• Journal of Chest Surgery
• /
• v.36 no.5
• /
• pp.348-355
• /
• 2003

Background: The prognostic significance of lymph node micrometastasis in non-small cell lung cancer remains controversial. We therefore investigated the clinicopathologic factors related to lymph node micrometastsis and evaluated the clinical relevance of micrometastasis with regard to recurrence. Material and Method: Five hundred six lymph nodes were obtained from 41 patients with stage 1 non-small ceil lung cancer who underwent curative resection between 1994 and 1998. Immunohistochemical staining using anti-cytokeratin Ab was used to detect micrometastasis in these lymph nodes. Result: Micrometastatic tumor cells were identified in pN0 lymph nodes in 14 (34.1%) of 41 patients. The presence of lymph node micrometastasis was not related to any clinicopathoiogic factor (p) 0.05). The recurrence rate was higher in patients with micrometastasis (57.1%) than in those without (37.0%), but the difference was not significant (p=0.22). Patients with micrometastasis had a lower 5-year recurrence-free survival rate (48.2%) than those without micrometastasis (64.1%), with a borderline significance (p=0.11), The S-year recurrence-free survival rate (25.0%) in the patients with 2 or more micrometastatic lymph nodes was significantly lower than that in the patients with no or single micrometastasis (p=0.02). In multivariate analysis, multiple lymph node micromestasis us was a significant independent predictor of recurrence (p=0.028, Risk ratio=3.568). Conclusion: Immunehistochemical anti-cytokeratin staining was a rapid, sensitive, and easy way of detecting lymph node micrometastasis. The presence of lymph node micrometastasis was not significantly associated with the recurrence, but had a tendency toward a poor prognosis in stage 1 non-small cell lung cancer. Especially, the presence of multiple micrometastatic lymph nodes was a significant and independent predictor of recurrence.

• The Journal of Engineering Geology
• /
• v.15 no.4 s.42
• /
• pp.447-462
• /
• 2005

The purposes of this study are to evaluate and discuss the importance of geochemical properties of soil materials that play an important role in the occurrence of the landslide, using analyses of microtexture, particle size distribution, XRC, and FE-SEM equipped with energy dispersive spectrum on soils collected from landslide slopes of gneiss, granite and sedimentary rock areas. Soils from gneiss and granite areas where landslides took place have much clay content relative to those from non landslide areas, particularly pronounced in the granite area. Therefore the clay content is considered a sensitive factor on landslide. Clay minerals contained in soils are illite, chlorite, kaolinite and montmorillonite. Especially the content of clay minerals in soils from the Tertiary sedimentary rocks is highest, with abundant montmorillonite as expandable species. It is believed that this area was much vulnerable to landslide comparable to other areas because of its high content of monoorillonite, even though there might be weak precipitation. Since no conspicuous differentiation in mineralogy between the landslide area and non landslide area can be made, the occurrence of landslide may be influenced not by mineralogy, but by local geography and mechanical properties of soils. Geochemical information on weathering properties, mineralogy, and microtexture of soils is helpful to better understand the causes and patterns of landslide, together with engineering geological analyses.

• Composites Research
• /
• v.35 no.4
• /
• pp.248-254
• /
• 2022

In this study, TiB₂-steel composite with high-fractional TiB₂ reinforcement was fabricated by gas pressure infiltration process and the microstructure analysis and compressive strength and hardness were evaluated. To elucidate the correlation between microstructure and mechanical properties for fabricated composite, after the compression test of TiB₂-steel composite, the fracture surface was analyzed and the fracture behavior on compression test was predicted. As a result of the compression fracture surface analysis, interfacial failure trace between the steel matrix and the reinforcement was observed, and the interface between the steel matrix and the reinforcement was analyzed using TEM. From the result of microstructure analysis on the fabricated composite, it was confirmed that, in addition to TiB₂ reinforcement and steel matrix, TiC phase and coarse (Fe,M)₂B (M=Cr,Mn) phase were formed. Throughout the thermodynamic calculation, it was confirmed that TiC and (Fe,M)₂B can be formed as a stable phase under the process condition. The fabricated TiB₂-steel composite had a significantly increased hardness, and the compressive strength and Young's modulus were improved by 3.07 times and 1.95 times, respectively, compared to steel matrix. It seems that the coarse (Fe,M)₂B (M=Cr,Mn) phase formed throughout the composite causes the deterioration of mechanical properties, and by controlling the formation of the (Fe,M)₂B (M=Cr,Mn) phase, it is judged that the mechanical properties of the TiB₂-steel composite can be further improved.

• Tunnel and Underground Space
• /
• v.8 no.3
• /
• pp.226-233
• /
• 1998

Microcracks in rock materials, whether natural or induced, provide useful information on the engineering performance of in situ rockmasses. A population of preferentially oriented microcracks has observable effects on the physical properties of a rockmass, but their effects may not be evident if the rock material is highly anisotropic due to other causes. An experimental program was undertaken to investigate the effect of rock fabrics on the physical properties of rock materials. In this study, anisotropy in the circumferential wave velocity and the direction of induced fractures under axial point loading were measured. Rock specimens (NX-size) of the leucocractic Pocheon granite were cored from rock blocks, retaining the relative directions of each specimen. Another set of specimens was prepared from the rock cores of the same meterial, obtained in the field. The master orientation line (MOL) was set to be the representative direction of the microcracks in the specimen. Variation of the circumferential wave velocity of each specimen was then measured along the core, keeping the MOL as reference. The direction of the minimum wave velocity was nearly perpendicular to the direction of the MOL. Coring of smaller-sized (EX-size), concentric specimens from the NX specimens were then followed, and axial point loading was applied. The direction of induced fractures due to axial point loading was closely related to the MOL direction, confirming the prior test result.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.29 no.3
• /
• pp.290-298
• /
• 2013

It will be possible to predict the success and failure of the prosthodontic treatment and prevent clinical complications if the oral environment including prostheses and their supporting teeth and periodontium can be monitored in real time. The aim of this report is to introduce the concept of a smart prosthesis, which monitors specific factors in the oral cavity, and investigate its feasibility through a literature review of MEMS (Micro-electro-mechanical System) and Biosensing.

• Journal of radiological science and technology
• /
• v.32 no.1
• /
• pp.45-52
• /
• 2009

Digital Mammography is an efficient imaging technique for the detection and diagnosis of breast pathological disorders. Six mammographic criteria such as number of cluster, number, size, extent and morphologic shape of microcalcification, and presence of mass, were reviewed and correlation with pathologic diagnosis were evaluated. It is very important to find breast cancer early when treatment can reduce deaths from breast cancer and breast incision. In screening breast cancer, mammography is typically used to view the internal organization. Clusterig microcalcifications on mammography represent an important feature of breast mass, especially that of intraductal carcinoma. Because microcalcification has high correlation with breast cancer, a cluster of a microcalcification can be very helpful for the clinical doctor to predict breast cancer. For this study, three steps of quantitative evaluation are proposed : DoG filter, adaptive thresholding, Expectation maximization. Through the proposed algorithm, each cluster in the distribution of microcalcification was able to measure the number calcification and length of cluster also can be used to automatically diagnose breast cancer as indicators of the primary diagnosis.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.19 no.6
• /
• pp.103-111
• /
• 2015

To evaluate the compressive strength of concrete, rebound test and ultra pulse velocity methods as well as core test were widely used. The predicted strength effected by age, maturity and degradation of concrete, is a slight difference between in-situ concrete strength. The compressive strength of standard cylinder specimens and core samples by obtained from drilling will have a difference since the concrete is disturbed during the drilling by machinery. And the rebound number and ultra pulse velocity are also changed according to the age and maturity of concrete that effected to the surface hardness and microscpic minuteness. The authors performed the experimental work to reflect the age and core effect to the results from NDE test. The test results considering on the core and age of concrete were compaired with the proposed equation to predict the compressive strength.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 1995.10a
• /
• pp.219-222
• /
• 1995

The objective of this study is to demonstrate the ability of a computer simulation of microstructural evolution in hot forging of C-Mn steels. The finite element method is applied to the prediction of the microstructural evolution, and it should be coupled with heat transfer analysis to consider the change of thermomechanical properties during the deformation. In this study, Yada's recrystallization model and rigid-thermoviscoplastic finite element method were employed in order to analyze microstructural evolution during hot forging process. To show the validity and effectveness of the proposed method, the experiment of hot compression process was accomplished and the results of experiment were compared with those of simulation. Consequently, this approach shows a good agreement with experimental results.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2007.10a
• /
• pp.31-34
• /
• 2007

In this study, optimum processing condition of AZ31 Mg alloy was investigated utilizing processing map and constitutive equation considering microstructure evolution (dynamic recrystallization) during hot-working. A series of mechanical tests were conducted at various temperatures and strain rates to construct a processing map and to formulate the recrystallization kinetics and grain size relation. Dynamic recrystallization (DRX) was observed to occur revealing maximum intensity at a domain of $250^{\circ}C$ and 1/s. The effect of DRX kinetics on microstructure evolution was implemented in a commercial FEM code followed by remapping of the state variables. The volume fraction and grain size of deformed part were predicted using a modified FEM code and compared with those of actual hot forged one. A good agreement was observed between the experimental results and predicted ones.

• Journal of the Korean Society for Precision Engineering
• /
• v.15 no.7
• /
• pp.129-138
• /
• 1998

The objective of this study is to demonstrate the ability of a computer simulation of microstructural evolution in hot forging of C-Mn steels. The development of microstructure is strongly dependent on process variables and metallurgical factors that affect time history of thermodynamical variables such as temperature, strain. and strain rate during deformation. Then finite element method is applied for the prediction of microstructural evolution, and it should be coupled with heat transfer analysis to consider the change of thermodynamical properties during forming process. In this study, Yada's recrystallization model and rigid-thermoviscoplastic finite element method are employed in order to analyze microstructural evolution during hot forging process. To show the validity and effectiveness of the proposed method, experiments are accomplished and the results of experiments are compared with those of simulations.