• Title/Summary/Keyword: 무작위 실험 연구

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Vitamin D and Risk of Respiratory Tract Infections in Children: A Systematic Review and Meta-analysis of Randomized Controlled Trials (비타민 D와 소아 호흡기 감염의 위험성: 무작위 대조 연구에 대한 체계적 문헌고찰 및 메타분석)

  • Ahn, Jong Gyun;Lee, Dokyung;Kim, Kyung-Hyo
    • Pediatric Infection and Vaccine
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    • v.23 no.2
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    • pp.109-116
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    • 2016
  • Purpose: Recent observational studies have found that vitamin D deficiency is associated with respiratory tract infections. However, randomized controlled trials (RCTs) regarding the efficacy of vitamin D in childhood respiratory tract infection (RTI) have yield inconsistent results. We performed a systematic review and meta-analysis to evaluate the association between vitamin D supplementation and the risk of RTI. Methods: A comprehensive search was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trial. Randomized controlled trials of vitamin D supplementation for prevention of RTI in children were included for the analysis. Cochrane Collaboration's tool for assessing the risk of bias was used to assess the quality of the studies. Pooled risk ratios with 95% confidence intervals (CIs) were meta-analyzed using Review Manager 5.3. Results: A total of seven RCTs were included in the meta-analysis. According to a random-effects model, the risk ratio for vitamin D supplementation was 0.82 (95% CI: 0.69-0.98) and $I^2=62%$ for heterogeneity. On subgroup analysis, heterogeneity decreased in the subgroup with follow-up less than 1 year, participants ${\geq}5years$ of age, patients subgroup, and subgroup with dosing daily. Funnel plot showed that there might be publication bias in the field. Conclusions: The present meta-analysis supports a beneficial effect of vitamin D supplementation for the prevention of RTI in children. However, the result should be interpreted with caution due to limitations including a small number of available RCTs, heterogeneity among the studies, and potential publication bias.

Differential Effects of Two Individual Acupuncture Points (BL62, KI6) on Heart Rate Variability in Healthy Volunteers : A Randomized, Single-Blind, Self-Controlled Trial (건강한 지원자에서 두 경혈(신맥, 조해)이 심박변이도에 미치는 영향의 차이 : 무작위, 단일 맹검, 자기 대조군 임상시험)

  • Lee, Ji-Hye;Choi, Young-Joon;Shin, Byung-Chul;Koo, Sung-Tae
    • Korean Journal of Acupuncture
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    • v.27 no.4
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    • pp.85-97
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    • 2010
  • 목적 : 이 연구는 서로 다른 두 경혈이 심박변이도에 미치는 영향을 비교하고, 자율신경계에 미치는 영향을 평가하기 위해 수행하였다. 재료 및 방법 : 13명의 지원자가 3개의 세션에 균등하게 무작위 배정되었다. 각 세션에서 지원자들은 신맥(BL62), 조해(KI6), 또는 비경혈에 각각 침처치를 받았다. 10분간 휴식을 한 후에 자침 전, 유침기간, 발침 후 기간에 5분 동안 심박변이도 측정을 하였다. 유침기간에는 2분 간격을 두고 2회 심박변이도를 측정하였다. 결과 : 신맥에 자침한 군에서는 자침후 기간에 total power(TP)와 standard deviation N-N interval(SDNN)이 유의하게 증가하였다. 유침기간 중 첫 5분 동안의 TP와 SDNN은 자침전 값과 유의한 차이가 없었으며 유침기간 중 마지막 5분 동안에는 다소 증가하는 경향은 있었지만 통계적인 유의성은 없었다. 반면에 조해와 비경혈에 자침한 군에서는 TP와 SDNN에 유의한 변화가 관찰되지 않았다. 발침 후에 신맥자침군에서는 조해와 비경혈 자극군과 비교해서 TP가 유의하게 변화하였다. 그러나 SDNN은 발침 후에 세 군 사이에 유의한 차이가 없었다. 결론 : 이 실험 결과는 조해와 비교했을 때 신맥에 자침한 경우 심장 기능 및 자율신경계와 관련이 있는 대체적인 활성이 증가한다는 것을 보여주었다. 이 결과는 신맥 자침이 자율신경계와 관계되어 있는 심장의 기능에 미치는 영향을 통해서 경혈의 특이성을 관찰할 수 있음을 의미한다.

A GCST-based Digital Image Watermarking Scheme (GCST 기반 디지털 영상 워터마킹 방법)

  • Lee, Juck-Sik
    • Journal of the Institute of Convergence Signal Processing
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    • v.13 no.3
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    • pp.142-149
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    • 2012
  • Various image transformations can be used to compress images, to reduce noises in images and to extract useful features. Watermarking techniques using DCT and DWT have been a lot of research interest in the spread of multimedia contents. In this paper, Gabor cosine and sine transform considered as human visual filter is applied to embedding and extraction of watermarks for digital images. The proposed transform is used for watermarking with fifteen attacks. Randomly normal distributed noises are used as an embedded watermark. To measure the similarity between the embedded watermark and extracted one, a correlation value is computed and furthermore is compared with that of existing DCT method. Correlation values of extracted watermark are computed with randomly normal distributed noise sequences, and the sequence with the largest correlation value is declared as the embedded watermark. Frequency components are divided into various bands. Experimental results for low frequency and mid-frequency bands have shown that the proposed GCST provides a good watermarking algorithm and its performance is better than DCT.

Effects of Virtual Reality Based Video game and Rehabilitation Exercise on the Balance and Activities of Daily Living of Chronic Stroke Patients (가상현실기반 비디오게임과 재활운동이 만성기 뇌졸중 환자의 균형 및 일상생활동작에 미치는 영향)

  • Lee, Hyun-Min
    • Journal of the Korean Society of Physical Medicine
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    • v.8 no.2
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    • pp.201-207
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    • 2013
  • 연구목적: 닌텐도 위를 이용한 가상현실기반 비디오게임 프로그램을 만성기 뇌졸중 환자에게 적용하여 균형능력 및 일상생활동작에 어떠한 영향을 미치는지 알아보고, 뇌졸중 환자의 재활프로그램으로서 적용 가능성이 있는지 알아보고자 한다. 연구방법: 만성기 뇌졸중 환자를 무작위로 가상현실기반 비디오게임 프로그램을 적용한 실험군(n=7)과 적용하지 않은 대조군(n=10)으로 구분하여 연구를 진행하였다. 연구에 참여한 모든 대상자에게 30분의 Bobath therapy와 15분간의 FES 치료를 기본적으로 실시하였다. 이에 더하여 실험군은 가상현실기반 비디오게임 프로그램을 1일 30분이내, 주 5회, 3주간 실시하였다. 대조군은 자전거 운동과 보행훈련으로 30분간 시행하였다. 실험 전 후 눈뜨고 외발서기(OLST; open leg standing test), Timed Up and Go(TUG) 검사, 10m 걷기 검사, Functional Independence Measure(FIM)를 측정하였다. 실험 전과 실험 후 측정값의 차이를 비교하기 위해 Wilcoxon Signed Ranks Test를 실시하였다. 그리고 각 측정값의 변화량에 대한 실험군과 대조군 사이의 차이를 알아보기 위해 Mann-Whitney U Test를 실시하였다. 연구결과: 실험결과는 다음과 같다. 1) 실험군에서는 FIM의 유의한 증가와 TUG, 10m 걷기 검사의 유의한 감소를(p<.05) 보였다. 대조군에서는 OLST의 증가와 TUG, 10m walking test의 감소가 나타났지만 통계적으로 유의하지 않았다. 오직 FIM에서만 유의한 증가가 나타났다(p<.05). 2) 실험 전 후의 실험군과 대조군의 각 측정값들의 평균차를 비교한 결과 실험군은 대조군보다 실험 전 후 OLST, TUG, 10m walking test 차이의 평균은 컸지만 통계적으로 유의하지 않았다. 결론: 이상의 결과로부터 가상현실기반 비디오게임이 만성기 뇌졸중 환자의 동적균형능력 및 일상생활동작 향상에 효과가 있음을 알 수 있었다.

Comparison of Range-of-motion test methods for measuring Clothing Mobility (의복의 기능성 측정을 위한 관절각도법에 관한 비교연구)

  • Kim, Young-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.27 no.12
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    • pp.1374-1380
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    • 2003
  • 본 연구의 목적은 의복의 기능성 측정의 객관적 평가를 위한 관절각도측정의 방법들 간에 상관관계를 분석하고, 컴퓨터를 이용한 측정방법을 개발, 이를 기존의 방법과 비교, 분석함으로써, 의복의 기능성 측정 및 기능적 디자인 개발에 기여함에 있다. 미국 Kansas 지역의 전문 소방수를 대상으로, 선택된 10가지 실험동작에서의 관절각(range-of-motion)을 computer-aided method, Leighton flexometer, goniometer를 사용하여 측정하였으며, 측정순서는 무작위 순서(random order)로 하였다. 독립변인으로는 3종류의 측정방법(computer-aided method, flexometer, goniometer)이며, 종속변인으로는 선택된 동작에서의 관절각(range-of-motion)이다. 또한 상관분석(correlation analysis)을 실시하여, 상관계수(correlation coefficient)를 측정한 통계처리결과, 각 측정방법들 간에 긍정적이며 유의적인 상관관계가 있는 것으로 나타났다.

The Research on video quality affected to visual emotion (시각 감성에 영향을 주는 동영상 화질변수에 관한 연구)

  • U, Jin-Cheol;Hwang, Min-Cheol;Park, Gang-Ryeong;Lee, Ui-Cheol;Kim, Jong-Hwa;Kim, Chi-Jung;Kim, Yong-U;Kim, Ji-Hye
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2009.11a
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    • pp.107-110
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    • 2009
  • 본 연구에서는 동영상 자극이 제시되었을 때 시각적으로 느껴지는 감성을 자율신경계 반응, 동공반응 그리고 주관 설문으로 평가하였다. 20~27세 사이의 대학생 남녀 20명이 실험에 참여 하였고 뉴스, 다큐멘터리1, 다큐멘터리2, 사랑, 스포츠 그리고 전쟁의 6가지 장르의 동영상에서 Gamma, Hue, Lightness 그리고 Saturation의 4가지 화질변수가 변경된 영상을 시각자극으로 제시하였다. 장르를 다르게 한 실험이 총 6회 진행되었으며 장르별로 기본영상 1개와 화질변수가 변경된 영상 16개가 무작위 순서로 제시되었다. 1회 실험이 진행되는 약 14분 동안 PPG, SKT 그리고 GSR 센서를 착용하여 생리 반응을 측정하였고 눈 영상을 기록하여 동공 반응을 측정하였다. 시각자극에 대한 주관적 평가를 위해 1~7점 척도의 불쾌도, 긴장도 그리고 피로도 항목의 설문을 실시하였다. 생리반응, 동공반응 그리고 주관설문 결과를 화질변수 별로 나누고 일원배치 분산분석을 실시하여 차이가 있는지를 확인하였다. 그 결과 시각 감성이 어떤 화질변수에 의해 유발되는지 확인할 수 있었다.

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Microleakage Assessment of Resin Infiltration Combined Restoration in Artificial Decalcified-Cavitated Lesion (인공 우식 수복시 레진 침투법 전처리의 미세누출에 대한 효과)

  • Jang, Eunjeong;Park, Soyoung;Shin, Jonghyun;Kim, Shin;Jeong, Taesung
    • Journal of the korean academy of Pediatric Dentistry
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    • v.47 no.3
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    • pp.257-265
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    • 2020
  • This study was performed to evaluate the restoration combined with resin infiltration (RI) of early cavitated smooth surface caries lesion in terms of microleakage. Flowable resin and resin-modified glass ionomer cement (RMGIC) were compared. Sound 20 extracted 3rd molars were divided into 2 groups randomly. Artificial decalcified lesion was induced. Cavities were prepared on the mesial and distal surfaces, and randomly set as experimental and control group. RI was applied to the experimental group before cavity restoration. The control group was restored without RI. In group I and II, flowable resin and RMGIC was used for restoration respectively. After thermocycling and silver nitrate immersion, microleakage was assessed by μ-CT. Depth of microleakage was lower in experimental group than control group only in group II (p = 0.05). Microleakage depth was lower in group II than group I in both experimental and control groups (p = 0.05). RI pretreatment before restoration of early cavitated caries lesions might reduce the microleakage and help long-term maintenance of restoration. In this study, RMGIC was less polymerization shrinkage. Restoration with RMGIC after RI pretreatment reduced the microleakage of the restoration compared to the flowable resin.

Study of the Effect of Blood-letting Cupping Treatment for Acute Ankle Sprain: A Randomize Controlled Trial (급성기 족관절 염좌에 있어 자락발관법의 효과에 대한 연구:무작위 대조 실험)

  • Hwang, Jong-soon;Lim, Dae-jung;Hwang, Ji-hye;Cho, Hyun-seok;Kim, Kyung-ho
    • Journal of Acupuncture Research
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    • v.22 no.3
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    • pp.243-252
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    • 2005
  • Objective : This study was performed to investigate the effect of blood-letting cupping treatment for acute ankle sprain because there are few studies with evidence-based approach. Method : Twenty-nine patients, who had no fracture and had injured by external force and had less than 1 week passed since onset and had not been treated, were randomly divided into control or treatment group by tossing a coin. The treatment group received blood-letting cupping. After 3rd treatment, the outcomes were assessed using Ankle-Hindfoot Scale (AHS) and Numeric Rating Scale (NRS). Result : Nineteen out of 29 patients were finally assessed. The treatment group (n=11) was significantly different from the control group (n=8) in AHS and NRS (p=0.041, 0.026, respectively). Conclusion : The blood-letting cupping has an objective effect on reduing pain for acute ankle sprain.

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The Effects of Group Occupational Therapy Including Education Programs on Depression, Anxiety, and Participation of Activities in People With Dementia (교육 프로그램을 포함한 집단작업치료가 치매환자의 우울, 불안, 활동참여에 미치는 영향: 무작위 대조군 사전-사후 설계)

  • Ham, Min-Joo;Kim, Hee
    • Korean Journal of Occupational Therapy
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    • v.26 no.4
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    • pp.97-109
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    • 2018
  • Objective : The purpose of this study was to examine the effect of group occupational therapy including education regarding depression, anxiety, and activity participation in people with dementia. Methods : Nineteen people with dementia were randomly assigned to experimental(n=10) and control group(n=9). The participants in experimental group conducted occupational therapy including education, whereas the control group occupational therapy only. Pre- and post- assessments were applied using Korean form of Geriatric Depression Scale(K-GDS), Hamilton Anxiety Scale(HAM-A), State Trait Anxiety Inventory(STAI-X-1), and Korean Activity Card Sort (K-ACS). Results : When comparing the differences between pre- and post- of the intervention, the depression and anxiety of occupational therapy group including the educational program decreased statistically(p<.05). Conclusion : This study has shown that occupational therapy including education has significant effects on reducing depression and anxiety in people with dementia. In the future, it will be necessary to develop an intervention program to strengthen the psychological and emotional aspects of people with dementia, and various studies in the field of occupational therapy focusing on care giver education should be conducted.

Effects of Light Therapy on Stress, Depression, Quality of Sleep and Quality of Life in Middle-Aged Women: A Randomized Controlled Trial (빛 요법이 중년여성의 스트레스, 우울, 수면의 질 및 삶의 질에 미치는 효과: 무작위 대조군 연구)

  • Jang, Mi-Kyeong;Hur, Myung-Haeng
    • Journal of the Korea Convergence Society
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    • v.12 no.7
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    • pp.317-327
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    • 2021
  • This study is a randomized controlled trial to compare the effects of light therapy on stress, depression, sleep quality and quality of life in middle-aged women. The participants of this study were 56 middle-aged women who worked at the same office. Data collection period was from August 26 to September 13 for the control group and from September 16 to October 4 for the experimental group. Subjective stress, depression, quality of sleep and quality of life in middle-aged women were measured by Numeric Rating Scale (NRS), Center for Epidemiology studies of scale (CES-D), Verran & Synder-Halpern Sleep scale (VHS) and WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF). Stress index was measured using a Canopy9 RSA (IEMBIO, Gangwondo, Korea) equipment. The data were analyzed by mean, standard deviation, real number and percentage, χ2-test, t-test, repeated measures ANOVA and ANCOVA using IBM SPSS Statistics version 25.0. The results showed that the experimental group applying light therapy had significantly lower subjective stress (F=6.30, p<.001) and higher quality of life (F=2.80, p=.049) than the control group, There was no difference in objective stress index, depression, and sleep quality. As a result, light therapy is partially effective in subjective stress and quality of life for middle-aged women, and further research is needed on middle-aged women working in work environments with limited light exposure.