• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.991-993
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• 2012

We analyzed RNA polymerase beta subunit gene (rpoB) mutation of rifampin-resistant Mycobacteria through analysis of nucleotide sequence of rpoB DNA (351 bp) containing rifampin resistant region, $rif^r$. For this study, we collected rifampin-resistant Mycobacteria that were identified by conventional culture methods from Masan National Hospital and The Korean Institute of Tuberculosis. We performed sequencing of DNA nucleotides and analyzed rpoB gene of those rifampin-resistant Mycobacteria. From this analysis, we invcestigated diverse mutations of rpoB gene included rifampin-resistant gene, which were not reported, from those rifampin-resistant Mycobacteria.

• Animal Systematics, Evolution and Diversity
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• v.2 no.2
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• pp.1-12
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• 1986

Genetic and morphological variation among seven populations of two species of the genus Liobagrus that had been collected from six separate river systems in Korea were analyzed by means of starch electrophoreiss and discriminant function analysis . The degree of genic variation among three population of L.andersoni was P=21.3%, H=0.068 , and that of four population of L.mediadiposalis was P=16.3%, H=0.560. Rogers' gentic similarity coefficient (S) of L.andersoni and L.mediadiposalis were S=0.592 , S=0.675 respectively. In morphometric characters of L. andersoni, the population from Kum River was distinctly different from other conspecific populations.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.05a
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• pp.349-352
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• 2009

최근 유비쿼터스 헬스케어가 부각됨에 따라 심장의 활동상태를 보다 편리하게 측정하기 위하여 이동성 및 휴대성을 강조한 심전도 계측 시스템 및 스트레스 상태를 분석하기 위한 연구들이 수행되고 있다. 하지만 기존 심전도 계측은 전극의 부착 및 계측시스템과의 연결을 위한 리드선의 사용으로 인해 활동의 불편함을 유발한다. 본 연구에서는 기 연구 수행된 가정 또는 사무실에서 무구속적인(unconstrained) 방법으로 지속적인 심장의 활동상태의 모니터링이 가능한 무구속 의자형 심탄도 계측 시스템을 구현하였다. 무구속적인 방법으로 심탄도 신호를 계측하고 심탄도신호로부터 심박동변이율을 추출함으로써 일상생활 중 스트레스를 모니터링 하고자 하였다. 구현된 시스템을 통한 스트레스 모니터링의 가능성을 평가하기위하여 안정상태의 심박동변이율과 인위적인 신체적 스트레스인 Valsalva 조작를 유도한 후 심박동 변이율을 비교평가 하였다. 건강한 대학생 10명을 대상으로 비교분석을 수행한 결과 안정 상태와 육체적 스트레스 인가 후 심박동 변이율의 변화 양상을 관찰할 수 있었으며, 무구속적인 방법에 의해 스트레스의 모니터링이 가능함을 확인 할 수 있었다.

• Journal of Digital Convergence
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• v.13 no.5
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• pp.277-288
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• 2015

This study aims to identify determinants affecting on geographic variations in the prevalence of arthritis in Korean women using data mining. Data from Korean Community Health Survey 2012 with 249 small districts were analyzed. Socio-demographic, health behavior and status, and morbidity status measures were analyzed using conventional regression model and convergence analysis method such as decision tree for convergence analysis. Rate of workers in agriculture, forestry, and fishing, salaried workers, persons higher than high school graduates, non-treatment of needing care, non-treatment of care because of economic reason, obesity, heavy drunkers, complaining persons of chewing difficulty, persons with experiencing depression, persons with perceiving stress, and persons with diagnosing hypertension and angina pectoris were variation determinants of prevalence of arthritis in 249 small districts and these districts were classified 10 area groups by decision tree model. Our finding suggest that the approach based characteristics by small area groups rather than national wide or individual level would be effective to reduce in variations of prevalence of arthritis.

• Journal of Digital Convergence
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• v.13 no.1
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• pp.353-366
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• 2015

The purpose of this study was to examine how region-specific characteristics affect the occurrence of cardiac arrest. To analyze, we combined a unique data set including key indicators of health condition and cardiac arrest occurrence at the 244 small administrative districts. Our data came from two main sources in Korea Center For Disease Control and Prevention (KCDC): 2010 Out-of-Hospital Cardiac Arrest Surveillance and Community Health Survey. We analyzed data by using multiple regression, geographically weighted regression and decision tree. Decision tree model is selected as the final model to explain regional variations of cardiac arrest. Factors of regional variations of cardiac arrest occurrence are population density, diagnosis rates of hypertension, stress level, participating screening level, high drinking rate, and smoking rate. Taken as a whole, accounting for geographical variations of health conditions, health behaviors and other socioeconomic factors are important when regionally customized health policy is implemented to decrease the cardiac arrest occurrence.

• Clinical and Experimental Pediatrics
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• v.45 no.3
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• pp.302-310
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• 2002

Purpose : X-linked agammaglobulinemia(XLA) is an immunodeficiency caused by abnormalities in Bruton's tyrosine kinase(Btk), and is characterized by a deficiency of peripheral blood B cells. We studied cytoplasmic expression of Btk protein and analyzed the Btk gene in peripheral blood mononuclear cells(PBMC) from three XLA families in Korea. Methods : Heparinized venous blood samples were collected from four XLA patients and additional family members in three unrelated XLA families. Mononuclear cells were separated from their blood and the intracellular Btk protein was characterized by a flow cytometry. The mutation analysis was performed using direct sequencing. Results : Cytoplasmic expression of Btk protein in monocytes was not detected in the patients with XLA. We observed a novel deletion and two point mutations within introns(intron 1 and intron 18) resulting in alternative splicings. In XLA family 2, a 980 bp deletion(from intron 9+191 T to intron 10-215 C) including exon 10 was found in patient P2. He was the only sporadic case in this study, because his mother and brother showed a normal Btk expression by flow cytometry. Conclusion : These identified genetic alterations support the molecular heterogeneity of Btk gene in XLA disease. Additionally, by means of flow cytometric analysis, we diagnosed three hypogammaglobulinemia patients as XLA. Advancements in diagnostic methods has facilitated a prompt and definite diagnosis of this disease.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.4
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• pp.372-382
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• 2009

A GNSS software for processing the SBAS correction data is developed, and Japan MSAS correction data is analyzed. MSAS orbit correction data is analyzed and compared with WAAS data. MSAS ionosphere correction data is analyzed and the effect of the equatorial anomaly on the correction accuracy is discussed. Degradation due to receive delay of correction information and effect of the degradation on protection level analyzed using partial remove of MSAS correction information. Integrity and availability for precision approch using the MSAS system analyzed.

• Animal Systematics, Evolution and Diversity
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• v.2 no.1
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• pp.1-10
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• 1986

문경산 흰 넓적다리 붉은 쥐, Apodemus peninsulae peninsulae, 의 염색체 핵형 분석과 단변량 및 다변량분석방법들을 사용한 등줄쥐, Apodemus agrarius coreae, 와의 형태적 형질의 비교를 하였다. 흰 넓적다리 붉은 쥐의 염색체수는 2n=50-54R지 수적 변이를 보였다. 차단부 염색체의 수는 48개로 개체간에 일정하였으나 , 중부 염색체의 수는 2-6개의 변이가 나타났다. 형태적 형질의 분석결과는 등줄쥐보다 흰 넓적다리 붉은 쥐가 크다고 판정되었으며 가장 구별이 잘 되는 경구개의 길이였다.

• Korean Journal of Psychosomatic Medicine
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• v.12 no.1
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• pp.3-14
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• 2004

In this article, the effects of stress on central nerve system and heart function and the concept of heart rate variability were reviewed. HRV(Heart Rate Variability), the periodical change of the heart rate, is indicated larger in the healthier because they respond flexibly to various sorts of facts influencing on HR. HRV analysis is largely composed of the time domain analysis and the frequency analysis. In the former the flexibility of heart function is analysed, while in the latter autonomic nerve function is examined, which is the degree of sympathetic and parasympathetic nerve activity and the state of balance. Furthermore, existence or nonexistence of disease and/or level of stress can be estimated by measuring the variability and normality of heart rate, and balance of autonomic nerve system, and through HRV biofeedback the symptoms of anxiety disorder or asthma can be reduced.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.6
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• pp.2668-2676
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• 2011

In order to analyze the variation in length of stay(LOS) of injury inpatients, we developed severity-adjusted LOS model using Korean National Discharge In-depth Injury Survey data of Center for Disease Control. Appling this model, we calculated predicted values and, after standardizing LOS using the differences from the actual values, analyzed the variation in LOS. Major factors affecting severity-adjusted LOS of injury inpatients were found to be severity, surgery(or no surgery), age, injury mechanism and channel of hospitalization. Result of analysis of the differences between the actual values and predicted values adjusted by decision tree model suggested that there were statistically significant differences by hospital size(number of beds), type of insurance and location of institution. In order to reduce the variation in LOS, efforts should be exerted in developing nationwide treatment protocol, inducing medical institutions to utilize it, and furthermore systematically evaluating it to reduce the variation continually.