• Environmental Mutagens and Carcinogens
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• v.11 no.2
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• pp.134-140
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• 1991

B형 간염바이러스의 표면항원, 파상풍, 디프테리아균의 toxoid, 백일해의 혼합백신인 PDT-Hepa의 효능을 실험하여 다음과 같은 결과를 얻었다. 시험물질을 기니픽에 접종하였을 때 B형 간염 바이러스의 표면 항원과 파상풍 및 디프테리아균의 toxoid에 대한 항체형성이 뚜렷이 관찰되었으며, 항체형성의 정도는 접종용량에 비례하였다. 백일해의 경우는 시험물질을 마우스에 접종시킨 후 마우스에 감수성이 있는 Bordetella pertussis 18323주로 직접 공격 접종하여 이 균에 대한 방어력이 형성되어 있음을 관찰하였으며, 이러한 방어정도는 투여 용량에 비레함을 알 수 있었다.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2003.11a
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• pp.341-342
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• 2003

대기 중의 부유분진 (suspended particulate matters)은 대기오염을 측정하는 일반지표 중의 한 항목으로, 보통 대기의 단위부피당 질량으로 그 오염정도를 판단하고 있다. 대기 중 부유분진은 입경별 농도분포에 따라 통해 오염원의 특성을 파악할 수 있고, 여러 오염원에서 배출되어지는 여러 화학물질들로 구성되어 있기 때문에 인체 위해성 측면에서 많은 관심의 대상이 되어 왔다. 또한 다환방향족탄화수소 (Polycyclic Aromatic Hydrocarbons, PAHs)는 환경에 존재하는 중요한 발암물질이자 돌연변이 유도체이다.(중략)

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2001.11a
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• pp.383-384
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• 2001

대기 중 formaldehyde는 눈, 코, 목을 자극하고 기관지 천식, 피부 알레르기를 일으킬 뿐만 아니라 동물실험 결과 발암 가능성 물질로 여겨지고 있다(황윤정, 등 1996). 미국 EPA는 formaldehyde를 유력한 인체발암물질(probable human carcinogen, weight of evidence-Group "B1")로 분류하고 있다(IARC, 1982; Edward 등, 1991). (중략)

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2002.04a
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• pp.193-194
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• 2002

휘발성 유기화합물(VOCs)은 환경에 광범위하게 분포되어 있으며 특히 벤젠(benzene)은 발암물질로 규제가 강화되고 있다 또한 높은 증기압과 헨리상수를 가지고 있으므로 환경 중 이동이 용이하므로 대기, 수중, 토양 모두에 심각한 오염물질이 되고 있다. 이런 유기화합물 처리에 높은 효율을 나타내는 것이 자외선을 이용한 광분해(UV/Photodegradation)로 TiO$_2$를 촉매로 이용하는 것이다(Blystone et al., 1991). (중략)

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2002.11a
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• pp.197-198
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• 2002

황사는 장거리를 이동해 한반도 둥에 영향을 미치는데, 호흡기 질환, 눈 질환, 알레르기 등 각종 질환을 유발하고, 최근에는 중국의 산업화에 따라 납, 카드뮴 같은 독성금속과 발암물질 둥 유해 오염물질까지 포함하고 있어 건강에 위협을 주고 있다. 나아가 황사에 포함된 미세 입자들이 대기 중에서 화학반응을 일으켜 각종 산화물을 생성하는 까닭에 만성기관지염을 악화시키고, 노인과 영아의 호흡기 질환을 유발하기도 한다 그밖에 황사는 햇빛을 차단해 시정거리를 감소시키고 항공기 운항에도 영향을 미친다. (중략)

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.4
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• pp.697-702
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• 2001

This study was done to investigate effects of Korean mistletoe extract and lectin on serum GOT, GPT and $\alpha$-L-fucosidase activities and the preneoplastic lesion in chemically induced rat hepatocarcinogenesis. To attain the above objectives weanling Sprangue-Dawley male rats were fed modified AIN-76 diets containing 10% corn oil for 9 weeks. One week after feeding rats were intraperitonealy injected twice with a dose of diethylnitrosamine (DEN, 50 mg/kg body weight(BW)) and were provided 0.05% phenobarbita (PB) with drinking water from one week after DEN treatment until the end of experiment. For the same period as PB treatment, rats were injected mistletoe extract (10 $\mu\textrm{g}$/kg BW European mistletoe, 10 $\mu\textrm{g}$/kg BW and 100 $\mu\textrm{g}$/kg BW Korean mistletoe) and lectin(1 ng/kg BW, 10 ng/kg BW) twice a week. At the end of 9th week rats were sacrificed and the formation of hepatic glutthione S-transferase placental form positive (GST-P+) foci serum GOT, GPT and $\alpha$-L-fucosidase activities were determined. By treatment of mistletoe extract or lectin there were no significant effects on serum GOP, GPT and $\alpha$-L-fucosidase activities whereas those activities showed a tendency to increase by DEN treatment. The formation of GST-P+ foci was significantly decreased by mistletoe extract or lectin treatment especially in group of 100$\mu\textrm{g}$/kg BW Korean mistletoe. These results suggest that Korean mistletoe extract and lectin have a possibility to inhibit hepatocarcinogenesis of animals.

• Korean Journal of Acupuncture
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• v.19 no.1
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• pp.7-13
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• 2002

The effects of Cnidium officinale Makino aqua-acupuncture solution (COMAS) and Cnidium officinale Makino water-extraced solution (COMWS) on the CYP1A1 activity and benzo[a]pyrene(B[a]P)-DNA adduct formation were examined. There were 6.8%, 12.1%, 15.1%, 18.3% and 22.6% inhibition in the activity of cytochrome 4501A1 enzyme with the treatment of $0.1{\times},\;0.5{\times},\;1{\times},\;3{\times},\;and\;5{\times}$ COMAS, respectively. At concentration of $0.1{\times}$ COMAS, the binding of $[^3H]B[a]P$ metabolites to DNA of NCTC-clone 1469 cell was significantly inhibited by 56.9%. These results suggest that COMAS has chemopreventive potential by inhibiting cytochrome P4501A1 activity and benzo[a]pyrene-DNA adduct formation.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2001.09a
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• pp.13-15
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• 2001

발암성시험연구에 사용되고 있는 형질전환 동물들은 랫드와 마우스 등이 있는데, 그 중 c-Ha-ras proto-oncogene 마우스 (ras H2 mice), v-Ha-ras 형질전환 마우스 (Tg.AC mice), pim-1 형질전환 마우스 및 p53 knockout 마우스 등이 발암유발물질에 감수성이 높아 현재 중기발암성시험에 이용되고 있다. (중략)

• Journal of Environmental Health Sciences
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• v.29 no.2
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• pp.50-55
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• 2003

3,3-dichlorobenzidine is suspected to be cancinogenic in experimental animal and human. Several studies have investigated excretion of metabolites in urine, hemoglobin adduction and cancer incidence among workers occupationally exposed to 3,3'-dichlorobenzidine. In these researches, metabolites of 3,3'-dichlorobenzidine had a very important role, and were required as highly purity. The purpose of this study was synthesis and isolation of its metabolites from 3,3'-dichlorobenzidine. 3,3'-dichlorobenzidine was partially dissolved in benzene, ether, ethanol and methanol, and completely dissolved in 70% acetic acid on mixtures of citric acid containing less than 1% DCB, pyridine, a mixture of 0.5N NaOH and toluene(1:2), and phenol saturated with 20 mM TRIZA base. DCB, monoacetyl-DCB and diacetyl-DCB were measured by using gas chromatography/mass spectrometry(GC/MS). Detection for checking them was nitrogen phosphorous detection mode(NPD), and for identifying them was selected ion monitoring mode(SIM). The base peaks were 252 m/z in DCB, 252, and 294 m/z in monoacetyl-DCB, and 252, 294 and 336 m/z in diacetyl-DCB, respectively. Diacetyl-DCB was synthesized by titrating DCB solution of pyridine with sufficient acetyl chloride. Precipitation was diacetyl-DCB, which was purity of 98.7%. And its supernatant was composed of DCB, monoacetyl-DCB and diacetyl-DCB. By using acetic acid as controller of acetylation, monoacetyl-DCB was isolated from diacetyl-DCB . And residual pyridine was removed by using acetone. The purity of monoacetyl-DCB was 98.8%.

• 월간산업보건
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• s.281
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• pp.2-4
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• 2011