• Journal of the Korean Chemical Society
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• v.28 no.4
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• pp.217-230
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• 1984

The MINDO/3 method was used in determination of transition states and activation barriers for various 1,2-, 1,3- and 1,5-sigmatropic hydrogen rearrangements involving systems with central carbon atom. It was found that, besides the consideration of orbital symmetry, steric effect, aromaticity, and orbital interactions were found to dictate the stability of the transition state. For systems with hetero atoms, lone pair orbitals tend to ease orbital distortion required at the transition state by participating in hydrogen transfer process and were found to lower the activation barrier accordingly. Comparison of the relative barrier heights with those obtained by using more sophisticated ab initio MO calculations showed that the MINDO/3 results give qualitatively the same tendency of the relative order of the activation barriers.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.47 no.1
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• pp.116-122
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• 2010

As the importance of HCI(Human-Computer Interface) caused by dramatically developed computer technology is getting high, the requirement for the design of human friendly systems is also getting high. First of all, the personality and Emotional factor should be considered for implementing more human friendly systems. Many studies on Knowledge, Emotion and personality have been made, but the combined methods connecting these three factors is not so many investigated yet. It is known that memorizing process includes not only knowledge but also the emotion and the emotion state has much effects on the process of reasoning and decision making step. Accordingly, for implementing more human friendly efficient sophisticated intelligent system, the system considering these three factors should be modeled and designed. In this paper, knowledge-emotion reaction model was designed. Five types are defined for representing the personality and emotion reaction mechanism calculating emotion vector based on the extracted Thought threads by Type matching selection was proposed. This system is applied to the virtual memory and its emotional reactions are simulated.

• Archives of design research
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• v.17 no.3
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• pp.179-188
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• 2004

Recently, design has emerged as a key factor of successful product development. This study reviewed the elements of form with a view point of addressing and defining the elements of aesthetics and how they influence consumer aesthetic response. Though past researches related to form aesthetics reported that form aesthetics exist as a single element with other sub-elements, this research made further investigations into form aesthetics and reported that form aesthetics in product design can be broadly divided into form aesthetics and content aesthetics. Empirical studies on each category was undertaken and from the results obtained, it was concluded that typicality is a dominant element in content aesthetics while rhythm is a dominant element in form aesthetics. Also, the study investigated the effect of conditional variables such as price and brand hierarchy on each category and it was observed that both content and form aesthetics elements are affected by conditional variables such as price and brand hierarchy, Furthermore, the study reports that both content and form aesthetics elements are mutually correlated and both categories affect user's aesthetics response. It is intended that the results obtained from this work will contribute to theoretical knowledge of aesthetic elements and can be put to use by product design and manufacturing companies.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2009.04a
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• pp.239-242
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• 2009

구조물의 표면에 부착된 압전소자(이하 PZT)의 전기역학적 어드미턴스(Electro-mechanical admittance)는 PZT와 구조물의 상호작용에 의해 발생하는 PZT의 압전효과와 유전성(dielectric)이 결합되어 발생되는 신호이다. 고주파수 대역에서 PZT의 전기역학적 어드미턴스는 구조물의 국부손상에 민감하게 반응하는 것으로 알려져 있다. 실험에서 측정된 PZT의 전기역학적 어드미턴스 분석에 널리 쓰이는 Liang 모델은 구조물을 단자유도계로 단순화하여 구조물의 동적특성이 전기역학적 어드미턴스에 미치는 영향을 정확하게 나타내기 어렵다. 유한요소법을 통해 PZT와 구조물의 상호작용을 해석하면 이러한 문제점을 해결할 수 있다. 그러나 고주파 대역에서 정확한 해석을 위해서는 유한요소망을 조밀하게 구성해야 하므로 많은 계산비용이 수반된다. 이 연구에서는 유한요소법과 비교하여 월등히 적은 계산비용으로 고주파 대역의 동적 응답을 매우 정확하게 모사할 수 있는 스펙트럼 요소법(Spectral Element Method ; 이하 SEM)을 통해 판구조물에 부착된 PZT의 전기-역학적 어드미턴스를 해석한다. 수치 예제 및 실험 예제를 통하여 내민보에 부착된 PZT에서 발생하는 전기-역학적 어드미턴스를 취득하고 이를 SEM해석 결과와 비교한다.

• Journal of the Korean Chemical Society
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• v.29 no.1
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• pp.45-51
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• 1985

Rate constants and activation parameters for the methanolysis of t-butyl halide (t-BuCl, t-BuBr, t-BuI) in various MeOH-DMSO mixtures were measured by conductometric method. Taft's solvatochromic parameters, such as polarity-polarizability(SPP's), ${\pi}^{\ast}$, hydrogen bond donor (HBD) acidity, ${\alpha}$, and hydrogen bond acceptor (HBA) basicity, ${\beta}$ of the solvents, were determined by the so called solvatochromic method using five indicators. The variation of methanolysis rate with the solvent composition was discussed on the basis of the activation parameters and the correlation of the rates with the solvatochromic parameters. It is concluded that the polarity-polarizability, HBD acidity and HBA basicity of the mixtures had an effect on the ionization of t-butyl halide cooperatively, also that the specific interaction between the leaving groups and the solvents, such as ion-dipole and hydrogen bond acceptor-donor interaction, is the most important factor of solvent effects on the stabilization of transition states.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.323-323
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• 1994

Allyl alcohol은 간에서 두 단계의 효소 반응을 거쳐 대사되는데, 먼저, alcohol dehydrogenase (ADH)에 의해 독성 활성체인 acrolein으로 바뀌고, 이후 계속하여 aldehyde dehydrogenase (ALDH)에 의해 acrylic acid로 무독화되어 배설된다. Ethanol 역시 간에서 대사되는데 있어 같은 효소들을 공유하므로 allyl alcohol과 경쟁적으로 반응할 것이다. 따라서, 본 실험에서는 ethanol에 의한 대사 효소 경쟁반응에 의해 allyl alcohol 의 간독성이 어떻게 변화하는지를 연구하였다. 우선 ethanol과 allyl alcohol을 동시 투여할 경우 5시간째에 allyl alcohol에 의해 증가된 ALT level을 낮춘다는 보고를 확인하고자 ethanol 2 g/kg과 allyl alcohol 40 mg/kg을 동시투여했으나 오히려 치사율이 증가했고, ethanol을 2시간 전처리한 군에서도 역시 치사율이 증가되고, 간의 glutathione 양은 allyl alcohol 단독 처리군에 비해 현저히 감소되는 양상을 보였다.

• Journal of the Korean Institute of Landscape Architecture
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• v.52 no.2
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• pp.64-78
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• 2024

Storytelling is a communication technique to express and convey the story using various media, where the audience accepts the story, reinterprets the topic and interacts with the storyteller. It was assumed that the user's significance and awareness about the storytelling technique applied to historical theme parks would have an impact on the satisfaction of using the theme park and intention to revisit. In this study, it was purposed to derive the structural factors of spatial storytelling in historical theme parks, and to understand the impact of user's awareness and constituent factors on user responses. Based on previous researches, the structural factors of spatial storytelling in historical theme parks were derived related to theme, experientiality, unusualness, educationalness, unity, expressiveness, interactivity, and interest, and for which the users' awareness was surveyed. The survey was conducted targeting the users of Samguk Yusa Theme Park located in Gunwi-gun, Gyeongsangbuk-do, where the collected data was analyzed using EXCEL2020 and SPSS 21.0 statistical programs, and the results are as follows: First, the spatial storytelling technique applied as a conveying method of the theme of Samguk Yusa Theme Park affects users' satisfaction and intention to revisit, and most respondents responded that the storytelling was significant. Second, it showed that the significance of unusualness and educationalness among the awareness of significance of the spatial storytelling constituent factors of Samguk Yusa Theme Park has a significant impact on user's satisfaction, and the significance of unusualness, interactivity, educationalness, and interest has a significant impact on intention to revisit. Third, it showed that the awareness of interest, theme, and unity has a significant impact on user's satisfaction depending on the user's awareness of spatial storytelling constituent factors of Samguk Yusa Theme Park, and the awareness of interactivity and experientiality has a significant impact on intention to revisit. This study is meaningful in quantitative analysis and interpretation of the influence of storytelling on user's response to historical theme parks by the exploratory analysis of characteristic factors and spatial storytelling constituent factors on historical theme parks and deriving the structural factors of spatial storytelling in historical theme parks.

• Journal of the Korean Chemical Society
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• v.62 no.1
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• pp.24-29
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• 2018

Despite the great potential for the versatile applications in food industry and medical area, chitosan as a biocompatible cationic polysaccharide has suffered from the limited solubility under physiological condition. Herein, we demonstrated the electrostatic formation of chitosan-based polyplex particles, counterbalanced by polyacrylate as an anionic polyelectrolyte. The resulting polyplex exhibited pH- and composition-dependent changes in their surface charges as measured by zeta potential, which can be employed to provide the interparticle repulsive forces for enhanced colloidal stability in homogeneous solution. Subsequently, amide coupling between the acrylates and glucosamine residues of chitosan inside the polyplex further generated the hydrogel particles, which showed the temperature-sensitive swelling property. This aspect can be attributed to the partial formation of acryl amide residues, which have been generally known to possess the lower critical solution temperature (LCST).

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.1057-1067
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• 2014

Many genetic variants have been identified to be associated with complex diseases such as hypertension, diabetes and cancers throughout genome-wide association studies (GWAS). However, there still exist a serious missing heritability problem since the proportion explained by genetic variants from GWAS is very weak less than 10~15%. Gene-gene interaction study may be helpful to explain the missing heritability because most of complex disease mechanisms are involved with more than one single SNP, which include multiple SNPs or gene-gene interactions. This paper focuses on gene-gene interactions with the survival phenotype by extending the multifactor dimensionality reduction (MDR) method to the accelerated failure time (AFT) model. The standardized residual from AFT model is used as a residual score for classifying multiple geno-types into high and low risk groups and algorithm of MDR is implemented. We call this method AFT-MDR and compares the power of AFT-MDR with those of Surv-MDR and Cox-MDR in simulation studies. Also a real data for leukemia Korean patients is analyzed. It was found that the power of AFT-MDR is greater than that of Surv-MDR and is comparable with that of Cox-MDR, but is very sensitive to the censoring fraction.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.133.1-133.1
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• 2010

슬러리 기포탑 반응기는 열 및 물질 전달의 용이성, 낮은 운전비용 및 장치의 간단성의 장점을 가지고 있어서 Fischer-Tropsch 반응, bio-reaction 등에 많이 응용되고 있다. 그러나 기포탑 반응기 내의 물질 거동은 매우 복잡하기 때문에 많은 연구가 이루어지고 있음에도 불구하고 그 현상에 대한 명확한 이해는 어려운 상황이다. 특히 기포탑반응기 내에 기체의 포집율(gas hold-up)을 증가시키는 것을 목적으로 하는 연구들이 활발히 진행되고 있다. 본 연구에서는 trayed bubble column 반응기에서 tray의 기공크기에 따른 기체 포집율의 변화를 관찰하였다. 실험에 사용된 반응기는 내경이 0.15 m이고 높이 2.0 m의 아크릴 반응기를 이용하였다. 사용된 연속상은 수돗물을 사용하였고 분산상 기체로는 압축공기를 이용하였다. Tray의 기공크기는 1.1 mm부터 14.0 mm까지 변화시키면서 높이별 기체 포집율의 변화를 관찰하였다. 기체 포집율의 변화를 균일흐름 영역과 불균일 흐름 영역에서 그 양상이 다르게 나타났다. 즉 균일계 영역에서는 기공의 크기가 1.1 mm부터 2.9 mm까지 증가시면 기체포집율이 감소하는 반면 2.9 mm 이상에서는 증가하는 것으로 관찰되었다. 반면 불균일 흐름 영역에서는 전반적으로 기공의 크기가 작아질수록 기체포집율이 증가하였다. 또한 각각의 흐흠 영역에서의 기체포집율 증가정도는 확연한 차이를 보이는 것을 알 수 있었다. 이것은 흐름영역의 유체거동에 따라서 기포와 tray 기공사이의 상호작용 메커니즘이 달라지기 때문인 것으로 보인다.