• Progress in Medical Physics
• /
• v.7 no.2
• /
• pp.29-40
• /
• 1996

We had designed and made the cylindrical ionization chamber which operated above 5 mR/h. Using commercial electrometer, we investigated the characterictic of charge collection in the ion chamber. The active volume was 190.4㎤ and overall length and diameter in the chamber was 15.5cm, 5.22cm, respectively. The chamber had three electrodes(inner, central, wall electrode). And background current was 8.39${\times}$10$\^$-14/${\pm}$1.5${\times}$10$\^$-15/A to arrange the electrodes which were coaxial in chamber axis. The collection efficiency of chamber for Cs$\^$137/ was 99.7％ when the opreating voltage was applied 400V. Comparing with the commertial dosimetry system, the exposure calibration constant was 4.531${\times}$19$\^$7/R/C. By normalizing to CS$\_$137/ the relative energy response of the chamber was 1.30 for Am$\_$24/, 1.05 for C0$\_$60/, respectively. When the irrarition tranversed to the chamber axis, the isotropic effect of the chamber was not considerable.

• Korean Journal of Veterinary Research
• /
• v.55 no.1
• /
• pp.21-30
• /
• 2015

The immune system is specifically sensitive to oxidative stress induced by ionizing radiation because of its rapid proliferative activity. For this reason, an instructive immune system is one of the best ways to minimize side effects, such immunodeficiency, of gamma radiation. Over the past few decades, several natural plants with antioxidant and immunomodulatory properties have been identified as adjuncts for nontoxic and successful radiotherapy. Hizikia fusiforme extract (HFE) containing plentiful dietary fiber and fucoidan is known for its instructive antioxidant capacity, immunomodulation abilities, and immune activation. In this study, we determined whether HFE protects radiosensitive immune cells from gamma radiation-induced damage. C57BL/6 mice were irradiated with gamma-ray. The effect of HFE on the ionizing radiation damage of immune cells was then evaluated with an MTT assay, 3H-thymidine incorporation assay, and PI staining. We found that HFE stimulated the proliferation of gamma-ray irradiated immune cells without cytotoxic effects. We also observed that HFE not only decreased DNA damage but also reduced gamma radiation-induced apoptosis of the immune cells. Our results suggest that HFE can protect immune cells from gamma-ray damage and may serve as an effective, non-toxic radioprotective agent.

• The Journal of Internal Korean Medicine
• /
• v.27 no.2
• /
• pp.316-326
• /
• 2006

Backgrounds & Objects: The aim of this study was to investigate the radioprotective effect of Shengmai-san(SMS), a herbal medicine, on mice jejunal crypt cell survival and Apoptosis. Methods: Mice were devided into 4 groups according to radiation dose and SMS treatment: Normal was the group without irradiation. Control was the group treated with D.W before 10 Gy irradiation. SMS 2.9 was sample group treated with 2.9 mg/10 g of SMS extract before 10 Gy irradiation and SMS 29 was sample group treated with 29 mg/10 g of SMS extract before 10 Gy irradiation. And Each group were sacrificedat 24 hours and 72 hours after irradiation. To analyze the crypt survival, hematoxylin-eosin staining was used and to analyze the apoptosis, the TUNEL assay was done. Results: 1. From the microcolony survival assay, the SMS 2.9 and SMS 29 showed the radioprotective effect with a statistical significance compared to the control group at 24 hr (P < 0.01) and 72 hr (p < 0.001) after 10 Gy irradiatien. And the differences of radioprotective effect between SMS 2.9 and SMS 29 were net significant. 2. The results of the TUNEL assay showed that the apoptotic index in SMS 2.9 and SMS 29 was significantly decreased, as compared to the control group at both 24 hr ( p < 0.01) and 72 hr (SMS 2.9 : p < 0.001. SMS 29 : P < 0.01) after 10Gy irradiation And the differences of between SMS 2.9 and SMS 29 were not significant. Conclusions: It could be suggested that the Shengmai-san has a prominent Protective effect in mice intestines against the radiation damage. And the radieprotective effect seems to be related to inhibition of the apoptosis.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
• /
• 2007.10a
• /
• pp.169-175
• /
• 2007

고리, 월성, 울진, 영광 등4개 원전부지와 하나로 연구용 원자로 부지에 대해 방사성물질의 대기 중 누출사고 발생 시 대축척 전자지도와 연계한 사고정보 파악, 예상피해분석, 방재시설 및 소개정보 활용 등을 통해 중앙정부 및 지방자치단체가 방사능 물질 피해지역관리 및 신속하고 효율적인 주민대응조치 수립을 위한 의사 결정 지원할 수 있는 방사능방재 지리정보시스템 구축이 필요하다. 본 연구에서는 고리, 월성, 울진, 영광, 대전지역의 원자력 발전소 및 연구용 원자로 반경 40km이내 지역의 행정경계, 도로, 등고, 수계, 건물 등의 일반지형지물정보와, 비상계획구역 내 마을의 상세정보, 집결지, 대피소, 교통통제소, 환경방사능감시기, TLD등의 방재시설물 위치 및 관련 상세정보, 관공서, 경찰서, 소방서, 보건소, 학교, 병원 등의 방재관련 지형지물 위치 및 관련 상세정보, 원전부지 내 인구분포, 보유 차량 분포, 농작물 재배 현황, 축산물 재배현황 등의 방재관련 사회통계정보를 포함하는 공간 및 속성 데이터베이스는 구축하였다. 이를 기반으로 방사선 피폭영향 평가시스템(FADAS)의 예상평가결과를 전자지도 상에 표출하고, 이에 근거한 예상피해를 분석하며, 소개단계 대상 마을 검색 및 바람장 분석을 활용한 소개경로 제시 등을 통해 주민보호조치 의사결정을 지원하며, 사고대응 및 소개현황 정보를 관리하는 웹 기반의 원자력방재 지리정보시스템을 확대 개발하였다. 방재시설물 및 방재관련 지형지물, 방재관련 사회통계자료의 검색기능 및 실시간 원전 바람장 정보조회, 실시간 ERMS 수집정보 조회, 수치예보 정보 조회, 온라인DB관리 등의 확대 구현을 통해 사고대응조치 및 피해분석업무를 지원하였다. 본 연구를 통한 원자력방재 지리정보시스템 완성을 통해 방사능 비상시 중앙본부와 지역본부 및 유관기관 간에 지리정보와 연계한 정확한 사고정보 및 방재정보의 신속한 공유를 제공하고, 적절한 비상대응조치 의사결정 및 주민보조조치 수행을 지원하여 효율적인 사고지역 관리 및 인적 물적 자원의 피해를 최소화하는데 기여할 것으로 기대된다.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.6 no.2
• /
• pp.111-117
• /
• 2008

The new type phoswich detector consisting of the ZnS(Ag) and plastic scintillator for alpha/beta-ray simultaneous counting was developed for monitoring radiological contamination inside pipes. The detection performance was estimated using the PSD (pulse shape discrimination) method as a function of distance between the scintillator and radioactive source. The attenuation of particles traveling through a thin film for preventing the detector from being contaminated was experimentally estimated. It is concluded from our investigation that the phoswich detector developed can provide a sufficient alpha/beta-ray discrimination. The application of a thin film for preventing the detector from being contaminated was proven to be feasible.

• Korean Journal of Veterinary Research
• /
• v.56 no.1
• /
• pp.29-35
• /
• 2016

When exposed to gamma-rays, hair follicular cells immediately go through apoptosis, which hampers their rapid differentiation essential for the regeneration of hair. Phloroglucinol (PG) is a phenolic compound of Ecklonia cava, brown algae abundant in Jeju island, Korea. Containing plentiful polyphenols, PG is known for its instructive effects by inhibiting apoptosis, scavenging oxygen radicals, and protecting cells against oxidative stress. In this study, we demonstrate that PG rescues radiosensitive hair follicular cells from gamma radiation-induced apoptosis and DNA damage. To identify protective capacity of PG on hair follicles, we irradiated with 8.5 Gy (1.5 Gy/min) of gamma-rays to the whole body of C57BL/6 mice at day 6 after depilation with or without PG. In mice exposed to radiation, the expression of proapoptotic molecule p53 was downregulated in the skin of PG treated group. On immunohistochemical observation of the skin, PG inhibited the immunoreactivity of p53 and cleaved caspase-3. PG treatment protected hair follicular cells from cell death due to gamma-radiation. Our results suggest that PG presents radioprotective effects by inhibiting apoptosis of radiosensitive hair follicular cells and can protect hair follicular cells from gamma-ray induced damage.

• Journal of Korean Society of Disaster and Security
• /
• v.16 no.4
• /
• pp.85-99
• /
• 2023

By the social advancement, radiological disaster prevention planning is getting important considering complex disasters as in the Fukushima radiological disaster occurred by a chain of natural disasters. However, it has yet to be suggested the specific prevention plans for the complex disasters in the field of national radiological disaster prevention. This study aims to analyze the types of complex disasters in order to select the ones that are relatively more likely to occur in the domestic environment. It is also to analyze the impact on the radiological disaster prevention by searching damage spread of the classified natural disasters. We provides the necessary criterial for establishing disaster prevention plans through the scenarios for radiological emergency responses based on complex disasters. it is thought that these criteria can help prepare for the worst case scenario and implement effective resident protection.

• The Journal of Korean Society for Radiation Therapy
• /
• v.21 no.1
• /
• pp.9-15
• /
• 2009

Purpose: We evaluated the device that was created for maintaining the patient's setup and protecting the testicles from scattered radiation during treatment of carcinoma of the penis. Materials and Methods: The phantom testicles were made of vaseline cotton gauze and the device consisted of 5 mm of acryl box and 4 mm of lead shielding. $3{\times}3\;cm^2$, $4{\times}4\;cm^2$, $5{\times}5\;cm^2$, $6{\times}6\;cm^2$, $7{\times}7\;cm^2$ field sizes were used for this study and measurement was made at 4, 5, 6, 7, 8, 10 cm from the lower edge of the field for 10 times with lead shielding and without the shielding respectively. 200 cGy was delivered using 6 MV photons. Results: The scatted radiation without lead shielding at 4, 5, 6, 7, 8, 10 cm from the lower edge of the field were 14.8-4.7 cGy with $3{\times}3\;cm^2$, 15.7-5.2 cGy with $4{\times}4\;cm^2$, 17.6-5.5 cGy with $5{\times}5\;cm^2$, 19.9-6.6 cGy with $6{\times}6\;cm^2$, 22.2-7.6 cGy with $7{\times}7\;cm^2$ and the measured dose without lead shielding were 7.1-2.6 cGy with $3{\times}3\;cm^2$, 8.9-3.6 cGy with $4{\times}4\;cm^2$, 12.3-4.8 cGy with $5{\times}5\;cm^2$, 14.6-5.0 cGy with $6{\times}6\;cm^2$ and 21.1~6.4 cGy with $7{\times}7\;cm^2$. As shown above, the scatted radiation decreased after using lead shielding. Depending of the range of field sizes, the resulting difference between without shielding values and with shielding values were: 7.8-1.1 cGy at 4 cm, 5.1-1.2 cGy at 5 cm, 3.8-1.1 cGy at 6 cm, 3.4-1.7 cGy at 7 cm, 2.8-1.7 cGy at 8 cm, 2.4-2.5 cGy at 9 cm and 2.1-1.8 cGy at 10 cm. In the situation as described above, the range in values depending on the distance was 7.8-1.1 cGy with $3{\times}3\;cm^2$, 6.9-1.6 cGy with $4{\times}4\;cm^2$, 5.3-0.8 cGy with $5{\times}5\;cm^2$, 5.3-1.5 cGy with $6{\times}6\;cm^2$ and 1.1-1.8 cGy with $7{\times}7\;cm^2$. Conclusion: Using the device we created to shield the testicles from scattered radiation during treatment of carcinoma of the penis, we have found that scattered radiation to the testicles is decreased by the phantom testicles, and by increasing the distance between the testicles and penis.

• 한국지구물리탐사학회:학술대회논문집
• /
• 2002.09a
• /
• pp.139-162
• /
• 2002

Since weak zones or geological lineaments are likely to be eroded, weak zones may develop beneath rivers, and a careful evaluation of ground condition is important to construct structures passing through a river. Dc resistivity surveys, however, have seldomly applied to the investigation of water-covered area, possibly because of difficulties in data aquisition and interpretation. The data aquisition having high quality may be the most important factor, and is more difficult than that in land survey, due to the water layer overlying the underground structure to be imaged. Through the numerical modeling and the analysis of case histories, we studied the method of resistivity survey at the water-covered area, starting from the characteristics of measured data, via data acquisition method, to the interpretation method. We unfolded our discussion according to the installed locations of electrodes, ie., floating them on the water surface, and installing at the water bottom, since the methods of data acquisition and interpretation vary depending on the electrode location. Through this study, we could confirm that the dc resistivity method can provide the fairly reasonable subsurface images. It was also shown that installing electrodes at the water bottom can give the subsurface image with much higher resolution than floating them on the water surface. Since the data acquired at the water-covered area have much lower sensitivity to the underground structure than those at the land, and can be contaminated by the higher noise, such as streaming potential, it would be very important to select the acquisition method and electrode array being able to provide the higher signal-to-noise ratio data as well as the high resolving power. The method installing electrodes at the water bottom is suitable to the detailed survey because of much higher resolving power, whereas the method floating them, especially streamer dc resistivity survey, is to the reconnaissance survey owing of very high speed of field work.

• The Journal of Korean Society for Radiation Therapy
• /
• v.18 no.2
• /
• pp.105-112
• /
• 2006

Purpose: To demonstrate that water bolus in the patient surface can decrease the dose inhomogeneity by patient surface large tissue defect when the surface is in an electron-beam field. And We tried to find a easy way to water control. Methods and Materials: To demonstrate the use of water bolus in the irregular surface clinically, the case of a patient with myxofibrosarcoma of the chest wall who was treated with electrons. We obtained dose distribution using missing tissue option of PINACLE 6.2b (ADAC, USA). We fabricate a Mev-green for water bolus in patient with defect of tissue. Then put the water bolus which is vinyl packed water into the designed Mev-green. We peformed CT scan with CT-simulator. Three-dimensional (3D) dose distributions with and without water bolus in the large irregular chest wall were calculated for a representative patient. Resulting dose distributions and dose-volume histograms of water bolus were compared with missing tissue option and non bolus plans. We fabricate a new water control device. Results: Controlled Water bolus markedly decrease the dose heterogeneity, and minimizes normal tissue exposure caused by the surface irregularities of the chest wall mass. In the test case, The non bolus plan has a maximum target dose of 132%. After applying water bolus, the maximum target dose has been reduced substantially to 110.4%. The maximum target dose was reduced by 21.6% using this technique. Conclusion: The results showed that controlled water bolus could significantly improve the dose homogeneity in the PTV for patients treated with electron therapy using water control device. This technique may reduce the incidence of normal organ complications that occur after electron-beam therapy in irregular surface. And our new device shows handiness of water control.