• Radiation Oncology Journal
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• v.4 no.1
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• pp.1-13
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• 1986

In order to clarify the effect of radiation on the mouse jejunal crypt cells by combined administration of administration and radiation and also to evaluate the enhancing effect of adriamycin, the authors performed this study by delivering single irradiation of 1,000 to 1,600 rad to the whole abdomen of mice by cobalt-60 teletherapy unit. In combination with adriyamycin treatment groups, the drug was administered as single dose of 10 mg/kg either 2 hours before or 4 hours after graded single dose,900 to 1,400 rad, of irradiation. The authors studied the quantitative changes of intestinal crypt cells by microcolony survival assay technique and the morphological changes of small intestinal villi by scanning electron microscope in mice following to combined therapy with adriamycin and irradiation, The average number of jejunal crypts per circumference was $130{\pm}16$ in control group. The mean lethal dose(Do) of each irradiation alone and combined therapy groups 2 hours before and 4 hours after irradiation, were 160, 170, and 170 rad in cell survival curves, respectively. The dose effect factor(DEF) of adriamycin in each groups of pre-irradiation and post-irradiation were 1.19 and 1.26, respectively. The conical shaped villi were noted on 1,200 rad in irradiation alone group and 1,000 rad in combined groups. For the proper clinical application we must be careful of the radiation injury to small bowel when the anticancer chemotherapy and radiation therapy to the abdomen and pelvic area are used as combined therapeutic modality.

• Journal of the Korean Society of Radiology
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• v.14 no.2
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• pp.139-148
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• 2020

The purpose of this study is to propose a method to optimize the performance of Digital Radiography (DR) by analyzing the effect of exposure time change on the stability of radiation output and image quality. The experimental method was used to change the exposure time to 50 msec, 100 msec, 200 msec, and 400 msec so that the Percentage Average Error (PAE), Time-to-Radiation Dose Curve, Signal to Noise Ratio (SNR), Contrast to Noise Ratio (CNR) and theses analysis were performed to evaluate the normal operation of parameters, radiation output and image quality. As a result, all the parameters used in the experiment showed the Percentage Average Error in the normal range, and the shorter the exposure time, the stability of radiation output and image quality decrease. In conclusion, it was found that the performance of Digital Radiography can be optimized when stable radiation output and image quality are applied by applying 100 msec ~ 200 msec exposure time.

• Journal of Digital Convergence
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• v.12 no.6
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• pp.433-438
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• 2014

This study aims to get more accurate and objective result by quantifying the result for the sperm changes through the quantitative analysis by the image processing based on the image obtained microscopically for the testicle cell and sperm change appeared with the passage of time when the radiation is irradiated to the white rat testicle. This study has targeted the white rat of 8 weeks lifespan, the X-ray of 6 MV with 1 time of 2 Gy has been irradiated to the whole body. The testicles of 5 rats at each test group immediately after irradiation, after 2 hours of irradiation, 4 hours, 8 hours and 24 hours has been respectively extracted targeting all 30 white rats of normal control group not irradiated by the radiation and the test group. The state of testicle cell and sperm has been observed in the normal control group and the test group by implementing Periodic acid Schiff dyeing after extraction. 24 hours after irradiation, a gradual decrease in sperm count and testicular cells qualitatively and quantitatively that were identified as significant.

• Journal of the Korean Society of Radiology
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• v.12 no.7
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• pp.887-893
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• 2018

The purpose of this study is to compare the performance of X-ray generators installed in hospitals and universities and apply the quality control items of diagnostic X-ray generators to recognize the importance of periodic performance management. First, the reproducibility and linearity test results showed that the PAE of the reproducibility evaluation was high for the GX-650 devices that met the acceptance criteria in all the experimental conditions and lacked the periodic quality control. In the linearity evaluation, when the tube voltage was set to 100 kVp, It was measured to deviate from the error. In addition, it was found that the PAE in the low-accuracy evaluation results relative to an X-ray tube voltage and tube current of the device low occurrence frequency. The HVL experiment was included in all of the devices at the HVL by tube voltage. Therefore, it is necessary to recognize the importance of quality control of all devices rather than hospital and laboratory, and to manage the device performance by actively managing the device, and to establish a short - term quality control system like special medical devices.

• Radiation Oncology Journal
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• v.3 no.2
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• pp.87-93
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• 1985

The interaction of radiation and 5-Fluorouracil (5-FU) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150mg/kg of 5-FU was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-FU was given 15 minutes before irradiation than giving it 6 hours after irradiation. The mean lethal doses (Do) of each of irradiation alone group, 5-FU injection group of 15 minutes preceding irradiation, and 5-FU injection group of 6 hours post irradiation were, 135, 135, and 114 rad respectively. The dose effect factor (DEF) of each of 5-FU injection groups of 15 minutes preceding irradiation and of 6 hours post irradiation were 1.13 and 1.27

• Journal of the Korean Society of Radiology
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• v.17 no.1
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• pp.149-156
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• 2023

The purpose of this study is to compare of growth and chlorophyl between old-barley seed (OBS, 2019) and New-barley seed (NBS, 2020) exposed by X-ray. After germination the OBS and NBS, experimental group was exposed by 30 Gy X-ray using linear accelerator (Clinac IS, VERIAN, USA), by 6 MV X-ray, SSD 100 cm, 18 × 10 cm², 600 MU/min. Length was measured every day until 9th day, and chlorophyl was analyzed using spectrophotometer(uv-1800, shimadzu, japan) after measuring weight in 9th day. Data analysis was performed the Independent T-test using SPSS ver 26.0(Chicago, IL, USA). NBS grow more faster than OBS in control group, but OBS grow more faster than NBS in experimental group. Length of control group was longer significantly every day than that of experimental group in OBS. NBS weighted more than OBS in control group, but OBS weighted more than NBS in experimental group. In comparing chlorophyl density, NBS high more than OBS in control group as well as experimental group. Growth and weight of OBS was effected more those than NBS by X-ray, but NBS in chlorophyl by X-ray. It is expected to be used as basic data for future X-ray research in barley seed.

• Journal of radiological science and technology
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• v.6 no.1
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• pp.69-80
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• 1983

• Journal of radiological science and technology
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• v.14 no.2
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• pp.55-55
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• 1991

I reduced overexposed X-Ray film image with farmer reduction method and $KMnO_4$ reduction method. The results are as follows : 1. In farmer reduction method, there appears linear decreasing film image density. 2. In $KMnO_4$ reduction method, there appears over proportional reduction. 3. When red prussiate is compared with $KMnO_4$ reduction method, the latter shows more intense reduction. 4. If the reduction solution isn't used within 10 minutes after dilution, it becomes oxidized and the ability is decreased remarkably.

• Journal of radiological science and technology
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• v.9 no.1
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• pp.131-135
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• 1986

The reciprocity law failure of the blue sensitive screen-film system was treasured, by authors. As a result, it has been found that reciprocity law failure is mote likely to occur at lower exposure, lower density and higher development temperature.

• Radiation Oncology Journal
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• v.16 no.2
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• pp.107-114
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• 1998

Purpose : Ginkgo biloba extract(GBE) is known to increase the peripheral blood circulation. This study was designed to evaluate the effect of GBE on the acute normal tissue radiation reaction. Materials and Methods : mice were divided into two groups, radiation alone and two doses GBE plus radiation, for both acute skin reaction and jejunal crypt assay. GBE was given i.p. one hour before irradiation with priming dose given one day earlier. Thirty to Fifty Gy for acute skin reaction and 11 to 14 Gy for jejunal crypt were irradiated to right hind leg and whole body, respectively. Results : Radiation doses($RD_{50}$) for Peak skin score of 2.0 were 44.2Gy (40.6-48.2Gy) for radiation alone and 44.4Gy(41.6-47.4Gy) for two doses GBE plus radiation, showing no effect of GBE on acute radiation skin damage. The numbers of regenerating jejunal crypts per circumference were also almost the same for each radiation dose level(p=0.57-0.94), and the mean lethal doses($D_o$) were 1.800y(1.57-2.09Gy) for radiation alone and 1.88Gy(1.65-2.18Gy) for two doses GBE plus radiation, indicating no effect of GBE on jejunal crypt cell survival after radiation. Conclusion : GBE doesn't increase acute normal tissue radiation reaction in this model system. As GBE was verified to enhance radiation effect on tumor, high therapeutic gain is expected when GBE is combined with radiation therapy.