• Journal of the KSME
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• v.50 no.11
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• pp.28-30
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• 2010

이 글에서는 미세유체 기술을 활용하여 혈관 내의 유동에 의하여 발생하는 전단응력이 혈관 내부의 다양한 세포의 기능 및 상호작용에 미치는 영향을 연구하는 기술에 대하여 소개하고자 한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.3
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• pp.880-890
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• 2010

The intrasvascular ultrasound (IVUS) imaging technique is used to diagnose cerebrovascular diseases such as stroke. Recently, elasticity imaging methods have been investigated to diagnose blood clots attached to blood vessel intima. However, the IVUS imaging technique is an invasive method that requires a transducer to be inserted into blood vessel. In this paper, strain images are obtained of blood clots attached to blood vessel intima with data acquired from outside the blood vessel using a linear array transducer. In order to measure the displacement of blood vessel accurately, experimental data are acquired by steering ultrasound beams so that they can intersect the blood vessel wall at right angles. The acquired rf data are demodulated to the baseband. The resulting complex baseband signals are then processed by an autocorrelation algorithm to compute the blood vessel movement and thereby produce strain image. This proposed method is verified by experiments on a plastic blood vessel mimicking phantom. The efficacy of the proposed method was verified using a home-made blood vessel mimicking phantom. The blood vessel mimicking phantom was constructed by making a 6 mm diameter hollow cylinder inside it to simulate a blood vessel and adhering 2 mm thick soft plaque to the inner wall of the hollow cylinder. The RF data were acquired using a clinical ultrasound scanner (Accuvix XQ, Medison, Seoul. Korea) with a 7.5 MHz linear array transducer by steering ultrasound beams in steps of $1^{\circ}$ from $-40^{\circ}$ to $40^{\circ}$ for a total of 81 angles. Experimental results show that the plaque region near the blood vessel wall is softer than background tissue. Although the imaging region is restricted due to the limited range of angles for which scan lines are perpendicular to the wall, the feasibility of strain imaging is demonstrated.

• Journal of IKEEE
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• v.26 no.1
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• pp.27-35
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• 2022

This paper proposes an ultrasound vessel-pattern imaging algorithm with low computational complexity. The proposed imaging algorithm reconstructs blood-vessel patterns by only detecting blood flow, and can be applied to a real-time signal processing hardware that extracts an ultrasonic finger-vessel pattern. Unlike a blood-flow imaging mode of typical ultrasound medical imaging device, the proposed imaging algorithm only reconstructs a presence of blood flow as an image. That is, since the proposed algorithm does not use an I/Q demodulation and detects a presence of blood flow by accumulating an absolute value of the clutter-filter output, a structure of the algorithm is relatively simple. To verify a complexity of the proposed algorithm, a simulation model for finger vessel was implemented using Field-II program. Through the behavioral simulation, it was confirmed that the processing time of the proposed algorithm is around 54 times less than that of the typical color-flow mode. Considering the required main building blocks and the amount of computation, the proposed algorithm is simple to implement in hardware such as an FPGA and an ASIC.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1484-1486
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• 2008

Characteristics of pulsatile flow in 3-dimensional elastic vessel wall should be investigated in order to understand the physiological blood flow in human body. In this study, the modelling of the physiological blood flow in the elastic blood vessel is proposed. Variation of the pressure and the velocity wavefroms are obtained using the FSI method

• Journal of Biomedical Engineering Research
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• v.23 no.5
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• pp.365-373
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• 2002

Accurate localization of target lesion is required to protect normal peripheral tissue and irradiate exactly to tumors in stereotactic radiosurgery(SRS). Digital angiography is one of the most effective diagnostic tools to detect and identify the target tumors. However, it shows pincushion distortion due to the characteristics of the image intensifier. We have implemented a simulation study for the correction of distortion using the geometric transformation. Phantom images were produced transformation. In conclusion, the geometric transformation could effectively be used for the pincushion distortion of image intensifier and there was no significant different between two methods indicating 2% correction error from the ideal image in all cases.

• Journal of the Korean Society of Visualization
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• v.14 no.1
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• pp.33-39
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• 2016

Radio-cephalic arteriovenous fistula(RC-AVF) is the most recommended operation of achieving access for hemodialysis. However, it has high rates of early failure depending on the many haemodynamic conditions. To increase RC-AVF patency rate, many researches were performed by in-vitro experiment via artificial vessel and blood analogue fluid, and there were conflicting opinions about whether the non-Newtonian properties of blood have an influence on the flow in large arteries. To investigate the influence of viscoelasticity of blood within the RC-AVF, we fabricated three dimensional artificial RC-AVF and two kinds of blood analogue fluid. The velocity field of two fluids within the vessel were measured by micro-particle velocimetry(m-PIV) and compared with each other. The velocity profiles of both fluids for systolic phase were matched well while those for diastolic phase did not correspond. Therefore, it is desired to use non-newtonian fluid for in-vitro experiment of RC-AVF.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.2
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• pp.29-33
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• 2010

We have investigated fs-laser ablation as well as optoperforation threshold of PDMS (Polydimethylsiloxane) thin lid cover on ${\mu}$-channel with changing the flow medium from water to hemoglobin. The ablation threshold is found to be independent of both PDMS thin film thickness and flow medium, but the optoperforation threshold is dependent on the films thickness. The observation that the ablation process is well described with simple two-temperature model supposed that the cover lid PDMS of $\mu$-channel be processed with minimized thermal effects by fs-laser with low laser fluence.

• The Korean Journal of Rheology
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• v.6 no.2
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• pp.157-164
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• 1994

인체 동맥혈관내 혈액의 유동현상을 수치적으로 해석하기 위해서는 혈액의 유변학 적 성질을 구성방정식으로 나타내어야한다. 본 연구에서는 혈액의 점성계수를 표현하기 위 하여 비뉴턴유체의 점성을 나타내는 식으로서 Carreau 모델, 수정 Cross 모델, 수정 Powell-Eyring 모델과 수정멱법칙모델을 사용하였고 원형관내 혈액의 정상유동을 수치모사 하기 위하여 겉보기점성계수를 이용하는 구성방정식을 운동량방정식에 적용하였다. Carreau 모델과 수정멱법칙모델을 적용할 때 레이놀즈수의 변화가 중심선상의 속도와 길이방향의 압 력변화에 미치는 영향을 고찰하였다. 전단율이 높은영역에서 혈액의 겉보기점성계수를 효과 적으로 나타낼수 있는 수정멱법칙모델을 제시하였다.

• Journal of Biomedical Engineering Research
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• v.23 no.4
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• pp.281-286
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• 2002

In this study, blood flow in a carotid artery supplying blood to the human's brain has been numerically simulated to find out how the blood flow affects the genesis and the growth of atherosclerosis and arterial thrombosis. Velocity Profiles and hemodynamic parameters have been investigated for the carotid arteries with three different stenoses under physiological flow condition. Blood has been treated as Newtonian and non-Newtonian fluid. To model the shear thinning properties of blood for non-Newtonian fluid, the Carreau-Yasuda model has been employed. The result shows that the wall shear stress(WSS) increases with the development of stenosis and that the wall shear stress in Newtonian fluid is highly evaluated compared with that in non-Newtonian Fluid. Oscillatory shear index has been employed to identify the time-averaged reattachment point and this point is located farther from the stenosis for Newtonian fluid than for non-Newtonian fluid The wall shear stress gradient(WSSG) along the wall has been estimated to be very high around the stenosis region when stenosis is developed much and the WSSG peak value of Newtonian fluid is higher than that of non-Newtonian fluid.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.915-918
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• 2016

Virtual testing devices are required due to rapid changes in the health care industry and the increase of the medical or nursing workforce. The importance of devices such as the simulator, blood vessels, and lab equipment for modeling blood flow to the heart is increasing too. In this study, we made heart pump by using a step motor and developed device which simulates arterial, venous blood pressure, and blood flow. We finally evaluated the function of proposed device. The proposed system is composed of the pump for simulating, the valve device to describe the resistance of the artery and vein, and a reducing device showing the characteristics of the venous system. We used BOXER pump for heart simulator and silicon tube for arterial and venous vessels, and designed a reducing device. We also used the pressure sensor to measure arterial blood pressure. For the evaluation of the proposed system, we selected a range of 50~100mmHg of the blood circuit 60 per minute and then compared the blood pressure of a person and the measured blood pressure.