And then recovered ovaries were minced and extracted mRNA and analyzed cell viability related gene expression. We chose the caspase-3 for cell apoptosis, MAPK and MPG genes for cell viability and DNA repair. To compare the differences, we set a control group treated with plain water at the same volume by the same way. Results : In case of administration of Palmultang, the mean number of total ovulated oocytes and the number of morphologically normal oocytes increased significantly compared to a control group. We were also examined the embryonic developmental competence in vitro. The administration of Palmultang in a concentration with 10 and 100 mg/ml were beneficial effect of embryonic development in preimplantation period. The administration of Palmultang play a role of prevention of cell apoptosis and DNA damages and also increased cell proliferation resulted in ovarian functions. Conclusion : From our results suggested that the medication of Palmultang has beneficial effect on reproductive functions of female mice via prevention of cell apoptosis and DNA damaging and promotion of cell proliferation.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.150-158
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• 2008

Purpose: The purpose of this analysis was to establish safety and efficacy of using herbal medicine during pregnancy. Methods: We investigated 18 patients of visiting Dongshin university Kwangju Oriental Hospital. from september 1, 2006 to December 31, 2007, who had taken herbal medicine in pregnancy for medical treatment. And we investigated birthhistory, newborn babies's condition, satisfaction of herbal treatment and so on. Results: 15 cases delivered normally, and they had no congenital malformation, 2 patients were pregnant yet, and 1 patient had an abortion. Most newborn babies had on the average height and weight, and were healthy condition. And patients's satisfaction score of herbal treatment was 3.4 point. Conclusion: The results of this study indicate that using herbal medicine in pregnancy is safe and effective.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.159-168
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• 2008

Purpose: The purpose of this study is to investigate the characters of Yangdorak in climacteric women. Methods: We analyzed the measurement value of Yangdorak on 37 climacteric women, aged 45-60 years. The patient's symptoms were assessed by modified Kupperman's index. Statistical analysis was performed using SPSS 13.0 for windows program. one-sample t-test. pearson correlation coefficient. Results: The results were as follows. 1. The average value of Yangdorak in 37 patients with climacteric women was 29.02$\pm$16.85. 2. According to the comparison of mean value with the each meridian value of Yangdorak. H1, H5 is high, F2, F3, F5 is low significantly. 3. The number of Pyesaek is more than Gyeokcha. 4. The Yangdorak value(F2) had significant correlation with modified Kupperman's index. Conclusion: The result suggests that Yangdorak values in H1, H5, F2, F3, F5 are related to climacteric. Further study on the yangdorak and climacteric syndrome measured by Kupperman's index is recommended.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.169-182
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• 2008

Purpose: The purpose of this study is to find out the relations between the index of obesity by body composition analysis (EMI. %BF and WHR) and results of other oriental health examinations (QSCC II, HRV and APG) on some women. Methods: 114 women who were tested by oriental health examination between May 2006 and August 2008 were studied. Results: As a result of the study on the relations between the index of obesity by body composition analysis and sasang constitution, it was found that each of them had significant differences among themselves and Taeumin had the highest significance than other sasang constitution. As a result of the study on the relations between the index of obesity by body composition analysis and HRV, it was discovered that there was no significant relationship between BMI and WHR and HRV. However, %BF had negative correlations with autonomic activity, stress resistance and stress index. As a result of the study on the relations between the index of obesity by body composition analysis and APG, it was found that they had positive correlations with each other. Conclusion: In conclusion, there are significant relations between the index of obesity by body composition analysis and results of other oriental health examinations.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.193-206
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• 2008

Purpose: In spite of many arguments on the result of WHI (Women's Health Initiative) study, no one can deny the necessity for researches on the alternative treatment to HRT (hormone replacement therapy). In this study, the author wanted to investigate the method of precedent acupuncture RCTs (randomized controlled trials) to make out the appropriate acupuncture study design on postmenopausal and perimenopausal hot flashes in Korea. Methods: Precedent studies were investigated using Pubmed search and key-words "acupuncture and hot flash", "acupuncture and menopause", "acupuncture and vasomotor", limited to RCT, from 2000 to 2008 April. Results: As a result. 10 studies were searched. In the hereafter studies, multi-center clinical trials which consist of population group of postmenopausal and perimenopausal women that would be pre-stratified and more than 50 patients per treatment arm seem adequate. Sham control study can make out the proper consequence because many people are get used to acupuncture in Korea. Flexible choice of acupoints addressed an individual's symptoms using standardized algorithm is recommended. Treatment consist of 4 weeks' observation, 11 acupuncture sessions during 7 weeks, follow-up of 3 months or more after treatment and hot flash score as a primary outcome measure seem appropriate. After all, higher level of description according to global standard must be obtained in the study report and publishing. Conclusion: The researchers should develope the methodology of acupuncture clinical trial on the postmenopausal and perimenopausal hot flashes.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.17-35
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• 2008

Purpose: It is the purpose of this study to investigate the anti-inflammatory effects of water extract from Gagamsoyosan(GGSYS) on the peritoneal macrophage. Methods: To evaluate anti-inflammatory effects of GGSYS. inflammatory cytokines were measured in lipopolysaccharide(LPS) -stimulated macrophages. Furthermore. the western blot has been done to look into the molecular mechanism. Results: GGSYS did not have any cytotoxicity in the peritoneal macrophages and suppressed production of LPS-induced NO. tumor necrosis factor-alpha (TNF-$\alpha$). interleukin(IL)-1$\beta$. IL-6. IL-12. GGSYS inhibited the activation of extracelluar signal-regulated kinase (ERK1/2). c-Jun N-terminal kinase(JNK), p38 kinase and the degradation of inhibitory kappa B-alpha($I_{k}B-\alpha$) in the LPS-stimulated peritoneal macro phages. GGSYS inhibited LPS-induced endotoxin shock and the production of TNF-$\alpha$. IL-l$\beta$. IL-6 in serum from LPS-stimulated mice. Conclusion: These results suggest that GGSYS may have the anti-inflammatory effect which can inhibit the production of NO and inflammatory cytokines. GGSYS is expected to protect against inflammatory diseases.