• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.1
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• pp.89-95
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• 2012

In this paper, microchannels for the flow control of two fluids with different volumes have been designed, fabricated, and verified. The dimensions of the inlets were determined based on the Stokes equation in order to realize that the flow of the two fluids meet at the same time, and to maintain a certain configuration when the flows passed through each inlet channel. The designed microchannels were confirmed using computational fluid dynamics simulation for the incompressible, Newtonian, and transient flows. In addition, a microfluidic system containing the designed microchannels was fabricated by soft lithography, and the pressure-driven flows of the two fluids were characterized by microfluidic experiments.

• Korean Chemical Engineering Research
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• v.53 no.4
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• pp.472-477
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• 2015

This study presents modified microfluidic picoinjector combined Faraday moat with silver nanoparticle electrode to increase electrical efficiency and fabrication yield. We perform simple dropping procedure of silver nanoparticles near the picoinjection channel, which solve complicate fabrication process of electrode deposition onto the microfluidic picoinjector. Based on this approach, the microfluidic picoinjector can be reliably operated at 180 V while conventional Faraday moat usually have performed above 260 V. Thus, we can reduce the operation voltage and increase safety. Furthermore, the microfluidic picoinjector is able to precisely control injection volume from 7.5 pL to 27.5 pL. We believe that the microfluidic picoinjector will be useful platform for microchemical reaction, biological assay, drug screening, cell culture device, and toxicology.

• Korean Chemical Engineering Research
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• v.48 no.5
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• pp.545-555
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• 2010

Recently, droplet-based microfluidic systems are widely used in various areas ranging from fundamental science including chemistry, biology, and physics to material science and engineering. This article reviews recent development in the droplet based microfluidic system from basic fabrication of tiny device, principle of droplet formation, merging, mixing, control of droplets, and application for the synthesis of novel functional materials. We discuss strong advantages of the droplet based microfluidics in point of control of particle size, morphologies, shapes, and structures.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.1
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• pp.47-53
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• 2015

In this paper, a novel fluid controlled phase tunable line using inkjet printed microfluidic composite right/left-handed(CRLH) transmission line(TL) is proposed. A CRLH-TL prototype has been inkjet-printed on a paper substrate using silver nano particle ink. In addition, a laser-etched microfluidic channel in poly methyl methacrylate(PMMA) has been integrated with the CRLH TL using inkjet-printed SU-8 as a bonding material. The proposed TL provides excellent phase-tuning capability that is dependent on the different fluidic materials used. As the fluid is changed, the proposed TL can have negative-phase, zero-phase, and positive-phase characteristics at 900 MHz and reflection coefficient is maintained to below -10 dB. The performance of the proposed TL is successfully validated using simulation and measurement results.

• Journal of the KSME
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• v.50 no.1
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• pp.37-41
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• 2010

최근 미세유체기술(microfluidics)을 기반으로 한 lab on a chip 기술이 기계, 의료, 바이오, 제약, 화학, 환경 분야 등의 다양한 분야에서 각광 받고 있다. 이 글에서는 일회용 고분자 lab on a chip 대량생산의 기반 기술에 해당하는 고분자 미세성형 기술에 대해 소개한다.

• Proceedings of the KAIS Fall Conference
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• 2002.11a
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• pp.163-166
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• 2002

21세기에 가장 시급하게 확보되어야 하는 기술은 BT (Biotechnology)와 NT(Nano technology)를 접목시키는 기술이다. 특히, 이들을 종합한 MEMS에 관한 연구는 가장 광범위한 분야에서 활발하게 이루어지고 있어 그 기술적 가치가 점차 중요시되고 있다 본 연구는 Simulation을 통하여 Bio-MEMS기술에서 사용되는 미세Pump 내에서의 유체흐름을 Fluent 프로그램을 사용하여 알아보고자 하였다. 즉, 미세Pump 내로 유체가 흐를 경우, 유체의 압력변화나 온도 변화 및 Model에 따른 유동의 흐름을 관찰하여 미세pump 내에서의 최적의 외부조건과 최적의 Pump모델을 알아보고자 실험하였다. 유동의 흐름을 조사해 본 결과 Chamber의 유무에 따라 압력과 온도의 변화를 관찰할 수 있었다. Chamber가 있는 경우 압력의 변화가 적었고 온도의 변화 또한 적었다. 따라서 Chamber가 있는 Pump가 유체의 흐름에 영향을 적게 줌을 알 수 있었으며 이는 Chamber가 있는 Pump를 설계하는 것이 필요하다고 할 수 있다.

• Journal of the KSME
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• v.44 no.3
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• pp.38-45
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• 2004

이 글에서는 분자동역학 시뮬레이션이 미세유체역학 분야에 응용된 예를 소개한다.

• Clean Technology
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• v.25 no.4
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• pp.283-288
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• 2019

Monodisperse microparticles has been particularly enabling for various applications in the encapsulation and delivery of pharmaceutical agents. The microfluidic devices are attractive candidates to produce highly uniform droplets that serve as templates to form monodisperse microparticles. The microfluidic devices that have micro-scale channel allow precise control of the balance between surface tension and viscous forces in two-phase flows. One of its essential abilities is to generate highly monodisperse droplets. In this paper, a microfluidic approach for preparing monodisperse polycaprolactone (PCL) microparticles is presented. The microfluidic devices that have a flow-focusing generator are manufactured by soft-lithography using polydimethylsiloxane (PDMS). The crucial factors in the droplet generation are the controllability of size and monodispersity of the microdroplets. For this, the volumetric flow rates of the dispersed phase of oil solution and the continuous phase of water to generate monodisperse droplets are optimized. As a result, the optimal flow condition for droplet dripping region that is able to generate uniform droplet is found. Furthermore, the droplets containing PCL polymer by solvent evaporation after collection of droplet from device is solidified to generate the microparticle. The particle size can be controlled by tuning the flow rate and the size of the microchannel. The monodispersity of the PCL particles is measured by a coefficient of variation (CV) below 5%.

• Proceedings of the KIEE Conference
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• 2005.11a
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• pp.116-118
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• 2005

열공압 방식으로 동작하는 마이크로 펌프와 밸브가 집적된 (polydimethylsiloxane)PDMS 미 세 유체 시스템을 제작하였다. 본 실험에서 제안한 미세 유체 시스템은 PDMS 마이크로 채널, PDMS membrane, 열공압 챔버, indium tin oxide(ITO) 히터로 구성되어 있다. 마이크로 펌프의 경우 가해주는 펄스 전압의 변화를 통해 유속을 최적화 하였고 마이크로 밸브의 경우 가해주는 직류 전압을 변화시켜 유체의 흐름을 제어할 수 있었다. 미세 유체 시스템의 최적화된 조건은 마이크로 펌프의 경우 duty 4%와 주파수 4Hz에서 최대 pumping rate을 나타냈고 그때의 pumping rate 68nl/min이었다. 마이크로 밸브의 유체를 closing 전력은 450mW이었다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.2
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• pp.447-452
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• 2013

Microfluidic devices can offer precise control for a verity of tasks involving biological specimen. In this paper, we propose an integrated system consisting of a microfluidic device along with a digital holographic microscope and present three-dimensional (3D) sensing and segmentation of biological microorganisms. When the individual microorganisms are inputted into the microfluidic channel, the holographic microscope records their holograms. The holograms are computationally reconstructed in 3D using Fresnel transform and the reconstructed phase images are used to search the position of microorganisms. Optical experiments are carried out and experimental results are presented to illustrate the usefulness of the proposed system.