• Korean Journal of Environment and Ecology
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• v.10 no.1
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• pp.160-168
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• 1996

To investigate the structure and the conservation strategy of natural forest at Turobong-Sangwangbong area in Odaesan, 19 plots(10*10m) were set up with random sampling method. Several characteristics - needle injury, rate of fallen needle, stem injury, shoot and twig, apical dominance, tree form- of Abies nephrolepis and Tavus cuspidata were investigated with checklist. Two groups(Taxus cuspidata community and Quercus mongolica-Betula ermanii community) were classified by cluster analysis. High positive correlations were prover between Taxus cuspidata and Tripterygium regelii, Sorbus commixta; Quercus mongolica and Euonymus sieboldianus. High negative correlations were proved between Taxus cuspidata and Abies nephrolepis, Quercus mongolica and Betula ermanii; Abies nephrolepis and Trioterygum regelii. Species diversity(H') of investigated area was 0.9608-1.24990. Mean score of Abies nephrolepis was calculated at 6.1 point and ratio of dead individuals was 10.9%. Mean score of Taxus cuspidata was calculated at 17.3 point. Injury of Taxus cuspieata was classified three types, such as branch dieback, wound cavity on the stem and crooked stem.

• Korean Journal of Environment and Ecology
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• v.13 no.4
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• pp.309-315
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• 2000

지리산국립공원 동부지역의 등산로 주연부식생 구조 및 훼손을 파악하기 위하여 7개 등산로를 대상으로 1999년 8월에 조사를 실시한 결과는 다음과 같다 등산로 상에 나타난 주연부식생의 주요 수종으로는 철쭉꽃 미역줄나무 조록싸리 등이었다 등산로 주연부의 종다양도 식생피도 개체수는 이용객 수와 깊은 상관관계는 없는 것으로 나타났다 입지환경별 드산로 주연부식생의 종구성은 남삼면과 북사면의 중복부에서 가장유사한 반면 동사면 상복부와 북사면 산록부간에 이질적이었다 한편 남, 북 사면간 등산로 주연부식생은 각 사면 산록부에서 종구성이 가장 이질적이었다 남.북사면의 중복부에서 조록싸리 철쭉꽃이 우세하였으나 북사면 상복부에서는 철쭉꽃이 우세하게 나타났다 등산로 주연부의 식생피도 능선부 남사면 북사면 동사면 순으로 높게 나타났다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.441-445
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• 2005

Tripterygium regelii has been used as an oriental medicine, especially antiparasitic, anti-inflammatory and detoxifying agents in East asia. During our research to develop new antitumor agents from natural products, MeOH ext. and CH2Cl2 ext. of Tripterygium regelii showed the potent antitumor activity. In order to purify active compounds from Tripterygium regelii, activity-guided fractionation was carried out. Silica gel and RP-18 column chromatography for the active fraction led to the isolation of two compounds and their antitumor activities were studied. Those two compounds didn't show potent antitumor activity against human tumor cell lines. The structure of two compounds were determined by $^1H-NMR$, $^{13}C-NMR$, DEPT, $^1H-^{13}C$ COSY and IR spectrum. Compound I and Compound II were turned out to be Celastrol, and ${\beta}-sitosteryl-3-o-{\beta}-D-glucopyranoside$ respectively.

• Korean Journal of Environment and Ecology
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• v.32 no.3
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• pp.313-322
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• 2018

To investigate the changing patterns of sub-alpine forest vegetation due to climate change requires accumulation of contiguous reference data and continuous monitoring. Furthermore, it is crucial to monitor short-term ecological change of lower level vegetation to understand the trend of long-term vegetation change. Therefore, this study carried out a vegetation survey and tree diameter measurement in 36 plots of Mt. Jiri inhabited by Abies koreana species from 2015 to 2017 to examine the short-term dynamics of Abies koreana seedling and the change of vegetation distribution according to altitude. We analyzed the importance value and MIV (mean importance value) of major species by each stratum as well as the importance value and species diversity index of major species and the change of seedling population by altitude. The results showed that Abies koreana had the highest importance value on tree layer, Rhododendron schlippenbachii on shrub layer and Tripterygium regelii on herb layer. MIV was high in the order of Abies koreana, Rhododendron schlippenbachii and Acer pseudosieboldianum. Regarding the species composition and species diversity index (H') along the altitudinal gradient, Sasa borealis showed high MI and low H' in the elevation less than 1,500 m, and IV of Tripterygium regelii and H' of herb layer were high in the elevation of 1,700 - 1,800 m. Abies koreana seedling decreased by 22.4% from 1,250 n/ha in 2015 to 970 n/ha in 2017 (p <0.05) throughout the investigated area. The decline rate along seedling and sapling height were 22.9% in less than 10 cm, 3.4% in 10-30 cm, 8.9% in 30-50 cm, 39.3% in 50-100 cm, and 55.1% more than 100 cm. Few of A. koreana seedlings appeared due to the dominance of Sasa borealis in the elevation of 1,500 m or less and due to the dominance and high species diversity of Tripterygium regelii in the elevation of 1,700-1,800 m. On the other hand, many of A. koreana seedlings appeared in the elevation of 1,600-1,700 m due to no distribution of S. borealis and T. regelii species in that altitude range. Therefore, we concluded that those seedlings and saplings of A. koreana could be more stable in the altitude of 1,600-1,700 m.

• Korean Journal of Agricultural and Forest Meteorology
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• v.7 no.3
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• pp.211-219
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• 2005

Vegetation composition and structure of Sorbus commixta - native forests of South Korea were studied using phytosociological procedures and its ecological characteristics analyzed with special respect to species correlations, importance values, and constancy classes. Vegetation types were divided (great division) into Tripterygium regelii - Quercus mongolica (Inland high mountain type) and Acer takesimense - Fague crenata var. multinervis (Ulleung Island type) and ten accompanying vegetation units. In between S. commixta and life-farms, 120 correlations were positive with 23 of these having a p-value < 0.01 for trees, 21 for shrubs, 10 for woody vines, and 25 for herbs. In trees, there was a positive correlation between S. commixta and A. takesimense and T. insularis on the $1\%$ level. In shrubs, there was a positive correlation between S. commixta and Sasa kurilensis, Callicarpa japonica, Ligustrum foliosum on the $5\%$ level. In woody vines, there was a negative correlation between S. commixta and Tripterygium regelii and Actinidia rufa on the $1\%$ level. In herbs, there was a positive correlation between S. commixta and Majanthemim dilatatum and Solidago virga-aurea var. gigantea on the $1\%$ level.

• Journal of Korean Society of Forest Science
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• v.84 no.2
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• pp.247-257
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• 1995

This research carried out forest community classification on the basis of the methods of ZM school, in order to furnish useful information needed for forest management, and for afforestation and preservations of Abies koreana forest which was Korean native species, and the research results could be summarized as follows. Abies koreana forest was divided into 10 vegetation units ; This forest was divided into Abies koreana-Quercus mongolica community and Abies koreana-Sasa quelpartensis community. Abies koreana-Quercus mongolica community was divided into Tripterygium regelii group, Patrinia saniculaefolia group, and Typical group, and Tripterygium regelii group seas divided into Typical subgroup. Pimpinella brachycarpa subgroup, and Hemirocallis fulva subgroup. Abies koreana-Sasa quelpartensis community was divided into Berberis koreana group, Trachelospermum asiaticum var. intermedium group, and Typical group. Berberis koreana group was divided into Typical subgroup and Hepatica asiatica subgroup, and Tranchelospermum asiaticum var. intermedium group was divided into Hepatica asiatica subgroup and Typical subgroup. According to the results of the analysis by coincidence method, Abies koreana-Quercus mongolica community represented in Mt. Chiri, Mt. Deokyu and Mt. Kaya which were located in the Sobaek mountains, Abies koreana-Sasa quelpartensis community represented in Mt. Hanla. Therefore it was thought that Abies koreana forest was classified by geographical position, and vegetation units of Abies koreana forest tended to be classified by the altitude and topography. As for DBH and height of Abies koreana, mean DBH and height of Abies koreana-Quercus mongolica community were each 28.4cm, 10.6m that were larger than mean DBH and mean height(each 23.6cm, 6.3m) of Sasa quelpartensis community. Among Abies koreana-Quercus mongolica community, Patrinia saniculae-folia group had the smallest mean DBH and mean height(20cm, 5m), and among Abies koreana-Sasa quelpartensis community, Typical group had the smallest mean DBH and mean height(4cm, 3m).

• Journal of Food Hygiene and Safety
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• v.31 no.1
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• pp.59-66
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• 2016

It has been generally accepted that obesity and overweight are associated with metabolic diseases and cancer incidence. In fact, obesity increased risks of cancers i.e. breast, liver, pancreatic and prostate. Celastrol is a pentacyclic triterpenoid isolated from Thunder god vine, was used as a Chinese traditional medicine for treatment of inflammatory disorders such as arthritis, lupus erythematosus and Alzheimer's disease. Also, celastrol has various biological properties of chemo-preventive, neuro-protective, and anti-oxidant effects. Recent studies demonstrated that celastrol has anti-proliferation effects in different type of obesity-related cancers and suppresses tumor progression and metastasis. Anticancer effects of celastrol include regulation of $NF-{\kappa}B$, heat shock protein, JNK, VEGF, CXCR4, Akt/mTOR, MMP-9 and so on. For these reasons, celastrol has shown to be a promising anti-tumor agent. In this review, we will address the anticancer activities and multiple mechanisms of celastrol in obesity-related cancers.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.234-234
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• 1994

최근 새롭게 조명된 생약에 관한 여러 연구를 통해, 기존의 항암제 보다는 더 효과적이고 인체에는 부작용이 적은 항암제를 개발해내기 위해 국내 자생 생약중 총 103 종류( 95 손 98종 )을 채집하였다. 이들 생약을 암세포주( L1210, P333 D$_1$)와 장상세포주(Vero)을 대상으로 MTT colorimetric assay를 실시하여 항종양성에 대해 알아보았다. 이들 세포주에 대한 $IC_{50}$/ 값으로 세포독성능을 알아보았다. 그리하여 정상세포주에는 적은 세포 독성능을 나타내면서, 암세포주에는 높은 세포 독성능을 나타내는 생약제 6종( BuOH 추출물 2종, MeOH) 추출물 4종 )을 선정하였다. 이중 항암활성능이 가장 높은 미역줄나무(Tripteryrium regelii)를 선택하여 유기용매별로 추출, 그 각각에 대한 세포 독성능이 가장 높게 나타난 2분획을 선택하여 기존에 시판중인 Adriamycin과의 병용 투여시의 세포 독성능의 상승효과를 확인 하였다. 즉 Adriamycin과의 단독 투여보다 복합 투여시에 암세포주에 대한 세포 독성능이 높아졌고, 정상세포주에 대한 독성이 감소되는 효과가 나타났다. 또한 in vitro 에서는 세포 독성능이 다소 적더라도 in vivo에서 면역학적 활성이 기대되는 생약제 3종을 선정하여 항암성분의 분리 및 정제를 하여 항암성에 대하여 알아보았다.

• Korean Journal of Environment and Ecology
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• v.18 no.3
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• pp.279-287
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• 2004

To investigate the vegetation structure of the section of Nakdong-jeongmaek from Gajisan to Neungdongsan, fifty plots of 100$m^2$ at ten locations were set up. In accordance with the requirements of DCA(detrended correspondance analysis), which is an ordination technique, the sites were chosen contiguously with each other. The vegetation structure analysis showed Quercus dentata, Pinus densiflora, Q. mongolica to be the major species at canopy layer, Rhododendron schlippenbachii at the layer below the canopy and Tripterygium regelii at the shrub level. Shannon's diversity index was 1.5315～2.4005 per unit area of 500$m^2$. It appeared that the Quercus dentata forest of this ridge section of Nakdong-jeongmaek is about 30 or 40 years old.

• Korean Journal of Environment and Ecology
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• v.17 no.3
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• pp.181-186
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• 2003

To obtain the basic data for monitoring and the conservation of native plant species at the sub-alpine zone Jongseogdae in Jirisan (Mt.).40 plots(5m${\times}$5m) set up by random sampling method and the distribution of native shrub and herb species at the subalpine zone was surveyed. Leading shrub species at the subalpine zone of Jongseogdae were Tripterygium regelii with IP value of 23.45% : followed by Lespedeza maximowiczii, Symplocos chinensis for. pilosa and Lespedeza tomentella. Dominant species at the subalpine zone were Lysimachia clethroides, Pteridium aquilinum var. latiusculum, Synurus deltoides, Veratrum maackii var. japonicum, Hemerocallis fulva and Astilbe chinensis var. davidii. Rhododendron tschonoskii recorded from the rare and endangered species list of the Korea Forest Service distributed among the rocks on the top of Jongseogdae. The long-term sustainable habitat monitoring might be required to conserve this subalpine zone.