• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.68-68
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• 2023

베리류 과수 가운데 블루베리, 아로니아, 복분자, 오디, 산딸기, 라즈베리 등 6종의 에탄올 추출물을 이용하여 총 폴리페놀 함량을 측정하고, DPPH법을 이용하여 항산화 활성을 측정하여 상호간 상관 관계를 분석하였다. 총 폴리페놀 함량은 아로니아> 복분자> 오디> 블루베리> 라즈베리> 산딸기 순으로 나타났으며, 항산화 활성은 아로니아> 라즈베리 >복분자> 블루베리> 오디> 산딸기 순으로 나타났다. 이러한 결과로 총폴리페놀 함량과 항산화 활성과의 상관관계가 있다는 것을 확인하였으며, 그 중에서도 아로니아와 복분자가 강력한 항산화 활성이 있는 것으로 나타났다. 그러나 라즈베리의 경우는 총폴리페놀 함량이 낮은데도 불구하고 항산화 활성이 높았다. 따라서 앞으로 라즈베리에 대한 선행연구가 필요하리라 생각된다. 이와 같은 결과들로 미루어 볼 때, 6종 베리류(블루베리, 아로니아, 복분자, 오디, 산딸기, 라즈베리) 에탄올 추출물은 농도 의존적으로 항산화 활성에 대한 효과가 양호하였으며, 이러한 연구결과들을 활용하여 트러블, 염증 억제제 및 항균활성으로 기능성 화장품의 신소재 개발이 가능하다고 판단된다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.1 s.60
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• pp.41-45
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• 2007

Recently plant extracts have obtained increased attention because of their health-related beneficial aspects. In this study, we evaluated anti-oxidation, whitening and anti-wrinkle of four different extracts obtained from Rubus coreanus (ethanol extracts of unripe, ripe fruits, leaves/stems, and roots). The ethanol extract of unripe fruits of Rubus coreanus generally showed stronger whitening and the anti-wrinkle activities than other extracts of Rubus coreanus. As a results, we knew that the ethanol extract of unripe Rubus coreanus fruit had mote possibility as a whitening and anti-wrinkle ingredient for skin care products.

• Journal of the Korean Applied Science and Technology
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• v.31 no.1
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• pp.130-135
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• 2014

To develop a natural antioxidant and anti-hemolytic agents, we investigated the effects of ethanol extracts of Rubus coreanus Miquel (crude extracts). Crude extract was extracted with ethanol. Antioxidant activity of crude extracts was evaluated by employing two different assays, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity and super oxide dismutase(SOD)-like activity. Also, anti-hemolytic activity of crude extract was determined using $H_2O_2$-induced hemolysis in normal rat red blood cells (RBC) or plasma. The extracts obtained from crude extract dose-dependently increased the scavenging activity on DPPH-induced radicals and SOD-like activity. RBC oxidative hemolysis induced by $H_2O_2$ was significantly suppressed by the extracts of Rubus coreanus Miquel in a dose-dependent manner. These results suggest that crude extracts may have value as the potential antioxidant and anti-hemolytic medicinal plant.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.149.2-149.2
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• 2014

진공용기를 배기하기 시작하면 짧은 시간 동안은 공기의 배기가 주를 이루지만 그 후에는 표면 방출 기체의 배기가 이어지고 표면방출 기체의 대부분은 물이라는 것은 누구나 알고 있는 사실이다. 그러나 배기 계산을 할 때는 막상 물 보다는 공기의 일부로 생각하거나 수분을 다른 기체들과 유사하게 다루는 것에 익숙해져 있다. 이런 계산 결과는 실제 상황을 재현하지 못할 뿐만 아니라 일반적으로 배기능력을 과대평가하게 만들어서 공정 계획대로 진공 시스템을 운전하는 것을 불가능하게 만든다. 물은 일반적인 기체와는 성격이 아주 다르다. 다른 기 체 분자들의 흡착 에너지가 ~0.3 eV이고 기름분자가 ~1 eV 정도인 것에 반해 물은 0.55 eV 내외로 상온에서도 비교적 흡착을 잘하고 또 적당히 방출도 일어나는 특별한 특성 때문에 용기 압력을 지배하면서도 신속한 배기를 방해한다. 만일 이런 물의 흡착률 및 방출률을 제대로 수치화할 수 있다면 배기 계산을 훨씬 현실화할 수 있다. 물의 흡착률은 물분자의 부착계수가 지배하고 방출률은 체류시간에 의해 결정되지만 표면상태에 따라 천차만별이므로 얼마라고 확정하기 어렵다. 우선 이번에는 물의 부착계수 최대값을 0.1 정도로 잡고 흡착량에 따라 직선적으로 줄어드는 것으로 가정하며, 물의 표면 체류시간도 몇 가지 값으로 가정해서 0-D 입자 평형 계산을 수행하여 특정 시스템에서 얻은 실험 결과와 비교하려고 한다. 앞으로 몬테카를로 방법과 연계하여 3차원적 분석을 할 수 있는 코드로 발전시켜 나갈 예정이다.

• KSBB Journal
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• v.19 no.2
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• pp.113-117
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• 2004

The effect of ultrasonification on immuno-stimulatory activities of the extracts from Ephedra sinica Stapf and Rubus coreanus Miq. was observed by the growth of human immune cells. The extraction yields from water extracts and water extract with ultrasonification at 40$^{\circ}C$, 60$^{\circ}C$ and 100$^{\circ}C$ were compared. The highest yield was observed enhancement ratio 2.34% in the extract at 40$^{\circ}C$ with ultrasonification. The growth of human T-cell was increased up to 13.8${\times}$10$^4$ viable cells/$m\ell$ in adding 1.0 g/L of the ultrasonification extracts. The treated extracts increased the specific secretion of TNF-${\alpha}$ up to 10.5${\times}$10$\^$-4/ pg/cell. It was suggested that of the extracts on water the extraction yield with ultrasonification compared improved the extraction with ultrasonification of low than.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.3
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• pp.327-332
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• 2012

In other to promote the utilization of native Gwangyang Rubus coreanus Miq. as an antioxidant material in functional food, its general composition, free sugars, vitamin C, vitamin E, and anthocyanin content were examined. Free sugars were mainly $2.83{\pm}0.01%$ glucose and $3.49{\pm}0.17%$ fructose. Native Gwangyang Rubus coreanus Miq. included higher vitamin C (0.04 g/100 g) and E (0.04 g/100 g) contents than other Rubus coreanus Miq. Anthocyanin was detected to be 2.41 g/100 g. Two extracts from native Gwangyang Rubus coreanus Miq., hot water extract (RCW) and 80% ethanol extract (RCE), were prepared by reflux, filter, and freeze-dry. The phenolic compound levels of RCW and RCE were 5.99% and 6.20%, respectively. In DPPH- and ABTS-radical scavenging activities, and lipid peroxidation formation inhibitory activity, RCE exhibited relatively high activities when compared to RCW (89.29% vs. 65.04%, 47.65% vs. 30.22%, 23.27% vs. 3.6%, respectively). Based upon these results, it is suggested that RCE from native Gwangyang Rubus coreanus Miq. possesses the antioxidant potentials for radical scavenging and anti-lipid peroxidation activities.

• Korean Journal of Organic Agriculture
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• v.24 no.4
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• pp.849-857
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• 2016

In the growth of the Rubus coreanus Miquel fruits, the unripened (10 days) and ripened (25 days) fruits after flowering were harvested. The chemical characteristics of different maturational stages of the unripened and ripened fruits were investigated. Total amount of phenolic compounds was 4.00-7.56% in the unripened fruits and 3.78-5.57% in the ripened fruits, respectively. Furthermore, total amounts of organic acids such as malic, citric, succinic, and oxalic acids were 16.40 mg/100 g in the unripened fruits and 28.82 mg/100 g in the ripened fruits, respectively. In organic acids of the unripened and the ripened fruits, citric acid (8.76-15.47 mg/100 g) was the highest amount among other organic acids. Soluble sugars were significantly increased from 11.07 to 21.54% in the unripened and ripened fruits. Therefore, ripened fruits had the high levels of phenolic compounds, organic acids and soluble sugars. For the biological studies of R. coreanus, methanol extracts of R. coreanus leaves, fruits, and stems were evaluated for their insecticidal activities against Myzus persicae (Hemiptera: Aphididae), Plutella xylostella (Lepioptera: Plutellidae) and Spodoptera litura (Lepioptera: Noctuidae) by leaf dipping method. From these results, the extract of R. coreanus leaves revealed potent insecticidal activity against P. xylostella. However, the methanol extracts of R. coreanus fruits and stems had no any insecticidal activity against M. persicae, P. xylostella and S. litura. The R. coreanus leaves have promising potential as new insecticidal agent against P. xylostella.

• Elastomers and Composites
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• v.35 no.4
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• pp.261-271
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• 2000

Physical properties of NR vulcanizates cured by both sulfur and resole were studied. Cure characteristics of the compounds were also investigated. Two types of resoles with different molecular weight distributions were employed. The scorch time of the NR compound containing the resole with a low molecular weight distribution was shorter than that of the compound containing the resole with a high one. Crosslink densities of the NR vulcanizates with a high resole content after the thermal aging at $95^{\circ}C$ decreased, while that of the vulcanizate without resole after the thermal aging at $95^{\circ}C$ increased. Though crosslink densities of the NR vulcanizates with a high resole content decreased with increasing the aging time, the moduli increased while the tensile strength and tear strength decreased.

• Journal of Environmental Impact Assessment
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• v.26 no.3
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• pp.207-216
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• 2017

Several bioassays have been performed for assessment of the impact of polluted sediments. The direct exposure method using sediments is limited by difficulty controlling feeding and its effects on organisms. Furthermore, only macro-organisms and benthic organisms are used. To evaluate the potential application of sediment elutriate as a complementary strategy for impact assessment, copepods, small organisms with a short life cycle, were exposed to sediment elutriates, and several end-points were measured. As a result, sediment elutriates prepared from polluted sites caused growth retardation in marine copepods. In terms of molecular biomarkers, antioxidant-related and chaperone protein gene expression levels were increased in a dose- and time-dependent manner. Thus, we suggest that sediment elutriate tests can provide an effective alternative for toxicity assessment using whole sediment samples. Further studies are required to obtain sufficient data for future applications.

• Korean Journal of Medicinal Crop Science
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• v.13 no.3
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• pp.81-86
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• 2005

The immune activities of the extracts from Ephedrae Herba and Rubi Frutus extraction with ultrasonification at $60^{\circ}C$ were compared with the extracts though water extraction at $100^{\circ}C$. The growth of human T cells was increased up to $13{\times}10^4\;viable\;cells/m{\ell}$ in adding $1.0\;g/{\ell}$ of the ultrasonification extracts of R. Fructus at $60^{\circ}C$, compared to adding the extracts at $100^{\circ}C$. The secretion of $TNF-{\alpha}$ for human T cells were also increased up to $13.9{\times}10^{-4}$ pg/cell by adding extracts at $60^{\circ}C$, compared to extracts at $100^{\circ}C$. The extracts of R. Fructus at $60^{\circ}C$ increased NK cell activities up to 50% and the secretion of $NO^{-1}$ from macrophage to $31\;{\mu}M$ for ultrasonification extracts at $60^{\circ}C$.