• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.103-103
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• 1993

목적: Estroge 결핍으로 나타나는 폐경기의 주요 증상을 경감 치료하기 위해, estrogen경구 투여시 위장장애, 위장에서의 대사, 간 초회효과, 자주 투여로 인한 환자의 불편 등의 단점이 있나, 이러한 점을 개선하기 위한 투여경로의 하나로 피부를 통해 일정약물을 장기간 일정속도로 송달시키는 경피 흡수 시스템의 개발이 필요하다. 따라서 (EE)의 장기제어방출을 위해 ethylene vinyl acetate (EVA)를 사용하여 장기 제어방출 및 경피 흡수의 최적화 조건을 설정하여 경피흡수 시스템을 위한 막의 개방을 목적으로 한다. 방법: VA 함량이 18-40％까지의 EVA를 사용하여 EE를 함유한 matrix를 casting 방법으로 제조하고 변형된 Keshary-Chien cell을 이용하여 방출실험을 실행하였다. 이때 방출에 미치는 여러 가지 인자로서 EVA 주의 VA함량, 막의 두께, receptor 중 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 량 등에 대해 검토하였다. 그리고 점개한 mouse skin에 대한 투과 실험을 행하고 이에 미치는 PEG 400과 자질층의 역할을 검토하였다. 결과: EE의 용해도는 saline so PEG 400의 용량 비율이 증가함에 따라 지수 함수적으로 증가하였다. 그리고 VA 함량이 증가될수록, PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 EE의 방출속도와 부과속도는 증가하였다. 또한 투과속도는 막두께의 역수와 직선상의 상관 관계를 보였다. 그리고 EVA matrix로부터 EE가 방출되는 양상은 diffusion-controlled model을 따랐으며 이때 단위면적당 방출된 총량은 T에 비례되었다. 절개한 mouse skin을 통한 EE의 permeation은 PEG 400의 첨가에 의해 상승되었다. 이와 같이 EVA 막이 EE의 부과 및 방출을 조절하는 것으로 보아 경피 흡수를 위해 사용될 수 있다고 사료된다.

• Journal of Korean Association for Spatial Structures
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• v.6 no.4 s.22
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• pp.35-44
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• 2006

The form-resistant Systems like a dome and shell are used more widely than post-beam structure system in large space structure. Single layer latticed dome system, one of the form-resistant system, has great merits in manufacturing and constructing but the failure mechanism is not clarified yet. The purpose of this paper is to find out the buckling characteristics of single-layer latticed domes with square network by using the experimental method. Major test parameters are the stiffness of lattice member and space of square lattice. The specimens are applied uniform loading of snow type.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.6
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• pp.1013-1028
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• 2017

This paper presents key findings obtained from the numerical experiment investigating into the use of the cylindrical cavity for rock splitting operations. The stress and strain path analyses were carried out in order to provide a better insight into the crack formation. The principal stress analysis carried out along the crack line using the results obtained from these numerical analyses allowed the failure of the brittle material and the crack propagation to be investigated. This paper also suggested possible reasons for the change in crack direction observed during the rock splitting operations using the results obtained.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.4
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• pp.884-892
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• 1996

An adaptive blind equalizer is used to combat the distortions caused by a nonideal channel without resorting to a training sequence, given the received signal and statistical information of the transmitted signal. Incidentally, a multipath channel may result in a fade which produces intersymbol interference in the received signal. Therefore, a new type of algorithm which can compenste the effects of this fade is required in the multipath channel environment. In this paper, a modified form of adaptive blind equalization algorithm using stop-and-go algorithm for multichannel system is proposed. It is demonstrated via computer simulations that the performance of the proposed multichannel stop-and-go algorithm is much better than that of the conventional multichannel algorithms.

• Journal of Korean Society for Geospatial Information Science
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• v.10 no.1 s.19
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• pp.51-57
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• 2002

GPS proved to very practical in the application of geodesy and surveying such Civil Engineering, control point surveying and the deformation surveying o( structure, but the accuracy of static GPS positioning is degraded at the sites which the visible satellites of GPS are less than 4, i.e. the urban area covered with the high building and the industrial zone. Thus, the combined GPS/GLONASS system was introduced to acquire the high accuracy of static positioning by a few satellites. So the combined GPS/GLONASS system show the good results at the sites which the accuracy of positioning is degraded due to few satellites, the cutoff of signal, and multipath in the urban area.

• Transactions of Materials Processing
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• v.24 no.3
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• pp.176-180
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• 2015

The current study is concerned with the prediction of fracture strains for DP980 steel sheets over a wide range of loading paths. The use of DP980 steel is increasing significantly in automotive industries for enhanced safety and higher fuel efficiency. The material behavior of advanced high-strength steels (AHSSs) sheets sometimes show unpredictable and sudden fracture during sheet metal forming. A modified Lou-Huh ductile fracture criterion is utilized to predict the formability of AHSSs because the conventional forming limit diagram (FLD) constructed based on necking is unable to evaluate the formability of AHSSs sheets. Fracture loci were extracted from three dimensional fracture envelopes by assuming the plane-stress condition to evaluate equivalent plastic strains at the onset of fracture for a wide range of loading paths. Three different types of specimens -- pure shear, dog-bone and plane strain grooved -- were utilized for tensile testing to calibrate the fracture model of DP980 steel sheets. Fracture strains of each loading path were evaluated such that there shows little deviation between fracture strains predicted from the fracture model and the experimental measurements. From the comparison, it is clearly shown that the three dimensional fracture envelopes can accurately predict the onset of the fracture of DP980 steel sheets for complicated loading conditions from compressive loading to shear loading and to equibiaxial tensile loading.

• Transactions of Materials Processing
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• v.17 no.6
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• pp.420-428
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• 2008

The effect of loading path changes on the strain and mechanical properties of a commercial pure aluminum was studied using flat rolling and groove rolling. Material during flat rolling undergoes a continuous monotonic compressive loading, while one during groove rolling experiences a series of cross compressive loading. Four-pass flat rolling and groove rolling experiment are designed such that the aluminum undergoes the same amount of the strain at each pass. The rolling experiment was performed at room temperatures. Specimens for tensile test are fabricated from the plate and bar rolled. In addition, the strain distribution for the plate and bar cold rolled specimens is also calculated by finite element method. The results reveal that differences of loading path attributed by monotonic loading(flat rolling) and cross loading(groove rolling) significantly influence the mechanical properties such as yield stress, ultimate tensile stress, strain hardening and elongation. It is clear that the different loading path can give raise to change the deformation history, although it is deformed with same amount of strain for same material.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.11
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• pp.945-952
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• 2015

In drawing sheet metal, the blank holding force is applied to prevent wrinkling of the product and to add a tensile stress to the material for the plastic deformation. Applying an inappropriate blank holding force can cause wrinkling or fracture. Therefore, it is important to determine the appropriate blank holding force. Recent developments of the servo cushion open up the possibility to reduce the possibility of fracture and wrinkling by controlling the blank holding force along the stroke. In this study, a method is presented to find the optimal variable blank holding force curve, which uses statistical analysis with consideration of the nonlinear deformation path. The optimal blank holding force curve was numerically and experimentally applied to door inner parts. Consequently, it was shown that the application of the variable blank holding force curve to door inner parts could effectively reduce the possibility of fracture and wrinkling.

• Journal of the Korean Geotechnical Society
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• v.24 no.5
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• pp.89-98
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• 2008

In this study, the behaviour of an unsaturated soil was analyzed by performing $K_0$ consolidated triaxial tests. Unsaturated triaxial tests were performed with matric suctions for weathered soils and stress paths under consolidation and stress-strain relationships under shear were obtained. As a result, the $K_0$ value decreased as the matric suction increased. Besides, both isotropic and $K_0$ conditions had similar shear strength envelopes at the same matric suction. Especially, strength parameters could be obtained by stress variables used in the critical state theory more reasonably than by those of Mohr circles at failure.

• Transactions of Materials Processing
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• v.32 no.4
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• pp.208-214
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• 2023

This paper discusses the deformation characteristics of a scaled-down automotive outer door panel with vacuum-assisted incremental sheet forming. The vacuum condition between the die and Al6052-H32 sheet with a thickness of 1.0 mm is reviewed with the goal of improving the geometrical accuracy of the target product. The material flow according to the forming tool path, including the multi-tool path and conventional contour tool path, is investigated considering the degradation of the pillow effect. To reduce friction between the tool and the sheet during incremental forming, automotive engine oil (5W-30) is used as a lubricant, and the strain field on the surface of the formed product is analyzed using ARGUS. By comparing the geometry and material flow characteristics of products under different test conditions, it is confirmed that the product surface quality can be significantly improved when the vacuum condition is employed in conjunction with a multi-tool path strategy.