• 대한한방소아과학회지
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• 제37권1호
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• pp.15-44
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• 2023

Objectives The purpose of this study is to analyze the types of childhood simple obesity and suggest clinical symptoms, treatment principles, and traditional Chinese medicine (TCM) treatments for each type. Methods All kinds of literature published by the China National Knowledge Infrastructure (CNKI) up to August 20, 2022 were analyzed. We extracted information about types of childhood simple obesity, relevant clinical symptoms, treatment principles and TCM treatments. Results 25 studies were included. Spleen deficiency with dampness obstruction, gastrointestinal dampness-heat, internal excess of phlegm-dampness were the most reported. Spleen deficiency with dampness obstruction has symptoms of powerless, heavy limbs, pale tongue, teeth-marked tongue, sunken and slippery pulse. As a treatment, herbal medicine (HM) like modified Banggihwanggitang and acupoint like Joksamri were mainly reported. Gastrointestinal dampness-heat has symptoms of thirst, constipation, edacity, rapid hungering, heavy limbs, red tongue, slippery and rapid pulse. HM like Modified Xiehuangsan to clear heat was mainly reported. Internal excess of phlegm-dampness has symptoms of heavy limbs, lack of strength, tongue with white slimy fur, slippery pulse. Modified Ijintang to dry dampness to resolve phlegm was mainly reported. Conclusions This study analyzed types of pattern, clinical symptoms, treatment principles, and TCM treatments of childhood simple obesity. Based on this study, it is necessary to derive a standardized dialectical information that reflects the domestic situation.

• 대한한방소아과학회지
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• 제37권3호
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• pp.75-93
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• 2023

Objectives We aimed to analyze the registration status of interventional clinical trials in children and adolescents with chronic cough. Methods All interventional clinical trials registered up to 3 July, 2023 on the international clinical trial registry platform (ICTRP) of the World Health Organization (WHO) were analyzed. Information was extracted including study design, interventions, inclusion and exclusion criteria, and outcome indicators. Results A total of 18 interventional clinical trials were analyzed. For study design, multicentre trials, randomized allocation, parallel group design and phase 4 trials were the most frequently reported. Blinding was used in 44.4% and informed consents were obtained from 61.1%. For intervention, drugs were used in 61.1%, using placebo control group in 27.8%. Quality of life questionnaires were most frequently reported in 50% as the primary outcome, and adverse events were the most as the secondary outcome. In most cases, the assessment timepoints were after two weeks. Conclusions Based on the characteristics of clinical trial design analyzed in this study, it is necessary to design traditional Korean medicine clinical trials with improved quality and accuracy of information.

• 대한한방소아과학회지
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• 제37권3호
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• pp.1-16
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• 2023

Objectives We aimed to investigate the effectiveness of the Korean medical critical pathway (CP) in treating childhood anorexia. Methods In total, 21 patients who met the criteria and agreed to provide information were assigned to the CP group, while 24 patients who met the criteria, agreed to provide information, but disagreed with CP application were assigned to the non-CP group. Demographic, clinical, and economic indices were compared between the two groups. Clinical indices before and after treatment were also compared between the two groups. Results In the CP group, height, weight, body mass index (BMI), BMI percentile, and food approach (FAP) increased significantly after treatment, and numeric rating scale (NRS) and food avoidance (FAV) scores decreased significantly. In the non-CP group, height, weight, weight percentile, BMI, BMI percentile, and FAP increased significantly, whereas NRS and FAV decreased significantly after treatment. Compared to the non-CP group, CP application increased FAP and decreased FAV, medical expenses per consultation, and the total treatment period. Conclusions The application of the Korean medical critical pathway for childhood anorexia is an effective cure system that decreases overall medical expenses with good-quality treatment by means of the standardization of medical practices.

• 문화기술의 융합
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• 제9권5호
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• pp.875-883
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• 2023

한국은 현재 문화유산의 전통을 후대에 연결해 주기 위한 보존과 관리 주체가 빠른 속도로 감소되고 있다. 이에 따라, 전통 문화유산을 후대에 이어주기 위한 인프라의 구축과 후대들의 보존·관리에 대한 관심이 무엇보다 중요하다. 특히 UNESCO에 등재된 세계문화유산인 '한국의 서원' 또한 후속세대들에게 온전히 그 가치를 이어가게 하는 것이 무엇보다 중요한 과제가 되었다. 본 연구는 전통 문화유산을 후대에게 온전히 그 가치를 이어가기 위해 빅데이터 분석기법을 통해서 UNESCO에 등재된 세계문화유산인 '한국의 서원'을 중심으로 전통문화재의 보존과 지원 등을 규정하고 있는 법률을 분석하였다. 각 법률에서 도출된 주요 키워드를 추출, 도식화 및 상호 워드네트워크를 구성하였다. 이렇게 함으로써 상호 연관성이 있는 네트워크워드들을 중심으로 정책적인 조언을 도출하였다. 정책적 조언으로는 서원의 보존과 활용, 서원의 보존과 관리 및 서원의 보존과 지원을 위해 해당 지역에 특화된 사업을 육성하고 지원하는 정책을 수립 및 실시해야 하며, 서원 인근 지역에서 서원과 연관된 사업을 추진하고 지원하기 위하여 관련된 행정적인 절차를 혁신적으로 개선을 해야 하는 것으로 나타났다.

• 대한한방소아과학회지
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• 제38권1호
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• pp.55-77
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• 2024

Objectives This study aimed to analyze the registration status and characteristics of clinical trials on herbal medicine (HM) and medication interventions for simple obesity in children and adolescents. Methods All interventional clinical trials registered in the International Clinical Trials Registry Platform of the World Health Organization until December 12, 2024, were collected. The study design, interventions, inclusion and exclusion criteria, and outcome measures were extracted. Results A total of 24 clinical trials (23 medications and 1 HM) were analyzed. The most common study designs were single-center, randomized controlled, parallel, and phase 2. Placebo controls were used in 87.5% of the studies, blinding was used in 79.1%, and quadruple blinding was the most common. Informed consent was obtained from 70.8% of the participants. Among the oral medications (66.6%), metformin was the most common (25%). Among the non-oral medications (29.1%), exenatide (Bydureon) was the most common intervention (42.8%). Body mass index was the most commonly reported primary outcome measure (79.1%), with most assessments performed at 6 months. Conclusions Based on the characteristics of the medication interventional clinical trial design analyzed in this study, additional high-quality multicenter traditional Korean medicine trials need to be designed in the future.

• 대한한방소아과학회지
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• 제38권2호
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• pp.21-31
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• 2024

Objectives This study aimed to develop consensus-based recommendations for establishing standard clinical practice guidelines for pediatric anorexia through the utilization of a Delphi study. Methods We analyzed existing randomized controlled trials for pediatric anorexia treatment using the Delphi method-a structured process for achieving consensus among a panel of experts. A questionnaire was distributed among a select panel of nine specialists in the field. Results The initial Delphi round led to consensus on 30 distinct recommendations; however, consensus was not reached for 19 other recommendations, prompting a second Delphi round. In the subsequent round, adjustments were made based on feedback from the initial round, and deliberations were held on recommendations that previously lacked consensus. Following these adjustments, consensus was achieved on all recommendations. Additionally, a third Delphi iteration was conducted to address three specific queries that required amendment due to a reevaluation of the evidence levels of certain recommendations. In total, three Delphi rounds were carried out to produce informed recommendations related to the diagnosis, treatment, and general management of anorexia. Conclusions This investigation successfully generated evidence-based recommendations for the diagnosis and treatment of pediatric anorexia. The recommendations encompassed various practices, including herbal medicine, acupuncture, moxibustion, cupping, and Chuna manual therapy, which can be integrated into clinical settings.

• 한국식품영양과학회지
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• 제46권3호
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• pp.320-326
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• 2017

본 연구에서는 낙과 배 물 추출물에 존재하는 미백기능 유효성분으로써 arbutin을 선정하여 HPLC를 통해 가장 높은 함량을 보인 낙과 배 물 추출물로 미백 효과를 알아보았다. 낙과 배 물 추출물의 미백 효과를 알아보기 위하여 B16F10 melanoma 세포를 이용하여 세포 내 tyrosinase 저해 효과, melanin 생성 저해 효과, tyrosinase와 관련된 단백질 발현에 미치는 영향을 연구하였다. 그 결과 낙과 배 물 추출물은 tyrosinase 활성과 B16F10 melanoma 세포의 melanin 생성 저해 효과를 나타내었다. 또한, MiTF와 tyrosinase의 발현의 억제를 통해 미백 효과를 나타내는 것으로 확인되었으며, mushroom tyrosinase 결과를 통해 melanin 생성 과정에 있어 tyrosinase를 직접 저해하는 것이 아닌 세포 내에서 tyrosinase의 발현 조절을 통해 저해하는 것으로 확인하였다. 따라서 낙과 배 물 추출물은 천연 arbutin 미백 기능성 화장품 소재 개발로 이용 가능성이 높은 것으로 판단된다. 낙과 배를 이용한 새로운 뷰티케어 소재를 개발하고 이들의 피부 기능성을 밝혀냄으로써 낙과 배의 다양한 활용성이 증대될 것으로 기대되며, 이를 통하여 국내 과실 농가 및 관련 사업에 기여할 것으로 생각된다.

• Journal of Nutrition and Health
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• 제35권2호
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• pp.183-191
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• 2002

The purpose of this study was to investigate the effect of dietary mushroom powder on blood glucose levels, seam lipid levels, glucose 6-phosphtase (G6Pase), thiobarbituric arid reactive substance (TBARS) and glutathione enzymes in diabetic rats treated with streptozotocin (STZ). Four groups of rats (Sprague-Dawley male rats, 180-200 g) were fed as follows: normal rats were fed a control diet (C), diabetic rats were file a control diet (CD), normal fats were fed a mushroom powder diet (M), and diabetic rals were find mushroom powder diet (MD). Diabetes was induced by single injection of streptozotocin (60 mg/kg B.W.). The animals were fed ad libium each of the experimental diets for five weeks. Food and water intake was determined every day. Blood glucose and serum total cholesterol levels were determined every week. After five weeks, the rats were sacrificed and blood glucose, serum total cholesterol, triglyceride levels and glutathione enzymes were measured. HDL-cholesterol levels were analyzed and LDL-cholesterol concentrations were calculated by equation. There was body weight loss in the diabetic rats, but the MD group showed less body weight loss than the CD group. Blood glucose and serum total cholesterol level of the MD group were lower than those of the CD group (p < 0.05). Also, serum total cholesterol of the M group was lower than that of the C group (p < 0.05). But the serum triglyceride level of the diabetic rats (CD and MD) was higher than that of the normal rats (C and M). However, there was no significant difference between the control diet group and the mushroom diet group. Serum HDL-cholesterol levels of the C group and CD group were higher than that of the M group (p < 0.05), and the MD group was not significantly different. But the serum LDL-cholesterol levels of the M group were lower than those of the C group (p < 0.05). Activity of hepatic microsomal G6Pase significantly increased in the CD and MD, reaching levels higher than those of the C and M groups. Hepateic gutathione S-transferase (GST, glutathione reductase (GR) and glutathione peroxidase (GPX) activity was not significant. But renal GST, GR and GPX activity in the MD group was lower than that of the CD group (p < 0.05). These results suggest that dietary mushroom reduces renal disorders such as oxidation and aging of tissue. In conclusion, dietary mushroom groups reduced blood glucose and cholesterol levels in STZ-induced diabetic rats and renal glutathione enzymes activity was averted in diabetic rats.

• 한국식품영양과학회지
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• 제31권5호
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• pp.840-846
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• 2002

염생 식물인 함초의 기능성을 규명하기 위하여 S.D.계 백서에 당뇨를 유도시킨 후 5% 함초 분말 식이로 5주간 실험 사육한 후 혈청지질ㆍ혈당농도와 주요장기의 당 대사 및 항산화 효소의 활성 변화활성을 측정하여 함초의 섭취가 당질ㆍ지질대사 및 항산화 효소계에 미치는 영향을 조사하였다. 당뇨군에서 함초의 섭취는 식이효율을 증가시켜, 당뇨에 의해 나타나는 체중감소현상을 억제하여 당뇨의 증세를 완화시켰다. 또한 함초의 섭취는 혈당강하효과 및 혈청 총 지질과 중성지방 저하효과를 보였다. 따라서 함초의 섭취는 당뇨쥐의 섭취는 당뇨쥐의 지질상승억제 및 혈당 저하 효과로 항당뇨 효능을 나타낼 수 있을 것으로 사료된다. 또한 당뇨합병증의 발생기전을 항산화효소와 관련시켜 연구하고자, 간과 시장의 항산화관련 인자를 측정한 결과, 당뇨에 의해 정상수준으로 회복되었다. 또 GR의 활성도는 함초 당뇨군(DH)의 간조직에서는 증가하였으나 신장에서는 오히려 감소하였다. 따라서 본 연구는 함초 섭취가 고혈당 및 고지혈증을 억제하고 당뇨로 인한 항산화 효소 활성변화를 정상으로 회복시킴을 밝혀 함초를 활용한 건강식품개발 위한 가능성을 제시하는 바이다.

• 자원환경지질
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• 제39권3호
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• pp.301-328
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• 2006

인도네시아 중부 칼리만탄 뚬방미리 지역의 지질은 하부로부터 석탄-페름기의 피노변성암류, 백악기 세파욱심성암류, 에오세말기의 탄중층과 올리고세의 말라산화산암류로 구성되며, 올리고세-마이오세초기의 신탕관입암류가 상기한 모든 지층들을 관입하고 있다. 지화학탐사와 지질조사 결과를 종합한 결과는 조사대상지역인 뚬방미리 전역에 걸쳐 상당량의 함금 석영맥이 존재했었음을 밝혀내었다. 하천의 바닥 퇴적물을 팬닝한 산물이나 제4기 퇴적층의 하부 역암질층에서 눈으로 관찰 할 수 있을 만큼 많은 곳에서 금이 관찰되었다. 타란 지역을 제외하고는 대부분의 조사대상지역에서 석영맥의 잔류가 남아있지는 않지만 부정합면 바로 상위나 고하상에 해당하는 부위가 석영자갈과 점토를 이루어져 있고 금입자를 함유하고 있다는 사실은 금 입자가 석영맥으로부터 분리되었음을 암시해주고 있다. 현재 강을 따라 여러 곳에서 수면보다 약 10-20cm 상위에 자갈과 점토층이 발달해 있고, 지화학탐사 시료를 채취하는 과정에서 무작위로 선정하여 금의 함유 여부를 점검한 결과 대부분의 경우 금 입자를 볼 수 있었다. 수면위의 역암질층은 제4기 고하상에 해당하므로 금이 퇴적되는 것은 하상의 모양이나, 강물의 유속과 강 흐름의 모양 그리고 근원암으로부터의 거리에 따라 좌우되었을 것으로 가정된다. 모든 결과를 종합하여 볼 때 타란지역과 따까오이 북부지역을 유망지역으로 추천한다.