• Title/Summary/Keyword: 베타 결정

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Ultrasonic relaxation associated with the complex formation of benzoic acid derivative and β-cyclodextrin (벤조산 유도체와 베타 사이클로덱스트린의 복합체 형성반응에 의한 초음파 완화)

  • Park, Shin;Bae, Jongrim
    • The Journal of the Acoustical Society of Korea
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    • v.36 no.6
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    • pp.387-393
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    • 2017
  • The dynamic interactions between benzoic acid derivative ($pH{\approx}7.0$)(guest) and ${\beta}$-cyclodextrin (${\beta}$-CD)(host) were investigated in an aqueous solutions in terms of ultrasonic absorption in the frequency range 0.2 MHz ~ 50 MHz with emphasis on the low-frequency range below 1 MHz at $25^{\circ}C$. We show that the interaction of ${\beta}$-CD and benzoic acid derivative complies with a typical spectrum of a single relaxation process around a few MHz. The ultrasonic relaxation observed in these solutions was due to a perturbation of a chemical equilibrium related to a reaction of an inclusion complex formed by the host and guest. The rate constant ($k_b=7.48{\times}10^6M^{-1}s^{-1}$) and equilibrium constant ($K=68.6M^{-1}$) were determined from the concentration dependences of benzoic acid on the relaxation frequency. The standard volume change (${\Delta}V=10.6{\times}10^{-6}m^3mol^{-1}$) of the reaction was also computed from the maximum absorption per wavelength. It was found that the hydrophobicity of guest molecules played an important role in the formation of the inclusion complex.

Beta Dosimetry for Applying $^{166}Ho$-chitosan Complex to Cystic Brain Tumor Treatment : Monte Carlo Simulations Using a Spherical Model ($^{166}Ho$-chitosan 복합체를 이용한 낭성뇌종양 치료를 위한 베타선의 흡수선량 평가 : 구형 모델을 이용한 Monte Cairo 모사계산)

  • Kim, Eun-Hee;Rhee, Chang-Hun;Lim, Sang-Moo;Park, Kyung-Bae
    • The Korean Journal of Nuclear Medicine
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    • v.31 no.4
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    • pp.433-439
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    • 1997
  • $^{166}Ho$-chitosan complex, or $^{166}Ho$-CHICO, is a candidate pharmaceutical for intracavitary radiation therapy of cystic brain tumors because of the desirable nuclear characteristics of $^{166}Ho$ for therapeutic use and the suitable biological and chemical characteristics of chitosan, not to mention its ready producibility The amount of $^{166}Ho$-CHICO to be administered to obtain the goal therapeutic effect can be suggested by predicting the dose to the cyst wall for a varying pharmaceutical dose. When $^{166}Ho$-CHICO is infused into the cyst, the major part of the energy delivery by beta particles emitted from $^{166}Ho$ occurs in the cyst wall within 4mm in depth from the cyst wall surface. Also, realizing the attachment of $^{166}Ho$-CHICO to the cyst wall surface would change the predictions of dose to the cyst wall.

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PAHs로 오염된 광양만 퇴적토의 미생물 군집분석

  • 권개경;정성영;이정현;바실리 스베타체프;김상진
    • Proceedings of the Korea Society of Environmental Biology Conference
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    • 2002.11a
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    • pp.51-58
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    • 2002
  • 연안에 가까운 광양만 퇴적토를 대상으로 하여 PAHs 오염도와 말단제한절편 다형성 분석방법(T-RFLP method)을 이용하여 미생물 군집구조를 조사하였다. 조사된 10개 정점의 PAHs오염도는 80$\pm$20~5,690$\pm$580 (평균 1,499$\pm$1,716) ng/g dry wt.였으며 폐수종말처리장이 위치하는 하천 입구에 위치한 정점 (Wl)과 광양제철소 우수배출구 입구에 위치한 정점에서 상대적으로 높은 농도를 보였다. T-RFLP방법으로 조사한 미생물 군집은 10개 정점이 4개의 그룹으로 구분되었으며 정점 Wl에서 다른 정점과 다른 독특한 군집구조를 형성하였다. PAHs 농후배양시료에서의 미생물군집구조 변화와 비교해 볼 때 조사대상지역 퇴적토의 미생물 군집구조는 PAHs의 오염에 부분적으로는 영향을 받지만 입도, 유기물 등과 같은 환경요인이 군집구조를 결정하는 주된 요인인 것으로 생각된다.

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A Study on Emotion and EEG to Improve the Accuracy of Judgmental Time Series Forecasting in a Web-based Computer Task (웹환경에서 시계열 예측의 정확성제고를 위한 감성조건과 뇌파특징 추출에 관한 연구)

  • 임좌상
    • Science of Emotion and Sensibility
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    • v.3 no.2
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    • pp.85-101
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    • 2000
  • 감성은 의사결정에 많은 영향을 미침에도 불구하고, 시계열예측에 있어서의 연구는 매우 적은 편이다. 본 연구는 감성이 시계열 예측에 미치는 영향을 시계열정보의 형태 (그래프, 계정성)와 더불어 살펴보았다. 감성은 피험자로 하여금 인터넷시험을 보게 하고 즉시 그 결과를 아려줌으로 유발하였다. 시험결과가 좋은 피험자에게는 상금을 주어서 그 효과를 극대화하도록 하였다. 본 연구는 팩토리얼로 설계되었으며, 86명의 학생이 인터넷에서 운용되는 실험프로그램을 직접 사용하였다. 그 결과 감성은 그 자체로는 효과가 없었지만, 정보가 주어진 형태와 관련되어 그 효과가 타나났다는 점이 매우 흥미롭다. 특히 좋은 감성이 유발된 경우, 계절성이 테이블형태로 (그래프에서 잘 표현될 수 있다는 점에도 불구하고) 더욱 정확하게 처리하는 경향이 있었다. 또한 피험자의 뇌파를 분석한 결과 전두엽 베타파가 정확성에 많은 기여를 하는 것으로 나타났다.

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Determination of Stability Constants for $\beta$-Blocker and Carboxymethyl-$\beta$-cyclodextrin Complexes by Capillary Electrophoresis (모세관 전기영동법을 이용한 베타차단제-시클로덱스트린 포접화합물의 안정도상수 결정)

  • 박경래;임환미;뉴엔티퐁;김경호;강종성
    • YAKHAK HOEJI
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    • v.47 no.4
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    • pp.200-205
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    • 2003
  • The stability constants for the inclusion complexes between carboxymethyl-$\beta$-cyclodextrin (CM-$\beta$-CD) and five $\beta$-blockers, such as atenolol (ATE), bisoprolol (BIS), metoprolol (MET), pindolol (PIN) and propranolol (PRO) were determined by capillary electrophoresis. The magnitude of stability was decreased as following order; PRO>MET>BIS>ATE>PIN. Among them PRO showed the highest affinity towards CM-$\beta$-CD with stability constants of 383 and 371 $M^{-l}$ for (R)- and (S)-enantiomer, respectively. PIN enantiomers showed the lowest stability towards CM-$\beta$-CD, while the selectivity between (R)- and (S)-enantiomer was higher than any other tested $\beta$-blocker.r.

Comparison of rainfall-based and model-bsed runoff ensemble members (강우기반 유출앙상블과 모형기반 유출앙상블의 비교 및 평가)

  • Kang, Minseok;Na, Wooyoung;Kim, Gildo;Yoo, Chulsang
    • Proceedings of the Korea Water Resources Association Conference
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    • 2020.06a
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    • pp.328-328
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    • 2020
  • 본 연구에서는 강우앙상블 멤버를 입력자료로 한 강우기반 유출앙상블 멤버와 관측 강우자료를 입력자료로 한 모형기반 유출앙상블 멤버를 생성하고 각 유출앙상블 멤버의 정확도를 비교·평가하였다. 본 연구에서는 강우앙상블 멤버 생성을 위해 서울 지역을 대상으로 강우장 이동 모의에 필요한 모의 격자망을 구축하였다. 다음으로 최근 10년 동안 발생한 37개 호우사상의 관측자료를 토대로 격자별 특성방향을 결정하고 특성방향의 통계치로부터 유도된 베타분포를 기반으로 강우앙상블 멤버를 생성하였다. 유출앙상블 멤버는 대한민국 서울에 위치한 구로1 빗물펌프장 배수유역을 대상으로 shot noise process 기반 강우-유출모형을 이용하여 생성하였다. 강우-유출모형 매개변수의 난수 생성을 위해서 감마분포를 이용하였다. 2017년과 2018년 발생한 호우사상을 대상으로 강우기반 및 모형기반 유출앙상블을 생성한 결과, 강우의 방향성을 조정하여 생성한 강우기반 유출앙상블의 정확도가 더 높은 것으로 나타났다.

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A Study on the Reliability Attributes of the Software Reliability Model Following the Shape Parameter of Minimax Life Distribution (미니맥스 수명분포의 형상모수를 따르는 소프트웨어 신뢰모형에 관한 신뢰속성에 관한 연구)

  • Kim, Hee-Cheul
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.11 no.4
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    • pp.325-330
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    • 2018
  • This paper, following the shape parameters of the minimax distribution, describes the special form of the beta distribution, the Minimax distribution, as a function of the shape parameters for the software reliability model based on the non-homogeneous Poisson process. Characteristics and usefulness were discussed. As a result, the case of the shape parameter 1 of Minimax distribution than less than and greate in mean squared error is the smallest, in determination coefficient, appears to be high, the shape parameter 1 of Minimax distribution regard as an efficient model. The estimated determination coefficient of the proposed model is estimated to be more than 95%, which is a useful model in the field of software reliability. Through this study, software design and users can identify the software failure characteristics using mean square error, decision coefficient, and confidence interval can be used as a basic guideline.

Radiation Absorbed Dose Calculation Using Planar Images after Ho-166-CHICO Therapy (Ho-166-CHICO 치료 후 평면 영상을 이용한 방사선 흡수선량의 계산)

  • 조철우;박찬희;원재환;왕희정;김영미;박경배;이병기
    • Progress in Medical Physics
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    • v.9 no.3
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    • pp.155-162
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    • 1998
  • Ho-l66 was produced by neutron reaction in a reactor at the Korea Atomic Energy Institute (Taejon, Korea). Ho-l66 emits a high energy beta particles with a maximum energy of 1.85 MeV and small proportion of gamma rays (80 keV). Therefore, the radiation absorbed dose estimation could be based on the in-vivo quantification of the activity in tumors from the gamma camera images. Approximately 1 mCi of Ho-l66 in solution was mixed into the flood phantom and planar scintigraphic images were acquired with and without patient interposed between the phantom and scintillation camera. Transmission factor over an area of interest was calculated from the ratio of counts in selected regions of the two images described above. A dual-head gamma camera(Multispect2, Siemens, Hoffman Estates, IL, USA) equipped with medium energy collimators was utilized for imaging(80 keV${\pm}$10%). Fifty-nine year old female patient with hepatoma was enrolled into the therapeutic protocol after the informed consent obtained. Thirty millicuries(110MBq) of Ho-166-CHICO was injected into the right hepatic arterial branch supplying hepatoma. When the injection was completed, anterior and posterior scintigraphic views of the chest and pelvic regions were obtained for 3 successive days. Regions of interest (ROIs) were drawn over the organs in both the anterior and posterior views. The activity in those ROIs was estimated from geometric mean, calibration factor and transmission factors. Absorbed dose was calculated using the Marinelli formula and Medical Internal Radiation Dose (MIRD) schema. Tumor dose of the patient treated with 1110 MBq(30 mCi) Ho-l66 was calculated to be 179.7 Gy. Dose distribution to normal liver, spleen, lung and bone was 9.1, 10.3, 3.9, 5.0 % of the tumor dose respectively. In conclusion, tumor dose and absorbed dose to surrounding structures were calculated by daily external imaging after the Ho-l66 therapy for hepatoma. In order to limit the thresholding dose to each surrounding organ, absorbed dose calculation provides useful information.

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Further Investigations on the Financial Characteristics of Credit Default Swap(CDS) spreads for Korean Firms (국내기업들의 신용부도스왑(CDS) 스프레드의 재무적 특성에 관한 심층분석 연구)

  • Kim, Han-Joon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.9
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    • pp.3900-3914
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    • 2012
  • This study examined the background of the recent global financial crisis and the concept of one of the financial derivatives such as the credit default swap(CDS) or synthetic CDO(collateral debt obligations), given the rapid growing and changing the over-the-counter derivative markets in their volume and structures. In comparison with the previous literature such as the study of Park & Kim (2011), this research empirically performed more thorough and comprehensive investigations to find any financial characteristics or attributes to determine the CDS spreads. Regarding the results obtained from the multiple regression models, the explanatory variables such as STYIELD3, SLOPE, INASSETS, and VOLATILITY, showed their statistically significant effects on all the tested dependent variables(DVs). Another procedure such as the principle component analysis(PCA), was also performed to account for additional IDVs as possible determinants of the dependent variables. Subsequent to this analysis, larger coefficients of each corresponding eigenvector such as BETA, PFT2, GROWTH, STD, and BLEVERAGE were found to be possible financial determinants. For robustness, all the IDVs were employed to be tested in the 'full' regression model with stepwise procedure. As a result, STYIELD3, SLOPE, and VOLATILITY, and BETA showed their statistically significant relationship with all the dependent variables of the CDS spreads.

A study on the impact of ESG (Environmental, Social, and Governance) management activities of small and medium-sized enterprises on the organization's non-financial performance (중소기업 ESG 경영 활동이 조직의 비재무적 경영성과에 미치는 영향에 관한 연구)

  • Hyun-Gyu Kang;Sang-Ho Lim
    • Industry Promotion Research
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    • v.9 no.2
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    • pp.23-28
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    • 2024
  • The study investigated the impact of ESG management activities on the non-financial performance of organizations, focusing on small and medium-sized manufacturing companies. Using data from 78 survey responses, the following results were summarized. Firstly, ESG management activities positively influenced internal customer satisfaction. The correlation coefficient was .679, indicating a moderately strong correlation, and the coefficient of determination (R2) was .461, explaining 46.1% of the variance. Additionally, with a beta value of .679, a t-value of 8.058, and a p-value of .000, ESG management activities had a statistically significant impact on internal customer satisfaction. Secondly, ESG management activities also had a positive impact on corporate trust. The correlation coefficient was .695, indicating a moderately strong correlation, and the coefficient of determination (R2) was .483, explaining 48.3% of the variance. The beta value was .695, the t-value was 8.429, and the significance probability was .000, indicating a significant influence on corporate trust.The study aimed to shed light on the relationship between ESG management activities of small and medium-sized enterprises and their non-financial performance. These results suggest that companies can enhance internal customer satisfaction and corporate trust through fulfilling social responsibilities and practicing sustainable management.