• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.622-624
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• 2015

Tumor hypoxia caused by the unique characteristics of solid tumor sites such as lowered vascular density, irregular vasculature, longitudinal oxygen gradient, and unbalanced oxygen consumption has decreased therapeutic efficacy in several clinical trials such as radiation, chemotherapy, and surgery. Hence, tumor oxygenation studies at microvascular levels are important to provide better understanding of the complexity of microvasculature oxygen transport and exchange with tissue. However, polarographic microelectodes, was employed to measure $pO_2$ at the microvasculature level, but it is difficult to perform and does not provide significant spatial and temporal information of oxygen delivery. In this research, we introduce the hyperspectral imaging system able to provide a wide range of vascular characteristics by spatial maps on hemoglobin saturation information for better understanding of the relationship between blood oxygen delivery, hypervascularity, aberrant angiogenesis at microvasculature levels during tumor growth.

• Radiation Oncology Journal
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• v.28 no.3
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• pp.147-154
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• 2010

Purpose: To investigate the radiosensitizing effect of the selective epidermal growth factor receptor (EGFR) inhibitor nimotuzumab in human colorectal cancer cell lines. Materials and Methods: Four human colorectal cancer cell lines, HCT-8, LoVo, WiDr, and HCT-116 were treated with nimotuzumab and/or radiation. The effects on cell proliferation, viability, and cell cycle progression were measured by MTT, clonogenic survival assay, flow cytometry, and Western blot. Results: An immunoblot analysis revealed that EGFR phosphorylation was inhibited by nimotuzumab in colorectal cancer cell lines. Under these experimental conditions, pre-treatment with nimotuzumab increased radiosensitivity of colorectal cancer cell lines, except for cell line HCT-116. However, cell proliferation or cell cycle progression was not affected by the addition of nimotuzumab, irrespective of irradiation. Conclusion: Nimotuzumab enhanced the radiosensitivity of colorectal cancer cells in vitro by inhibiting EGFR-mediated cell survival signaling. This study provided a rationale for the clinical application of the selective EGFR inhibitor, nimotuzumab in combination with radiation in colorectal cancer cells.

• 한국지구물리탐사학회:학술대회논문집
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• 2008.10a
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• pp.125-130
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• 2008

Electrical resistivity and seismic refraction surveys were conducted to investigate geologic structures and geotechnical characteristics of the subsurface in Dok-do island, along with rock physical properties. The resistivity results in Seo-do island show that the fault adjacent to the fisherman's shelter is a normal fault and extended towards the NW direction. Bedded Rapilli Tuff in the downstream was more severely influenced in depth by weathering and erosion than Trachy Andesite II in the upstream area. The physical properties of the rocks illustrate that Trachyte and Trachy Andesite are hardest, Massive Tuff Breccia is next, and Tuffs are the most soft rocks in Dok-do island.

• Journal of Hospice and Palliative Care
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• v.18 no.1
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• pp.25-34
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• 2015

Purpose: This study is to find relationship between cancer patient's spiritual health and the level of their anxiety and pain. Methods: From April 27 through May 11, 2012, a survey was conducted with 167 cancer patients hospitalized at a university hospital in Busan. Spiritual health was measured by the Spiritual Health Inventory developed by Highfield (1992). The instrument for anxiety measurement was the State-Trait Anxiety Inventory by Spielberger (1975) and that for pain was the Visual Analogue Scale (2009). The association between patients' characteristics and spiritual health, anxiety or pain degree were analyzed using the ANOVA test. The interrelationship between spiritual health, anxiety and pain was analyzed using Pearson's correlation coefficients. Results: The patients exhibited a moderate degree of spiritual health and anxiety and a mild level of pain. Patients' spiritual health significantly differed by their religion, education, monthly income of the family, illness conditions, physical conditions, metastasis, daily living and support. Their anxiety level was significantly different according to age, religion, education, illness conditions, physical conditions, metastasis, daily living, family/friends' support and use of analgesics. Significant differences were also found in the level of pain according to illness conditions, physical conditions, metastasis, daily living, family/friends' support and use of analgesics. We found a moderately negative correlation between spiritual health and anxiety. Anxiety and pain showed a positive correlation, and spiritual health and pain exhibited a negative correlation. Conclusion: To help cancer patients to manage their spiritual health, anxiety and pain, a program should be developed considering the primary factors discussed in this study.

• Journal of Nutrition and Health
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• v.41 no.8
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• pp.754-766
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• 2008

This study was performed to evaluate the effect of nutrient intake levels on the relative risk of breast cancer in the Daegu and Gyeongbuk area. The case subjects were 103 patients newly diagnosed as breast cancer at Kyungpook National University Hospital. The control subjects were 159 healthy women without breast cancer-related disease in the same community selected by frequency matching of age and menopausal status. The survey was administered by individual interviews by trained dietitians using semiquantitative food frequency questionnaires. The odds ratios were determined by using unconditional logistic regression after adjusting for the confounding factors found in the analysis of general characteristics of the subjects. In overall, it has been found that high consumptions of energy and carbohydrates significantly raised the relative risk of breast cancer, and that high intakes of total fat, plant fat, dietary fiber, all kinds of fatty acids, vitamin E and calcium significantly lowered the risk of breast cancer. The results of the study suggest that the possible protective factors to the breast cancer risk include a higher intakes of total fat, especially plant fat, dietary fiber, and micronutrients such as vitamin E, folic acid, calcium, phosphorus and potassium. On the other hand, high intakes of energy and carbohydrate appeared to be the risk factors.

• Radiation Oncology Journal
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• v.11 no.1
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• pp.43-50
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• 1993

We evaluated frequency and types of chromosomal aberrations by ionizing radiation in cancer patients treated with radiotherapy in our institution. Twenty-five patients with various types of carcinomas such as lung, uterine cervix, esophagus, rectum, head and neck and pancreatic cancers were studied immediately before and after external beam radiotherapy. The frequency of aberrant metaphase prior to treatment was $4.93{\%}$, which was higher than that of control group. Especially in lung cancer, the freuqency of aberrant metaphase was three times higher than control group. A comparison of chromosomal abnormalities observed before and after radiotherapy demonstrated that proportion of aberrant rnetaphases was significantly inreased to $22.13{\%}$. Major chromosomal aberrations like structural abnormalities showed remarkalbe increase from 65.45 to $88.45{\%}$ after the treatment. Also the numbers of chromosomal alterations per cell were increased by a factor of 6.5. Aberrations with two or more break points were more prominently increased, compared with aberrations with single break point. The number of chromosomal break points was noted to be higher than expected value in No.1, 3, 8 and 11 chromosomes and lower in No.13, 15, 17 and 21 chromosomes. Based on this study, we believe that the distribution of chromosomal breakage is related with gene and chromosomal rearrangement which could result in the development of cancers.

• The Journal of the Korea Contents Association
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• v.17 no.3
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• pp.337-349
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• 2017

The purpose of this study was to provide basic materials to standardized cancer prevention programs for promotion of health of workers by identifying knowledge, attitude, and preventive health behaviors on the cancer and investigating factors influencing cancer preventive health behaviors in workers. This study included survey data of 723 workers from 9 work places in 5 areas and analyzed using SPSS/WIN 20.0. In the results, the mean score for knowledge about cancer was $10.52{\pm}4.02$(range: 0~30), the mean score of attitude toward cancer was $31.61{\pm}3.51$(range: 10~50) and the mean score of preventive health behavior for cancer was $62.37{\pm}9.05$(range: 19~95). 40.3% of preventive health behaviors for cancer was explained by perceived health condition, attitude toward cancer, age, smoking, drinking alcohol, exercise, and working hours per day. The results of this study can be used for developing cancer preventive health promotion programs suitable for workers' condition in workplaces.

• Journal of Digital Convergence
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• v.17 no.7
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• pp.179-186
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• 2019

This study was to investigate the factors influencing colorectal cancer(CRC) screening behavior using the health belief model(HBM). It was a descriptive cross-sectional survey. A total of 148 adults aged 50 or older participants were surveyed using structured questionnaires including general characteristics,, health beliefs, and behavioral variables. The data were analyzed by descriptive statistics, t-test, chi-square test and multiple logistic regression using SPSS/WIN 25.0 program. The significant factors influecing CRC screening behavior were perceived sensitivity, spousal experience of CRC screening and family history. Therefore, in order to improve the CRC screening rate, it is necessary to increase the perceived sensitivity through systematic education about the importance of early CRC screening. In addition, it is necessary to assess the spousal screening experience and the family history of subjects and to develop the education program using the partnership of the couple.

• Journal of the Mineralogical Society of Korea
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• v.19 no.4 s.50
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• pp.325-336
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• 2006

Domestic serpentinite is one of the important industrial minerals utilizing in the iron manufacturing company such as POSCO in Korea. Serpentinite is distributed in the Ulsan Fe deposit, Andong, Hongseong-Cheongyang, and Gapyeong areas. This study tries to interpret the relationship among the formation of carbonate rocks, iron mineralization, and serpentinite alteration throughout the study of field occurrence, mineralogy, and chemical compositions. Serpentine is formed by the break-down of olivine and pyroxene of parent peridotite. The serpentinization is inferred to be formed by the hydrothermal fluid derived from intruded Cretaceous granite and the addition of meteoric water. Variation of major oxides such as $SiO_2,\;Fe_2O_3$, and MgO in serpentinized rocks are controlled by the degree of serpentinization and Fe mineralization. Variation of $Al_2O_3$ and CaO contents of altered rocks is dependent on the amount of the residual minerals such as calcite and homblende, and on the degree of chloritization. The presence of carbonate rocks reported in the sedimentary origin or igneous origin (carbonatite) provided a geological environment to form skarn type Fe deposit regardless of its origin. The geological processes of Ulsan Fe deposits are inferred to be formed as the order of the formation of carbonate rocks ${\to}$ the intrusion of Cretaceous granite ${\to}$ serpentinization ${\to}$ Fe mineralization by the interprelation of field occurrence and mineralogical characteristics.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1979.05a
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• pp.10.4-10
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• 1979

The cause of esophageal cancer is still unknown in the majority of patients, but pre-existing diseases of esophagus related to the development of cancer were reported by many authors: e.g. lye stricture, achalasia, Plummer-Vinson syndrome, dietary and alocholic habbits etc. Recently the authors had experienced one case of esophageal cancer with complaint of dysphagia, developing at the site of lye stricture, which was diagnosed by the esophagogram and esophagoscopic biopsy.