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http://dx.doi.org/10.12925/jkocs.2014.31.1.130

Antioxidant and Antihemolytic Activity of Ethanol Extracts of Rubus coreanus Miquel  

Jang, Tae-Su (Institute of Green Bio Science & Technology Seoul National University)
Yang, Jae-Chan (College of Sciences & Technology, Division of Biomedicinal & Cosmetics, Mokwon University)
Lim, Sun-Young (Institute of Green Bio Science & Technology Seoul National University)
Kim, Bo-Ae (College of Sciences & Technology, Division of Biomedicinal & Cosmetics, Mokwon University)
Publication Information
Journal of the Korean Applied Science and Technology / v.31, no.1, 2014 , pp. 130-135 More about this Journal
Abstract
To develop a natural antioxidant and anti-hemolytic agents, we investigated the effects of ethanol extracts of Rubus coreanus Miquel (crude extracts). Crude extract was extracted with ethanol. Antioxidant activity of crude extracts was evaluated by employing two different assays, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity and super oxide dismutase(SOD)-like activity. Also, anti-hemolytic activity of crude extract was determined using $H_2O_2$-induced hemolysis in normal rat red blood cells (RBC) or plasma. The extracts obtained from crude extract dose-dependently increased the scavenging activity on DPPH-induced radicals and SOD-like activity. RBC oxidative hemolysis induced by $H_2O_2$ was significantly suppressed by the extracts of Rubus coreanus Miquel in a dose-dependent manner. These results suggest that crude extracts may have value as the potential antioxidant and anti-hemolytic medicinal plant.
Keywords
Rubus coreanus Miquel; antioxidant; antihemolytic activity;
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